BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  19 SLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 98
Cdd:cd18412    1 SLPPEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663795  99 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 145
Cdd:cd18412   81 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  19 SLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 98
Cdd:cd18412    1 SLPPEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663795  99 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 145
Cdd:cd18412   81 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795   37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNthesllevCDDYNLNENEYFFDRHPGAFTSILNFYRT-GKLHMMEEMC 115
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 164663795  116 ALSFGQELDYWGIDEIYLESC 136
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

voltage-gated potassium channel protein;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795 348 IFSSLVFfaeKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI-----PIIVNNFSE 422
Cdd:PRK10537 152 TFGALYL---GDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSIsaifgPVIRGNLKR 228

                 ....*..
gi 164663795 423 FYKEQKR 429
Cdd:PRK10537 229 LVKGRIS 235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  19 SLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 98
Cdd:cd18412    1 SLPPEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 164663795  99 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 145
Cdd:cd18412   81 ILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEE 113
Cdd:cd18378    1 SRRVLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEE 80

                         90       100
                 ....*....|....*....|....*....
gi 164663795 114 MCALSFGQELDYWGIDEIYLESCCQARYH 142
Cdd:cd18378   81 MCVLSFSQELEYWGIDEIYLESCCQHRYH 109

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  192 AKILAIVSILFIVLSTIALSLNTLPELQEndefgqpSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDL 271
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEE-------PLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  272 LAILPYYVTIFLTEsnksvlqfQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSS 351
Cdd:pfam00520  74 VVVLPSLISLVLSS--------VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  352 LVF---------FAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGK-------IVGGLCCIAGVLVIALPIPI 415
Cdd:pfam00520 146 IGYqlfggklktWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAV 225

                         250
                  ....*....|...
gi 164663795  416 IVNNFSEFYKEQK 428
Cdd:pfam00520 226 IIDNFQELTERTE 238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  35 RRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 114
Cdd:cd18421    4 RHVIINVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREM 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 164663795 115 CALSFGQELDYWGIDEIYLESCCQARYHQK 144
Cdd:cd18421   84 CALSFQEELLYWGIEEENLEWCCRRRLLQK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 116
Cdd:cd18384    1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHSEEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                         90       100
                 ....*....|....*....|....*.
gi 164663795 117 LSFGQELDYWGIDEIYLESCCQARYH 142
Cdd:cd18384   81 FSFSQEIEYWGINEFFLDSCCSYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 116
Cdd:cd18427    2 ISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 81

                         90       100
                 ....*....|....*....|....*.
gi 164663795 117 LSFGQELDYWGIDEIYLESCCQARYH 142
Cdd:cd18427   82 FSFSQEIEYWGINEFFIDSCCSYSYH 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  35 RRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 114
Cdd:cd18423    2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSSYEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 164663795 115 CALSFGQELDYWGIDEIYLESCCQARYHQK 144
Cdd:cd18423   82 CALSFQEELTYWGIEEANLERCCLRKLFQK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESllevcdDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 116
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAF------DYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCG 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 164663795 117 LSFGQELDYWGIDEIYLESCCQARYHQKKE 146
Cdd:cd18379   75 PLFEEELAFWGIDETQIEPCCWMTYRQHRD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLlevcdDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEE 113
Cdd:cd18414    2 SDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPAD 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 164663795 114 MCALSFGQELDYWGIDEIYLESCCQARYHQKKE 146
Cdd:cd18414   77 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRD 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRdcnthESLLevcdDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMC 115
Cdd:cd18416    3 RVVLNVGGIRHETYKATLKKIPATRLSRLT-----EALA----NYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVC 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 164663795 116 ALSFGQELDYWGIDEIYLESCCQARYHQKKE 146
Cdd:cd18416   74 GPLFEEELEFWGLDANQVEPCCWMTYTAHRD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGK 107
Cdd:cd18415    1 NERIILNVGGTRHETYRSTLKTLPGTRLALLAssdpqgDCLTQCSQVGGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 164663795 108 LHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKE 146
Cdd:cd18415   81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRD 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  36 RVKINVGGLNHEVLWRTLDRLPRTRLGKlrdcNTHESLlevcddYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMC 115
Cdd:cd18380    1 RIVINVSGRRFETWKNTLEKYPDTLLGS----TEKEFF------YDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHEC 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 164663795 116 ALSFGQELDYWGIDEIYLESCCQARYHQKKEQ 147
Cdd:cd18380   71 ISAYDDELAFFGILPEIIGDCCYEDYRDRKRE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  20 LPPEPVDiiRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGklrdcNTHESLLevcddYNLNENEYFFDRHPGAFTSI 99
Cdd:cd18417   22 MPKPPSD--KKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLG-----SSEKEFF-----YNEDTQEYFFDRDPEMFRHI 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 164663795 100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQ 147
Cdd:cd18417   90 LNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKE 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGklrdcNTHESLLevcddYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 116
Cdd:cd18418    2 IVLNVSGTRFQTWRNTLERYPDTLLG-----SSERDFF-----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECI 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 164663795 117 LSFGQELDYWGIDEIYLESCCQARYHQKKEQ 147
Cdd:cd18418   72 SAYDEELAFFGIIPEIIGDCCYEEYKDRRRE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESllevcddYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 116
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFT-------FPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISI 73

