|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
159-636 |
6.73e-157 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 479.58 E-value: 6.73e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 159 PQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIV 238
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 239 GYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnPLRLIIMSA 318
Cdd:COG1643 88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRP---DLKLLVMSA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 319 TLQAEKFQSYFNNAKVVLVAGRTFPIEVFHVNPKINKSfSSTDYVYNAVICVkyvhLTEPKGrDILVFLTGSEEIEAVAS 398
Cdd:COG1643 165 TLDAERFARLLGDAPVIESSGRTYPVEVRYRPLPADER-DLEDAVADAVREA----LAEEPG-DILVFLPGEREIRRTAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 399 QLAelnGSLPASADVLmpvPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRI 478
Cdd:COG1643 239 ALR---GRLPPDTEIL---PLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 479 DVLKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETD 558
Cdd:COG1643 313 TRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPAR 392
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71990212 559 NINAALLELTSLGAIRPvnsdrsKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSGAGDS 636
Cdd:COG1643 393 AIADARALLQELGALDA------DGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAGS 464
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
160-818 |
1.39e-128 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 416.86 E-value: 1.39e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 160 QLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVG 239
Cdd:TIGR01967 65 NLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 240 YHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSAT 319
Cdd:TIGR01967 145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD----LKIIITSAT 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 320 LQAEKFQSYFNNAKVVLVAGRTFPIEVFHvNPKINKSFSSTDYVYNAvICVKYVHLTEPKGRDILVFLTGSEEIEAVASQ 399
Cdd:TIGR01967 221 IDPERFSRHFNNAPIIEVSGRTYPVEVRY-RPLVEEQEDDDLDQLEA-ILDAVDELFAEGPGDILIFLPGEREIRDAAEI 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 400 LAELNgslPASADVLmpvPLYAALRPEKQKEAFRktPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRID 479
Cdd:TIGR01967 299 LRKRN---LRHTEIL---PLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQ 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 480 VLKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDN 559
Cdd:TIGR01967 371 RLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRA 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 560 INAALLELTSLGAirpVNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSGAGDSKSD 639
Cdd:TIGR01967 451 IRDGFRLLEELGA---LDDDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQA 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 640 AdvDRIRRRFETREGDHITLLKLVlvtnQFFDQLNKKTESDArygkankslereynqtIRKFCNDNMINEQHLKTASMIE 719
Cdd:TIGR01967 528 A--DQAHARFKDPRSDFLSRVNLW----RHIEEQRQALSANQ----------------FRNACRKQYLNYLRVREWQDIY 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 720 EQLKQIAIEQKVTFSTCGADFMKMRKAL------ALGMFLNSCEYDRQEDRyRLMinpaitlkIHPSSCLSRSKPAYIVF 793
Cdd:TIGR01967 586 RQLTQVVKELGLKLNEEPADYDAIHKALlsgllsQIGMKDEKHEYDGARGR-KFH--------IFPGSPLFKKPPKWVMA 656
|
650 660
....*....|....*....|....*
gi 71990212 794 SELMKTNDLFALQVTLIDGDWVRPL 818
Cdd:TIGR01967 657 AELVETSKLYARLVAKIEPEWVEPV 681
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
159-830 |
7.60e-113 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 374.01 E-value: 7.60e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 159 PQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIV 238
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 239 GYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSA 318
Cdd:PRK11131 151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD----LKVIITSA 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 319 TLQAEKFQSYFNNAKVVLVAGRTFPIEVFH---VNPKINKSFSSTDYVYNAV--ICVkyvhltEPKGrDILVFLTGSEEI 393
Cdd:PRK11131 227 TIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpiVEEADDTERDQLQAIFDAVdeLGR------EGPG-DILIFMSGEREI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 394 EAVASQLAELNgsLPaSADVLmpvPLYAALRPEKQKEAFRktPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFE 473
Cdd:PRK11131 300 RDTADALNKLN--LR-HTEIL---PLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 474 AFNRIDVLKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLID 553
Cdd:PRK11131 372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 554 PPETDNINAALLELTSLGAIRPvNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSGA 633
