|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
190-570 |
2.52e-137 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 407.23 E-value: 2.52e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 190 SFLEMKFPKSLLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMfcleqemKLPFMRSEGPFG 269
Cdd:COG0513 3 SFADLGLSPPLLKALAEL-GYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQ-------RLDPSRPRAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 270 LIIVPSRELARQIFdliiEMFDALGK-AGLpemRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCR 348
Cdd:COG0513 75 LILAPTRELALQVA----EELRKLAKyLGL---RVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 349 YLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSEN 428
Cdd:COG0513 148 TLVLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 429 K---LVRVLEclQKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGL 505
Cdd:COG0513 228 KlelLRRLLR--DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGI 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17507945 506 DFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFINKKsEMSVLSDLKQLLaeaGQELPE 570
Cdd:COG0513 306 DIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPD-ERRLLRAIEKLI---GQKIEE 366
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
206-406 |
5.35e-121 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 357.42 E-value: 5.35e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17951 6 KKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGEGPYGLIVCPSRELARQTHEV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEMFDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd17951 86 IEYYCKALQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFEE 165
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17507945 366 EIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVN 406
Cdd:cd17951 166 DIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTVN 206
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
164-576 |
1.86e-111 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 345.22 E-value: 1.86e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 164 SQEDYEIQRKRLGISCEGDHIPPPIGSFLEMKFPKSLLEFMqKQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMT 243
Cdd:PTZ00110 105 SKEVDEIRKEKEITIIAGENVPKPVVSFEYTSFPDYILKSL-KNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLA 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 244 FVLPLVMFCLEQemklPFMR-SEGPFGLIIVPSRELARQIFDLIIEmFDALGKaglpeMRAGLCIGGVPIGEQAKDVRDG 322
Cdd:PTZ00110 184 FLLPAIVHINAQ----PLLRyGDGPIVLVLAPTRELAEQIREQCNK-FGASSK-----IRNTVAYGGVPKRGQIYALRRG 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 323 IHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALV-K 401
Cdd:PTZ00110 254 VEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKeE 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 402 PIVVNVGRAG-AASLNVLQELEFVRSENKLVRVLECLQK---TSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQ 477
Cdd:PTZ00110 334 PVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRimrDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQ 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 478 SDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFINkKSEMSVLSDL 557
Cdd:PTZ00110 414 EERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT-PDKYRLARDL 492
|
410
....*....|....*....
gi 17507945 558 KQLLAEAGQELPEFLKMLA 576
Cdd:PTZ00110 493 VKVLREAKQPVPPELEKLS 511
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
155-569 |
1.95e-84 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 273.97 E-value: 1.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 155 RPPGHIRRQSQEDYEIQRKRLGISCEGDHIPPPIGSFLEMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIA 234
Cdd:PLN00206 87 RDPGSTSGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLET-AGYEFPTPIQMQAIPAALSGRSLLVSA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 235 STGSGKTMTFVLPLVMFCLEQEMKLPfMRSEGPFGLIIVPSRELARQIFDliieMFDALGKaGLPeMRAGLCIGGVPIGE 314
Cdd:PLN00206 166 DTGSGKTASFLVPIISRCCTIRSGHP-SEQRNPLAMVLTPTRELCVQVED----QAKVLGK-GLP-FKTALVVGGDAMPQ 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 315 QAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFkAQRQTLLFSATMPRKIQFF 394
Cdd:PLN00206 239 QLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKF 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 395 AKSALVKPIVVNVGRAGAASLNVLQELEFVRSENKLVRVLECLQKTS---PKVLIFAEKKVDVDNIYEYL-LVKGVEVAS 470
Cdd:PLN00206 318 ASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILKSKQhfkPPAVVFVSSRLGADLLANAItVVTGLKALS 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 471 IHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFINKKSE 550
Cdd:PLN00206 398 IHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDR 477
|
410
....*....|....*....
gi 17507945 551 mSVLSDLKQLLAEAGQELP 569
Cdd:PLN00206 478 -NLFPELVALLKSSGAAIP 495
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
206-405 |
3.50e-78 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 246.58 E-value: 3.50e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKlpfmRSEGPFGLIIVPSRELARQIFdl 285
Cdd:cd00268 6 KKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKK----KGRGPQALVLAPTRELAMQIA-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iiEMFDALGKAglPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd00268 80 --EVARKLGKG--TGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 17507945 366 EIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd00268 156 DVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
190-561 |
6.49e-77 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 252.41 E-value: 6.49e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 190 SFLEMKFPKSLLEFMQkQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfcleQEMKLPFMRSEGpfg 269
Cdd:PRK11776 5 AFSTLPLPPALLANLN-ELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLL-----QKLDVKRFRVQA--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 270 LIIVPSRELARQIFDLIiemfDALGKaGLPEMRA-GLCiGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCR 348
Cdd:PRK11776 76 LVLCPTRELADQVAKEI----RRLAR-FIPNIKVlTLC-GGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 349 YLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASlNVLQELEFVRSEN 428
Cdd:PRK11776 150 TLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLP-AIEQRFYEVSPDE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 429 K---LVRVLECLQKTSpkVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGL 505
Cdd:PRK11776 229 RlpaLQRLLLHHQPES--CVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 17507945 506 DFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFINKKsEMSVLSDLKQLL 561
Cdd:PRK11776 307 DIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPE-EMQRANAIEDYL 361
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
191-545 |
3.67e-70 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 233.68 E-value: 3.67e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 191 FLEMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEqemkLPFMRSEGPFGL 270
Cdd:PRK11192 3 FSELELDESLLEALQD-KGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLD----FPRRKSGPPRIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 271 IIVPSRELARQIFDliiemfDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYL 350
Cdd:PRK11192 78 ILTPTRELAMQVAD------QARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 351 VLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRK-IQFFAKSALVKPIVVNVgragaaslnvlqelEFVRSENK 429
Cdd:PRK11192 152 ILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEVEA--------------EPSRRERK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 430 ------------------LVRVLEclQKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNE 491
Cdd:PRK11192 218 kihqwyyraddlehktalLCHLLK--QPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGR 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 17507945 492 KDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFI 545
Cdd:PRK11192 296 VNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
207-561 |
3.60e-69 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 231.62 E-value: 3.60e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 207 QKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEmklPFMRSEGPF-GLIIVPSRELARQIFDL 285
Cdd:PRK10590 18 EQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQ---PHAKGRRPVrALILTPTRELAAQIGEN 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:PRK10590 95 VRDYSKYLN------IRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIH 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 366 EIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSENKlvRVLECL---QKTSP 442
Cdd:PRK10590 169 DIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRK--RELLSQmigKGNWQ 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 443 KVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDI 522
Cdd:PRK10590 247 QVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVP 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 17507945 523 ENYVHRIGRTGRSGRKGLATTFINkKSEMSVLSDLKQLL 561
Cdd:PRK10590 327 EDYVHRIGRTGRAAATGEALSLVC-VDEHKLLRDIEKLL 364
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
181-403 |
1.62e-67 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 219.56 E-value: 1.62e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 181 GDHIPPPIGSFLEMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQemkLP 260
Cdd:cd17953 4 GKDCPKPIQKWSQCGLSEKVLDLIKK-LGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQ---RP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 261 FMRSEGPFGLIIVPSRELARQIFDLIIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTK- 339
Cdd:cd17953 80 VKPGEGPIGLIMAPTRELALQIYVECKKFSKALG------LRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTAn 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507945 340 --KIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPI 403
Cdd:cd17953 154 ngRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
214-544 |
2.20e-66 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 224.79 E-value: 2.20e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 214 TAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSEgPFGLIIVPSRELARQIFDliiemfDAL 293
Cdd:PRK01297 111 TPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGE-PRALIIAPTRELVVQIAK------DAA 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 294 GKAGLPEMRAGLCIGGVPIGEQAKDVRDG-IHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFY 372
Cdd:PRK01297 184 ALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 373 F--FKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSENKLvRVLECLQKTSP--KVLIFA 448
Cdd:PRK01297 264 QtpRKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKY-KLLYNLVTQNPweRVMVFA 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 449 EKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHR 528
Cdd:PRK01297 343 NRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHR 422
|
330
....*....|....*.