                         90
                 ....*....|
gi 164663795 117 LSFGQELDYW 126
Cdd:cd18187   74 PDLREECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  33 CSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHesllevcddYNLNENEYFFDRHPGAFTSILNFYRT-GKLHMM 111
Cdd:cd18408    4 CCERVVLNVAGLRFETRARTLGRFPDTLLGDPARRGRF---------YDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRP 74

                         90
                 ....*....|....*....
gi 164663795 112 EEMCALSFGQELDYWGIDE 130
Cdd:cd18408   75 AHVPLDVFLEEVAFYGLGA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEvcddynlnENEYFFDRHPGAFTSILNFYRTGKL 108
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDE--------DGSIFIDRDPELFRHILNFLRTGKL 64

voltage-gated potassium channel protein;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795 348 IFSSLVFfaeKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPI-----PIIVNNFSE 422
Cdd:PRK10537 152 TFGALYL---GDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSIsaifgPVIRGNLKR 228

                 ....*..
gi 164663795 423 FYKEQKR 429
Cdd:PRK10537 229 LVKGRIS 235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHesllevcddYNLNENEYFFDRHPGAFTSILNFYRT-GKLHMMEEM 114
Cdd:cd18403    2 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRY---------FDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNV 72

                         90       100
                 ....*....|....*....|
gi 164663795 115 CALSFGQELDYWGIDEIYLE 134
Cdd:cd18403   73 PLDIFSEEIRFYELGEEAME 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164663795  36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHesllevcddYNLNENEYFFDRHPGAFTSILNFYRTG 106
Cdd:cd18405    2 RVVINVSGLRFETQLKTLAQFPETLLGDPEKRMRY---------FDPLRNEYFFDRNRPSFDAILYYYQSG 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  35 RRVKINVGGLNHEVLWRTLDRLPRTRLGKLrdCNTHESLLEVCDDynlnENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 114
Cdd:cd18389    1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRL--CQEDPDLDSDKDE----TGAYLIDRDPTYFGPILNYLRHGKLIINKEL 74

                         90
                 ....*....|....
gi 164663795 115 CALSFGQELDYWGI 128
Cdd:cd18389   75 AEEGVLEEAEFYNI 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLrdCNTHESLleVCDDYnlnENEYFFDRHPGAFTSILNFYRTGKLHMMEemca 116
Cdd:cd18361    1 VHIDVGGHIYTSSLETLTKYPESRLGKL--FNGSIPI--VLDSL---KQHYFIDRDGKMFRHILNFLRTSKLLLPD---- 69

                         90       100       110
                 ....*....|....*....|....*....|....
gi 164663795 117 lsfgqelDYWGIDEIYLEsccqARYHQKKEQMNE 150
Cdd:cd18361   70 -------DFTEFDLLYEE----ARYYELQPMVKQ 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 164663795  37 VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDdynlNENEYFFDRHPGAFTSILNFYRTGKLHMME 112
Cdd:cd18370    1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGTPIPPNLNMQ----GGGHYFIDRDGKAFRHILNFLRLGRLDLPR 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663795  34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLrdCNTHESLlevcdDYNLNEN-EYFFDRHPGAFTSILNFYRTGKLHMME 112
Cdd:cd18390    4 SKWVRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDL-----DSDKDETgAYLIDRDPTYFGPVLNYLRHGKLVINK 76