Cdd:PRK11131 452 APDKRNIQDGVRLLEELGAITT-DEQASAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERP 530
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 634 GDSKSDAdvDRIRRRFETREGDHITLLKL---------VLVTNQFfdqlnkktesdarygkankslereynqtiRKFCND 704
Cdd:PRK11131 531 MDKQQAS--DEKHRRFADKESDFLAFVNLwnylqeqqkALSSNQF-----------------------------RRLCRT 579
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 705 NMINEQHLKTASMIEEQLKQIAIEQKVTFSTCGADFMKMRKALALGMFLNSCEYDRQEDRYRLMINPaiTLKIHPSSCLS 784
Cdd:PRK11131 580 DYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEKQEYTGARNA--RFSIFPGSGLF 657
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 71990212 785 RSKPAYIVFSELMKTNDLFALQVTLIDGDWVRPLisdhkkmrANHL 830
Cdd:PRK11131 658 KKPPKWVMVAELVETSRLWGRIAARIEPEWIEPL--------AQHL 695
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
161-635 |
4.37e-104 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 340.59 E-value: 4.37e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANsGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIG-GKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRETnnpLRLIIMSATL 320
Cdd:TIGR01970 80 RVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLRED---LKILAMSATL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 321 QAEKFQSYFNNAKVVLVAGRTFPIEVFHVNPKINKSFSstDYVYNAVIcvkyvHLTEPKGRDILVFLTGSEEIEAVASQL 400
Cdd:TIGR01970 157 DGERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLE--DAVSRAVE-----HALASETGSILVFLPGQAEIRRVQEQL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 401 AELNGSlpasaDVLMpVPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDV 480
Cdd:TIGR01970 230 AERLDS-----DVLI-CPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITR 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 481 LKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDNI 560
Cdd:TIGR01970 304 LETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVAL 383
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71990212 561 NAALLELTSLGAIRPVNSdrskfaLTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSGAGD 635
Cdd:TIGR01970 384 AAARQLLQRLGALDAQGR------LTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGLPRQGGA 452
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
159-573 |
1.27e-92 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 309.55 E-value: 1.27e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 159 PQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVP-QLCVRAGIanSGSIAVTQPRRVAAISLASRVATEMGTNIGGI 237
Cdd:PRK11664 2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGI--NGKIIMLEPRRLAARNVAQRLAEQLGEKPGET 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 238 VGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRETnnpLRLIIMS 317
Cdd:PRK11664 80 VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDD---LKLLIMS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 318 ATLQAEKFQSYFNNAKVVLVAGRTFPIEvFHVNPkinksFSSTDYVYNAVICVKYVHLTEPKGrDILVFLTGSEEIEAVA 397
Cdd:PRK11664 157 ATLDNDRLQQLLPDAPVIVSEGRSFPVE-RRYQP-----LPAHQRFDEAVARATAELLRQESG-SLLLFLPGVGEIQRVQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 398 SQLAELNGSlpasaDVLMpVPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNR 477
Cdd:PRK11664 230 EQLASRVAS-----DVLL-CPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 478 IDVLKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPET 557
Cdd:PRK11664 304 LTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPA 383
|
410
....*....|....*.
gi 71990212 558 DNINAALLELTSLGAI 573
Cdd:PRK11664 384 AALAAAKRLLQQLGAL 399
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
178-337 |
1.41e-80 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 256.23 E-value: 1.41e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 178 ETLIVIGETGSGKSTQVPQLCVRAGIAN--SGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGYHVRFENATCHKTKIE 255
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKggKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 256 YMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSATLQAEKFQSYFNNAKVV 335
Cdd:cd17917 82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPD----LKVILMSATLDAEKFSSYFGGAPVI 157
|
..
gi 71990212 336 LV 337
Cdd:cd17917 158 HI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
161-335 |
3.52e-79 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 253.43 E-value: 3.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRETN-NPLRLIIMSAT 319
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKlSPLKVIIMSAT 160
|
170
....*....|....*.
