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Conserved domains on  [gi|17508325|ref|NP_491635|]
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Protein-S-isoprenylcysteine O-methyltransferase [Caenorhabditis elegans]

Protein Classification

protein-S-isoprenylcysteine O-methyltransferase( domain architecture ID 10514227)

protein-S-isoprenylcysteine O-methyltransferase catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 177-267 1.23e-33

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


:

Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 118.23  E-value: 1.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508325   177 CIIGEIFRKVGMVHAGLAFTHRLAMtkRSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNP--ICCVVYAYVTWHFF 254
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82

                          90
                  ....*....|...
gi 17508325   255 ASRIYDEEKDLIS 267
Cdd:pfam04140  83 SVRIRQEEKALAH 95
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 177-267 1.23e-33

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 118.23  E-value: 1.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508325   177 CIIGEIFRKVGMVHAGLAFTHRLAMtkRSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNP--ICCVVYAYVTWHFF 254
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82

                          90
                  ....*....|...
gi 17508325   255 ASRIYDEEKDLIS 267
Cdd:pfam04140  83 SVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 173-287 4.98e-16

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 72.50  E-value: 4.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508325 173 GTLGCIIGEIFRKVGMVHAGLAFTHRLamTKRSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNPICCVVYAyVTWH 252
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLV--PPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLAL-LLLL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17508325 253 FFASRIYDEEKDLISFFGDSYVEYQQNVWCGVPFV 287
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVPRLIPRL 113
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
204-278 3.66e-10

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 58.03  E-value: 3.66e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17508325  204 RSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNPICCV--VYAYVTWHFFasRIYDEEKDLISFFGDSYVEYQQ 278
Cdd:NF040696 107 REGHTLVTSGVYRYIRHPMYAAFWLWAIAQALLLPNWIAGLagLVGFGILYFL--RVPREEQMMLETFGDEYRAYMQ 181
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 177-267 1.23e-33

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 118.23  E-value: 1.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508325   177 CIIGEIFRKVGMVHAGLAFTHRLAMtkRSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNP--ICCVVYAYVTWHFF 254
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVAI--LPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82

                          90
                  ....*....|...
gi 17508325   255 ASRIYDEEKDLIS 267
Cdd:pfam04140  83 SVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 173-287 4.98e-16

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 72.50  E-value: 4.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508325 173 GTLGCIIGEIFRKVGMVHAGLAFTHRLamTKRSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNPICCVVYAyVTWH 252
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLV--PPRKAHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLAL-LLLL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17508325 253 FFASRIYDEEKDLISFFGDSYVEYQQNVWCGVPFV 287
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVPRLIPRL 113
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
204-278 3.66e-10

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 58.03  E-value: 3.66e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17508325  204 RSDHRLVKDGIYAYLRHPGYFGWFLWAVSTQIILCNPICCV--VYAYVTWHFFasRIYDEEKDLISFFGDSYVEYQQ 278
Cdd:NF040696 107 REGHTLVTSGVYRYIRHPMYAAFWLWAIAQALLLPNWIAGLagLVGFGILYFL--RVPREEQMMLETFGDEYRAYMQ 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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