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Conserved domains on  [gi|17510001|ref|NP_491173|]
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Histone acetyltransferase GCN5 [Caenorhabditis elegans]

Protein Classification

PCAF_N and Bromo_gcn5_like domain-containing protein( domain architecture ID 13075348)

PCAF_N and Bromo_gcn5_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 650-748 1.15e-40

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 144.23  E-value: 1.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 650 SLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAE 729
Cdd:cd05509   1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                        90
                ....*....|....*....
gi 17510001 730 AVYYKYGYKLNELALKLLK 748
Cdd:cd05509  81 TEYYKCANKLEKFFWKKLK 99
COG5076 super family cl34891
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 408-735 2.75e-22

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


The actual alignment was detected with superfamily member COG5076:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 99.49  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 408 QEEESGLIEFRVIGNDLDPFqhhEQLVHLVELQNLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICFRTF-- 485
Cdd:COG5076  17 LKEEFGNELLRLVDNDSSPF---PNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFek 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 486 ---PSRGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKN---KIYHMLTYADEFAIGYFTKQGFSEKLEINDTVYQGWI 559
Cdd:COG5076  94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 560 KEYEGATLMGCHLHP--------QISYTKFPDFSKGIQALH-----CgyKSENGAESrgkvfgglehlfreSSPQLLELR 626
Cdd:COG5076 174 SKREYPDYYEIIKSPmdlltiqkKLKNGRYKSFEEFVSDLNlmfdnC--KLYNGPDS--------------SVYVDAKEL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 627 KVPGTDSLKMH--KKSCYHLDERDDSLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKA 704
Cdd:COG5076 238 EKYFLKLIEEIpeEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNY 317

                       330       340       350
                ....*....|....*....|....*....|.
gi 17510001 705 YTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:COG5076 318 YRPEETFVRDAKLFFDNCVMYNGEVTDYYKN 348
PCAF_N super family cl05793
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 6-247 5.47e-11

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


The actual alignment was detected with superfamily member pfam06466:

Pssm-ID: 461923  Cd Length: 249  Bit Score: 63.48  E-value: 5.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001     6 SLDEKRRQLTYFTSCNAGTCQCRGFRpvlNHEDETVERRATRAERENDFAPmtrdletlgseeiieCRTCGHSISFHAEP 85
Cdd:pfam06466  13 PRMKKLEKLAVYSSCQVEECKCNGWK---NTQPPTKPKCDEQQPCANFSDP---------------CRSCNHPLESHISH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001    86 LKYLSQEDLDTYTDQISDLQT---CCSELSEIDpshesLQTLYITMQILLKS--LRTLTPVDVPFIGKPNFEPESLSPYI 160
Cdd:pfam06466  75 LENASEEELNRLLGMVVDVENlfmSVHKEEDAD-----TKQVYFYLFKLLRKciLSMTKPVIEGPLGQPPFERPSIAKAV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   161 L---VKKF--IASRpvdnaEKQRLAEIGTLFLTEMNHWKLEGFQSLadKLNVPLEQGK-YRMMYVRMDYYVNMPAKYVSF 234
Cdd:pfam06466 150 MnfvLYKFshLPQR-----EWQTMYDLAKMFLHCLNHWNFETPSAR--KQRAKAEDASaYKINYTRWLCFCHVPAFCDSL 222

                         250
                  ....*....|...
gi 17510001   235 KQFQTVDIFGEKF 247
Cdd:pfam06466 223 PHYETTLVFGRTL 235
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 650-748 1.15e-40

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 144.23  E-value: 1.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 650 SLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAE 729
Cdd:cd05509   1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                        90
                ....*....|....*....
gi 17510001 730 AVYYKYGYKLNELALKLLK 748
Cdd:cd05509  81 TEYYKCANKLEKFFWKKLK 99
BROMO smart00297
bromo domain;
651-749 2.20e-25

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 101.20  E-value: 2.20e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001    651 LDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEA 730
Cdd:smart00297   8 LQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDS 87

                           90
                   ....*....|....*....
gi 17510001    731 VYYKYGYKLNELALKLLKT 749
Cdd:smart00297  88 EVYKDAKKLEKFFEKKLRE 106
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 408-735 2.75e-22