gi 71990212 320 LQAEKFQSYFNNAKVV 335
Cdd:cd17978 161 LDADLFSEYFNGAPVL 176
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
342-510 |
9.89e-66 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 217.02 E-value: 9.89e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 342 FPIEVFH---VNPKINKSFSSTDYVYN--AVICVKYVHLTEPKGrDILVFLTGSEEIEAVASQLAELNGSLPASAdvLMP 416
Cdd:cd18791 1 FPVEVYYledILELLGISSEKEDPDYVdaAVRLILQIHRTEEPG-DILVFLPGQEEIERLCELLREELLSPDLGK--LLV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 417 VPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVSKAQAKQRAG 496
Cdd:cd18791 78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157
|
170
....*....|....
gi 71990212 497 RAGRDAPGKCYRLY 510
Cdd:cd18791 158 RAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
158-337 |
1.87e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 211.51 E-value: 1.87e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 158 RPQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG--SIAVTQPRRVAAISLASRVATEMGTNIG 235
Cdd:cd17973 10 RRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPkkLVACTQPRRVAAMSVAQRVAEEMDVKLG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 236 GIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLII 315
Cdd:cd17973 90 EEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD----LKLIV 165
|
170 180
....*....|....*....|..
gi 71990212 316 MSATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17973 166 MSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
161-334 |
1.07e-59 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 200.38 E-value: 1.07e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSATL 320
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD----LKLIVTSATM 156
|
170
....*....|....
gi 71990212 321 QAEKFQSYFNNAKV 334
Cdd:cd17983 157 DADKFADFFGNVPI 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
161-325 |
3.68e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 197.19 E-value: 3.68e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIA-----NSGSIAVTQPRRVAAISLASRVATEMGTnIG 235
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGspesdNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 236 GIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRRE------TNN 309
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqTVK 159
|
170
....*....|....*.
gi 71990212 310 PLRLIIMSATLQAEKF 325
Cdd:cd17982 160 PLKLVIMSATLRVEDF 175
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
158-334 |
6.92e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 195.78 E-value: 6.92e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 158 RPQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGI 237
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 238 VGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMS 317
Cdd:cd17971 83 VGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD----LKLIVTS 158
|
170
....*....|....*..
gi 71990212 318 ATLQAEKFQSYFNNAKV 334
Cdd:cd17971 159 ATLDAVKFSQYFYEAPI 175
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
161-330 |
4.02e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 191.14 E-value: 4.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG-SIAVTQPRRVAAISLASRVATEMGTNIGGIVG 239
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 240 YHVRFENATCH-KTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSA 318
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD----LRLIVASA 156
|
170
....*....|..
gi 71990212 319 TLQAEKFQSYFN 330
Cdd:cd17980 157 TLDAEKFRDFFN 168
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
161-334 |
7.15e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 190.02 E-value: 7.15e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG-SIAVTQPRRVAAISLASRVATEMGTNIGGIVG 239
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGgKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 240 YHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSAT 319
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD----LKLLISSAT 156
|
170
....*....|....*
gi 71990212 320 LQAEKFQSYFNNAKV 334
Cdd:cd17974 157 MDAEKFSAFFDDAPI 171
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
161-335 |
3.95e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 185.44 E-value: 3.95e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCIL-RQCQDQRRETNNPLRLIIMSAT 319
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLkKLFQEKSPNRKEHLKVVVMSAT 160
|
170
....*....|....*.
gi 71990212 320 LQAEKFQSYFNNAKVV 335
Cdd:cd17984 161 LELAKLSAFFGNCPVF 176
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
161-337 |
4.47e-54 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 184.97 E-value: 4.47e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSATL 320
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD----LKVIITSATI 156
|
170
....*....|....*..
gi 71990212 321 QAEKFQSYFNNAKVVLV 337
Cdd:cd17989 157 DAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
161-337 |
2.15e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 166.08 E-value: 2.15e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIansGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGY 240
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGF---RHIACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 241 HVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMSATL 320
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD----LKLILMSATI 153
|
170
....*....|....*..
gi 71990212 321 QAEKFQSYFNNAKVVLV 337
Cdd:cd17979 154 NIELFSGYFEGAPVVQV 170
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
161-335 |
1.07e-46 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 164.43 E-value: 1.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVP-QLCVRAGIANsGSIAVTQPRRVAAISLASRVATEMGTNIGGIVG 239
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWIAG-GKIIVLEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 240 YHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnPLRLIIMSAT 319
Cdd:cd17990 80 YRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRD---DLRLLAMSAT 156
|
170
....*....|....*.
