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Conserved domains on  [gi|25143708|ref|NP_491075|]
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tRNA (guanine(10)-N2)-methyltransferase homolog [Caenorhabditis elegans]

Protein Classification

TRM11 family methyltransferase( domain architecture ID 1004176)

TRM11 family SAM-dependent methyltransferase containing a THUMP domain, similar to Homo sapiens tRNA (guanine(10)-N2)-methyltransferase, the catalytic subunit of a tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs

EC:  2.1.1.-
Gene Ontology:  GO:0003676|GO:0008168
PubMed:  2690010

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
188-304 1.13e-15

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 74.60  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 188 TTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARAqgrssrqgvgqrgesesIKANFEQ 267
Cdd:COG1041   8 GSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEG-----------------ARENLEH 70
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25143708 268 YKSESQFlgVLIADSSKHGIWscNAKFDAIVADPPYG 304
Cdd:COG1041  71 YGYEDAD--VIRGDARDLPLA--DESVDAIVTDPPYG 103
TIGR01177 super family cl36838
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
5-309 6.96e-15

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


The actual alignment was detected with superfamily member TIGR01177:

Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 75.17  E-value: 6.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708     5 LVIFSQSHVDFRIAEFEAICSMFSI--KVDLSEKLNTTDHMfivnfeshlEVRKLLSRSILVKYAIELSIEAESYDImye 82
Cdd:TIGR01177   2 YVELSGEHPELPLAELKALAEVYGRvgDVEGVDRGLAIISA---------PIIDILERLAFTHEVGRSYDTCAAKDL--- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708    83 qiDNKPEIIEKFDKLEESFAIRFFAIgRKKKLDSIERIKAFLDVVPFNKAPICLKSPKNELflveeyenpsdeapkKVYF 162
Cdd:TIGR01177  70 --YDFVAGLEASDLDRKSFAVRVRDL-RGYSVDKARLERKIGAILKKKGFKVSLRRPDIVV---------------RVVI 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708   163 GK---LIGEGRAELKTK-YNLR---DRCYIGNTTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTE 235
Cdd:TIGR01177 132 TEdifYLGRVLEERDKEqFIERkpdRRPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTGGFLIEAGLMGAKVIGCD 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25143708   236 INYQTARaqgrssrqgvGQRgesesikANFEQYKSESQFlgVLIADSSKHGIWScnAKFDAIVADPPYGVREKA 309
Cdd:TIGR01177 212 IDWKMVA----------GAR-------INLEHYGIEDFF--VKRGDATKLPLSS--ESVDAIATDPPYGRSTTA 264
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
188-304 1.13e-15

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 74.60  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 188 TTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARAqgrssrqgvgqrgesesIKANFEQ 267
Cdd:COG1041   8 GSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEG-----------------ARENLEH 70
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25143708 268 YKSESQFlgVLIADSSKHGIWscNAKFDAIVADPPYG 304
Cdd:COG1041  71 YGYEDAD--VIRGDARDLPLA--DESVDAIVTDPPYG 103
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
5-309 6.96e-15

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 75.17  E-value: 6.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708     5 LVIFSQSHVDFRIAEFEAICSMFSI--KVDLSEKLNTTDHMfivnfeshlEVRKLLSRSILVKYAIELSIEAESYDImye 82
Cdd:TIGR01177   2 YVELSGEHPELPLAELKALAEVYGRvgDVEGVDRGLAIISA---------PIIDILERLAFTHEVGRSYDTCAAKDL--- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708    83 qiDNKPEIIEKFDKLEESFAIRFFAIgRKKKLDSIERIKAFLDVVPFNKAPICLKSPKNELflveeyenpsdeapkKVYF 162
Cdd:TIGR01177  70 --YDFVAGLEASDLDRKSFAVRVRDL-RGYSVDKARLERKIGAILKKKGFKVSLRRPDIVV---------------RVVI 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708   163 GK---LIGEGRAELKTK-YNLR---DRCYIGNTTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTE 235
Cdd:TIGR01177 132 TEdifYLGRVLEERDKEqFIERkpdRRPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTGGFLIEAGLMGAKVIGCD 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25143708   236 INYQTARaqgrssrqgvGQRgesesikANFEQYKSESQFlgVLIADSSKHGIWScnAKFDAIVADPPYGVREKA 309
Cdd:TIGR01177 212 IDWKMVA----------GAR-------INLEHYGIEDFF--VKRGDATKLPLSS--ESVDAIATDPPYGRSTTA 264
PRK14968 PRK14968
putative methyltransferase; Provisional
193-303 3.85e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708  193 ELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARAqgrssrqgvgqrgesesIKANFEQYKSES 272
Cdd:PRK14968  10 EDSFLLAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVEC-----------------AKCNAKLNNIRN 72
                         90       100       110
                 ....*....|....*....|....*....|...
gi 25143708  273 QFLGVLIADsskhgIWSC--NAKFDAIVADPPY 303
Cdd:PRK14968  73 NGVEVIRSD-----LFEPfrGDKFDVILFNPPY 100
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
192-315 3.95e-04