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 99.49  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 408 QEEESGLIEFRVIGNDLDPFqhhEQLVHLVELQNLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICFRTF-- 485
Cdd:COG5076  17 LKEEFGNELLRLVDNDSSPF---PNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFek 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 486 ---PSRGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKN---KIYHMLTYADEFAIGYFTKQGFSEKLEINDTVYQGWI 559
Cdd:COG5076  94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 560 KEYEGATLMGCHLHP--------QISYTKFPDFSKGIQALH-----CgyKSENGAESrgkvfgglehlfreSSPQLLELR 626
Cdd:COG5076 174 SKREYPDYYEIIKSPmdlltiqkKLKNGRYKSFEEFVSDLNlmfdnC--KLYNGPDS--------------SVYVDAKEL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 627 KVPGTDSLKMH--KKSCYHLDERDDSLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKA 704
Cdd:COG5076 238 EKYFLKLIEEIpeEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNY 317

                       330       340       350
                ....*....|....*....|....*....|.
gi 17510001 705 YTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:COG5076 318 YRPEETFVRDAKLFFDNCVMYNGEVTDYYKN 348
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 657-735 1.78e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 88.91  E-value: 1.78e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17510001   657 AILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:pfam00439   3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81
PCAF_N pfam06466
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 6-247 5.47e-11

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


Pssm-ID: 461923  Cd Length: 249  Bit Score: 63.48  E-value: 5.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001     6 SLDEKRRQLTYFTSCNAGTCQCRGFRpvlNHEDETVERRATRAERENDFAPmtrdletlgseeiieCRTCGHSISFHAEP 85
Cdd:pfam06466  13 PRMKKLEKLAVYSSCQVEECKCNGWK---NTQPPTKPKCDEQQPCANFSDP---------------CRSCNHPLESHISH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001    86 LKYLSQEDLDTYTDQISDLQT---CCSELSEIDpshesLQTLYITMQILLKS--LRTLTPVDVPFIGKPNFEPESLSPYI 160
Cdd:pfam06466  75 LENASEEELNRLLGMVVDVENlfmSVHKEEDAD-----TKQVYFYLFKLLRKciLSMTKPVIEGPLGQPPFERPSIAKAV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   161 L---VKKF--IASRpvdnaEKQRLAEIGTLFLTEMNHWKLEGFQSLadKLNVPLEQGK-YRMMYVRMDYYVNMPAKYVSF 234
Cdd:pfam06466 150 MnfvLYKFshLPQR-----EWQTMYDLAKMFLHCLNHWNFETPSAR--KQRAKAEDASaYKINYTRWLCFCHVPAFCDSL 222

                         250
                  ....*....|...
gi 17510001   235 KQFQTVDIFGEKF 247
Cdd:pfam06466 223 PHYETTLVFGRTL 235
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 436-544 1.18e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.98  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   436 LVELQNLFGAQLPKMPKEYVTRLIFDSRHQN---MVILKRDMGVIGGICFRTFPSRGFV-EIVFCAITAMEQVKGYGTHL 511
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDAsegFFVAEEDGELVGFASLSIIDDEPPVgEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 17510001   512 MNHCKDYMIKNKIYHM---LTYADEFAIGYFTKQGF 544
Cdd:pfam00583  81 LQALLEWARERGCERIfleVAADNLAAIALYEKLGF 116
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 650-748 1.15e-40

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 144.23  E-value: 1.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 650 SLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAE 729
Cdd:cd05509   1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                        90
                ....*....|....*....
gi 17510001 730 AVYYKYGYKLNELALKLLK 748
Cdd:cd05509  81 TEYYKCANKLEKFFWKKLK 99
BROMO smart00297
bromo domain;
651-749 2.20e-25

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 101.20  E-value: 2.20e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001    651 LDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEA 730
Cdd:smart00297   8 LQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDS 87

                           90
                   ....*....|....*....
gi 17510001    731 VYYKYGYKLNELALKLLKT 749
Cdd:smart00297  88 EVYKDAKKLEKFFEKKLRE 106
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 658-747 7.22e-23

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 93.59  E-value: 7.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 658 ILKKLTADkNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGY 737
Cdd:cd04369  11 ALKKLKRD-LSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAK 89