gi 71990212 320 LQAEKFQSYFNNAKVV 335
Cdd:cd17990 157 LDGDGLAALLPEAPVV 172
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
161-335 |
6.65e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 159.70 E-value: 6.65e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG-----SIAVTQPRRVAAISLASRVATEMGTNIG 235
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGtaqkcNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 236 -----GIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnp 310
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD---- 156
|
170 180
....*....|....*....|....*
gi 71990212 311 LRLIIMSATLQAEKFQSYFNNAKVV 335
Cdd:cd17975 157 LHLILMSATVDCEKFSSYFTHCPIL 181
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
161-335 |
3.11e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 140.75 E-value: 3.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLC----VRAGIANSGSIAVTQPRRVAAISLASRVATEMGTN--I 234
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 235 GGIVGYHVRFENATCHK-TKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRL 313
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD----LKV 156
|
170 180
....*....|....*....|..
gi 71990212 314 IIMSATLQAEKFQSYFNNAKVV 335
Cdd:cd17981 157 ILMSATLNAEKFSDYFNNCPMI 178
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
152-337 |
4.45e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 142.28 E-value: 4.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 152 NYEKF--SRPQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLC----VRAGIANSGSIAVTQPRRVAAISLASR 225
Cdd:cd17972 48 NLQQIlqERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYIlddfIQNDRAAECNIVVTQPRRISAVSVAER 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 226 VATEMGTNIGGIVGYHVRFENATCHK-TKIEYMTDGIVLRKalVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQR 304
Cdd:cd17972 128 VAFERGEEVGKSCGYSVRFESVLPRPhASILFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAY 205
|
170 180 190
....*....|....*....|....*....|...
gi 71990212 305 REtnnpLRLIIMSATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17972 206 PD----LRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
161-335 |
1.76e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 138.43 E-value: 1.76e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANS----GSIAVTQPRRVAAISLASRVATEMGTNIGG 236
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPplpvANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 237 IVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIM 316
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD----LKVILM 156
|
170
....*....|....*....
gi 71990212 317 SATLQAEKFQSYFNNAKVV 335
Cdd:cd17985 157 SATLNAELFSDYFNSCPVI 175
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
161-337 |
2.86e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 131.87 E-value: 2.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVR---AGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGI 237
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEyclSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 238 VGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIMS 317
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE----LKLVIIT 156
|
170 180
....*....|....*....|
gi 71990212 318 ATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17977 157 CPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
161-329 |
1.28e-34 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 130.31 E-value: 1.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG--SIAVTQPRRVAAISLASRVATEMGTNIGGIV 238
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKycNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 239 GYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCqdqRRETNNPLRLIIMSA 318
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRL---LRTNSRHVKIILMSA 157
|
170
....*....|.
gi 71990212 319 TLQAEKFQSYF 329
Cdd:cd17988 158 TISCKEFADYF 168
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
161-337 |
1.46e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 129.91 E-value: 1.46e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG----SIAVTQPRRVAAISLASRVATEMGTNIGG 236
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRgarcNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 237 IVGYHVRFENATCHK-TKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLII 315
Cdd:cd17976 81 NVGYQVRLESRPPPRgGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE----LRVVL 156
|
170 180
....*....|....*....|..
gi 71990212 316 MSATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17976 157 MSATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
161-337 |
2.44e-34 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 129.18 E-value: 2.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSG--SIAVTQPRRVAAISLASRVATEMGTNIGGIV 238
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIpcRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 239 GYHVRFENATCHKTKIEYMTDGIVLRKALV-SPLLDKYSCVIIDEAHERSLHSDVLMCILRqcqDQRRETNNpLRLIIMS 317
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLR---DILQKHPN-LKLILSS 156
|
170 180
....*....|....*....|
gi 71990212 318 ATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17987 157 AALDVNLFIRYFGSCPVIYI 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
161-337 |
6.68e-33 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 125.40 E-value: 6.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 161 LPIDAVEQQLMYELASQETLIVI-GETGSGKSTQVPQLCVRAGIA---NSGSIAVTQPRRVAAISLASRVATEMGTNIGG 236
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSrgfQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 237 IVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRREtnnpLRLIIM 316
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPE----LRVVVV 156
|
170 180
....*....|....*....|.