gi 17507945 529 IGRTGRSGRKGLATTF 544
Cdd:PRK01297 423 IGRTGRAGASGVSISF 438
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
206-406 |
5.09e-65 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 212.23 E-value: 5.09e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEmklPFMRSEGPFGLIIVPSRELARQIFdl 285
Cdd:cd17966 6 KRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQP---PLERGDGPIVLVLAPTRELAQQIQ-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iiEMFDALGKAGlpEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd17966 81 --QEANKFGGSS--RLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEP 156
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17507945 366 EIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVN 406
Cdd:cd17966 157 QIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
200-405 |
3.21e-64 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 209.96 E-value: 3.21e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 200 LLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQ-EMKlpfmRSEGPFGLIIVPSREL 278
Cdd:cd17952 1 LLNAIRKQ-EYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQrELE----KGEGPIAVIVAPTREL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 279 ARQIFDliiemfDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRM 358
Cdd:cd17952 76 AQQIYL------EAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRM 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 17507945 359 LDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17952 150 FDMGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
190-411 |
3.10e-63 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 208.11 E-value: 3.10e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 190 SFLEMKFPKSLLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSEG--P 267
Cdd:cd17967 1 SFEEAGLRELLLENIKRA-GYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRRKayP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 268 FGLIIVPSRELARQIFDliiemfdalgkaglpE---------MRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLT 338
Cdd:cd17967 80 SALILAPTRELAIQIYE---------------EarkfsyrsgVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIE 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17507945 339 KKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFF----KAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAG 411
Cdd:cd17967 145 RGRISLSSIKFLVLDEADRMLDMGFEPQIRKIVEHPdmppKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
208-544 |
2.18e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 212.91 E-value: 2.18e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 208 KGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFvLPLVMFCLEQEMKLPFMRSEGPFGLIIVPSRELARQIFDlii 287
Cdd:PRK04837 26 KGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAF-LTATFHYLLSHPAPEDRKVNQPRALIMAPTRELAVQIHA--- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 288 emfDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFedeI 367
Cdd:PRK04837 102 ---DAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFDLGF---I 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 368 KSIFYFFK-----AQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSENKLVRVLECLQKTSP 442
Cdd:PRK04837 176 KDIRWLFRrmppaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 443 -KVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPED 521
Cdd:PRK04837 256 dRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDD 335
|
330 340
....*....|....*....|...
gi 17507945 522 IENYVHRIGRTGRSGRKGLATTF 544
Cdd:PRK04837 336 CEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
166-408 |
2.68e-62 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 206.40 E-value: 2.68e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 166 EDYEIQRKRLGISCEGDHIPPPIGSFLEMKFPKSLLEFMQKQKgIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFV 245
Cdd:cd18049 1 QEVEQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQN-FTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 246 LPLVMFCLEQemklPFM-RSEGPFGLIIVPSRELARQIFDLIIEMfdalGKAGlpEMRAGLCIGGVPIGEQAKDVRDGIH 324
Cdd:cd18049 80 LPAIVHINHQ----PFLeRGDGPICLVLAPTRELAQQVQQVAAEY----GRAC--RLKSTCIYGGAPKGPQIRDLERGVE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 325 IVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIV 404
Cdd:cd18049 150 ICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIH 229
|
....
gi 17507945 405 VNVG 408
Cdd:cd18049 230 INIG 233
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
209-592 |
6.81e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 215.58 E-value: 6.81e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFvLPLVMFCLEQEMKLPFMRSEGPFGLIIVPSRELARQIFDLIIE 288
Cdd:PRK04537 28 GFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAF-LVAVMNRLLSRPALADRKPEDPRALILAPTRELAIQIHKDAVK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTK-KIINLEVCRYLVLDEADRMLDMGFedeI 367
Cdd:PRK04537 107 FGADLG------LRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQhKVVSLHACEICVLDEADRMFDLGF---I 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 368 KSIFYFFK-----AQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSENKLVRVLECLQKTS- 441
Cdd:PRK04537 178 KDIRFLLRrmperGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLLGLLSRSEg 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 442 PKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPED 521
Cdd:PRK04537 258 ARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFD 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17507945 522 IENYVHRIGRTGRSGRKGLATTFINKKSEMSvLSDLKqllAEAGQELP------EFLKMLAGDEEGTAPA-GTNAEKG 592
Cdd:PRK04537 338 AEDYVHRIGRTARLGEEGDAISFACERYAMS-LPDIE---AYIEQKIPvepvtaELLTPLPRPPRVPVEGeEADDEAG 411
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
206-405 |
2.44e-59 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 197.93 E-value: 2.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17945 6 RKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQQIEEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd17945 86 TQKFAKPLG------IRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 366 EIKSI--------------------FYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17945 160 QVTKIldampvsnkkpdteeaeklaASGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
160-408 |
2.53e-59 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 199.85 E-value: 2.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 160 IRRQSQEDYEIQRKRLGISCEGDHIPPPIGSFLEMKFPKSLLEFMQKQKgIVTPTAIQIQGIPVALSGRDMIGIASTGSG 239
Cdd:cd18050 33 VARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQN-FKEPTPIQCQGFPLALSGRDMVGIAQTGSG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 240 KTMTFVLPLVMFCLEQemklPFM-RSEGPFGLIIVPSRELARQIfdliIEMFDALGKAGlpEMRAGLCIGGVPIGEQAKD 318
Cdd:cd18050 112 KTLAYLLPAIVHINHQ----PYLeRGDGPICLVLAPTRELAQQV----QQVADDYGKSS--RLKSTCIYGGAPKGPQIRD 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 319 VRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSA 398
Cdd:cd18050 182 LERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDF 261
|
250
....*....|
gi 17507945 399 LVKPIVVNVG 408
Cdd:cd18050 262 LRDYVQINIG 271
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
177-411 |
3.00e-59 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 199.42 E-value: 3.00e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 177 ISCEGDHIPPPIGSFLEMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQE 256
Cdd:cd18052 31 VEVTGRNPPPAILTFEEANLCETLLKNIRK-AGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 257 MKLP-FMRSEGPFGLIIVPSRELARQIFDliiemfDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSD 335
Cdd:cd18052 110 LTASsFSEVQEPQALIVAPTRELANQIFL------EARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 336 MLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFF----KAQRQTLLFSATMPRKIQFFAKSAL-VKPIVVNVGRA 410
Cdd:cd18052 184 FIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLkEDYLFLTVGRV 263
|
.
