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Conserved domains on  [gi|71997604|ref|NP_492450|]
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TM2 domain-containing protein ZK858.5 [Caenorhabditis elegans]

Protein Classification

TM2 domain-containing protein( domain architecture ID 10524121)

TM2 domain-containing protein similar to Homo sapiens TM2 domain-containing protein 1 (TM2D1) that may participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42

Gene Ontology:  GO:0097190|GO:0004930|GO:0001540

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 6-55 1.20e-06

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


:

Pssm-ID: 428337  Cd Length: 50  Bit Score: 45.18  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71997604     6 TEVKPWIVRIILIVGGLFGAHRLYLKQVPEAFVFFSTLGVLLIGWLYDSF 55
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 146-229 9.53e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member pfam05977:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 523  Bit Score: 38.19  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997604   146 IIGQCGGQSRELSYIW-MASFSSMFIMVRLAQTTVFRAIFLTAIVSTVIGNrsaRLKKRRhtwkhFLFWSSLFLMLVCVI 224
Cdd:pfam05977  20 LASNLGTLMQDVAASWlMTSLSASPLMVALVQAAATLPIFLLSIPAGALAD---NFDRRK-----IMLAGQLLLALVSTL 91


                  ....*
gi 71997604   225 LLGCS 229
Cdd:pfam05977  92 LTLLA 96
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 6-55 1.20e-06

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 45.18  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71997604     6 TEVKPWIVRIILIVGGLFGAHRLYLKQVPEAFVFFSTLGVLLIGWLYDSF 55
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 1-57 2.35e-03

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 36.82  E-value: 2.35e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 71997604   1 MNNEETEVKPWIVRIILIVGGLFGAHRLYLKQVPEAFV--FFSTLGVLLIGWLYDSFMF 57
Cdd:COG2314   1 AELPKSEKSKLVAGLLAIFLGGFGIHRFYLGKTGTGIIylLFFWTGIPGIIGLIDGILY 59
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 146-229 9.53e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 38.19  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997604   146 IIGQCGGQSRELSYIW-MASFSSMFIMVRLAQTTVFRAIFLTAIVSTVIGNrsaRLKKRRhtwkhFLFWSSLFLMLVCVI 224
Cdd:pfam05977  20 LASNLGTLMQDVAASWlMTSLSASPLMVALVQAAATLPIFLLSIPAGALAD---NFDRRK-----IMLAGQLLLALVSTL 91


                  ....*
gi 71997604   225 LLGCS 229
Cdd:pfam05977  92 LTLLA 96
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 6-55 1.20e-06

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 45.18  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71997604     6 TEVKPWIVRIILIVGGLFGAHRLYLKQVPEAFVFFSTLGVLLIGWLYDSF 55
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 1-57 2.35e-03

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 36.82  E-value: 2.35e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 71997604   1 MNNEETEVKPWIVRIILIVGGLFGAHRLYLKQVPEAFV--FFSTLGVLLIGWLYDSFMF 57
Cdd:COG2314   1 AELPKSEKSKLVAGLLAIFLGGFGIHRFYLGKTGTGIIylLFFWTGIPGIIGLIDGILY 59
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 146-229 9.53e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 38.19  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997604   146 IIGQCGGQSRELSYIW-MASFSSMFIMVRLAQTTVFRAIFLTAIVSTVIGNrsaRLKKRRhtwkhFLFWSSLFLMLVCVI 224
Cdd:pfam05977  20 LASNLGTLMQDVAASWlMTSLSASPLMVALVQAAATLPIFLLSIPAGALAD---NFDRRK-----IMLAGQLLLALVSTL 91


                  ....*
gi 71997604   225 LLGCS 229
Cdd:pfam05977  92 LTLLA 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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