gi 71990212 317 SATLQAEKFQSYFNNAKVVLV 337
Cdd:cd17986 157 TSPALEPKLRAFWGNPPVVHV 177
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
180-347 |
5.82e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 91.78 E-value: 5.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 180 LIVIGETGSGKSTQVPQLCVRAGIANSG-SIAVTQPRRVAAISLASRVATEMGTNIGGIVGYHV------RFENATCHKT 252
Cdd:smart00487 27 VILAAPTGSGKTLAALLPALEALKRGKGgRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGgdskreQLRKLESGKT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 253 KIEYMTDGIVLRKALVSPL-LDKYSCVIIDEAHERS--LHSDVLMCILRQCQDQRretnnplRLIIMSATL--QAEKFQS 327
Cdd:smart00487 107 DILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV-------QLLLLSATPpeEIENLLE 179
|
170 180
....*....|....*....|..
gi 71990212 328 YFNNAKVVLVAGRT--FPIEVF 347
Cdd:smart00487 180 LFLNDPVFIDVGFTplEPIEQF 201
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
152-511 |
4.36e-18 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 89.27 E-value: 4.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 152 NYEKFSR---PQLPIDaVEQQLMYELASQETLIVIGETGSGKSTQVPQLC-----VRAGIANSGSIAVTQPRRVAAISLA 223
Cdd:PHA02653 152 NPEPFSKiplASLQPD-VQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLlwfnyLFGGFDNLDKIDPNFIERPIVLSLP 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 224 sRVA--TEMGTNIGGIVGYH--------VRFENAT---CHKTKIEYmtdGIVLR-KALVSPLLDKYSCVIIDEAHERSLH 289
Cdd:PHA02653 231 -RVAlvRLHSITLLKSLGFDeidgspisLKYGSIPdelINTNPKPY---GLVFStHKLTLNKLFDYGTVIIDEVHEHDQI 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 290 SDVLMCILRQCQDQRREtnnplrLIIMSATLQ--AEKFQSYFNNAKVVLVAGRT-FPI-EVFhvnpKINKSFSSTDYVY- 364
Cdd:PHA02653 307 GDIIIAVARKHIDKIRS------LFLMTATLEddRDRIKEFFPNPAFVHIPGGTlFPIsEVY----VKNKYNPKNKRAYi 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 365 -----NAVICVKYvhLTEPKGRDILVFLTGSEEIEAVASQLAELN---------GSLPASADVLMPVplYAALRPEkqke 430
Cdd:PHA02653 377 eeekkNIVTALKK--YTPPKGSSGIVFVASVSQCEEYKKYLEKRLpiydfyiihGKVPNIDEILEKV--YSSKNPS---- 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 431 afrktpqgarkVIISTNIAETSVTIPGIRVVIDSGKVKTKRF----EAFnridvlkvhnVSKAQAKQRAGRAGRDAPGKC 506
Cdd:PHA02653 449 -----------IIISTPYLESSVTIRNATHVYDTGRVYVPEPfggkEMF----------ISKSMRTQRKGRVGRVSPGTY 507
|
....*
gi 71990212 507 YRLYS 511
Cdd:PHA02653 508 VYFYD 512
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
563-659 |
4.79e-15 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 71.50 E-value: 4.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 563 ALLELTSLGAIRpvnsdrSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALF--SGAGDSKSDA 640
Cdd:pfam04408 1 ALELLYYLGALD------EDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFvqPNFLDPRSAA 74
|
90 100 110
....*....|....*....|....*....|
gi 71990212 641 DVDRIRRRFE-----------TREGDHITL 659
Cdd:pfam04408 75 KAARRRRRAAdekarakfarlDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
569-660 |
3.53e-13 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 65.37 E-value: 3.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 569 SLGAIRPvnsdrsKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFsgagDSKSDADVDRIRRR 648
Cdd:smart00847 1 ELGALDD------DGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR----PKEKREDADAARRR 70
|
90
....*....|..