gi 17507945 411 G 411
Cdd:cd18052 264 G 264
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
209-548 |
3.59e-57 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 203.93 E-value: 3.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLvMFCLEQEMKLPFMrsegpfgLIIVPSRELARQIFDLIIE 288
Cdd:PRK11634 25 GYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPL-LHNLDPELKAPQI-------LVLAPTRELAVQVAEAMTD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALGKAGLPEMraglcIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIK 368
Cdd:PRK11634 97 FSKHMRGVNVVAL-----YGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIEDVE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 369 SIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFV---RSENKLVRVLEClqKTSPKVL 445
Cdd:PRK11634 172 TIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVwgmRKNEALVRFLEA--EDFDAAI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 446 IFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENY 525
Cdd:PRK11634 250 IFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESY 329
|
330 340
....*....|....*....|...
gi 17507945 526 VHRIGRTGRSGRKGLATTFINKK 548
Cdd:PRK11634 330 VHRIGRTGRAGRAGRALLFVENR 352
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
209-569 |
9.01e-57 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 196.97 E-value: 9.01e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPlvmfCLeQEMKLPFMRSEGpfgLIIVPSRELARQIFDLIIE 288
Cdd:PTZ00424 47 GFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIA----AL-QLIDYDLNACQA---LILAPTRELAQQIQKVVLA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALgkaglpEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIK 368
Cdd:PTZ00424 119 LGDYL------KVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKGQIY 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 369 SIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRAGAASLNVLQELEFVRSE----NKLVRVLECLqkTSPKV 444
Cdd:PTZ00424 193 DVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEewkfDTLCDLYETL--TITQA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 445 LIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIEN 524
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPEN 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 17507945 525 YVHRIGRTGRSGRKGLATTFINkKSEMSVLSDLKQLLAEAGQELP 569
Cdd:PTZ00424 351 YIHRIGRSGRFGRKGVAINFVT-PDDIEQLKEIERHYNTQIEEMP 394
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
181-412 |
4.31e-55 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 187.55 E-value: 4.31e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 181 GDHIPPPIGSFLEMKFPKSLLEFMQKQKgIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLP 260
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRNNIELAR-YTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGES 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 261 FMRSEG--------PFGLIIVPSRELARQIFDliiemfDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGR 332
Cdd:cd18051 92 LPSESGyygrrkqyPLALVLAPTRELASQIYD------EARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 333 LSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIF----YFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVG 408
Cdd:cd18051 166 LVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVeqdtMPPTGERQTLMFSATFPKEIQMLARDFLDNYIFLAVG 245
|
....
gi 17507945 409 RAGA 412
Cdd:cd18051 246 RVGS 249
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
206-387 |
6.15e-54 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 182.81 E-value: 6.15e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLvmfcLEQEMKLPFmrseGPFGLIIVPSRELARQIfdl 285
Cdd:cd17955 15 ASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPI----LQRLSEDPY----GIFALVLTPTRELAYQI--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iIEMFDALGKAglPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLT---KKIINLEVCRYLVLDEADRMLDMG 362
Cdd:cd17955 84 -AEQFRALGAP--LGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDEADRLLTGS 160
|
170 180
....*....|....*....|....*
gi 17507945 363 FEDEIKSIFYFFKAQRQTLLFSATM 387
Cdd:cd17955 161 FEDDLATILSALPPKRQTLLFSATL 185
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
209-405 |
4.09e-53 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 180.53 E-value: 4.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRsegpfGLIIVPSRELARQIFdliiE 288
Cdd:cd17947 9 GFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATR-----VLVLVPTRELAMQCF----S 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALGKAGlpEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTK-KIINLEVCRYLVLDEADRMLDMGFEDEI 367
Cdd:cd17947 80 VLQQLAQFT--DITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNsPSFDLDSIEILVLDEADRMLEEGFADEL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 17507945 368 KSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17947 158 KEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
206-405 |
1.03e-52 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 179.82 E-value: 1.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLpfmrsegpFGLIIVPSRELARQIfdl 285
Cdd:cd17954 16 EKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRF--------FALVLAPTRELAQQI--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iIEMFDALGkaGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTK-KIINLEVCRYLVLDEADRMLDMGFE 364
Cdd:cd17954 85 -SEQFEALG--SSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENtKGFSLKSLKFLVMDEADRLLNMDFE 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17507945 365 DEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17954 162 PEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
214-392 |
2.92e-51 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 174.35 E-value: 2.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 214 TAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfcleQEMKLpfmRSEGPFGLIIVPSRELARQIFDLIIEMFDAL 293
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPAL-----EALDK---LDNGPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 294 GkaglpeMRAGLCIGGVPIGEQAKDVRdGIHIVVATPGRLSDMLTKKIiNLEVCRYLVLDEADRMLDMGFEDEIKSIFYF 373
Cdd:pfam00270 73 G------LKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRR 144
|
170
....*....|....*....
