Transmembrane protein 208 [Caenorhabditis elegans]
Protein Classification
SND2/TMEM208 family protein( domain architecture ID 6072)
SRP-independent targeting protein 2 (SND2)/transmembrane protein 208 (TMEM208) family protein is a DUF788 domain-containing protein similar to vertebrate TMEM208 that may function as a negative regulator of endoplasmic reticulum-stress induced autophagy, and yeast SND2 that functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| TMEM208_SND2 super family | cl05277 | SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting ... |
4-163 | 3.85e-33 | ||||
SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER). SND2 works together with SND1 and SND3 in an alternative targeting route to the ER. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homolog as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology and meiosis, respectively. The actual alignment was detected with superfamily member pfam05620: Pssm-ID: 428546 Cd Length: 167 Bit Score: 115.34 E-value: 3.85e-33
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| Name | Accession | Description | Interval | E-value | ||||
| TMEM208_SND2 | pfam05620 | SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting ... |
4-163 | 3.85e-33 | ||||
SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER). SND2 works together with SND1 and SND3 in an alternative targeting route to the ER. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homolog as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology and meiosis, respectively. Pssm-ID: 428546 Cd Length: 167 Bit Score: 115.34 E-value: 3.85e-33
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| Name | Accession | Description | Interval | E-value | ||||
| TMEM208_SND2 | pfam05620 | SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting ... |
4-163 | 3.85e-33 | ||||
SRP-independent targeting protein 2/TMEM208; This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER). SND2 works together with SND1 and SND3 in an alternative targeting route to the ER. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homolog as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology and meiosis, respectively. Pssm-ID: 428546 Cd Length: 167 Bit Score: 115.34 E-value: 3.85e-33
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