gi 71990212 649 FETREGDHITLL 660
Cdd:smart00847 71 FADPESDHLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
743-815 |
1.44e-12 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 63.81 E-value: 1.44e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71990212 743 MRKALALGMFLNSCEYDRQEDRYRLMINPAITLkIHPSSCLSR---SKPAYIVFSELMKTNDLFALQVTLIDGDWV 815
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVF-IHPSSVLFNektFPPEWVVYQELVETTKVYIRTVTAISPEWL 75
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
417-501 |
1.27e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 61.07 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 417 VPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKtkrfeafnridvlkvhnvSKAQAKQRAG 496
Cdd:smart00490 15 ARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPW------------------SPASYIQRIG 76
|
....*
gi 71990212 497 RAGRD 501
Cdd:smart00490 77 RAGRA 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
375-500 |
9.24e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 59.53 E-value: 9.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 375 LTEPKGRDILVFLTGSEEIEAvaSQLAELNGslpasadvLMPVPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVT 454
Cdd:pfam00271 10 LKKERGGKVLIFSQTKKTLEA--ELLLEKEG--------IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 71990212 455 IPGIRVVIDSGKVKtkrfeafnridvlkvhnvSKAQAKQRAGRAGR 500
Cdd:pfam00271 80 LPDVDLVINYDLPW------------------NPASYIQRIGRAGR 107
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
153-505 |
1.19e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 58.37 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 153 YEKFSRPQlpIDAVEQQLMyelaSQETLIVIGETGSGKsTQVPQLCVRAGIANSGSIAVTQPRRvaaiSLASRVATEMGT 232
Cdd:COG1204 20 IEELYPPQ--AEALEAGLL----EGKNLVVSAPTASGK-TLIAELAILKALLNGGKALYIVPLR----ALASEKYREFKR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 233 NIGGIvGYHV------------RFENATchktkIEYMT----DGIVLRKAlvsPLLDKYSCVIIDEAH-----ERSLhsd 291
Cdd:COG1204 89 DFEEL-GIKVgvstgdydsddeWLGRYD-----ILVATpeklDSLLRNGP---SWLRDVDLVVVDEAHliddeSRGP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 292 VLMCILrqcqDQRRETNNPLRLIIMSATLQ-AEKFQSYFNnAKVVLVAGRTFPIEV-FHVNPKIN---KSFSSTDYVYNA 366
Cdd:COG1204 157 TLEVLL----ARLRRLNPEAQIVALSATIGnAEEIAEWLD-AELVKSDWRPVPLNEgVLYDGVLRfddGSRRSKDPTLAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 367 VIcvkyvHLTEPKGRdILVFLTGSEEIEAVASQLAEL---NGSLPASADVLMPV--------------PLYAALR----- 424
Cdd:COG1204 232 AL-----DLLEEGGQ-VLVFVSSRRDAESLAKKLADElkrRLTPEEREELEELAeellevseethtneKLADCLEkgvaf 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 425 -----PEKQK----EAFRKtpqGARKVIISTN-IAEtSVTIPGIRVVIDSgkvkTKRfEAFNRIDVLKVHNVskaqakqr 494
Cdd:COG1204 306 hhaglPSELRrlveDAFRE---GLIKVLVATPtLAA-GVNLPARRVIIRD----TKR-GGMVPIPVLEFKQM-------- 368
|
410
....*....|.