gi 17507945 374 FKAQRQTLLFSATMPRKIQ 392
Cdd:pfam00270 145 LPKKRQILLLSATLPRNLE 163
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
417-545 |
7.74e-51 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 171.92 E-value: 7.74e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 417 VLQELEFVRSENKLVRVLECL--QKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDV 494
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLleKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 17507945 495 LVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGRSGRKGLATTFI 545
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
200-406 |
8.34e-48 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 166.21 E-value: 8.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 200 LLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMrseGPFGLIIVPSRELA 279
Cdd:cd17960 1 ILDVVAEL-GFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKG---QVGALIISPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 280 RQIFDLIIEMFdalgKAGLPEMRAGLCIGGVPIGEQAKD-VRDGIHIVVATPGRLSDMLTKK--IINLEVCRYLVLDEAD 356
Cdd:cd17960 77 TQIYEVLQSFL----EHHLPKLKCQLLIGGTNVEEDVKKfKRNGPNILVGTPGRLEELLSRKadKVKVKSLEVLVLDEAD 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 17507945 357 RMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVN 406
Cdd:cd17960 153 RLLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
206-405 |
3.54e-47 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 164.26 E-value: 3.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQemklpfmrSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17962 6 KKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTE--------HRNPSALILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEmfdaLGKaGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd17962 78 AKE----LMK-GLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQ 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 17507945 366 EIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17962 153 QVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
206-399 |
5.17e-47 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 164.68 E-value: 5.17e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALS-GRDMIGIASTGSGKTMTFVLPlvmfCLEQEMKLPFMRSEGPFG-LIIVPSRELARQIF 283
Cdd:cd17964 10 TRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLP----AIQSLLNTKPAGRRSGVSaLIISPTRELALQIA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 284 DLIIEMFdalgkAGLPEMRAGLCIGGVPIGEQAKD-VRDGIHIVVATPGRLSDML--TKKIINLEVCRYLVLDEADRMLD 360
Cdd:cd17964 86 AEAKKLL-----QGLRKLRVQSAVGGTSRRAELNRlRRGRPDILVATPGRLIDHLenPGVAKAFTDLDYLVLDEADRLLD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 17507945 361 MGFEDEIKSIFY----FFKAQRQTLLFSATMPRKIQFFAKSAL 399
Cdd:cd17964 161 MGFRPDLEQILRhlpeKNADPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
189-406 |
1.29e-46 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 163.24 E-value: 1.29e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 189 GSFLEMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfcleQEMKLPFMRSeGPF 268
Cdd:cd17959 1 GGFQSMGLSPPLLRAIKK-KGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI-----EKLKAHSPTV-GAR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 269 GLIIVPSRELARQIFDLIIEmfdaLGKagLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCR 348
Cdd:cd17959 74 ALILSPTRELALQTLKVTKE----LGK--FTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVE 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 17507945 349 YLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVN 406
Cdd:cd17959 148 YVVFDEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
206-407 |
2.38e-46 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 162.46 E-value: 2.38e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLvmfcLEQEMKLPFMRSEGPFGLIIVPSRELARQIFdl 285
Cdd:cd17941 6 KEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPL----LEKLYRERWTPEDGLGALIISPTRELAMQIF-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iiEMFDALGKagLPEMRAGLCIGGVPIGEQAKDVrDGIHIVVATPGRLSDMLTKKII----NLEVcryLVLDEADRMLDM 361
Cdd:cd17941 80 --EVLRKVGK--YHSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGfdtsNLQM---LVLDEADRILDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 17507945 362 GFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNV 407
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
209-405 |
9.75e-46 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 161.21 E-value: 9.75e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfCLEQEMKLPFMRSEGPFGLIIVPSRELARQIFDLIIE 288
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPII--QRLLSLEPRVDRSDGTLALVLVPTRELALQIYEVLEK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 mfdaLGKAgLPEMRAGLCIGGvpigEQAKD----VRDGIHIVVATPGRLSDMLTK-KIINLEVCRYLVLDEADRMLDMGF 363
Cdd:cd17949 88 ----LLKP-FHWIVPGYLIGG----EKRKSekarLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGF 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 17507945 364 EDEIKSIFYFFKAQ-------------RQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17949 159 EKDITKILELLDDKrskaggekskpsrRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
198-406 |
3.26e-45 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 159.06 E-value: 3.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 198 KSLLEFmqkqkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfclEQEMKLPFMRSEGPFGLIIVPSRE 277
Cdd:cd17942 3 KAIEEM-----GFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAI----ELLYKLKFKPRNGTGVIIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 278 LARQIFDLIIEMFDalgkagLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKK----IINLEVcryLVLD 353
Cdd:cd17942 74 LALQIYGVAKELLK------YHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTkgflYKNLQC---LIID 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 17507945 354 EADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALV-KPIVVN 406
Cdd:cd17942 145 EADRILEIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKkKPLYVG 198
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
206-410 |
4.16e-45 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 159.19 E-value: 4.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSG-RDMIGIASTGSGKTMTFVLPLVMFcleqemklpFMRSEGPFGLIIVPSRELARQIFD 284
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEA---------LKRGKGGRVLVLVPTRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 285 liiEMFDALGKAGLpemRAGLCIGGVPIGEQAKDVRDG-IHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGF 363
Cdd:smart00487 73 ---ELKKLGPSLGL---KVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGF 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 17507945 364 EDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNVGRA 410
Cdd:smart00487 147 GDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFT 193
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
206-405 |
8.41e-45 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 158.01 E-value: 8.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMklPFMRSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17958 6 KKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPI--PREQRNGPGVLVLTPTRELALQIEAE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IiemfdalGKAGLPEMRAgLCI-GGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFE 364
Cdd:cd17958 84 C-------SKYSYKGLKS-VCVyGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17507945 365 DEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17958 156 PQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
207-406 |
1.89e-43 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 154.38 E-value: 1.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 207 QKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPlvmfCLEQ-EMKLPFMRSegpfgLIIVPSRELARQIFDL 285
Cdd:cd17940 16 EKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIP----ILEKiDPKKDVIQA-----LILVPTRELALQTSQV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEmfdaLGKA-GLPEMragLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFE 364
Cdd:cd17940 87 CKE----LGKHmGVKVM---VTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQ 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 17507945 365 DEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVN 406
Cdd:cd17940 160 PIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEIN 201
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
200-408 |
7.24e-41 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 147.35 E-value: 7.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 200 LLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKlpfmrsEGPFGLIIVPSRELA 279
Cdd:cd17957 1 LLNNLEES-GYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKK------KGLRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 280 RQIFdliIEMFDALGKAGLpemRAGLCIGG-VPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRM 358
Cdd:cd17957 74 SQIY---RELLKLSKGTGL---RIVLLSKSlEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 17507945 359 LDMGFEDEIKSIfyfFKA----QRQTLLFSATMPRKIQFFAKSALVKPIVVNVG 408
Cdd:cd17957 148 FEPGFREQTDEI---LAActnpNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
200-387 |
5.13e-40 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 146.23 E-value: 5.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 200 LLEFMQKQkGIVTPTAIQIQGIPVALS-GRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSE-GPFGLIIVPSRE 277
Cdd:cd17946 1 ILRALADL-GFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQkPLRALILTPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 278 LARQIFDLIiemfDALGKAglPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKK---IINLEVCRYLVLDE 354
Cdd:cd17946 80 LAVQVKDHL----KAIAKY--TNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGnehLANLKSLRFLVLDE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 17507945 355 ADRMLDMGFEDEIKSIFYFFKA-------QRQTLLFSATM 387
Cdd:cd17946 154 ADRMLEKGHFAELEKILELLNKdragkkrKRQTFVFSATL 193
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
193-403 |
3.24e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 142.85 E-value: 3.24e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 193 EMKFPKSLLEFMQKqKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLpLVMFCLEqemklpfMRSEGPFGLII 272
Cdd:cd17939 1 DMGLSEDLLRGIYA-YGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSI-GALQRID-------TTVRETQALVL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 273 VPSRELARQIFDLIIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVL 352
Cdd:cd17939 72 APTRELAQQIQKVVKALGDYMG------VKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVL 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 17507945 353 DEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPI 403
Cdd:cd17939 146 DEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
213-387 |
4.67e-37 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 137.07 E-value: 4.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 213 PTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLeqemklpfmrsegpfGLIIVPSRELARQIFDLIiEMFDA 292
Cdd:cd17938 22 PTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV---------------ALILEPSRELAEQTYNCI-ENFKK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 293 LGKAglPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIKSIF- 371
Cdd:cd17938 86 YLDN--PKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETINRIYn 163
|
170 180
....*....|....*....|.
