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Conserved domains on  [gi|17510635|ref|NP_490663|]
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REST corepressor rcor-1 [Caenorhabditis elegans]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10446569)

SANT/Myb domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.10.10.60
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  1631139|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 499-538 6.37e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.56  E-value: 6.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17510635   499 WSPEEKKNAIRCFHWYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 193-235 7.90e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 7.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17510635   193 WTAEEISLFSTCFFHFGKRFKKIHAAMPQRSLSSIIQYYYNTK 235
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 499-538 6.37e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.56  E-value: 6.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17510635   499 WSPEEKKNAIRCFHWYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 193-235 7.90e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 7.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17510635   193 WTAEEISLFSTCFFHFGKRFKKIHAAMPQRSLSSIIQYYYNTK 235
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 192-236 9.73e-05

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.91  E-value: 9.73e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17510635 192 DWTAEEISLFSTCFFHFGKRFKKIHAA-MPQRSLSSIIQYYYNTKK 236
Cdd:cd11661   1 EWSESEAKLFEEGLRKYGKDFHDIRQDfLPWKSVGELVEFYYMWKK 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 499-538 1.18e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 39.87  E-value: 1.18e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 17510635 499 WSPEEKKNAIRCFH-WYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:cd00167   2 WTEEEDELLLEAVKkYGKNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
499-538 9.51e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 9.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17510635    499 WSPEEKKNAIRCFH-WYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:smart00717   4 WTEEEDELLIELVKkYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
193-236 1.06e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 1.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 17510635    193 WTAEEISLFSTCFFHFG-KRFKKIHAAMPQRSLSSIIQYYYNTKK 236
Cdd:smart00717   4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 499-538 6.37e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.56  E-value: 6.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17510635   499 WSPEEKKNAIRCFHWYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 193-235 7.90e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 7.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17510635   193 WTAEEISLFSTCFFHFGKRFKKIHAAMPQRSLSSIIQYYYNTK 235
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 192-236 9.73e-05

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.91  E-value: 9.73e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17510635 192 DWTAEEISLFSTCFFHFGKRFKKIHAA-MPQRSLSSIIQYYYNTKK 236
Cdd:cd11661   1 EWSESEAKLFEEGLRKYGKDFHDIRQDfLPWKSVGELVEFYYMWKK 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 499-538 1.18e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 39.87  E-value: 1.18e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 17510635 499 WSPEEKKNAIRCFH-WYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:cd00167   2 WTEEEDELLLEAVKkYGKNNWEKIAKELPGRTPKQCRERWR 42
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 193-235 3.18e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 38.33  E-value: 3.18e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 17510635 193 WTAEEISLFSTCFFHFG-KRFKKIHAAMPQRSLSSIIQYYYNTK 235
Cdd:cd00167   2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
499-538 9.51e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 9.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17510635    499 WSPEEKKNAIRCFH-WYKDNFELIAELMATKTVEQIKKFYM 538
Cdd:smart00717   4 WTEEEDELLIELVKkYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
193-236 1.06e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 1.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 17510635    193 WTAEEISLFSTCFFHFG-KRFKKIHAAMPQRSLSSIIQYYYNTKK 236
Cdd:smart00717   4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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