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 42.31  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708   192 PELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEF--------GAFVI-GTEINYQTARAqgrssrqgvgqrgesesIK 262
Cdd:pfam02384  31 REVSKLIVELLDPKPGESIYDPACGSGGFLIQAEKFvkehdgdtNDLSIyGQEKNPTTYRL-----------------AR 93
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25143708   263 ANFEQYKSESQFLGVLIADSSKHGIWSCNAKFDAIVADPPYGVREKARKTVKN 315
Cdd:pfam02384  94 MNMILHGIEYDDFHIRHGDTLTSPKFEDDKKFDVVVANPPFSDKWDANDTLEN 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
210-303 8.87e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.87  E-value: 8.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 210 VLDPFVGTGGLILPAAEFGAF-VIGTEIN---YQTARaqgRSSRQGVGQRGEsesikanfeqyksesqflgVLIADSSKh 285
Cdd:cd02440   2 VLDLGCGTGALALALASGPGArVTGVDISpvaLELAR---KAAAALLADNVE-------------------VLKGDAEE- 58
                        90
                ....*....|....*...
gi 25143708 286 GIWSCNAKFDAIVADPPY 303
Cdd:cd02440  59 LPPEADESFDVIISDPPL 76
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
188-304 1.13e-15

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 74.60  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 188 TTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARAqgrssrqgvgqrgesesIKANFEQ 267
Cdd:COG1041   8 GSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEG-----------------ARENLEH 70
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25143708 268 YKSESQFlgVLIADSSKHGIWscNAKFDAIVADPPYG 304
Cdd:COG1041  71 YGYEDAD--VIRGDARDLPLA--DESVDAIVTDPPYG 103
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
5-309 6.96e-15

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 75.17  E-value: 6.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708     5 LVIFSQSHVDFRIAEFEAICSMFSI--KVDLSEKLNTTDHMfivnfeshlEVRKLLSRSILVKYAIELSIEAESYDImye 82
Cdd:TIGR01177   2 YVELSGEHPELPLAELKALAEVYGRvgDVEGVDRGLAIISA---------PIIDILERLAFTHEVGRSYDTCAAKDL--- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708    83 qiDNKPEIIEKFDKLEESFAIRFFAIgRKKKLDSIERIKAFLDVVPFNKAPICLKSPKNELflveeyenpsdeapkKVYF 162
Cdd:TIGR01177  70 --YDFVAGLEASDLDRKSFAVRVRDL-RGYSVDKARLERKIGAILKKKGFKVSLRRPDIVV---------------RVVI 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708   163 GK---LIGEGRAELKTK-YNLR---DRCYIGNTTMDPELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTE 235
Cdd:TIGR01177 132 TEdifYLGRVLEERDKEqFIERkpdRRPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTGGFLIEAGLMGAKVIGCD 211
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25143708   236 INYQTARaqgrssrqgvGQRgesesikANFEQYKSESQFlgVLIADSSKHGIWScnAKFDAIVADPPYGVREKA 309
Cdd:TIGR01177 212 IDWKMVA----------GAR-------INLEHYGIEDFF--VKRGDATKLPLSS--ESVDAIATDPPYGRSTTA 264
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
200-317 1.64e-04

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 42.87  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 200 NLAMISPGDIVLDPFVGTGGLILPAAEFGA----------FVIGTEINYQTAR-AqgrssrqgvgqrgesesiKANFeqy 268
Cdd:COG0286  37 ELLDPKPGETVYDPACGSGGFLVEAAEYLKehggderkklSLYGQEINPTTYRlA------------------KMNL--- 95
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25143708 269 ksesqflgvLIADSSKHGIWSCNA---------KFDAIVADPPYGVREKARKTVKNKK 317
Cdd:COG0286  96 ---------LLHGIGDPNIELGDTlsndgdeleKFDVVLANPPFGGKWKKEELKDDLL 144
PRK14968 PRK14968
putative methyltransferase; Provisional
193-303 3.85e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708  193 ELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARAqgrssrqgvgqrgesesIKANFEQYKSES 272
Cdd:PRK14968  10 EDSFLLAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVEC-----------------AKCNAKLNNIRN 72
                         90       100       110
                 ....*....|....*....|....*....|...
gi 25143708  273 QFLGVLIADsskhgIWSC--NAKFDAIVADPPY 303
Cdd:PRK14968  73 NGVEVIRSD-----LFEPfrGDKFDVILFNPPY 100
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
192-315 3.95e-04

