first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 217 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 296
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17136874 297 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 217 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 296
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17136874 297 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 353 PITITGWLGVYMQLNVNNRTPAsfsqigrqksaEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 432
Cdd:cd20520   1 PPTPNSWLNLYLQLAQLNPPPK-----------ENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYL 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17136874 433 TFSR-EMALRCSGLDWQVIQPCARWMEPFFRVISQ 466
Cdd:cd20520  70 VSPDdEAIEQVTGYSWEQLAPCVEWMTPFAEVLEE 104

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874    260 DWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDgaCTERDILNH 339
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77

                   ....*.
gi 17136874    340 EKILLQ 345
Cdd:smart00385  78 ERLLLE 83

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 217 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 296
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17136874 297 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 212 PLPALAWANAADVWRLMCHRDEQdsRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAH 291
Cdd:cd20580   2 PLPELSWGNSKDVWLNMLKKESK--YVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQK 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136874 292 KVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20580  80 NINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 229 CHRDEQDSRLRSiSMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFV 308
Cdd:cd20507  12 LRQLEKKYAIDP-DYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKK-QVPRKKLQLVGVTALLI 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 17136874 309 AAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALD 348
Cdd:cd20507  90 ASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 244 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 323
Cdd:cd20568  30 MDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLS-KRVVSLNKLQLVGISALFIASKYEEVNSPSIKNF 108

                        90       100
                ....*....|....*....|....*.
gi 17136874 324 AYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20568 109 AYMTDGAYTVEDILRAERYMLNTLEF 134

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 231 RDEQDSRLRSISMLEQhPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAA 310
Cdd:cd20567  31 KVEPESCVPPYYMSQQ-PDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSV-KQVPRKELQLVGVTAMLIAS 108

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 17136874 311 KVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 349
Cdd:cd20567 109 KYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 252 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGAC 331
Cdd:cd20562  39 PSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLS-GNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTY 117

                        90
                ....*....|....*....
gi 17136874 332 TERDILNHEKILLQALDWD 350
Cdd:cd20562 118 TKQEVLEMEIDVLNALQFE 136

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 221 AADVWRLMCHRDEQdsrLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQL 300
Cdd:cd20508  17 AKDIFDYMKEREEK---FVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK-VVKKEKLQL 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 17136874 301 IGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWD 350
Cdd:cd20508  93 LGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 254 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTE 333
Cdd:cd20565  35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQ-NNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTK 113

                        90
                ....*....|....*.
gi 17136874 334 RDILNHEKILLQALDW 349
Cdd:cd20565 114 HQIRQMEMKILRALDF 129

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 250 LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 329
Cdd:cd20515  51 IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSL-VPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDN 129

                        90       100
                ....*....|....*....|.
gi 17136874 330 ACTERDILNHEKILLQALDWD 350
Cdd:cd20515 130 SITLQELLDWELLVLTKLKWD 150

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 255 RAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTER 334
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSR-QKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                        90
                ....*....|....*..
gi 17136874 335 DILNHEKILLQALDWDI 351
Cdd:cd20542  80 QVLRMERRVLRRLRFDL 96

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874    260 DWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDgaCTERDILNH 339
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77

                   ....*.
gi 17136874    340 EKILLQ 345
Cdd:smart00385  78 ERLLLE 83

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 252 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGAC 331
Cdd:cd20573  52 PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSV-EPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSI 130

                        90
                ....*....|....*....
gi 17136874 332 TERDILNHEKILLQALDWD 350
Cdd:cd20573 131 RPEELLQMELLVLNKLKWD 149

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 250 LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 329
Cdd:cd20574  51 IQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVV-PTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDN 129

                        90       100
                ....*....|....*....|.
gi 17136874 330 ACTERDILNHEKILLQALDWD 350
Cdd:cd20574 130 SIKPQELLEWELVVLGKLKWN 150

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 254 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYP--PKIGEF-AYVTDGA 330
Cdd:cd20528   6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMD-RYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnRYLCNSV 84

                        90
                ....*....|....*....
gi 17136874 331 CTERDILNHEKILLQALDW 349
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136874 252 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 329
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMV-RKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDN 77

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 255 RAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQ--KTH-LQLIGITCLFVAAKVEEIYPP-----KIGEFAYV 326
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSS-YDLPkdKPWmLQLLAVACLSLAAKMEETDVPllvdlQVEEPKYV 80

                        90       100
                ....*....|....*....|...
gi 17136874 327 tdgaCTERDILNHEKILLQALDW 349
Cdd:cd20543  81 ----FEAKTIQRMELLVLSTLEW 99

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 258 LLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYP--PKIGEFAYVTDGACTERD 335
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCS-KRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                        90
                ....*....|....*
gi 17136874 336 ILNHEKILLQALDWD 350
Cdd:cd20559  81 FIQMEMHILNTLNWD 95

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 262 LIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNH 339
Cdd:cd20583   9 LLSLTQFFGFSTETFSLAVNLLDRFLAKM-KVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRM 87

                        90
                ....*....|
gi 17136874 340 EKILLQALDW 349
Cdd:cd20583  88 EKIILEKLCW 97

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17136874   407 LLDLCTLDVGMANYSYSVLAAAAISHTFS-------REMALRCSGLDWQVIQPCARWMEPF 460
Cdd:pfam02984  29 LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHYTGYSEEDLKPCVKLLLEL 89

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 270 KLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEIypPK----IGEFAYV--------TDGACTERDIL 337
Cdd:cd20530  26 GLPYDTIATGIVYFHRF-YMFHSFKDFDRYVTAACCLFLAGKVEET--PKkckdIIKTARSllndkqfaQFGDDPKEEVM 102

                        90
                ....*....|...
gi 17136874 338 NHEKILLQALDWD 350
Cdd:cd20530 103 VLERILLQTIKFD 115

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 279 AVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEiYPPKIGEFAYVTDgACTER-----------------DILNHEK 341
Cdd:cd20538  52 AIVYMHRF-YMFHSFTKFHRNSIAAAALFLAAKVEE-QPRKLEHVIKVAH-ACLHRgepdldtkseaylqqaqELVINEN 128

                ....*....
gi 17136874 342 ILLQALDWD 350
Cdd:cd20538 129 ILLQTLGFE 137

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 261 WLIEVCEVYKLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEIyPPKIGEFAYVTDGACTERD----- 335
Cdd:COG5333  51 LIMDLCTRLNLPQTVLATAILFFSRF-YLKNSVEEISLYSVVTTCVYLACKVEDT-PRDISIESFEARDLWSEEPkssre 128

                        90
                ....*....|....*.
gi 17136874 336 -ILNHEKILLQALDWD 350
Cdd:COG5333 129 rILEYEFELLEALDFD 144

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136874 258 LLDWLIEVCEVYKLHRETFYLAVDYLDRYLH---VAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACteR 334
Cdd:cd20557   2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRrlpEALLGQEGSPYRLFLVALMLASKYLDDESYSNKSWAEISGLPV--R 79

                        90
                ....*....|....*
gi 17136874 335 DILNHEKILLQALDW 349
Cdd:cd20557  80 ELNAMEREFLEALDW 94

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136874 262 LIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIyPPKIgefayvtdgacteRDILN 338
Cdd:cd20534   9 IREAGLKLELSSVTIATACVLYHRFYR-ELSLEDYDPYLVAMACLYLAGKAEEQ-PRRL-------------RDIIN 70