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Conserved domains on  [gi|17510521|ref|NP_491035|]
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eLRR (extracellular Leucine-Rich Repeat) ONly [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-368 4.36e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 4.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  33 KGSSLRSIPILLDPRTTVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNE 112
Cdd:COG4886  28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 113 VFSKLKNLKTLIISSNDVQLGPECFAGLSQLQTLSIADNRLSFLPPSvLKPLSGLRNLDLSANKLLSMPASvMNNLGGLE 192
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 193 TLKLKQNLLSSLetGMFLSQ-KELKHLDVSENLIGDIEEgALYGLEKLETLNLTNNQLVRLPgNTWSLPALKTLDLSSNL 271
Cdd:COG4886 186 ELDLSNNQITDL--PEPLGNlTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 272 FVSLETASfdGLPALQYLNISHSR----NLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNELRY 347
Cdd:COG4886 262 LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
                       330       340
                ....*....|....*....|.
gi 17510521 348 VAPGMLQWPNIRNLHLANNDW 368
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLS 360
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-368 4.36e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 4.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  33 KGSSLRSIPILLDPRTTVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNE 112
Cdd:COG4886  28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 113 VFSKLKNLKTLIISSNDVQLGPECFAGLSQLQTLSIADNRLSFLPPSvLKPLSGLRNLDLSANKLLSMPASvMNNLGGLE 192
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 193 TLKLKQNLLSSLetGMFLSQ-KELKHLDVSENLIGDIEEgALYGLEKLETLNLTNNQLVRLPgNTWSLPALKTLDLSSNL 271
Cdd:COG4886 186 ELDLSNNQITDL--PEPLGNlTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 272 FVSLETASfdGLPALQYLNISHSR----NLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNELRY 347
Cdd:COG4886 262 LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
                       330       340
                ....*....|....*....|.
gi 17510521 348 VAPGMLQWPNIRNLHLANNDW 368
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLS 360
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
22-295 8.24e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 8.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   22 CKCPTKTTAVCKGSSLRSIPILLDPRTTVLDLSNNRISRLSADelsLYPNLEQLILHNNSITHLSAdvfsTLP-SLRVLD 100
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA----TLPdTIQEME 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  101 LSSNSLLSLPNEVFSKLKnlkTLIISSNDVQLGPECFAglSQLQTLSIADNRLSFLPPSVlkPlSGLRNLDLSANKLLSM 180
Cdd:PRK15370 248 LSINRITELPERLPSALQ---SLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--P-SGITHLNVQSNSLTAL 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  181 PASVMNNLgglETLKLKQNLLSSLETGMflsQKELKHLDVSENLIGDIEEgalyglekletlnltnnqlvRLPgntwslP 260
Cdd:PRK15370 320 PETLPPGL---KTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPE--------------------TLP------P 367
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 17510521  261 ALKTLDLSSNLFVSLEtasfDGLP-ALQYLNISHSR 295
Cdd:PRK15370 368 TITTLDVSRNALTNLP----ENLPaALQIMQASRNN 399
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
47-270 5.88e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 5.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  47 RTTVLDLSNNRISRLsaDELSLYPNLEQLILHNNSIThlsadvfstlpslrvldlssnsllslpnevfsKLKNLKTliis 126
Cdd:cd21340   3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKIT--------------------------------KIENLEF---- 44
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 127 sndvqlgpecfagLSQLQTLSIADNRLSFLPPsvLKPLSGLRNLDLSANKLlsmpaSVMNNLGG---LETLKL-KQNL-- 200
Cdd:cd21340  45 -------------LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-----SVVEGLENltnLEELHIeNQRLpp 104
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17510521 201 ---LSSLETGMFLSQKELKHLDVSENLIGDIEEgaLYGLEKLETLNLTNNQLVRLPGNTW---SLPALKTLDLSSN 270
Cdd:cd21340 105 gekLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDllsSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
190-249 9.22e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.22e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   190 GLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQL 249
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-368 4.36e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 4.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  33 KGSSLRSIPILLDPRTTVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNE 112
Cdd:COG4886  28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 113 VFSKLKNLKTLIISSNDVQLGPECFAGLSQLQTLSIADNRLSFLPPSvLKPLSGLRNLDLSANKLLSMPASvMNNLGGLE 192
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 193 TLKLKQNLLSSLetGMFLSQ-KELKHLDVSENLIGDIEEgALYGLEKLETLNLTNNQLVRLPgNTWSLPALKTLDLSSNL 271
Cdd:COG4886 186 ELDLSNNQITDL--PEPLGNlTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 272 FVSLETASfdGLPALQYLNISHSR----NLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNELRY 347
Cdd:COG4886 262 LTDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
                       330       340
                ....*....|....*....|.