                        90
                ....*....|
gi 17510001 738 KLNELALKLL 747
Cdd:cd04369  90 KLEKLFEKLL 99
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 408-735 2.75e-22

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 99.49  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 408 QEEESGLIEFRVIGNDLDPFqhhEQLVHLVELQNLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICFRTF-- 485
Cdd:COG5076  17 LKEEFGNELLRLVDNDSSPF---PNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSPFek 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 486 ---PSRGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKN---KIYHMLTYADEFAIGYFTKQGFSEKLEINDTVYQGWI 559
Cdd:COG5076  94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 560 KEYEGATLMGCHLHP--------QISYTKFPDFSKGIQALH-----CgyKSENGAESrgkvfgglehlfreSSPQLLELR 626
Cdd:COG5076 174 SKREYPDYYEIIKSPmdlltiqkKLKNGRYKSFEEFVSDLNlmfdnC--KLYNGPDS--------------SVYVDAKEL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 627 KVPGTDSLKMH--KKSCYHLDERDDSLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKA 704
Cdd:COG5076 238 EKYFLKLIEEIpeEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNY 317

                       330       340       350
                ....*....|....*....|....*....|.
gi 17510001 705 YTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:COG5076 318 YRPEETFVRDAKLFFDNCVMYNGEVTDYYKN 348
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 657-735 1.78e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 88.91  E-value: 1.78e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17510001   657 AILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:pfam00439   3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 659-741 7.54e-20

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 85.06  E-value: 7.54e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 659 LKKLtadKNAWPFASPVD-VK-EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYG 736
Cdd:cd05500  16 LKRL---KDARPFLVPVDpVKlNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMG 92


                ....*
gi 17510001 737 YKLNE 741
Cdd:cd05500  93 KRLQA 97
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 658-726 1.97e-19

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 83.58  E-value: 1.97e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17510001 658 ILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFN 726
Cdd:cd05503   8 ILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFN 76
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 657-748 2.05e-19

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 84.37  E-value: 2.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 657 AILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYG 736
Cdd:cd05504  19 QLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKAG 98

                        90
                ....*....|..
gi 17510001 737 YKLNELALKLLK 748
Cdd:cd05504  99 TRLQRFFIKRCR 110
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 671-747 5.65e-19

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 82.45  E-value: 5.65e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17510001 671 FASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNELALKLL 747
Cdd:cd05512  22 FSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAAVRLRDQGGAIL 98
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 667-748 7.38e-18

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 79.62  E-value: 7.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 667 NAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNELALKL 746
Cdd:cd05511  17 DSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEMLELAEEL 96


                ..
gi 17510001 747 LK 748
Cdd:cd05511  97 LA 98
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 657-748 9.27e-17

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 76.31  E-value: 9.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 657 AILKKLTADKNAWPFASPVDVK--EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK 734
Cdd:cd05497  12 VVLKALWKHKFAWPFQQPVDAVklNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVL 91

                        90
                ....*....|....
gi 17510001 735 YGYKLNELALKLLK 748
Cdd:cd05497  92 MAQTLEKLFLQKLA 105
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 658-742 4.96e-16

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 74.24  E-value: 4.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 658 ILKKLTADKN---AWPFASPVD--VKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVY 732
Cdd:cd05499   8 VLKELMKPKHsayNWPFLDPVDpvALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDV 87

                        90
                ....*....|
gi 17510001 733 YKYGYKLNEL 742
Cdd:cd05499  88 YMMGHQLEEV 97
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 645-748 6.72e-16

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 74.01  E-value: 6.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 645 DERDDSLDsKIGAILKKLTADknAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYV 724
Cdd:cd05510   6 EEFYESLD-KVLNELKTYTEH--STPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLL 82

                        90       100
                ....*....|....*....|....*
gi 17510001 725 FNGAEA-VYYKYGYKLNELALKLLK 748
Cdd:cd05510  83 YNSDPShPLRRHANFMKKKAEHLLK 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 657-739 1.56e-15

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 72.70  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 657 AILKKLTADKN---AWPFASPVDVK--EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAV 731
Cdd:cd05498   7 GILKELFSKKHkayAWPFYKPVDPEalGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHP 86


