NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|59710099|ref|NP_446112|]
View 

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [Rattus norvegicus]

Protein Classification

GGL domain-containing protein( domain architecture ID 10049206)

G-protein gamma like (GGL) domain-containing protein is found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins; it is involved in signal transduction via G-protein-coupled receptors

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 7-63 1.17e-23

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


:

Pssm-ID: 238024  Cd Length: 57  Bit Score: 83.88  E-value: 1.17e-23
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710099  7 VSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFREPR 63
Cdd:cd00068  1 VDQLKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
 
Name Accession Description Interval E-value
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 7-63 1.17e-23

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 83.88  E-value: 1.17e-23
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710099  7 VSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFREPR 63
Cdd:cd00068  1 VDQLKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
GGL smart00224
G protein gamma subunit-like motifs;
7-68 1.66e-21

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 78.47  E-value: 1.66e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59710099     7 VSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFRE-PRSCALL 68
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEdKTSCWIL 63
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 5-65 7.43e-18

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 69.30  E-value: 7.43e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59710099    5 ASVSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGV---PAGSNPFREPRSC 65
Cdd:pfam00631  2 QLKLKLKREIEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGC 65
 
Name Accession Description Interval E-value
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 7-63 1.17e-23

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 83.88  E-value: 1.17e-23
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
gi 59710099  7 VSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFREPR 63
Cdd:cd00068  1 VDQLKKEVEQLRKELSRERLKVSKAAAELLKYCEQNAENDPLLTGPPSPSNPWIEKK 57
GGL smart00224
G protein gamma subunit-like motifs;
7-68 1.66e-21

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 78.47  E-value: 1.66e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59710099     7 VSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFRE-PRSCALL 68
Cdd:smart00224  1 KDQLRKEVEQLRKELSRERIKVSKAAEELLAYCEQHAEEDPLLTGPPPSKNPFIEdKTSCWIL 63
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 5-65 7.43e-18

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 69.30  E-value: 7.43e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59710099    5 ASVSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGV---PAGSNPFREPRSC 65
Cdd:pfam00631  2 QLKLKLKREIEQLREELKRERIKVSKACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDDGC 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH