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Conserved domains on  [gi|17136934|ref|NP_477003|]
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NADH dehydrogenase (ubiquinone) acyl carrier protein, isoform A [Drosophila melanogaster]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Ontology:  GO:0009245|GO:0000036|GO:0000035
PubMed:  20662770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 89-147 2.34e-21

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 81.76  E-value: 2.34e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17136934   89 IDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 89-147 2.34e-21

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 81.76  E-value: 2.34e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17136934   89 IDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 75-147 4.69e-18

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 73.58  E-value: 4.69e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136934    75 INERVLLVLKLYDKIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:TIGR00517   4 IFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 88-147 8.51e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 70.27  E-value: 8.51e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136934  88 KIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 77-130 1.54e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.94  E-value: 1.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17136934    77 ERVLLVLKLYDKIDPSKLNVESHFInDLGLDSLDHVEVIMAMEDEFGFEIPDSD 130
Cdd:pfam00550   1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 89-147 2.34e-21

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 81.76  E-value: 2.34e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17136934   89 IDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:PRK00982  18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 70-147 1.11e-19

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 79.74  E-value: 1.11e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136934   70 LSLKLINERVLLVLKLYDKIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQN 143
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 75-147 4.69e-18

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 73.58  E-value: 4.69e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136934    75 INERVLLVLKLYDKIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:TIGR00517   4 IFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
acpP CHL00124
acyl carrier protein; Validated
 89-147 8.09e-18

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 73.13  E-value: 8.09e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17136934   89 IDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:CHL00124  20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQK 78
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 88-147 8.51e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 70.27  E-value: 8.51e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136934  88 KIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:COG0236  19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PRK12449 PRK12449
acyl carrier protein; Provisional
 75-147 2.61e-08

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 48.16  E-value: 2.61e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136934   75 INERVLLVLKLYDKIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYVADK 147
Cdd:PRK12449   6 IFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQR 78
PRK06508 PRK06508
acyl carrier protein; Provisional
 89-127 1.57e-07

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 46.73  E-value: 1.57e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17136934   89 IDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIP 127
Cdd:PRK06508  18 IPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 77-130 1.54e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.94  E-value: 1.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17136934    77 ERVLLVLKLYDKIDPSKLNVESHFInDLGLDSLDHVEVIMAMEDEFGFEIPDSD 130
Cdd:pfam00550   1 ERLRELLAEVLGVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
PRK08172 PRK08172
acyl carrier protein;
75-144 5.05e-05

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 39.49  E-value: 5.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136934   75 INERVLLVLKLYDKIDPSKLNVESHFINDLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYV 144
Cdd:PRK08172   5 IEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTFADICRVV 74
PRK05828 PRK05828
acyl carrier protein; Validated
 79-144 1.38e-04

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 38.69  E-value: 1.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136934   79 VLLVLKLYDKIDPSKLNVESHFIN----DLGLDSLDHVEVIMAMEDEFGFEIPDSDAEKLLKPADIIKYV 144
Cdd:PRK05828   6 ILLKIKEIAKKKNFAVTLDESNINkpyrELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEV 75
PRK07081 PRK07081
acyl carrier protein; Provisional
 103-129 2.55e-04

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 37.63  E-value: 2.55e-04
                         10        20
                 ....*....|....*....|....*..
gi 17136934  103 DLGLDSLDHVEVIMAMEDEFGFEIPDS 129
Cdd:PRK07081  30 EAGLSSLATVQLMLAIEDAFDIEIPDE 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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