gi 17510521 348 VAPGMLQWPNIRNLHLANNDW 368
Cdd:COG4886 340 LALSLSLLALLTLLLLLNLLS 360
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-312 1.22e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 1.22e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  49 TVLDLSNNRISRLSaDELSLYPNLEQLILHNNSITHLSADvFSTLPSLRVLDLSSNSLLSLPNEvFSKLKNLKTLIISSN 128
Cdd:COG4886 116 ESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN 192
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 129 DVQLGPECFAGLSQLQTLSIADNRLSFLPPSvLKPLSGLRNLDLSANKLLSMPAsvMNNLGGLETLKLKQNLLSSLETGM 208
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 209 FLSQkeLKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVRLPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQY 288
Cdd:COG4886 270 NLTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
                       250       260
                ....*....|....*....|....
gi 17510521 289 LNISHSRNLKTIQMATFVQLSSLH 312
Cdd:COG4886 348 ALLTLLLLLNLLSLLLTLLLTLGL 371
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-366 3.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 3.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 117 LKNLKTLIISSNDVQLGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASvmNNLGGLETLKL 196
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLL--LSLLLLLLLSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 197 KQNLLSSLETGMFLSQKELKHLDVSENligdieeGALYGLEKLETLNLTNNQLVRLPGNTWSLPALKTLDLSSNLFVSLE 276
Cdd:COG4886  80 LLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 277 tASFDGLPALQYLNISHSRnLKTIQmATFVQLSSLHWLSISSSALTHIhPSAFNPIPPLSHLDLSNNELRYVAPGMLQWP 356
Cdd:COG4886 153 -EPLGNLTNLKSLDLSNNQ-LTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLT 228
                       250
                ....*....|
gi 17510521 357 NIRNLHLANN 366
Cdd:COG4886 229 NLETLDLSNN 238
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
22-295 8.24e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 8.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   22 CKCPTKTTAVCKGSSLRSIPILLDPRTTVLDLSNNRISRLSADelsLYPNLEQLILHNNSITHLSAdvfsTLP-SLRVLD 100
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA----TLPdTIQEME 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  101 LSSNSLLSLPNEVFSKLKnlkTLIISSNDVQLGPECFAglSQLQTLSIADNRLSFLPPSVlkPlSGLRNLDLSANKLLSM 180
Cdd:PRK15370 248 LSINRITELPERLPSALQ---SLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--P-SGITHLNVQSNSLTAL 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  181 PASVMNNLgglETLKLKQNLLSSLETGMflsQKELKHLDVSENLIGDIEEgalyglekletlnltnnqlvRLPgntwslP 260
Cdd:PRK15370 320 PETLPPGL---KTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPE--------------------TLP------P 367
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 17510521  261 ALKTLDLSSNLFVSLEtasfDGLP-ALQYLNISHSR 295
Cdd:PRK15370 368 TITTLDVSRNALTNLP----ENLPaALQIMQASRNN 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-290 2.37e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  49 TVLDLSNNRISRLSAdELSLYPNLEQLILHNNSITHLSaDVFSTLPSLRVLDLSSNSLLSLPNEvFSKLKNLKTLIISSN 128
Cdd:COG4886 162 KSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN 238
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 129 DVQLGPEcFAGLSQLQTLSIADNRLSFLPPsvLKPLSGLRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLLSSLETGM 208
Cdd:COG4886 239 QLTDLPE-LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 209 FLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVRLPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQY 288
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                ..
