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Conserved domains on  [gi|17506607|ref|NP_492063|]
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DYnein Light chain (Tctex type) [Caenorhabditis elegans]

Protein Classification

dynein light chain Tctex-type family protein( domain architecture ID 16901526)

dynein light chain Tctex-type family protein similar to dynein light chain Tctex-type protein, which acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function

CATH:  3.30.1140.40
Gene Ontology:  GO:0005868|GO:0007018|GO:0045505
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 6-104 2.79e-33

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


:

Pssm-ID: 412003  Cd Length: 97  Bit Score: 111.13  E-value: 2.79e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGaSTQYTHKDSVQWNQKAVEQITKKLVAAGKPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:cd21455   1 EEVESIVKEAIEAVLG-DKTYSHSKVNQWSNSIVEEILKRLAKLNKPFKYIVTCVIMQ-KTGAGLHTASSCYWDPTTDGS 78

                        90
                ....*....|....*....
gi 17506607  86 YMYRWEAKTMLAIVYVFAI 104
Cdd:cd21455  79 VTVRWENKTMYCIVTVFGL 97
 
Name Accession Description Interval E-value
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 6-104 2.79e-33

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 111.13  E-value: 2.79e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGaSTQYTHKDSVQWNQKAVEQITKKLVAAGKPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:cd21455   1 EEVESIVKEAIEAVLG-DKTYSHSKVNQWSNSIVEEILKRLAKLNKPFKYIVTCVIMQ-KTGAGLHTASSCYWDPTTDGS 78

                        90
                ....*....|....*....
gi 17506607  86 YMYRWEAKTMLAIVYVFAI 104
Cdd:cd21455  79 VTVRWENKTMYCIVTVFGL 97
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 7-102 2.56e-22

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 82.96  E-value: 2.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607     7 DVHMIIKQVLDEVVGASTQYTHKDSVQWNQKAVEQITKKLVAAG-KPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:pfam03645   1 EVKEIIKEVLEEVLGGGETYDHEKVPQWTKEISEEILDRLKELGfKRYKYIVNVTIGQ-KNGQGVHVASRCLWDPETDGY 79

                          90
                  ....*....|....*..
gi 17506607    86 YMYRWEAKTMLAIVYVF 102
Cdd:pfam03645  80 ASYKFENKSLFAVVTVF 96
 
Name Accession Description Interval E-value
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 6-104 2.79e-33

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 111.13  E-value: 2.79e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGaSTQYTHKDSVQWNQKAVEQITKKLVAAGKPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:cd21455   1 EEVESIVKEAIEAVLG-DKTYSHSKVNQWSNSIVEEILKRLAKLNKPFKYIVTCVIMQ-KTGAGLHTASSCYWDPTTDGS 78

                        90
                ....*....|....*....
gi 17506607  86 YMYRWEAKTMLAIVYVFAI 104
Cdd:cd21455  79 VTVRWENKTMYCIVTVFGL 97
DLC-like_DYNLT1 cd21462
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and ...
 6-106 2.11e-22

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins; Dynein light chain Tctex-type 1 (DYNLT1), also called TCTEL1, or TCTEX1, or protein CW-1, or T-complex testis-specific protein 1 homolog, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It plays a role in neuronal morphogenesis. It is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1.


Pssm-ID: 412010  Cd Length: 102  Bit Score: 83.66  E-value: 2.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGASTqYTHKDSVQWNQKAVEQITKKLVAAGKPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:cd21462   4 DEVSNIIKEAIESTIGGNA-YQHNKVNQWTSNVVEQCLNQLTKLGKPFKYIVTCVIMQ-KNGAGLHTASSCFWDNSTDGS 81

                        90       100
                ....*....|....*....|.
gi 17506607  86 YMYRWEAKTMLAIVYVFAIAI 106
Cdd:cd21462  82 CTVRWENKTMYCIVSVFGLAI 102
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 7-102 2.56e-22

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 82.96  E-value: 2.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607     7 DVHMIIKQVLDEVVGASTQYTHKDSVQWNQKAVEQITKKLVAAG-KPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:pfam03645   1 EVKEIIKEVLEEVLGGGETYDHEKVPQWTKEISEEILDRLKELGfKRYKYIVNVTIGQ-KNGQGVHVASRCLWDPETDGY 79

                          90
                  ....*....|....*..
gi 17506607    86 YMYRWEAKTMLAIVYVF 102
Cdd:pfam03645  80 ASYKFENKSLFAVVTVF 96
DLC-like_DYNLT3 cd21463
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and ...
 6-104 2.26e-19

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins; Dynein light chain Tctex-type 3 (DYNLT3), also called rp3, or protein 91/23, or T-complex-associated testis-expressed 1-like, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It has a potential role in chromosome congression in human mitosis and is required for chromosome alignment during mouse oocyte meiotic maturation. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT3.


