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Conserved domains on  [gi|17509855|ref|NP_490922|]
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Tetratricopeptide repeat protein 5 OB fold domain-containing protein [Caenorhabditis elegans]

Protein Classification

tetratricopeptide repeat protein 5( domain architecture ID 11421408)

tetratricopeptide repeat protein 5 (TTC5) is a cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation, and DNA repair

CATH:  1.25.40.10
Gene Ontology:  GO:0043022|GO:0006281|GO:0006974|GO:0003677
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC5_OB pfam16669
Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the ...
 276-396 3.95e-35

Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the C-terminus of Tetratricopeptide repeat protein 5 and is required for effective p53 response.


:

Pssm-ID: 465225  Cd Length: 115  Bit Score: 125.42  E-value: 3.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855   276 KMKAKRMQEMINELKKSSdGFRAKIIGNIGHDETIPVALVGVDAAGEVYGITIYNCLSNFGFVIGDTVTIAKPDFREIKn 355
Cdd:pfam16669   1 KLKRATLDDLKEGLNKGK-VVLGKVVGSITHEEPVPLTFVLVDSEGTCFVVTVYNLAQGKGVKIGDSVAIPEPYLRFID- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 17509855   356 ltIPSdpEIHVDSVKWIRVATPTQMKKNGVPLPESVLARAV 396
Cdd:pfam16669  79 --FSW--KGKHFQFKSIRVDTPLQLLVNGKKLGPDSQARAV 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
87-272 3.16e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  87 VRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIS-KTAPILTSLAVAmrLVALEHPEpaqaeirtKAMELIIEARR 165
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEALYNLGLA--YLRLGRYE--------EALADYEQALE 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 166 LDSAYGPA--NIAFAtglfycffstaKVELKFLDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAV 243
Cdd:COG0457  71 LDPDDAEAlnNLGLA-----------LQALGRYEEALEDYDKALE--LDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                       170       180
                ....*....|....*....|....*....
gi 17509855 244 EYDPRNElETREKLASFVSYLSKFTDAIQ 272
Cdd:COG0457 138 ELDPDDA-DALYNLGIALEKLGRYEEALE 165
 
Name Accession Description Interval E-value
TTC5_OB pfam16669
Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the ...
 276-396 3.95e-35

Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the C-terminus of Tetratricopeptide repeat protein 5 and is required for effective p53 response.


Pssm-ID: 465225  Cd Length: 115  Bit Score: 125.42  E-value: 3.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855   276 KMKAKRMQEMINELKKSSdGFRAKIIGNIGHDETIPVALVGVDAAGEVYGITIYNCLSNFGFVIGDTVTIAKPDFREIKn 355
Cdd:pfam16669   1 KLKRATLDDLKEGLNKGK-VVLGKVVGSITHEEPVPLTFVLVDSEGTCFVVTVYNLAQGKGVKIGDSVAIPEPYLRFID- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 17509855   356 ltIPSdpEIHVDSVKWIRVATPTQMKKNGVPLPESVLARAV 396
Cdd:pfam16669  79 --FSW--KGKHFQFKSIRVDTPLQLLVNGKKLGPDSQARAV 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
87-272 3.16e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  87 VRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIS-KTAPILTSLAVAmrLVALEHPEpaqaeirtKAMELIIEARR 165
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEALYNLGLA--YLRLGRYE--------EALADYEQALE 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 166 LDSAYGPA--NIAFAtglfycffstaKVELKFLDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAV 243
Cdd:COG0457  71 LDPDDAEAlnNLGLA-----------LQALGRYEEALEDYDKALE--LDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                       170       180
                ....*....|....*....|....*....
gi 17509855 244 EYDPRNElETREKLASFVSYLSKFTDAIQ 272
Cdd:COG0457 138 ELDPDDA-DALYNLGIALEKLGRYEEALE 165
TPR_1 pfam00515
Tetratricopeptide repeat;
216-249 2.20e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 2.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17509855   216 PQVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 216-249 3.07e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 3.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 17509855    216 PQVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 194-271 1.91e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.35  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17509855   194 KFLDKVIENYKKALECelsRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPrNELETREKLASFVSYLSKFTDAI 271
Cdd:TIGR00990 141 KDFNKAIKLYSKAIEC---KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDP-DYSKALNRRANAYDGLGKYADAL 214
PRK10370 PRK10370
formate-dependent nitrite reductase complex subunit NrfG; Provisional
 59-159 3.03e-03

formate-dependent nitrite reductase complex subunit NrfG; Provisional


Pssm-ID: 182415 [Multi-domain]  Cd Length: 198  Bit Score: 38.73  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855   59 ALLLAEGGKMYNVLEDYNE--TAEKMLS---KSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGI-SKTAPILTS 132
Cdd:PRK10370  33 QAVRAEYQRLADPLHQFASqqTPEAQLQalqDKIRANPQNSEQWALLGEYYLWRNDYDNALLAYRQALQLrGENAELYAA 112