gi 17510521 289 LN 290
Cdd:COG4886 396 TT 397
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
39-410 3.22e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 3.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   39 SIPILLDPRTTVLDLSNNRISRLSADELSLYPNLEQLILHNN--------SITHLSADVFSTLPSLRVldlssnsLLSLP 110
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnSLTNLTSLEFLTLASNQL-------VGQIP 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  111 NEVfSKLKNLKTLIISSNDVQLG-PECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLL-SMPASVMnNL 188
Cdd:PLN00113 206 REL-GQMKSLKWIYLGYNNLSGEiPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SL 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  189 GGLETLKLKQNLLSSL--ETGMFLSQKELKHLdVSENLIGDIeEGALYGLEKLETLNLTNNQLV-RLPGNTWSLPALKTL 265
Cdd:PLN00113 284 QKLISLDLSDNSLSGEipELVIQLQNLEILHL-FSNNFTGKI-PVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVL 361
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  266 DLSSN---------------LF-VSLETASFDG-LPAlqylNISHSRNLKTIQM----------ATFVQLSSLHWLSISS 318
Cdd:PLN00113 362 DLSTNnltgeipeglcssgnLFkLILFSNSLEGeIPK----SLGACRSLRRVRLqdnsfsgelpSEFTKLPLVYFLDISN 437
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  319 SALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDWHCSCDLRVSNLNPRDDAKCSGPEnLAGAPI 398
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK-LSGEIP 516
                        410
                 ....*....|..
gi 17510521  399 NELSSCSILGGL 410
Cdd:PLN00113 517 DELSSCKKLVSL 528
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
47-270 5.88e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 5.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  47 RTTVLDLSNNRISRLsaDELSLYPNLEQLILHNNSIThlsadvfstlpslrvldlssnsllslpnevfsKLKNLKTliis 126
Cdd:cd21340   3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKIT--------------------------------KIENLEF---- 44
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 127 sndvqlgpecfagLSQLQTLSIADNRLSFLPPsvLKPLSGLRNLDLSANKLlsmpaSVMNNLGG---LETLKL-KQNL-- 200
Cdd:cd21340  45 -------------LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-----SVVEGLENltnLEELHIeNQRLpp 104
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17510521 201 ---LSSLETGMFLSQKELKHLDVSENLIGDIEEgaLYGLEKLETLNLTNNQLVRLPGNTW---SLPALKTLDLSSN 270
Cdd:cd21340 105 gekLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDllsSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
51-371 7.12e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   51 LDLSNNRISRLSADELSLYPNLEQLILHNNSIT-HLSADVFSTLPSLRVLDLSSNSLLSLPnEVFSKLKNLKTLIISSND 129
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIP-ELVIQLQNLEILHLFSNN 319
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  130 VQLG-PECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLL---------------------SMPASVMNN 187
Cdd:PLN00113 320 FTGKiPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnSLEGEIPKS 399
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  188 LG---GLETLKLKQNLLSSLETGMFLSQKELKHLDVSEN-LIGDIEEGAlYGLEKLETLNLTNNQLV-RLPGNTWSlPAL 262
Cdd:PLN00113 400 LGacrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNnLQGRINSRK-WDMPSLQMLSLARNKFFgGLPDSFGS-KRL 477
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  263 KTLDLSSNLFVSLETASFDGLPALQYLNISHSRNLKTIQMatfvQLSS---LHWLSISSSALTHIHPSAFNPIPPLSHLD 339
Cdd:PLN00113 478 ENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPD----ELSSckkLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 17510521  340 LSNNELRYVAPGMLQwpNIRNL---HLANNDWHCS 371
Cdd:PLN00113 554 LSQNQLSGEIPKNLG--NVESLvqvNISHNHLHGS 586
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-275 1.83e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   35 SSLRSIPILLDPRTTVLDLSNNRISRLSadelslypnleqlilhnnsithlsadvfSTLPSLrvldlssnsllslpnevf 114
Cdd:PRK15370 230 NQLTSIPATLPDTIQEMELSINRITELP----------------------------ERLPSA------------------ 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  115 sklknLKTLIISSNDVQLGPECFAglSQLQTLSIADNRLSFLPPSVlkPlSGLRNLDLSANKLLSMPASVMNNlggLETL 194
Cdd:PRK15370 264 -----LQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--P-SGITHLNVQSNSLTALPETLPPG---LKTL 330
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  195 KLKQNLLSSLETGMflsQKELKHLDVSENLIGDIEEGAlygLEKLETLNLTNNQLVRLPGNtwsLP-ALKTLDLSSNLFV 273
Cdd:PRK15370 331 EAGENALTSLPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPEN---LPaALQIMQASRNNLV 401

                 ..
gi 17510521  274 SL 275
Cdd:PRK15370 402 RL 403
LRR_8 pfam13855
Leucine rich repeat;
190-249 9.22e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.22e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   190 GLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQL 249
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
238-295 1.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17510521   238 KLETLNLTNNQLVRLPGNTWS-LPALKTLDLSSNLFVSLETASFDGLPALQYLNISHSR 295
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
214-272 1.32e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   214 ELKHLDVSENLIGDIEEGALYGLEKLETLNLTNNQLVRLPGNTWS-LPALKTLDLSSNLF 272
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
49-249 3.21e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 3.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   49 TVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSL-RVLDLSSNSLLSLPNEvFSKLKNLKTLIISS 127
Cdd:PLN00113 359 TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLrRVRLQDNSFSGELPSE-FTKLPLVYFLDISN 437
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  128 NDVQ-----------------------LG--PECFaGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPA 182
Cdd:PLN00113 438 NNLQgrinsrkwdmpslqmlslarnkfFGglPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP 516
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17510521  183 SVMNNLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSEN-LIGDIEEGaLYGLEKLETLNLTNNQL 249
Cdd:PLN00113 517 DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNqLSGEIPKN-LGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
119-177 4.15e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.15e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   119 NLKTLIISSNDVQ-LGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKL 177
Cdd:pfam13855   2 NLRSLDLSNNRLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
47-345 8.06e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   47 RTTVLDLSNNRIS-RLSADELSLyPNLEQLILHNNSIT-HLSADVFSTLPSLRVLdlssnsllslpnevfsklkNLktli 124
Cdd:PLN00113  70 RVVSIDLSGKNISgKISSAIFRL-PYIQTINLSNNQLSgPIPDDIFTTSSSLRYL-------------------NL---- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  125 isSNDVQLGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLLSS- 203
Cdd:PLN00113 126 --SNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGq 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  204 --LETGMFLSQK---------------------ELKHLD-VSENLIGDIEEgALYGLEKLETLNLTNNQLV-RLPGNTWS 258
Cdd:PLN00113 204 ipRELGQMKSLKwiylgynnlsgeipyeiggltSLNHLDlVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFS 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  259 LPALKTLDLSSNlFVSLETASFdgLPALQYLNISH--SRNLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLS 336
Cdd:PLN00113 283 LQKLISLDLSDN-SLSGEIPEL--VIQLQNLEILHlfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT 359

                 ....*....
gi 17510521  337 HLDLSNNEL 345
Cdd:PLN00113 360 VLDLSTNNL 368
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
213-366 1.63e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 1.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 213 KELKHLDVSENLIGDIEegALYGLEKLETLNLTNNQLVRLPgNTWSLPALKTLDLSSNLFVSLEtaSFDGLPALQYLNIS 292
Cdd:cd21340  24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIE 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 293 H------------SRNLKTIQmatfvqlSSLHWLSISSSALTHIHPsaFNPIPPLSHLDLSNNELR---YVAPGMLQWPN 357
Cdd:cd21340  99 NqrlppgekltfdPRSLAALS-------NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdleELLDLLSSWPS 169

                ....*....
gi 17510521 358 IRNLHLANN 366
Cdd:cd21340 170 LRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
284-345 4.45e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 4.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17510521   284 PALQYLNISHSRnLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNEL 345
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
309-367 1.16e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   309 SSLHWLSISSSALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQ-WPNIRNLHLANND 367
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
43-270 2.93e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  43 LLDPRTTVLDLSNNRIS----RLSADELSLYPNLEQLILHNNSITHLSADVFStlpslrvldlssnsllslpnEVFSKLK 118
Cdd:COG5238 177 LQNNSVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIGDEGAEILA--------------------EALKGNK 236
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 119 NLKTLIISSNdvQLGPECFAGLSQlqtlsiadnrlsflppsVLKPLSGLRNLDLSANKLlsmpasvmnnlgGLETLKLKQ 198
Cdd:COG5238 237 SLTTLDLSNN--QIGDEGVIALAE-----------------ALKNNTTVETLYLSGNQI------------GAEGAIALA 285
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 199 NLLSSletgmflsQKELKHLDVSENLIGDieEGALY---GLEK---LETLNLTNNQL-----VRLPGNTWSLPALKTLDL 267
Cdd:COG5238 286 KALQG--------NTTLTSLDLSVNRIGD--EGAIAlaeGLQGnktLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDL 355

                ...
