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Conserved domains on  [gi|24639410|ref|NP_477105|]
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cramped, isoform A [Drosophila melanogaster]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 12218804)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|15040448|16877755
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
111-171 3.15e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 3.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24639410    111 KTTWTNVERNCFFDALNEFG-KDFEAVANCINaklkrrnansdysFKTKDQVRQHYYQTHHK 171
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP-------------GRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
111-171 3.15e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 3.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24639410    111 KTTWTNVERNCFFDALNEFG-KDFEAVANCINaklkrrnansdysFKTKDQVRQHYYQTHHK 171
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP-------------GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 113-167 3.74e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.01  E-value: 3.74e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639410 113 TWTNVERNCFFDALNEFG-KDFEAVANCINaklkrrnansdysFKTKDQVRQHYYQ 167
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELP-------------GRTPKQCRERWRN 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 111-167 4.80e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 35.94  E-value: 4.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24639410   111 KTTWTNVERNCFFDALNEFGKDFEAVANCINAklkrrnansdysfKTKDQVRQHYYQ 167
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPG-------------RTDNQCKNRWQN 44
 
Name Accession Description Interval E-value
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
111-171 3.15e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 3.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24639410    111 KTTWTNVERNCFFDALNEFG-KDFEAVANCINaklkrrnansdysFKTKDQVRQHYYQTHHK 171
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP-------------GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 113-167 3.74e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.01  E-value: 3.74e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24639410 113 TWTNVERNCFFDALNEFG-KDFEAVANCINaklkrrnansdysFKTKDQVRQHYYQ 167
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELP-------------GRTPKQCRERWRN 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 111-167 4.80e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 35.94  E-value: 4.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24639410   111 KTTWTNVERNCFFDALNEFGKDFEAVANCINAklkrrnansdysfKTKDQVRQHYYQ 167
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPG-------------RTDNQCKNRWQN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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