gi 71990212 495 AGRAGRdaPGK 505
Cdd:COG1204 369 AGRAGR--PGY 377
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
180-319 |
5.82e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 49.71 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 180 LIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATE--MGTNIGGIVGY---HVRFENATCHKtKI 254
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELfgPGIRVAVLVGGssaEEREKNKLGDA-DI 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71990212 255 EYMTDGIVLRK--ALVSPLLDKYSCVIIDEAHERSLHSDVlmcILRQCQDQRRETNNPLRLIIMSAT 319
Cdd:cd00046 83 IIATPDMLLNLllREDRLFLKDLKLIIVDEAHALLIDSRG---ALILDLAVRKAGLKNAQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
163-587 |
6.90e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 52.72 E-value: 6.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 163 IDAVEQQLMYELASQETLIVIGETGSGKSTqVPQLCVRAgIANSGSIAVTQPRRVaaisLASRVATEMGTNIGGIVGYHV 242
Cdd:COG1061 86 QEALEALLAALERGGGRGLVVAPTGTGKTV-LALALAAE-LLRGKRVLVLVPRRE----LLEQWAEELRRFLGDPLAGGG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 243 RFENatchKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHerslH--SDVLMCILRQCQDQRRetnnpLRLiimSATL 320
Cdd:COG1061 160 KKDS----DAPITVATYQSLARRAHLDELGDRFGLVIIDEAH----HagAPSYRRILEAFPAAYR-----LGL---TATP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 321 ----QAEKFQSYFNN------AKVVLVAGRTFPIEVFHV----NPKINKSFSSTDYVYNAVIC--------VKYVHLTEP 378
Cdd:COG1061 224 frsdGREILLFLFDGivyeysLKEAIEDGYLAPPEYYGIrvdlTDERAEYDALSERLREALAAdaerkdkiLRELLREHP 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 379 KGRDILVFLTGSEEIEAVASQLAELNGSLPAsadvlmpvpLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGI 458
Cdd:COG1061 304 DDRKTLVFCSSVDHAEALAELLNEAGIRAAV---------VTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRL 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 459 RVVIDSGKVKTKRFEAfnridvlkvhnvskaqakQRAGRAGRDAPGK--CY-------------RLYSREDFHKFEAENM 523
Cdd:COG1061 375 DVAILLRPTGSPREFI------------------QRLGRGLRPAPGKedALvydfvgndvpvleELAKDLRDLAGYRVEF 436
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71990212 524 PEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDNINAALLELTSLGAIRPVNSDRSKFALTE 587
Cdd:COG1061 437 LDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAK 500
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
180-320 |
1.12e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 46.47 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 180 LIVIGETGSGKST--QVPQLCVRAGIANSGSIAVTQPRRvaaiSLAS---RVATEMGTNIGGIV-----GYHVRFENATC 249
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLPALEALDKLDNGPQALVLAPTR----ELAEqiyEELKKLGKGLGLKVasllgGDSRKEQLEKL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71990212 250 HKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHErsLHSDVLMCILRQCqdqRRETNNPLRLIIMSATL 320
Cdd:pfam00270 93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR--LLDMGFGPDLEEI---LRRLPKKRQILLLSATL 158
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|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
441-510 |
4.69e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 42.31 E-value: 4.69e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71990212 441 KVIISTNIAETSVTIPGIRVVIDSGKVKtkrfeafnridvlkvhnvSKAQAKQRAGRAGRDA--PGKCYRLY 510
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGkdEGEVILFV 77
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|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
186-319 |
4.27e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.38 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 186 TGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLA-------------SRVATEMGTNIggivgyhvrfenatchkt 252
Cdd:cd17931 10 PGAGKTTRVLPQIIREAIKKRLRTLVLAPTRVVAAEMYealrglpiryrtgAVKEEHGGNEI------------------ 71
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71990212 253 kIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSdvlmcILRQCQDQRRETNNPLRLIIMSAT 319
Cdd:cd17931 72 -VDYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPAS-----IAARGYIHTRVEMGEAAVIFMTAT 132
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|
| AAA_22 |
pfam13401 |
AAA domain; |
180-316 |
3.09e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 38.48 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71990212 180 LIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVATEMGtniggiVGYHVRFENATChktkIEYMTD 259
Cdd:pfam13401 8 LVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALG------LPLSGRLSKEEL----LAALQQ 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 71990212 260 giVLRKALVSPLLdkyscvIIDEAHerSLHSDVLMcILRQCQDQRRetnNPLRLIIM 316
Cdd:pfam13401 78 --LLLALAVAVVL------IIDEAQ--HLSLEALE-ELRDLLNLSS---KLLQLILV 120
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|
| PTZ00265 |
PTZ00265 |
multidrug resistance protein (mdr1); Provisional |
150-192 |
6.22e-03 |
|
multidrug resistance protein (mdr1); Provisional
Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 40.40 E-value: 6.22e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 71990212 150 EANYEKFSRPQLPIdavEQQLMYELASQETLIVIGETGSGKST 192
Cdd:PTZ00265 1170 DVNFRYISRPNVPI---YKDLTFSCDSKKTTAIVGETGSGKST 1209
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