gi 17507945 372 ----YFFKAQR-QTLLFSATM 387
Cdd:cd17938 164 ripkITSDGKRlQVIVCSATL 184
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
209-405 |
4.65e-36 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 133.93 E-value: 4.65e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLeqemklpfMRSEGPFGLIIVPSRELARQIFDliie 288
Cdd:cd17943 9 GFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD--------LERRHPQVLILAPTREIAVQIHD---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALGKAgLPEMRAGLCIGGVPIGEQAKDVRdGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIK 368
Cdd:cd17943 77 VFKKIGKK-LEGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVN 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 17507945 369 SIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17943 155 WIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
206-405 |
1.82e-35 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 132.71 E-value: 1.82e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMKLPFMRseGPFGLIIVPSRELARQIFDl 285
Cdd:cd17961 10 AKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQ--GTRALILVPTRELAQQVSK- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 iieMFDALGKAGLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKK-IINLEVCRYLVLDEADRMLDMGFE 364
Cdd:cd17961 87 ---VLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVLSYGYE 163
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17507945 365 DEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17961 164 EDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
209-391 |
1.00e-33 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 127.56 E-value: 1.00e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 209 GIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfcleQEMKLPFMRSEGpfgLIIVPSRELARQIFDLIIE 288
Cdd:cd18046 18 GFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISIL-----QQIDTSLKATQA---LVLAPTRELAQQIQKVVMA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 289 MFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIK 368
Cdd:cd18046 90 LGDYMG------IKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKDQIY 163
|
170 180
....*....|....*....|...
gi 17507945 369 SIFYFFKAQRQTLLFSATMPRKI 391
Cdd:cd18046 164 DIFQKLPPDTQVVLLSATMPNDV 186
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
206-389 |
1.67e-33 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 127.87 E-value: 1.67e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCLEQEMkLPFMRSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17948 6 QRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKL-LAEGPFNAPRGLVITPSRELAEQIGSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFED 365
Cdd:cd17948 85 AQSLTEGLG------LKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNE 158
|
170 180 190
....*....|....*....|....*....|....*..
gi 17507945 366 EIKSI---FYFFKAQR----------QTLLFSATMPR 389
Cdd:cd17948 159 KLSHFlrrFPLASRRSentdgldpgtQLVLVSATMPS 195
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
213-405 |
1.56e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 124.22 E-value: 1.56e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 213 PTAIQIQGIPVALSG--RDMIGIASTGSGKTMTFVLPlVMFCLEQEMKLPFMrsegpfgLIIVPSRELARQIFDLIIEMf 290
Cdd:cd17963 17 PSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLA-MLSRVDPTLKSPQA-------LCLAPTRELARQIGEVVEKM- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 291 dalGKagLPEMRAGLCIGG--VPIGEQAKDvrdgiHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDM-GFEDEI 367
Cdd:cd17963 88 ---GK--FTGVKVALAVPGndVPRGKKITA-----QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGDQS 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 17507945 368 KSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd17963 158 IRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
191-405 |
2.30e-32 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 123.73 E-value: 2.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 191 FLEMKFPKSLLEFMQKQkGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPlVMFCLEQEMKlpfmrseGPFGL 270
Cdd:cd18045 1 FETMGLREDLLRGIYAY-GFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSIS-VLQCLDIQVR-------ETQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 271 IIVPSRELARQIFDLIIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYL 350
Cdd:cd18045 72 ILSPTRELAVQIQKVLLALGDYMN------VQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKML 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 17507945 351 VLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd18045 146 VLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
428-536 |
1.13e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 115.77 E-value: 1.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 428 NKLVRVLECLQKTSP-KVLIFAEKKVDVDniYEYLLVK-GVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGL 505
Cdd:pfam00271 1 EKLEALLELLKKERGgKVLIFSQTKKTLE--AELLLEKeGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 17507945 506 DFQGIEHVINFDMPEDIENYVHRIGRTGRSG 536
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
206-396 |
6.57e-30 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 116.87 E-value: 6.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVMFCleQEMKLPFMRSEGPFGLIIVPSRELARQIFDL 285
Cdd:cd17944 6 QARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKL--QEDQQPRKRGRAPKVLVLAPTRELANQVTKD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 286 IIEMFDALGKAglpemraglCI-GGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRMLDMGFE 364
Cdd:cd17944 84 FKDITRKLSVA---------CFyGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFA 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 17507945 365 DEIKSIFYF-FKAQR----QTLLFSATMPRKIQFFAK 396
Cdd:cd17944 155 EQVEEILSVsYKKDSednpQTLLFSATCPDWVYNVAK 191
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
213-407 |
2.49e-27 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 109.74 E-value: 2.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 213 PTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLvmfcLEQEMKLPFMRSegpfGLIIVPSRELARQIFDliieMFDA 292
Cdd:cd17950 25 PSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLST----LQQLEPVDGQVS----VLVICHTRELAFQISN----EYER 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 293 LGKAgLPEMRAGLCIGGVPIGEQAKDVRDGI-HIVVATPGRLSDMLTKKIINLEVCRYLVLDEADRML-DMGFEDEIKSI 370
Cdd:cd17950 93 FSKY-MPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQLDMRRDVQEI 171
|
170 180 190
....*....|....*....|....*....|....*..