                ....*...
gi 17510001 732 YYKYGYKL 739
Cdd:cd05498  87 VHAMARKL 94
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 656-756 2.45e-15

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 71.98  E-value: 2.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 656 GAILKKLTADKNAWPFASPVDVK--EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAeavyy 733
Cdd:cd05506   6 GTLLRKLMKHKWGWVFNAPVDVValGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPP----- 80

                        90       100
                ....*....|....*....|...
gi 17510001 734 kyGYKLNELALKLLKtSFpESSW 756
Cdd:cd05506  81 --GNDVHTMAKELLK-IF-ETRW 99
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 670-753 1.28e-12

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 64.62  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 670 PFASPVDvKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQ---HLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNELALKL 746
Cdd:cd05502  24 PFHEPVS-PSVPNYYKIIKTPMDLSLIRKKLQPKSPQHYsspEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQ 102


                ....*..
gi 17510001 747 LKTSFPE 753
Cdd:cd05502 103 LKEILPD 109
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 658-726 3.07e-12

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 63.32  E-value: 3.07e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17510001 658 ILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFN 726
Cdd:cd05505   8 ILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYY 76
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 658-727 1.61e-11

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 61.60  E-value: 1.61e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 658 ILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNG 727
Cdd:cd05528  11 VLKRLASDKRFNAFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNP 80
PCAF_N pfam06466
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 6-247 5.47e-11

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


Pssm-ID: 461923  Cd Length: 249  Bit Score: 63.48  E-value: 5.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001     6 SLDEKRRQLTYFTSCNAGTCQCRGFRpvlNHEDETVERRATRAERENDFAPmtrdletlgseeiieCRTCGHSISFHAEP 85
Cdd:pfam06466  13 PRMKKLEKLAVYSSCQVEECKCNGWK---NTQPPTKPKCDEQQPCANFSDP---------------CRSCNHPLESHISH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001    86 LKYLSQEDLDTYTDQISDLQT---CCSELSEIDpshesLQTLYITMQILLKS--LRTLTPVDVPFIGKPNFEPESLSPYI 160
Cdd:pfam06466  75 LENASEEELNRLLGMVVDVENlfmSVHKEEDAD-----TKQVYFYLFKLLRKciLSMTKPVIEGPLGQPPFERPSIAKAV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   161 L---VKKF--IASRpvdnaEKQRLAEIGTLFLTEMNHWKLEGFQSLadKLNVPLEQGK-YRMMYVRMDYYVNMPAKYVSF 234
Cdd:pfam06466 150 MnfvLYKFshLPQR-----EWQTMYDLAKMFLHCLNHWNFETPSAR--KQRAKAEDASaYKINYTRWLCFCHVPAFCDSL 222

                         250
                  ....*....|...
gi 17510001   235 KQFQTVDIFGEKF 247
Cdd:pfam06466 223 PHYETTLVFGRTL 235
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 671-747 6.03e-11

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 59.73  E-value: 6.03e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17510001 671 FASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNELALKLL 747
Cdd:cd05513  22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAKKLLHSGMKIL 98
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 658-742 4.00e-10

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 57.45  E-value: 4.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 658 ILKKLTADKNAWPFASPVDVK--EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:cd05495  12 LEKLYKQDPESLPFRQPVDPKllGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKY 91


                ....*..
gi 17510001 736 GYKLNEL 742
Cdd:cd05495  92 CTKLAEV 98
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 670-748 5.02e-10

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 57.01  E-value: 5.02e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17510001 670 PFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGaeavyykYGYKLNELALKLLK 748
Cdd:cd05508  22 PFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNG-------GDHKLTQAAKAIVK 93
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 645-750 2.12e-08

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 53.11  E-value: 2.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 645 DERDDSLDSKIGAILKKLTADKNAwPFASPVDVK-EVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCY 723
Cdd:cd05529  23 DEERERLISGLDKLLLSLQLEIAE-YFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAE 101