Pssm-ID: 412011  Cd Length: 97  Bit Score: 75.70  E-value: 2.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGAsTQYTHKDSVQWNQKAVEQITKKLVAAGKPYKYVVTSSFLQiSSGSGLNVSTISYWNKVTDSS 85
Cdd:cd21463   1 DEASNVVKECIEGILGG-VDYNHNKINQWTAAIVEQSLTHLVKLGKPFKYIVTCAVMQ-KSGAGLHTASSCFWDTTTDGS 78

                        90
                ....*....|....*....
gi 17506607  86 YMYRWEAKTMLAIVYVFAI 104
Cdd:cd21463  79 CTVRWENRTMYCVVSVFAV 97
DLC-like_SpDlc1-like cd21456
dynein light chain (DLC)-like domain found in Schizosaccharomyces pombe dynein light chain ...
 11-99 6.63e-11

dynein light chain (DLC)-like domain found in Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1) and similar proteins; Schizosaccharomyces pombe dynein light chain 1 (SpDlc1) belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. The model corresponds to the dynein light chain (DLC)-like domain found in SpDlc1 and similar proteins.


Pssm-ID: 412004  Cd Length: 110  Bit Score: 54.29  E-value: 6.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607  11 IIKQVLDEVVGASTQYTHKDSVQWNQKAVEQITKKLV-AAGKPYKYVVTSSFLQISSGS----GLNVSTISYWNKVTDSS 85
Cdd:cd21456  10 IASEACTSALGSVESYDHDKTSTWNSEIINTILKALIkETSPSYKFIVNSTIVQHLPPShgrrGMHSATGAFWNNEKDGM 89

                        90
                ....*....|....
gi 17506607  86 YMYRWEAKTMLAIV 99
Cdd:cd21456  90 WTYKWSGGKGVDVV 103
DLC-like_DYNLT1-like cd21448
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 6-102 1.52e-10

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) subfamily and similar proteins; The dynein light chain Tctex-type 1 (DYNLT1) subfamily includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The family also includes Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1), Saccharomyces cerevisiae topoisomerase I damage affected protein 2 (TDA2) and similar proteins. SpDlc1 belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. TDA2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules.


Pssm-ID: 411996  Cd Length: 98  Bit Score: 53.22  E-value: 1.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   6 EDVHMIIKQVLDEVVGaSTQYTHKDSVQWNQKAVEQITKKLVAAGK-PYKYVVTSSFLQISsGSGLNVSTISYWNKVTDS 84
Cdd:cd21448   1 RKLVTIIQEAIDSALD-DNEYDHAKTESWSNLIIKLVLSELEKLSKsPFKYIANCTILSIN-NFGLHTATGAFWDSKKDG 78

                        90
                ....*....|....*...
gi 17506607  85 SYMYRWEAKTMLAIVYVF 102
Cdd:cd21448  79 SFTYKWENKNMCQCITIL 96
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 5-104 3.50e-08

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 47.10  E-value: 3.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607   5 EEDVHMIIKQVLDEVVgASTQYTHKDSVQWNQKAVEQITKKLVAAGKP-YKYVVTSSFLQISsGSGLNVSTISYWNKVTD 83
Cdd:cd21451   3 PEKVKKIIKEVLEERL-ENVTYDPEECAQLCKELSEEIKDRVKELGFDrYKIVVQVTIGEKK-GQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 17506607  84 SSYMYRWEAKTMLAIVYVFAI 104
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 11-103 1.48e-05

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 40.01  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506607  11 IIKQVLDEVVGaSTQYTHKDSVQWNQKAVEQITKKLVAAGKP-YKYVVTSSFLQISsGSGLNVSTISYWNKVTDSSYMYR 89
Cdd:cd21449   5 IIKEVLESILD-DKEYDPLKLKEIAKKISEEIKEKLKELSPSrYKYIVHVTISENN-GQGIRADSGCLWDPDTDGFVSEV 82

                        90
                ....*....|....
gi 17506607  90 WEAKTMLAIVYVFA 103
Cdd:cd21449  83 YENDNIICTVTVFG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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