                         90       100
                 ....*....|....*....|....*..
gi 17509855  133 LAVAMRLVALEHPEPAQAEIRTKAMEL 159
Cdd:PRK10370 113 LATVLYYQAGQHMTPQTREMIDKALAL 139
 
Name Accession Description Interval E-value
TTC5_OB pfam16669
Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the ...
 276-396 3.95e-35

Tetratricopeptide repeat protein 5 OB fold domain; This OB fold domain is located at the C-terminus of Tetratricopeptide repeat protein 5 and is required for effective p53 response.


Pssm-ID: 465225  Cd Length: 115  Bit Score: 125.42  E-value: 3.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855   276 KMKAKRMQEMINELKKSSdGFRAKIIGNIGHDETIPVALVGVDAAGEVYGITIYNCLSNFGFVIGDTVTIAKPDFREIKn 355
Cdd:pfam16669   1 KLKRATLDDLKEGLNKGK-VVLGKVVGSITHEEPVPLTFVLVDSEGTCFVVTVYNLAQGKGVKIGDSVAIPEPYLRFID- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 17509855   356 ltIPSdpEIHVDSVKWIRVATPTQMKKNGVPLPESVLARAV 396
Cdd:pfam16669  79 --FSW--KGKHFQFKSIRVDTPLQLLVNGKKLGPDSQARAV 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
87-272 3.16e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  87 VRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIS-KTAPILTSLAVAmrLVALEHPEpaqaeirtKAMELIIEARR 165
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDpDDAEALYNLGLA--YLRLGRYE--------EALADYEQALE 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 166 LDSAYGPA--NIAFAtglfycffstaKVELKFLDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAV 243
Cdd:COG0457  71 LDPDDAEAlnNLGLA-----------LQALGRYEEALEDYDKALE--LDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                       170       180
                ....*....|....*....|....*....
gi 17509855 244 EYDPRNElETREKLASFVSYLSKFTDAIQ 272
Cdd:COG0457 138 ELDPDDA-DALYNLGIALEKLGRYEEALE 165
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-259 4.45e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 4.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  66 GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGI-SKTAPILTSLAVAmrLVALEH 144
Cdd:COG0457  15 GLAYRRLGRYEE-AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELdPDDAEALNNLGLA--LQALGR 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 145 PEpaqaeirtKAMELIIEARRLDSAYGPAniafatglfYCFFSTAKVELKFLDKVIENYKKALecELSRTDPQVYINMAT 224
Cdd:COG0457  92 YE--------EALEDYDKALELDPDDAEA---------LYNLGLALLELGRYDEAIEAYERAL--ELDPDDADALYNLGI 152

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17509855 225 CLKFMEKYDEALAVLQKAVEYDPRNELETREKLAS 259
Cdd:COG0457 153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAA 187
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 57-272 1.08e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  57 QKALLLAEGGKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIS-KTAPILTSLAV 135
Cdd:COG2956  74 DRAEALLELAQDYLKAGLLDR-AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpENAHAYCELAE 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 136 AmrlvALEHPEPAqaeirtKAMELIIEARRLDSAYGPANIAfatglfycffsTAKVELKF--LDKVIENYKKALEceLSR 213
Cdd:COG2956 153 L----YLEQGDYD------EAIEALEKALKLDPDCARALLL-----------LAELYLEQgdYEEAIAALERALE--QDP 209

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17509855 214 TDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPRNELetREKLASFVSYLSKFTDAIQ 272
Cdd:COG2956 210 DYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL--LLALADLLERKEGLEAALA 266
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-249 4.92e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 4.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  57 QKALLLAEGGKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEfaqscfkialgisktapiltslava 136
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDE-AEALLEKALELDPDNPEAFALLGEILLQLGDLD------------------------- 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 137 mrlvalehpepaqaeirtKAMELIIEARRLDSAYGPANIAFATglfycffstAKVELKFLDKVIENYKKALEceLSRTDP 216
Cdd:COG4783  56 ------------------EAIVLLHEALELDPDEPEARLNLGL---------ALLKAGDYDEALALLEKALK--LDPEHP 106