                        90       100
                ....*....|....*....|....*..
gi 17510001 724 VFNGAEAVYYKYGYKLNELALKLLKTS 750
Cdd:cd05529 102 TFNEPNSEIAKKAKRLSDWLLRILSSL 128
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 436-544 1.18e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.98  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   436 LVELQNLFGAQLPKMPKEYVTRLIFDSRHQN---MVILKRDMGVIGGICFRTFPSRGFV-EIVFCAITAMEQVKGYGTHL 511
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDAsegFFVAEEDGELVGFASLSIIDDEPPVgEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 17510001   512 MNHCKDYMIKNKIYHM---LTYADEFAIGYFTKQGF 544
Cdd:pfam00583  81 LQALLEWARERGCERIfleVAADNLAAIALYEKLGF 116
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 678-734 1.44e-07

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 50.38  E-value: 1.44e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK 734
Cdd:cd05515  34 SEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYK 90
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 681-742 6.53e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 48.48  E-value: 6.53e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17510001 681 PEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNEL 742
Cdd:cd05524  39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWEL 100
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 676-726 1.25e-06

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 47.62  E-value: 1.25e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17510001 676 DVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFN 726
Cdd:cd05522  33 DKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYN 83
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 670-726 4.63e-06

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 46.30  E-value: 4.63e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17510001 670 PFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFN 726
Cdd:cd05496  25 PFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 678-735 5.64e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 45.78  E-value: 5.64e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRkaYTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735
Cdd:cd05521  35 KDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKY 90
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 455-546 6.93e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.14  E-value: 6.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 455 VTRLIFDSRHQNMVILKRDMGVIGGICFRTFPSrGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKNKIYHMLTYADEF 534
Cdd:COG1246  18 IRPYALEEEIGEFWVAEEDGEIVGCAALHPLDE-DLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSA 96

                        90
                ....*....|..
gi 17510001 535 AIGYFTKQGFSE 546
Cdd:COG1246  97 AIHFYEKLGFEE 108
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 659-698 1.10e-05

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 45.13  E-value: 1.10e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17510001 659 LKKLTADKNAWPFASPVD--VKEVPEYYDHIKHPIDFKTMQE 698
Cdd:cd05494  12 LKRHRRNEDAWPFLEPVNppRRGAPDYRDVIKRPMSFGTKVN 53
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 678-726 1.30e-05

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 44.73  E-value: 1.30e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17510001 678 KEVPEYYDHIKHPIDFKtmqeKLKRKAYTHQHLFIADLNR----LFQNCYVFN 726
Cdd:cd05516  35 KELPEYYELIRKPVDFK----KIKERIRNHKYRSLEDLEKdvmlLCQNAQTFN 83
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 463-546 2.95e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.83  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001   463 RHQNMVILKRDMGVIGGICFRTFPSRGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKNKIYHMLTYADEFAIGYFTKQ 542
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ....
gi 17510001   543 GFSE 546
Cdd:pfam13508  81 GFEE 84
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 678-743 4.38e-05

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 43.10  E-value: 4.38e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYGYKLNELA 743
Cdd:cd05520  34 RKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLM 99
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 678-733 7.89e-05

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 42.43  E-value: 7.89e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYY 733
Cdd:cd05518  34 KDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVY 89
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 678-727 9.03e-05

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 42.38  E-value: 9.03e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNG 727
Cdd:cd05525  36 KKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYG 85
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 654-734 1.50e-04

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 41.58  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 654 KIGAILKKLTADKNAWPFASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYY 733
Cdd:cd05507   7 AILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVY 86


                .
gi 17510001 734 K 734
Cdd:cd05507  87 L 87
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 678-734 2.18e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 41.27  E-value: 2.18e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17510001 678 KEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK 734
Cdd:cd05517  34 VLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYK 90
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 671-726 2.15e-03

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 38.09  E-value: 2.15e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17510001 671 FASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFN 726
Cdd:cd05519  27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYN 82
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 682-751 7.42e-03

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 36.64  E-value: 7.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510001 682 EYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAvYYKYGYKLNELALKLLKTSF 751
Cdd:cd05501  32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDDD-FGQVGITLEKKFEKNFKEVF 100
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 687-744 8.67e-03

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 36.59  E-value: 8.67e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17510001 687 IKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKYG--------YKLNELAL 744
Cdd:cd05492  43 IHTHLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHGADSEQYDAArwlyrdtcHDLRELRL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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