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Conserved domains on  [gi|281306750|ref|NP_476475|]
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chordin precursor [Rattus norvegicus]

Protein Classification

follistatin-related protein 1( domain architecture ID 10356082)

follistatin-related protein 1 is an extracellular calcium-binding protein belonging to the BM-40/SPARC/osteonectin family and containing Kazal-type serine protease inhibitor/follistatin-like and EF-hand domains, that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
530-642 9.17e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 102.81  E-value: 9.17e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   530 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 604
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   605 GVVKDLEPVLLRHLTQGTASLLITTKSNPRGELRGQVH 642
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
400-517 1.32e-24

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 99.34  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   400 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVIGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQLGGHM 476
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 281306750   477 AVGVCSGLGARGAHMLLQNELFLNIGTKDFPDGELRGHVTA 517
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
170-273 6.87e-12

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 63.13  E-value: 6.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   170 TDFVALLTG------PRTQAVARARVSLL-RSSLRFSISYQRLDRPSRV-----RFTDPTG---NILFEHPAAptQDGLV 234
Cdd:smart00754   1 ETFSALLTGsqevppVNTGAVGGAWFTLDdDGSLHYQVTLSGLSGPETAahiheGEIGTNGpvvRIPLPNPTS--REGPF 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 281306750   235 CGVWRAVPRLSVRLLRAEQLRVALVTPTHPSEEVWGPLI 273
Cdd:smart00754  79 AGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
281-394 1.62e-09

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 56.59  E-value: 1.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   281 ETFSAILTLE---DPLQRGVGGIALLTLSDTEDAL-HFLLLFRGLLGGLAHVPLKlQILHQGQLLRELQANASAQEPGFA 356
Cdd:smart00754   1 ETFSALLTGSqevPPVNTGAVGGAWFTLDDDGSLHyQVTLSGLSGPETAAHIHEG-EIGTNGPVVRIPLPNPTSREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   357 EVLPSLTDQEMDWLVLGELQMVLEKMGGPELRISGYIT 394
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
VWC smart00214
von Willebrand factor (vWF) type C domain;
779-845 6.87e-07

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.13  E-value: 6.87e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281306750   779 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 845
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 51-125 2.67e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.49  E-value: 2.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281306750   51 CSFGGKVYALDETWHPDLgepfgvmrCVLCACEapqwarrgrgPGRVSCKNIKpqCPTLACRQPR--QLPGHCCQTC 125
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL--------CTICTCD----------DGKVLCDKII--CPPLDCPNPRleIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 867-927 3.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 3.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281306750  867 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 927
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 701-758 4.33e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.33  E-value: 4.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  701 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 758
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
530-642 9.17e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 102.81  E-value: 9.17e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   530 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 604
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   605 GVVKDLEPVLLRHLTQGTASLLITTKSNPRGELRGQVH 642
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
400-517 1.32e-24

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 99.34  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   400 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVIGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQLGGHM 476
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 281306750   477 AVGVCSGLGARGAHMLLQNELFLNIGTKDFPDGELRGHVTA 517
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 530-641 2.87e-15

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 72.90  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  530 LPVPLAGALVLPP-VRSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGMPGPQRL-----LKGFYGS 601
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGPVVVpleggPRKTTLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 281306750  602 EAQGVVKDLEPVLLRHLTQGTASLLIT--TKSNPRGELRGQV 641
Cdd:pfam07452  77 AVPEGLATLTAAQLAALLAQQGELYVNvhTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
170-273 6.87e-12

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 63.13  E-value: 6.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   170 TDFVALLTG------PRTQAVARARVSLL-RSSLRFSISYQRLDRPSRV-----RFTDPTG---NILFEHPAAptQDGLV 234
Cdd:smart00754   1 ETFSALLTGsqevppVNTGAVGGAWFTLDdDGSLHYQVTLSGLSGPETAahiheGEIGTNGpvvRIPLPNPTS--REGPF 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 281306750   235 CGVWRAVPRLSVRLLRAEQLRVALVTPTHPSEEVWGPLI 273
Cdd:smart00754  79 AGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 402-515 1.72e-11

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 62.11  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  402 LQSVLCGADALIP-VQTGAAGSASFIL-LGNGSLIYQVQVIGTG--------------SEVVAMTLETKPQRKNQRTVlc 465
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTTLLAV-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281306750  466 hmaglqlgghmaVGVCSGLGARGAHMLLQN--ELFLNIGTKDFPDGELRGHV 515
Cdd:pfam07452  79 ------------PEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
281-394 1.62e-09

