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Conserved domains on  [gi|16763810|ref|NP_459425|]
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2-aminoethylphosphonate transport, repressor [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

Protein Classification

similar to transcriptional regulator of 2-aminoethylphosphonate degradation operons( domain architecture ID 11496622)

protein similar to transcriptional regulator of 2-aminoethylphosphonate degradation operons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.79e-153

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


:

Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 424.62  E-value: 4.79e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    89 HKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEV 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16763810   169 YESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.79e-153

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 424.62  E-value: 4.79e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    89 HKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEV 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16763810   169 YESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-237 8.01e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 213.96  E-value: 8.01e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   5 PGDIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188   1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810  85 NTNFHKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDL-NG 163
Cdd:COG2188  81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16763810 164 SLTEVYESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVD 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 4.49e-40

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 134.65  E-value: 4.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    94 EQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDL-NGSLTEVYESH 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16763810   173 YNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLR 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-230 8.90e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.54  E-value: 8.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     94 EQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEVYESHY 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    174 NLV---YTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHD 230
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.54e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.35  E-value: 3.54e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16763810   9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVT 74
Cdd:cd07377   1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
9-218 6.15e-19

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 82.58  E-value: 6.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   89 HKLCREQGREPKTALLSGVLtTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNG-SLTE 167
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTYQ 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16763810  168 VYESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGR 218
Cdd:PRK11402 168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDK 218
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.79e-153

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 424.62  E-value: 4.79e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    89 HKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEV 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16763810   169 YESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-237 8.01e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 213.96  E-value: 8.01e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   5 PGDIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188   1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810  85 NTNFHKLCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDL-NG 163
Cdd:COG2188  81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16763810 164 SLTEVYESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLRIEVD 237
Cdd:COG2188 161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 4.49e-40

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 134.65  E-value: 4.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    94 EQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDL-NGSLTEVYESH 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16763810   173 YNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLR 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-230 8.90e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.54  E-value: 8.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     94 EQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNGSLTEVYESHY 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    174 NLV---YTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHD 230
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-218 6.34e-25

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 98.32  E-value: 6.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    11 YLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNFHK 90
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    91 LCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQ-YDLNGSLTEVY 169
Cdd:TIGR02325  90 NLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQaYAASGSITDAL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 16763810   170 ESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGR 218
Cdd:TIGR02325 170 REQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGR 218
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.54e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 86.35  E-value: 3.54e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16763810   9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVT 74
Cdd:cd07377   1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
9-218 6.15e-19

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 82.58  E-value: 6.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   89 HKLCREQGREPKTALLSGVLtTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNG-SLTE 167
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTYQ 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16763810  168 VYESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGR 218
Cdd:PRK11402 168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDK 218
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 11-73 5.79e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 74.96  E-value: 5.79e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16763810    11 YLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFV 73
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 1.02e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 74.53  E-value: 1.02e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810     14 IKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
16-79 2.51e-16

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 75.36  E-value: 2.51e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16763810  16 AQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLW 79
Cdd:COG2186  14 EQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPW 77
PRK09764 PRK09764
GntR family transcriptional regulator;
6-233 1.92e-14

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 70.24  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810    6 GDIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQN 85
Cdd:PRK09764   2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   86 TNFHKLCREQGREPKTALLsgVLTTVPVE--VMEPLQLQPFDQIYLLTRLRYADGRAVCYCENHCLPARVPELLQYDLNG 163
Cdd:PRK09764  82 TSFDEKLSDRHVDTHSEVL--IFEVIPADdfLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMEN 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810  164 SLTEVYESHYNLVYTSMHLSFYPTAMPAQAAQALGVMEGRPALLLRRLNYDQHGRVLDLDIEYWRHDSLR 233
Cdd:PRK09764 160 SKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 6-77 3.78e-13

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 67.93  E-value: 3.78e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16763810   6 GDIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPER 77
Cdd:COG1167   9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
7-75 4.35e-12

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 60.96  E-value: 4.35e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16763810   7 DIPQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTP 75
Cdd:COG1725   8 GVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-75 9.26e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 59.55  E-value: 9.26e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810  16 AQLQARIQSGALKSGDKLpSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTP 75
Cdd:COG1802  18 EALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-63 1.05e-09

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 56.95  E-value: 1.05e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 16763810   16 AQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLI 63
Cdd:PRK03837  20 ERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 11-212 3.20e-09

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 55.55  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   11 YLLIKAQLQARIQsGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTPERLWLDPTQNTNFHK 90
Cdd:PRK10079  14 YQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   91 LCREQGREPKTALLSGVLTTVPVEVMEPLQLQPFDQIYLLTRLRYADGRAVCYCeNHCLP--ARVPELLQYDlNGSLTEV 168
Cdd:PRK10079  93 NLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLI-DHYFAdlTWWPTLQRFD-SGSLHDF 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 16763810  169 YESHynlvyTSMHLSFYPTAMPAQAAQA-----LGVMEGRPALLLRRLN 212
Cdd:PRK10079 171 LREQ-----LGIALRRSQTRISARRAQAkesqlLEIPNMSPLLCVRTLN 214
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
14-79 4.73e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 55.03  E-value: 4.73e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16763810   14 IKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFVTpERLW 79
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ-SSLW 79
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 17-70 3.39e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.46  E-value: 3.39e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16763810   17 QLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIwrADRRG 70
Cdd:PRK10421  10 RVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVL--LSRRG 61
PRK14999 PRK14999
histidine utilization repressor; Provisional
 9-73 9.05e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 45.31  E-value: 9.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16763810    9 PQYLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFV 73
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK11523 PRK11523
transcriptional regulator ExuR;
11-63 3.38e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.68  E-value: 3.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 16763810   11 YLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLI 63
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYV 62
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 22-73 4.38e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.60  E-value: 4.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16763810   22 IQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIWRADRRGWFV 73
Cdd:PRK09990  20 IVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK10225 PRK10225
Uxu operon transcriptional regulator;
11-70 7.81e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.70  E-value: 7.81e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16763810   11 YLLIKAQLQARIQSGALKSGDKLPSERELCAIFNTTRITIRESLAQLESSGLIwrADRRG 70
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLV--EVRRG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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