                       170       180       190
                ....*....|....*....|....*....|...
gi 17509855 217 QVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:COG4783 107 EAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 148-272 9.60e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 9.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 148 AQAEIRTKAMELIIEARRLDSAYGPANIAFATGLFYCFFSTAKVELKFLDKVIENYKKALEceLSRTDPQVYINMATCLK 227
Cdd:COG5010  22 TLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ--LDPNNPELYYNLALLYS 99

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 17509855 228 FMEKYDEALAVLQKAVEYDPRNElETREKLASFVSYLSKFTDAIQ 272
Cdd:COG5010 100 RSGDKDEAKEYYEKALALSPDNP-NAYSNLAALLLSLGQDDEAKA 143
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 71-249 4.56e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 4.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  71 VLEDYNETAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKTApiltslAVAMRLVALEHpepAQA 150
Cdd:COG2956  19 LLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------AEALLELAQDY---LKA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 151 EIRTKAMELIIEARRLDsaygPANIAFATGLFYCFFSTAKvelkfLDKVIENYKKALEceLSRTDPQVYINMATCLKFME 230
Cdd:COG2956  90 GLLDRAEELLEKLLELD----PDDAEALRLLAEIYEQEGD-----WEKAIEVLERLLK--LGPENAHAYCELAELYLEQG 158

                       170
                ....*....|....*....
gi 17509855 231 KYDEALAVLQKAVEYDPRN 249
Cdd:COG2956 159 DYDEAIEALEKALKLDPDC 177
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 72-250 4.78e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.92  E-value: 4.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  72 LEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIsktapiltslavamrlvalehpEPAQAE 151
Cdd:COG3914  91 LGRYEE-ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL----------------------NPDFAE 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 152 IRtkameliiearrldSAYGpaNIAFATGLFycffstakvelkflDKVIENYKKALEceLSRTDPQVYINMATCLKFMEK 231
Cdd:COG3914 148 AY--------------LNLG--EALRRLGRL--------------EEAIAALRRALE--LDPDNAEALNNLGNALQDLGR 195

                       170
                ....*....|....*....
gi 17509855 232 YDEALAVLQKAVEYDPRNE 250
Cdd:COG3914 196 LEEAIAAYRRALELDPDNA 214
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 94-272 9.21e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 9.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  94 ADAWHELGLCVMKRRDLEFAQSCFKIALGIsktAPILTSLAVAMRLVALEHPEPAQAEIRTKAMELIIEARRLDSAYGPA 173
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAA---ELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 174 NIAFATGLFYCffstakVELKFLDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPRNeLET 253
Cdd:COG3914  78 AALLELAALLL------QALGRYEEALALYRRALA--LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF-AEA 148

                       170
                ....*....|....*....
gi 17509855 254 REKLASFVSYLSKFTDAIQ 272
Cdd:COG3914 149 YLNLGEALRRLGRLEEAIA 167
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-244 1.26e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  66 GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKT-APILTSLAvamrLVALEH 144
Cdd:COG2956 117 AEIYEQEGDWEK-AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDcARALLLLA----ELYLEQ 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 145 PEPAQAEirtKAMELIIEARrldsaygPANIAFATGLFYCFfstakVELKFLDKVIENYKKALEcelSRTDPQVYINMAT 224
Cdd:COG2956 192 GDYEEAI---AALERALEQD-------PDYLPALPRLAELY-----EKLGDPEEALELLRKALE---LDPSDDLLLALAD 253

                       170       180
                ....*....|....*....|
gi 17509855 225 CLKFMEKYDEALAVLQKAVE 244
Cdd:COG2956 254 LLERKEGLEAALALLERQLR 273
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 66-257 1.53e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  66 GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKT-APILTSLAVAmrLVALEH 144
Cdd:COG3914 119 GNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDnAEALNNLGNA--LQDLGR 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 145 PEPAQAEIRtKAMELiiearrldsayGPANIAFATGLFYCFFSTAKVElkfLDKVIENYKKALECELSRTDPQV--YIN- 221
Cdd:COG3914 196 LEEAIAAYR-RALEL-----------DPDNADAHSNLLFALRQACDWE---VYDRFEELLAALARGPSELSPFAllYLPd 260