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 56.59  E-value: 1.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   281 ETFSAILTLE---DPLQRGVGGIALLTLSDTEDAL-HFLLLFRGLLGGLAHVPLKlQILHQGQLLRELQANASAQEPGFA 356
Cdd:smart00754   1 ETFSALLTGSqevPPVNTGAVGGAWFTLDDDGSLHyQVTLSGLSGPETAAHIHEG-EIGTNGPVVRIPLPNPTSREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   357 EVLPSLTDQEMDWLVLGELQMVLEKMGGPELRISGYIT 394
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
VWC smart00214
von Willebrand factor (vWF) type C domain;
779-845 6.87e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.13  E-value: 6.87e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281306750   779 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 845
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 51-125 2.67e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.49  E-value: 2.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281306750   51 CSFGGKVYALDETWHPDLgepfgvmrCVLCACEapqwarrgrgPGRVSCKNIKpqCPTLACRQPR--QLPGHCCQTC 125
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL--------CTICTCD----------DGKVLCDKII--CPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 867-927 3.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 3.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281306750  867 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 927
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 701-758 4.33e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.33  E-value: 4.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  701 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 758
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
530-642 9.17e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 102.81  E-value: 9.17e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   530 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 604
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   605 GVVKDLEPVLLRHLTQGTASLLITTKSNPRGELRGQVH 642
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
400-517 1.32e-24

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 99.34  E-value: 1.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   400 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVIGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQLGGHM 476
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 281306750   477 AVGVCSGLGARGAHMLLQNELFLNIGTKDFPDGELRGHVTA 517
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 530-641 2.87e-15

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 72.90  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  530 LPVPLAGALVLPP-VRSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGMPGPQRL-----LKGFYGS 601
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGPVVVpleggPRKTTLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 281306750  602 EAQGVVKDLEPVLLRHLTQGTASLLIT--TKSNPRGELRGQV 641
Cdd:pfam07452  77 AVPEGLATLTAAQLAALLAQQGELYVNvhTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
170-273 6.87e-12

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 63.13  E-value: 6.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   170 TDFVALLTG------PRTQAVARARVSLL-RSSLRFSISYQRLDRPSRV-----RFTDPTG---NILFEHPAAptQDGLV 234
Cdd:smart00754   1 ETFSALLTGsqevppVNTGAVGGAWFTLDdDGSLHYQVTLSGLSGPETAahiheGEIGTNGpvvRIPLPNPTS--REGPF 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 281306750   235 CGVWRAVPRLSVRLLRAEQLRVALVTPTHPSEEVWGPLI 273
Cdd:smart00754  79 AGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 402-515 1.72e-11

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 62.11  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  402 LQSVLCGADALIP-VQTGAAGSASFIL-LGNGSLIYQVQVIGTG--------------SEVVAMTLETKPQRKNQRTVlc 465
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTTLLAV-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281306750  466 hmaglqlgghmaVGVCSGLGARGAHMLLQN--ELFLNIGTKDFPDGELRGHV 515
Cdd:pfam07452  79 ------------PEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
281-394 1.62e-09

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 56.59  E-value: 1.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   281 ETFSAILTLE---DPLQRGVGGIALLTLSDTEDAL-HFLLLFRGLLGGLAHVPLKlQILHQGQLLRELQANASAQEPGFA 356
Cdd:smart00754   1 ETFSALLTGSqevPPVNTGAVGGAWFTLDDDGSLHyQVTLSGLSGPETAAHIHEG-EIGTNGPVVRIPLPNPTSREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 281306750   357 EVLPSLTDQEMDWLVLGELQMVLEKMGGPELRISGYIT 394
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
VWC smart00214
von Willebrand factor (vWF) type C domain;
779-845 6.87e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.13  E-value: 6.87e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281306750   779 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 845
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 51-125 2.67e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.49  E-value: 2.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281306750   51 CSFGGKVYALDETWHPDLgepfgvmrCVLCACEapqwarrgrgPGRVSCKNIKpqCPTLACRQPR--QLPGHCCQTC 125
Cdd:pfam00093   1 CVQNGVVYENGETWKPDL--------CTICTCD----------DGKVLCDKII--CPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 867-927 3.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 3.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281306750  867 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 927
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 701-758 4.33e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.33  E-value: 4.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750  701 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 758
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 41-125 7.34e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 43.15  E-value: 7.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306750   41 EPLPVRGAagcSFGGKVYALDETWHPDLGEPFGVM----------------RCVLCAC---EAPQWArrgrgpgrvsCKN 101
Cdd:pfam14828 145 RPIRVKSV---SLLGQTFTSDEDFAEFLSSRLGQLqfhgagalrvgpeacsDPSGCGCgndENLERI----------CAN 211

                          90       100
                  ....*....|....*....|....
gi 281306750  102 IKPQCPTLACRQPRQLPGHCCQTC 125
Cdd:pfam14828 212 VLQRCPPPHCLSPLRPEGHCCDVC 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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