gi 17507945 371 FYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNV 407
Cdd:cd17950 172 FRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
455-536 |
2.27e-26 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 102.68 E-value: 2.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 455 DNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGR 534
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 17507945 535 SG 536
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
205-394 |
2.10e-24 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 101.94 E-value: 2.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 205 QKQkgiVTPTAIQIQGIPVALSGRDMIGIASTGSGKTMTFVLPLVmfcleQEMK---LPFMRsegpfGLIIVPSRELARQ 281
Cdd:cd17956 17 QAA---VIPWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIV-----QALSkrvVPRLR-----ALIVVPTKELVQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 282 IFDliieMFDALGKAGlpEMRAGLCIGGVPIGEQAKDVRDGIH--------IVVATPGRLSDMLTKKI-INLEVCRYLVL 352
Cdd:cd17956 84 VYK----VFESLCKGT--GLKVVSLSGQKSFKKEQKLLLVDTSgrylsrvdILVATPGRLVDHLNSTPgFTLKHLRFLVI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17507945 353 DEADRMLDMGFED----EIKSIFY--------FFKAQR--------QTLLFSATM---PRKIQFF 394
Cdd:cd17956 158 DEADRLLNQSFQDwletVMKALGRptapdlgsFGDANLlersvrplQKLLFSATLtrdPEKLSSL 222
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
206-389 |
1.98e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 88.20 E-value: 1.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 206 KQKGIVTPTAIQIQGIPvALSGRDMIGI-----------------ASTGSGKTMTFVLPLVMFCLEQEMKLPFMRSEG-- 266
Cdd:cd17965 24 KTDEEIKPSPIQTLAIK-KLLKTLMRKVtkqtsneepklevfllaAETGSGKTLAYLAPLLDYLKRQEQEPFEEAEEEye 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 267 -------PFGLIIVPSRELARQIFDlIIEMFDALGKAGLPEMRAGLcigGVPIGEQAKDVRDGIHIVVATPGRLSDMLTK 339
Cdd:cd17965 103 sakdtgrPRSVILVPTHELVEQVYS-VLKKLSHTVKLGIKTFSSGF---GPSYQRLQLAFKGRIDILVTTPGKLASLAKS 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 17507945 340 KIINLEVCRYLVLDEADRMLDMGFEDEIKSIFYFFKAQRQTLLFSATMPR 389
Cdd:cd17965 179 RPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPK 228
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
227-514 |
7.64e-16 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 80.84 E-value: 7.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 227 GRDMIGIASTGSGKTMTFvlplvMFCLEQEMKLPFMrsegpfgLIIVPSRELARQIFDLIIEMFdalgkaglpemraglc 306
Cdd:COG1061 100 GGRGLVVAPTGTGKTVLA-----LALAAELLRGKRV-------LVLVPRRELLEQWAEELRRFL---------------- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 307 iGGVPIGEQAKDVRDgiHIVVATPGRLSDMLTKKIINlEVCRYLVLDEADRMLDMGFEDeiksIFYFFKAQRqTLLFSAT 386
Cdd:COG1061 152 -GDPLAGGGKKDSDA--PITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSYRR----ILEAFPAAY-RLGLTAT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 387 ------MPRKIQFF-------------AKSALVKPIVVNV-------GRAGAASLNVLQELEFVRSENKLVRVLECLQKT 440
Cdd:COG1061 223 pfrsdgREILLFLFdgivyeyslkeaiEDGYLAPPEYYGIrvdltdeRAEYDALSERLREALAADAERKDKILRELLREH 302
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507945 441 SP--KVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVI 514
Cdd:COG1061 303 PDdrKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
428-530 |
6.34e-14 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 69.04 E-value: 6.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 428 NKLVRVLECLQKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKD--VLVATDVASKGL 505
Cdd:cd18793 14 EALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGL 93
|
90 100 110
....*....|....*....|....*....|.
gi 17507945 506 DFQGIEHVINFDMP--EDIENY----VHRIG 530
Cdd:cd18793 94 NLTAANRVILYDPWwnPAVEEQaidrAHRIG 124
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
188-407 |
9.22e-14 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 71.21 E-value: 9.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 188 IGSFLEMKFPKSLLEFMQKQkGIVTPTAIQIQGIPVALSG--RDMIGIASTGSGKTMTFVLPLVMFCLEQEMKlpfmrse 265
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAM-GFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 266 gPFGLIIVPSRELARQIFDLIIEMfdalGK--AGLPEMRAglcIGGVPIGeqaKDVRDGIHIVVATPGRLSDMLTK-KII 342
Cdd:cd18048 89 -PQCLCLSPTFELALQTGKVVEEM----GKfcVGIQVIYA---IRGNRPG---KGTDIEAQIVIGTPGTVLDWCFKlRLI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507945 343 NLEVCRYLVLDEADRMLDM-GFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVVNV 407
Cdd:cd18048 158 DVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKL 223
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
234-386 |
3.34e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 64.35 E-value: 3.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 234 ASTGSGKTmtFVLPLVMFCLeqemklpfMRSEGPFGLIIVPSRELARQIfdliIEMFDALGKAGLpemRAGLCIGGVPIG 313
Cdd:cd00046 8 APTGSGKT--LAALLAALLL--------LLKKGKKVLVLVPTKALALQT----AERLRELFGPGI---RVAVLVGGSSAE 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17507945 314 EQAKDVRDGIHIVVATPGRL-SDMLTKKIINLEVCRYLVLDEADRMLDMGFEDEIkSIFYFFKAQR---QTLLFSAT 386
Cdd:cd00046 71 EREKNKLGDADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALI-LDLAVRKAGLknaQVILLSAT 146
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
427-544 |
2.15e-11 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 66.32 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 427 ENKLVRVLECLQKTSPKV-LIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVAT------- 498
Cdd:COG0514 215 DDKLAQLLDFLKEHPGGSgIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATiafgmgi 294
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 17507945 499 ---DVAskgldFqgiehVINFDMPEDIENYVHRIGRTGRSGRKGLATTF 544
Cdd:COG0514 295 dkpDVR-----F-----VIHYDLPKSIEAYYQEIGRAGRDGLPAEALLL 333
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
137-541 |
3.72e-11 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 66.40 E-value: 3.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 137 VAELTKGEKYEEPIVTAWRPPGHirrqsqedyeiqrkrlgiscEGDHIPPPIGsflemkFPKSLLEFMQKqKGIVTPTAI 216
Cdd:COG1205 8 LERLRASPRYGDQIVHVRTIPAR--------------------EARYAPWPDW------LPPELRAALKK-RGIERLYSH 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 217 QIQGIPVALSGRDMIGIASTGSGKTMTFVLPLvmfcLEQemklpFMRSEGPFGLIIVPSRELAR-QifdliIEMFDALGK 295
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPV----LEA-----LLEDPGATALYLYPTKALARdQ-----LRRLRELAE 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 296 AGLPEMRAGLCIGGVPIGEQAKdVRDGIHIVVATPgrlsDML--------TKKIINLEVCRYLVLDEA------------ 355
Cdd:COG1205 127 ALGLGVRVATYDGDTPPEERRW-IREHPDIVLTNP----DMLhygllphhTRWARFFRNLRYVVIDEAhtyrgvfgshva 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 356 ---DRMldmgfedeiKSIFYFFKAQRQTLLFSATMPRKIQFFAKsaLV-KPIVVnVGRAGAASlnvlQELEFV------- 424
Cdd:COG1205 202 nvlRRL---------RRICRHYGSDPQFILASATIGNPAEHAER--LTgRPVTV-VDEDGSPR----GERTFVlwnpplv 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 425 -----RSENKLVR--VLECLQKTSpKVLIFAEKKVDVDNIYEYLL------VKGVEVASIHGGKDQSDRHAGIEAFRKNE 491
Cdd:COG1205 266 ddgirRSALAEAArlLADLVREGL-RTLVFTRSRRGAELLARYARralrepDLADRVAAYRAGYLPEERREIERGLRSGE 344
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 17507945 492 KDVLVAT-------DVAskGLDFqgiehVINFDMPEDIENYVHRIGRTGRSGRKGLA 541
Cdd:COG1205 345 LLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQDSLV 394
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
429-538 |
1.12e-10 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 64.75 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 429 KLVRVLECLQKT-----SPKVLIFAEKKVDVDNIYEYLLVKGVEV------ASIHGGK--DQSDRHAGIEAFRKNEKDVL 495
Cdd:COG1111 336 KLSKLREILKEQlgtnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAgrfvgqASKEGDKglTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 17507945 496 VATDVASKGLDFQGIEHVINFD-MPEDIEnYVHRIGRTGRSGRK 538
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGRKREG 458
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
429-532 |
1.20e-10 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 64.48 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 429 KLVRVLECLQKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNE--KDVLVATDVASKGLD 506
Cdd:COG0553 537 ALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLN 616
|
90 100 110
....*....|....*....|....*....|..