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 17509855 222 --MATCLKFMEKYDEALAVLQKAVEYDPRNELETREKL 257
Cdd:COG3914 261 ddPAELLALARAWAQLVAAAAAPELPPPPNPRDPDRKL 298
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 196-272 1.86e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 1.86e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17509855 196 LDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPrNELETREKLASFVSYLSKFTDAIQ 272
Cdd:COG4783  20 YDEAEALLEKALE--LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP-DEPEARLNLGLALLKAGDYDEALA 93
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 196-272 1.87e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 1.87e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17509855 196 LDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPRNeLETREKLASFVSYLSKFTDAIQ 272
Cdd:COG4235  33 YDEALAAYEKALR--LDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDN-PEALYLLGLAAFQQGDYAEAIA 106
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 79-250 2.75e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 2.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  79 AEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIS-KTAPILTSLAVAmrLVALEHPEPAQAEIRtkam 157
Cdd:COG4235   2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDpDNADALLDLAEA--LLAAGDTEEAEELLE---- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 158 eliiEARRLDSaygpaniafatglfycffstakvelkfldkvienykkalecelsrTDPQVYINMATCLKFMEKYDEALA 237
Cdd:COG4235  76 ----RALALDP---------------------------------------------DNPEALYLLGLAAFQQGDYAEAIA 106

                       170
                ....*....|...
gi 17509855 238 VLQKAVEYDPRNE 250
Cdd:COG4235 107 AWQKLLALLPADA 119
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
124-249 3.71e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.52  E-value: 3.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 124 SKTAPILTSLAVAMRLVALEHPEPAQA---EIRTKAMELIIEARRLDSAYGPANIAFATGLFYCFFS--TAKVELKFLDK 198
Cdd:COG4785  12 LALAAAAASKAAILLAALLFAAVLALAialADLALALAAAALAAAALAAERIDRALALPDLAQLYYErgVAYDSLGDYDL 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17509855 199 VIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:COG4785  92 AIADFDQALE--LDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDY 140
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 57-159 4.52e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.41  E-value: 4.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  57 QKALLLAEGGKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKTAP-ILTSLAV 135
Cdd:COG5010  52 KAFAIESPSDNLYNKLGDFEE-SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPnAYSNLAA 130

                        90       100
                ....*....|....*....|....
gi 17509855 136 AmrLVALEHPEPAQAEIRtKAMEL 159
Cdd:COG5010 131 L--LLSLGQDDEAKAALQ-RALGT 151
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 155-247 8.00e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 8.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 155 KAMELIIEARRLDsaygPANIAFATGLFYCFFstakvELKFLDKVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDE 234
Cdd:COG5010  72 ESLALLEQALQLD----PNNPELYYNLALLYS-----RSGDKDEAKEYYEKALA--LSPDNPNAYSNLAALLLSLGQDDE 140

                        90
                ....*....|...
gi 17509855 235 ALAVLQKAVEYDP 247
Cdd:COG5010 141 AKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
50-247 1.95e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 1.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  50 SRAYDTNQKALLLAEGGKMYNVLEDYNETAEKmlSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGIsktapi 129
Cdd:COG4785  31 FAAVLALAIALADLALALAAAALAAAALAAER--IDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALEL------ 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 130 ltslavamrlvalehpEPAQAEIrtkameliiearrldsaygpaniafatglfYCFFSTAKVELKFLDKVIENYKKALEc 209
Cdd:COG4785 103 ----------------DPDLAEA------------------------------YNNRGLAYLLLGDYDAALEDFDRALE- 135

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 17509855 210 eLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDP 247
Cdd:COG4785 136 -LDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDP 172
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
155-248 2.09e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855 155 KAMELIIEARRLDSAYGPANIAFatGLFYCffstakvELKFLDKVIEnYKKALEceLSRTDPQVYINMATCLKFMEKYDE 234
Cdd:COG3063  10 EAEEYYEKALELDPDNADALNNL--GLLLL-------EQGRYDEAIA-LEKALK--LDPNNAEALLNLAELLLELGDYDE 77