gi 17510521 268 SSN 270
Cdd:COG5238 356 SDN 358
LRR_8 pfam13855
Leucine rich repeat;
46-97 5.17e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17510521    46 PRTTVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLR 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLR 52
LRR_8 pfam13855
Leucine rich repeat;
141-201 4.85e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17510521   141 SQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSANKLLSMPASVMNNLGGLETLKLKQNLL 201
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
141-270 1.22e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 141 SQLQTLSIADNRLS-----FLPPSVLKPLSGLRNLDLSANKLLSMP----ASVMNNLGGLETLKLKQNLLS-----SLET 206
Cdd:cd00116 108 SSLQELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdagirALAE 187
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17510521 207 GmFLSQKELKHLDVSENLIGDIEEGALYG----LEKLETLNLTNNQLVR------LPGNTWSLPALKTLDLSSN 270
Cdd:cd00116 188 G-LKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
41-97 1.35e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.35e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17510521  41 PILLDPRT--------TVLDLSNNRISRLSadELSLYPNLEQLILHNNSITHLS--ADVFSTLPSLR 97
Cdd:cd21340 107 KLTFDPRSlaalsnslRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLR 171
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
50-177 2.14e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  50 VLDLSNNRIS----RLSADEL-SLYPNLEQLILHNNSITHLS----ADVFSTLPSLRVLDLS----SNSLLSLPNEVFSK 116
Cdd:cd00116 112 ELKLNNNGLGdrglRLLAKGLkDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLAnngiGDAGIRALAEGLKA 191
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17510521 117 LKNLKTLIISSN------DVQLGpECFAGLSQLQTLSIADNRLSF-----LPPSVLKPLSGLRNLDLSANKL 177
Cdd:cd00116 192 NCNLEVLDLNNNgltdegASALA-ETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
70-130 5.83e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17510521    70 PNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNEVFSKLKNLKTLIISSNDV 130
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
143-367 1.17e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 143 LQTLSIADNRLSFLPPSVLKPLSGLRN------LDLSANKLLSMPASVMNNL---GGLETLKLKQNLLSslETGMFLSQK 213
Cdd:cd00116  53 LKELCLSLNETGRIPRGLQSLLQGLTKgcglqeLDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLG--DRGLRLLAK 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 214 ELKH-------LDVSENLI--GDIEE--GALYGLEKLETLNLTNNQLvRLPGNTW------SLPALKTLDLSSNLFVSLE 276
Cdd:cd00116 131 GLKDlppalekLVLGRNRLegASCEAlaKALRANRDLKELNLANNGI-GDAGIRAlaeglkANCNLEVLDLNNNGLTDEG 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521 277 TASFDG----LPALQYLNISHSrnlktiqmatfvqlsslhwlSISSSALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGM 352
Cdd:cd00116 210 ASALAEtlasLKSLEVLNLGDN--------------------NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKD 269
                       250       260
                ....*....|....*....|
gi 17510521 353 L-----QWPNIRNLHLANND 367
Cdd:cd00116 270 LaevlaEKESLLELDLRGNK 289
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
68-368 2.78e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.53  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521   68 LYPNLEQLILHNNSITHLSAdvfsTLPSLRVLDLSSNSLLSLPnevfSKLKNLKTLIISSNDVQLGPECFAGLSQLQtls 147
Cdd:PRK15387 220 LPAHITTLVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLW--- 288
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  148 IADNRLSFLPpsVLKPlsGLRNLDLSANKLLSMPAsVMNNLGGLETLKLKQNLLSSLETGmflsqkeLKHLDVSENLIGD 227
Cdd:PRK15387 289 IFGNQLTSLP--VLPP--GLQELSVSDNQLASLPA-LPSELCKLWAYNNQLTSLPTLPSG-------LQELSVSDNQLAS 356
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17510521  228 IEEGAlyglEKLETLNLTNNQLVRLPgntwSLPA-LKTLDLSSNLFVSLETA------------SFDGLPALQ--YLNIS 292
Cdd:PRK15387 357 LPTLP----SELYKLWAYNNRLTSLP----ALPSgLKELIVSGNRLTSLPVLpselkelmvsgnRLTSLPMLPsgLLSLS 428
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17510521  293 HSRNLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPplSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDW 368
Cdd:PRK15387 429 VYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREIT--SAPGYSGPIIRFDMAGASAPRETRALHLAAADW 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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