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Conserved domains on  [gi|115533628|ref|NP_491131|]
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Tyrosinase copper-binding domain-containing protein [Caenorhabditis elegans]

Protein Classification

tyrosinase family protein( domain architecture ID 10447028)

tyrosinase family protein such as tyrosinase, a metal-containing oxidase that catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine

Gene Ontology:  GO:0046872|GO:0016491
PubMed:  29473882|11412044

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
149-338 3.01e-25

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


:

Pssm-ID: 425566  Cd Length: 209  Bit Score: 102.93  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  149 YNKIGRVHKY----SGVHSGPAFTLWHREFLKRLELALRD--HMKNPDFGLPFWDSTLDSLLPE--PKDSIIFSELFLGE 220
Cdd:pfam00264   4 YDDFAAIHGIpftpWPIHGNGLFLPWHRYYLLLFEQALREecGYADPTGTLPYWDWTDDPTSPGisSPTSLGGNGTFIPP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  221 VDDKGFVKNGPYHNWETMEGRAQIFRNFGEDDSGEM---LNDARVDWLINNPDINMILGATMPLSTCP-MNHTLDARMLE 296
Cdd:pfam00264  84 NGGVGEVTNGPFANYTVPNLGPHTIRRPPDNALAYNprcLTRDNPLLKQQLNTLDVVDDLLTYQPDYTsFSNTLEGDGGN 163
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 115533628  297 FS---HDYVHFFVNGDMSKSYSSSNDVCFVYHHGMIDWIFEHWRQ 338
Cdd:pfam00264 164 EEglpHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
149-338 3.01e-25

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 102.93  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  149 YNKIGRVHKY----SGVHSGPAFTLWHREFLKRLELALRD--HMKNPDFGLPFWDSTLDSLLPE--PKDSIIFSELFLGE 220
Cdd:pfam00264   4 YDDFAAIHGIpftpWPIHGNGLFLPWHRYYLLLFEQALREecGYADPTGTLPYWDWTDDPTSPGisSPTSLGGNGTFIPP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  221 VDDKGFVKNGPYHNWETMEGRAQIFRNFGEDDSGEM---LNDARVDWLINNPDINMILGATMPLSTCP-MNHTLDARMLE 296
Cdd:pfam00264  84 NGGVGEVTNGPFANYTVPNLGPHTIRRPPDNALAYNprcLTRDNPLLKQQLNTLDVVDDLLTYQPDYTsFSNTLEGDGGN 163
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 115533628  297 FS---HDYVHFFVNGDMSKSYSSSNDVCFVYHHGMIDWIFEHWRQ 338
Cdd:pfam00264 164 EEglpHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
149-338 3.01e-25

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 102.93  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  149 YNKIGRVHKY----SGVHSGPAFTLWHREFLKRLELALRD--HMKNPDFGLPFWDSTLDSLLPE--PKDSIIFSELFLGE 220
Cdd:pfam00264   4 YDDFAAIHGIpftpWPIHGNGLFLPWHRYYLLLFEQALREecGYADPTGTLPYWDWTDDPTSPGisSPTSLGGNGTFIPP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533628  221 VDDKGFVKNGPYHNWETMEGRAQIFRNFGEDDSGEM---LNDARVDWLINNPDINMILGATMPLSTCP-MNHTLDARMLE 296
Cdd:pfam00264  84 NGGVGEVTNGPFANYTVPNLGPHTIRRPPDNALAYNprcLTRDNPLLKQQLNTLDVVDDLLTYQPDYTsFSNTLEGDGGN 163
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 115533628  297 FS---HDYVHFFVNGDMSKSYSSSNDVCFVYHHGMIDWIFEHWRQ 338
Cdd:pfam00264 164 EEglpHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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