gi 17507945 507 FQGIEHVINFDMP--EDIENY----VHRIGRT 532
Cdd:COG0553 617 LTAADHVIHYDLWwnPAVEEQaidrAHRIGQT 648
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
190-405 |
1.77e-10 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 60.89 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 190 SFLEMKFPKSLLEFMQkQKGIVTPTAIQIQGIPVALSG--RDMIGIASTGSGKTMTFVLPLVMF----CLEQEMklpfmr 263
Cdd:cd18047 2 SFEELRLKPQLLQGVY-AMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQvepaNKYPQC------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 264 segpfgLIIVPSRELARQIFDLIIEMfdalGKAgLPEMRAGLCIGGvpiGEQAKDVRDGIHIVVATPGRLSDMLTK-KII 342
Cdd:cd18047 75 ------LCLSPTYELALQTGKVIEQM----GKF-YPELKLAYAVRG---NKLERGQKISEQIVIGTPGTVLDWCSKlKFI 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17507945 343 NLEVCRYLVLDEADRML-DMGFEDEIKSIFYFFKAQRQTLLFSATMPRKIQFFAKSALVKPIVV 405
Cdd:cd18047 141 DPKKIKVFVLDEADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
422-531 |
1.18e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 56.83 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 422 EFVRSEnKLVRVLECLQKTSPKV-----LIFAEKKVDVDNIYEYLLVKGVEVASIHGG------------------KDQS 478
Cdd:cd18802 2 EIVVIP-KLQKLIEILREYFPKTpdfrgIIFVERRATAVVLSRLLKEHPSTLAFIRCGfligrgnssqrkrslmtqRKQK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 17507945 479 DRhagIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGR 531
Cdd:cd18802 81 ET---LDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
453-537 |
1.75e-09 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 56.06 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 453 DVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRT 532
Cdd:cd18794 42 ECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRA 121
|
....*
gi 17507945 533 GRSGR 537
Cdd:cd18794 122 GRDGL 126
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
445-540 |
2.18e-08 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 57.03 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 445 LIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIEN 524
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90
....*....|....*.
gi 17507945 525 YVHrigRTGRSGRKGL 540
Cdd:PRK11057 320 YYQ---ETGRAGRDGL 332
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
227-354 |
2.26e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 53.74 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 227 GRDMIGIASTGSGKTMTFVLPLvmfcLEQEMKLPfmrsEGPFGLI-IVPSRELARQIFDLIIEMFDALGkaglPEMRAGL 305
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPA----LSSLADEP----EKGVQVLyISPLKALINDQERRLEEPLDEID----LEIPVAV 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 17507945 306 CIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKKIIN--LEVCRYLVLDE 354
Cdd:cd17922 69 RHGDTSQSEKAKQLKNPPGILITTPESLELLLVNKKLRelFAGLRYVVVDE 119
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
494-545 |
2.43e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.17 E-value: 2.43e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 17507945 494 VLVATDVASKGLDFQGIEHVINFDMPEDIENYVHRIGRTGR-SGRKGLATTFI 545
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
429-537 |
3.14e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 56.81 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 429 KLVRVLECLQKT-----SPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGgkdQSDRHAG-----------IEAFRKNEK 492
Cdd:PRK13766 348 KLEKLREIVKEQlgknpDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVG---QASKDGDkgmsqkeqieiLDKFRAGEF 424
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 17507945 493 DVLVATDVASKGLDFQGIEHVINFD-MPEDIENyVHRIGRTGR--SGR 537
Cdd:PRK13766 425 NVLVSTSVAEEGLDIPSVDLVIFYEpVPSEIRS-IQRKGRTGRqeEGR 471
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
224-355 |
2.01e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 51.43 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 224 ALSGRDMIGIASTGSGKTMTFVLPLvmfcLEQemklpFMRSEGPFGLIIVPSRELAR-QifdliIEMFDALGKAGLPEMR 302
Cdd:cd17923 12 ARAGRSVVVTTGTASGKSLCYQLPI----LEA-----LLRDPGSRALYLYPTKALAQdQ-----LRSLRELLEQLGLGIR 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17507945 303 AGLCIGGVPIGEQAKDVRDGIHIVVATPgrlsDMLTKKII--------NLEVCRYLVLDEA 355
Cdd:cd17923 78 VATYDGDTPREERRAIIRNPPRILLTNP----DMLHYALLphhdrwarFLRNLRYVVLDEA 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
212-355 |
1.47e-06 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 48.80 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 212 TPTAIQIQGI-PVALSGRDMIGIASTGSGKTMTFVLPLVMfCLEQEMKLpfmrsegpfGLIIVPSRELARQIFDLIIEMF 290
Cdd:cd17921 1 LLNPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILR-ALATSGGK---------AVYIAPTRALVNQKEADLRERF 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507945 291 DALGKaglpemRAGLCIGGVPIGEQAKDVRDgihIVVATPGRLSDMLTK-KIINLEVCRYLVLDEA 355
Cdd:cd17921 71 GPLGK------NVGLLTGDPSVNKLLLAEAD---ILVATPEKLDLLLRNgGERLIQDVRLVVVDEA 127
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
428-539 |
1.51e-06 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 48.12 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 428 NKLVRVL-ECLQKTSP----KVLIFAEKKVDVDNIYEYLL--VKGVEVASIHG--------GKDQSDRHAGIEAFRKNEK 492
Cdd:cd18801 12 EKLEEIVkEHFKKKQEgsdtRVIIFSEFRDSAEEIVNFLSkiRPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKGGY 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 17507945 493 DVLVATDVASKGLDFQGIEHVINFD-MPEDIENyVHRIGRTGRsGRKG 539
Cdd:cd18801 92 NVLVATSIGEEGLDIGEVDLIICYDaSPSPIRM-IQRMGRTGR-KRQG 137
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
350-538 |
