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Conserved domains on  [gi|17137282|ref|NP_477207|]
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cag, isoform A [Drosophila melanogaster]

Protein Classification

DNA-binding domain-containing protein( domain architecture ID 10514947)

DNA-binding domain-containing protein containing a Tc5 transposase-like DNA-binding domain; similar to Chaetomium globosum chaetoglobosin A biosynthesis cluster protein C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
78-141 7.11e-18

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


:

Pssm-ID: 197828  Cd Length: 66  Bit Score: 74.64  E-value: 7.11e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137282     78 RGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSASSGWLEKWRKRHNVRYND 141
Cdd:smart00674   3 LYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRHNIVKTK 66
CENP-B_N super family cl47877
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-56 6.88e-07

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


The actual alignment was detected with superfamily member pfam04218:

Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.10  E-value: 6.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17137282     7 RKPRTSLTLEEKMEVIQSQERNKlSVRDLAKRFNIGKTQAADILKHKQSI 56
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGE-SKASLARRFGVPASTLRRILKNKKKL 49
 
Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
78-141 7.11e-18

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 74.64  E-value: 7.11e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137282     78 RGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSASSGWLEKWRKRHNVRYND 141
Cdd:smart00674   3 LYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRHNIVKTK 66
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
80-137 1.53e-15

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 68.43  E-value: 1.53e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137282    80 AQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLA---VELGHSNFSASSGWLEKWRKRHNV 137
Cdd:pfam03221   2 PDLEKALYEWILQLRARGIPITGPMIREKALELAqlaADLGEPDFKASKGWLDRFKKRHGI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-56 6.88e-07

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.10  E-value: 6.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17137282     7 RKPRTSLTLEEKMEVIQSQERNKlSVRDLAKRFNIGKTQAADILKHKQSI 56
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGE-SKASLARRFGVPASTLRRILKNKKKL 49
 
Name Accession Description Interval E-value
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
78-141 7.11e-18

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 74.64  E-value: 7.11e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137282     78 RGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELGHSNFSASSGWLEKWRKRHNVRYND 141
Cdd:smart00674   3 LYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRHNIVKTK 66
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
80-137 1.53e-15

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 68.43  E-value: 1.53e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137282    80 AQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLA---VELGHSNFSASSGWLEKWRKRHNV 137
Cdd:pfam03221   2 PDLEKALYEWILQLRARGIPITGPMIREKALELAqlaADLGEPDFKASKGWLDRFKKRHGI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-56 6.88e-07

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.10  E-value: 6.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17137282     7 RKPRTSLTLEEKMEVIQSQERNKlSVRDLAKRFNIGKTQAADILKHKQSI 56
Cdd:pfam04218   1 RRKRRSLTLREKIAIIQRYEEGE-SKASLARRFGVPASTLRRILKNKKKL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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