                        90
                ....*....|....
gi 17509855 235 ALAVLQKAVEYDPR 248
Cdd:COG3063  78 ALAYLERALELDPS 91
TPR_1 pfam00515
Tetratricopeptide repeat;
216-249 2.20e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 2.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17509855   216 PQVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 40-159 2.29e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  40 QEILPTIIstsRAYDTNQKALLLAegGKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKI 119
Cdd:COG4783  24 EALLEKAL---ELDPDNPEAFALL--GEILLQLGDLDE-AIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEK 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 17509855 120 ALGISKTAP-ILTSLAVAMRlvALEHPEPAQAEIRtKAMEL 159
Cdd:COG4783  98 ALKLDPEHPeAYLRLARAYR--ALGRPDEAIAALE-KALEL 135
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 216-249 3.07e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 3.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 17509855    216 PQVYINMATCLKFMEKYDEALAVLQKAVEYDPRN 249
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 51-127 9.87e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 9.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  51 RAYDTNQKALLLAEG--------GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALG 122
Cdd:COG5010  72 ESLALLEQALQLDPNnpelyynlALLYSRSGDKDE-AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150


                ....*
gi 17509855 123 ISKTA 127
Cdd:COG5010 151 TSPLK 155
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
43-159 1.40e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.90  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  43 LPTIISTSRAYDTNQKALLLAEGGKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALG 122
Cdd:COG4785  57 ALAAERIDRALALPDLAQLYYERGVAYDSLGDYDL-AIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALE 135

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17509855 123 IS-KTAPILTSLAVAmrLVALEHPEPAQAEIRtKAMEL 159
Cdd:COG4785 136 LDpDYAYAYLNRGIA--LYYLGRYELAIADLE-KALEL 170
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 66-150 1.88e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 1.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  66 GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKTAP-ILTSLAVAmrlvALEH 144
Cdd:COG4235  24 GRAYLRLGRYDE-ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPeALYLLGLA----AFQQ 98


                ....*.
gi 17509855 145 PEPAQA 150
Cdd:COG4235  99 GDYAEA 104
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 194-271 1.91e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.35  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17509855   194 KFLDKVIENYKKALECelsRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPrNELETREKLASFVSYLSKFTDAI 271
Cdd:TIGR00990 141 KDFNKAIKLYSKAIEC---KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDP-DYSKALNRRANAYDGLGKYADAL 214
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
72-165 2.33e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  72 LEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQScFKIALGISKT-APILTSLAVAmrLVALEHPEPAQA 150
Cdd:COG3063   5 LGDLEE-AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNnAEALLNLAEL--LLELGDYDEALA 80

                        90
                ....*....|....*
gi 17509855 151 EIRtKAMELIIEARR 165
Cdd:COG3063  81 YLE-RALELDPSALR 94
PRK10370 PRK10370
formate-dependent nitrite reductase complex subunit NrfG; Provisional
 59-159 3.03e-03

formate-dependent nitrite reductase complex subunit NrfG; Provisional


Pssm-ID: 182415 [Multi-domain]  Cd Length: 198  Bit Score: 38.73  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855   59 ALLLAEGGKMYNVLEDYNE--TAEKMLS---KSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGI-SKTAPILTS 132
Cdd:PRK10370  33 QAVRAEYQRLADPLHQFASqqTPEAQLQalqDKIRANPQNSEQWALLGEYYLWRNDYDNALLAYRQALQLrGENAELYAA 112

                         90       100
                 ....*....|....*....|....*..
gi 17509855  133 LAVAMRLVALEHPEPAQAEIRTKAMEL 159
Cdd:PRK10370 113 LATVLYYQAGQHMTPQTREMIDKALAL 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 198-272 7.85e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 7.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17509855 198 KVIENYKKALEceLSRTDPQVYINMATCLKFMEKYDEALAVLQKAVEYDPRNeLETREKLASFVSYLSKFTDAIQ 272
Cdd:COG4235   1 EAIARLRQALA--ANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDN-ADALLDLAEALLAAGDTEEAEE 72
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-170 9.77e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 9.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509855  66 GKMYNVLEDYNEtAEKMLSKSVRMNPKNADAWHELGLCVMKRRDLEFAQSCFKIALGISKTAPILTSLAVAMRLVALEHP 145
Cdd:COG0457 117 GLALLELGRYDE-AIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEV 195

                        90       100
                ....*....|....*....|....*
gi 17509855 146 EPAQAEIRTKAMELIIEARRLDSAY 170
Cdd:COG0457 196 LLALLLALEQALRKKLAILTLAALA 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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