8.19e-06 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 48.19 E-value: 8.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 350 LVLDEADrmldmGFEDEIKSIFYF-FKAQRQT----LLFSATMPRKI-QFFAKSALVKPIVVNVGRAGAASLNVLQELEF 423
Cdd:cd09639 127 LIFDEVH-----FYDEYTLALILAvLEVLKDNdvpiLLMSATLPKFLkEYAEKIGYVEENEPLDLKPNERAPFIKIESDK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 424 VRSENKLVRVLECLQKTSPKVLIFAEKKVDVDnIYEYLLVKG--VEVASIHGGKDQSDRHAG----IEAFRKNEKDVLVA 497
Cdd:cd09639 202 VGEISSLERLLEFIKKGGSVAIIVNTVDRAQE-FYQQLKEKGpeEEIMLIHSRFTEKDRAKKeaelLLEFKKSEKFVIVA 280
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 17507945 498 TDVASKGLDfqgiehvINFDM----PEDIENYVHRIGRTGRSGRK 538
Cdd:cd09639 281 TQVIEASLD-------ISVDVmiteLAPIDSLIQRLGRLHRYGEK 318
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
197-498 |
9.74e-05 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 45.27 E-value: 9.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 197 PKSLLEFMqKQKGIVTPTAIQIQGIPVAL-SGRDMIGIASTGSGKtmTFVLPLVMFcleQEMKlpfmrsEGPFGLIIVPS 275
Cdd:COG1204 8 LEKVIEFL-KERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGK--TLIAELAIL---KALL------NGGKALYIVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 276 RELARQIFDLIIEMFDALGkaglpeMRAGLCIGGVPIGEQAKDVRDgihIVVATPGRLSDMLTKKIINLEVCRYLVLDEA 355
Cdd:COG1204 76 RALASEKYREFKRDFEELG------IKVGVSTGDYDSDDEWLGRYD---ILVATPEKLDSLLRNGPSWLRDVDLVVVDEA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 356 dRMLDmgfeDE------------IKSIfyffKAQRQTLLFSATMPrKIQFFAK---SALVK----PIVVNVG-------- 408
Cdd:COG1204 147 -HLID----DEsrgptlevllarLRRL----NPEAQIVALSATIG-NAEEIAEwldAELVKsdwrPVPLNEGvlydgvlr 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 409 ----------RAGAASLNVLQE----LEFVRSENKLVRVLECLQKTSPKVLIFAEKKvDVDNIYE------------YLL 462
Cdd:COG1204 217 fddgsrrskdPTLALALDLLEEggqvLVFVSSRRDAESLAKKLADELKRRLTPEERE-ELEELAEellevseethtnEKL 295
|
330 340 350
....*....|....*....|....*....|....*...
gi 17507945 463 VKGVE--VASIHGGKDQSDRHAGIEAFRKNEKDVLVAT 498
Cdd:COG1204 296 ADCLEkgVAFHHAGLPSELRRLVEDAFREGLIKVLVAT 333
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
424-506 |
1.25e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 42.62 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 424 VRSENKLVRVLECLQKTSP--KVLIFAEkkvDVDNIYEYLLVKGVEVasIHGGKDQSDRHAGIEAFRKNEKDVLVATDVA 501
Cdd:cd18789 30 AMNPNKLRALEELLKRHEQgdKIIVFTD---NVEALYRYAKRLLKPF--ITGETPQSEREEILQNFREGEYNTLVVSKVG 104
|
....*
gi 17507945 502 SKGLD 506
Cdd:cd18789 105 DEGID 109
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
236-386 |
1.81e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.91 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 236 TGSGKTmtfvlpLVMfcleqeMKLPFMRSEGPFgLIIVPSRELARQIFDLIIEMF--DALGKaglpemraglciggvpIG 313
Cdd:cd17926 27 TGSGKT------LTA------LALIAYLKELRT-LIVVPTDALLDQWKERFEDFLgdSSIGL----------------IG 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17507945 314 EQAKDVRDGIHIVVATPGRLSDML--TKKIINLevCRYLVLDEADRMLDMGFEdEIKSIFYFFKaqrqTLLFSAT 386
Cdd:cd17926 78 GGKKKDFDDANVVVATYQSLSNLAeeEKDLFDQ--FGLLIVDEAHHLPAKTFS-EILKELNAKY----RLGLTAT 145
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
212-354 |
2.90e-04 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 43.94 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 212 TPTAIQIQGIPVALSGRDMIGIASTGSGKTMT-FVLPLVMFCleqEMKLPFMRSEGPFGLIIVPSRELARqifDL----- 285
Cdd:COG1201 24 APTPPQREAWPAIAAGESTLLIAPTGSGKTLAaFLPALDELA---RRPRPGELPDGLRVLYISPLKALAN---DIernlr 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17507945 286 --IIEMFDALGKAgLPEMRAGLCIGGVPIGEQAKDVRDGIHIVVATPGRLSDMLTKK--IINLEVCRYLVLDE 354
Cdd:COG1201 98 apLEEIGEAAGLP-LPEIRVGVRTGDTPASERQRQRRRPPHILITTPESLALLLTSPdaRELLRGVRTVIVDE 169
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
445-538 |
4.34e-04 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 43.73 E-value: 4.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 445 LIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINFDMPEDIEN 524
Cdd:PLN03137 684 IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEG 763
|
90
....*....|....
gi 17507945 525 YVHRIGRTGRSGRK 538
Cdd:PLN03137 764 YHQECGRAGRDGQR 777
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
236-355 |
4.18e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 38.79 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 236 TGSGKTMTFVLpLVMFCLEQEMKLPfmrSEGPFGLIIVPSRELARQIFDLIIEMFDALGKaglpEMRAGLcigGVPIGEQ 315
Cdd:cd18034 25 TGSGKTLIAVM-LIKEMGELNRKEK---NPKKRAVFLVPTVPLVAQQAEAIRSHTDLKVG----EYSGEM---GVDKWTK 93
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 17507945 316 A--KDVRDGIHIVVATPGRLSDMLTKKIINLEVCRYLVLDEA 355
Cdd:cd18034 94 ErwKEELEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
443-536 |
7.84e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 37.24 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 443 KVLIFAEKKVDVDNIYEYL------LVKGVEVASIHGGKDQSDRHAGIEAFRKNEKDVLVATDVASKGLDFQGIEHVINF 516
Cdd:cd18796 40 STLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQI 119
|
90 100
....*....|....*....|
gi 17507945 517 DMPEDIENYVHRIGRTGRSG 536
Cdd:cd18796 120 GSPKSVARLLQRLGRSGHRP 139
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
424-532 |
8.16e-03 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 39.40 E-value: 8.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507945 424 VRSENKLV---RVLECLQKTSPKVLIFAEKKVDVDNIYEYLLVKGVEVASIHGGKDQSDRHAGIEAFRK--NEKDV-LVA 497
Cdd:PLN03142 467 VENSGKMVlldKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpgSEKFVfLLS 546
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 17507945 498 TDVASKGLDFQGIEHVINFD------MPEDIENYVHRIGRT 532
Cdd:PLN03142 547 TRAGGLGINLATADIVILYDsdwnpqVDLQAQDRAHRIGQK 587
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