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 42.31  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708   192 PELSFIQSNLAMISPGDIVLDPFVGTGGLILPAAEF--------GAFVI-GTEINYQTARAqgrssrqgvgqrgesesIK 262
Cdd:pfam02384  31 REVSKLIVELLDPKPGESIYDPACGSGGFLIQAEKFvkehdgdtNDLSIyGQEKNPTTYRL-----------------AR 93
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25143708   263 ANFEQYKSESQFLGVLIADSSKHGIWSCNAKFDAIVADPPYGVREKARKTVKN 315
Cdd:pfam02384  94 MNMILHGIEYDDFHIRHGDTLTSPKFEDDKKFDVVVANPPFSDKWDANDTLEN 146
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
195-320 8.94e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 41.32  E-value: 8.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 195 SFIQSNLAM-------------ISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQ-TARAQGRSSRQGVGQrgeses 260
Cdd:COG2265 209 SFFQVNPEQaealyaaalewldLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEaVEDARENARLNGLKN------ 282
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25143708 261 ikANFEQYKSEsQFLGVLIADsskhgiwscnAKFDAIVADPPY-GVREKARKTVKNKKVDT 320
Cdd:COG2265 283 --VEFVAGDLE-EVLPELLWG----------GRPDVVVLDPPRaGAGPEVLEALAALGPRR 330
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
206-237 1.18e-03

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 40.08  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 25143708   206 PGDIVLDPFVGTGGLILPAAEFGAFVIGTEIN 237
Cdd:pfam01555 181 PGDIVLDPFAGSGTTGAAAKELGRNFIGIEIE 212
PRK13699 PRK13699
putative methylase; Provisional
206-243 2.94e-03

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 39.05  E-value: 2.94e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 25143708  206 PGDIVLDPFVGTGGLILPAAEFGAFVIGTEINYQTARA 243
Cdd:PRK13699 163 PNAIVLDPFAGSGSTCVAALQSGRRYIGIELLEQYHRA 200
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
204-252 4.90e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 37.28  E-value: 4.90e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 25143708 204 ISPGDIVLDPFVGTGGLILPAAEFGAFVIGTEIN-YQTARAQGRSSRQGV 252
Cdd:COG2226  20 LRPGARVLDLGCGTGRLALALAERGARVTGVDISpEMLELARERAAEAGL 69
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
206-304 5.29e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 37.75  E-value: 5.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 206 PGDIVLDPFVGTGGLILPA----AEFGAFVigtEINYQTARAqgrssrqgvgqrgesesIKANFEQYKSESQFLgVLIAD 281
Cdd:COG0742  41 EGARVLDLFAGSGALGLEAlsrgAASVVFV---EKDRKAAAV-----------------IRKNLEKLGLEDRAR-VIRGD 99
                        90       100
                ....*....|....*....|...
gi 25143708 282 SSKHGIWSCNAKFDAIVADPPYG 304
Cdd:COG0742 100 ALRFLKRLAGEPFDLVFLDPPYA 122
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
206-237 7.61e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 37.98  E-value: 7.61e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 25143708 206 PGDIVLDPFVGTGGLILPAAEFGAFVIGTEIN 237
Cdd:COG0863 182 PGDIVLDPFAGSGTTLVAAERLGRRFIGIEID 213
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
210-303 8.87e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.87  E-value: 8.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143708 210 VLDPFVGTGGLILPAAEFGAF-VIGTEIN---YQTARaqgRSSRQGVGQRGEsesikanfeqyksesqflgVLIADSSKh 285
Cdd:cd02440   2 VLDLGCGTGALALALASGPGArVTGVDISpvaLELAR---KAAAALLADNVE-------------------VLKGDAEE- 58
                        90
                ....*....|....*...
gi 25143708 286 GIWSCNAKFDAIVADPPY 303
Cdd:cd02440  59 LPPEADESFDVIISDPPL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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