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Conserved domains on  [gi|17865341|ref|NP_446024|]
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cadherin-related family member 1 precursor [Rattus norvegicus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 1.64e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 139 PYNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLH-SSKFTVDRHSGVLRLQagATLDYEKSRAHFITVVAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 17865341 218 GRlrgadvVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 2.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 2.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 478 YIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 17865341 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.58e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGLFEINETSGAISVLQSpaqLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 17865341 327 nsSGSPAAQSTVPVIIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 2.90e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNitpsgeyswsLQVQ 658
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdREEQSSYT----------LTVT 73

                        90       100
                ....*....|....*....|.
gi 17865341 659 AKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 1.25e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKSLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 17865341 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.61e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 17865341 119 E---KVVIVVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 1.64e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 139 PYNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLH-SSKFTVDRHSGVLRLQagATLDYEKSRAHFITVVAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 17865341 218 GRlrgadvVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 2.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 2.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 478 YIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 17865341 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.58e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGLFEINETSGAISVLQSpaqLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 17865341 327 nsSGSPAAQSTVPVIIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-238 1.70e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   140 YNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLHSS-KFTVDRHSGVLRLQagATLDYEKSRAHFITVVAKDGGG 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 17865341   219 RLRgadvvfSATTTVTINVE 238
Cdd:pfam00028  79 PPL------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
478-568 2.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   478 YIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIYGTGSD-LFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMD- 555
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 17865341   556 -GRYSLAEVFVTLL 568
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-245 3.69e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.69e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    158 QAEDKDTGSGGSVTYFLQSL-HSSKFTVDRHSGVLRLQAgaTLDYEKSRAHFITVVAKDGGGRLRgadvvfSATTTVTIN 236
Cdd:smart00112   1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 17865341    237 VEDVQDTAP 245
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-575 1.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    496 TAVDPDTGPWGKVQYSI-YGTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVND 572
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 17865341    573 HYP 575
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 2.90e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNitpsgeyswsLQVQ 658
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdREEQSSYT----------LTVT 73

                        90       100
                ....*....|....*....|.
gi 17865341 659 AKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 1.25e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKSLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 17865341 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 2.50e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    270 VAIDGDRGKPNHILYRLLNESD-GLFEINETSGAISVLqspAQLRRE---VYELHVQVTEvnsSGSPAAQSTVPVIIRIV 345
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATD---GGGPPLSSTATVTITVL 74


                   ....*..
gi 17865341    346 DLNNHPP 352
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
252-344 3.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   252 YYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLN-ESDGLFEINETSGAISVLQspaQLRREV---YELHVQVTevn 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTK---PLDRESigeYELTVEAT--- 74

                          90
                  ....*....|....*..
gi 17865341   328 SSGSPAAQSTVPVIIRI 344
Cdd:pfam00028  75 DSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.61e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 17865341 119 E---KVVIVVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-679 4.12e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    596 ATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNitpsgeyswsLQVQAKDRGSPSFSTTALLK 674
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdREEQPEYT----------LTVEATDGGGPPLSSTATVT 70


                   ....*
gi 17865341    675 IDITD 679
Cdd:smart00112  71 ITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-471 2.61e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    384 TVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKfSSTADIVI 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 17865341    462 QLLDTNDNVP 471
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 2.35e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   590 TPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKnsiRSLEALHNitpsGEYswSLQVQAKDRGSPSFST 669
Cdd:pfam00028  14 EVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDRESI----GEY--ELTVEATDSGGPPLSS 83


                  ....*....
gi 17865341   670 TALLKIDIT 678
Cdd:pfam00028  84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 7.85e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 7.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17865341    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPNFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 1.56e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.56e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17865341     61 DPEGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVIVVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 1.64e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 139 PYNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLH-SSKFTVDRHSGVLRLQagATLDYEKSRAHFITVVAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 17865341 218 GRlrgadvVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 2.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.55  E-value: 2.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 478 YIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 17865341 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.58e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGLFEINETSGAISVLQSpaqLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 17865341 327 nsSGSPAAQSTVPVIIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
140-238 1.70e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   140 YNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLHSS-KFTVDRHSGVLRLQagATLDYEKSRAHFITVVAKDGGG 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 17865341   219 RLRgadvvfSATTTVTINVE 238
Cdd:pfam00028  79 PPL------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
478-568 2.71e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 2.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   478 YIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIYGTGSD-LFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMD- 555
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 17865341   556 -GRYSLAEVFVTLL 568
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-245 3.69e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.69e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    158 QAEDKDTGSGGSVTYFLQSL-HSSKFTVDRHSGVLRLQAgaTLDYEKSRAHFITVVAKDGGGRLRgadvvfSATTTVTIN 236
Cdd:smart00112   1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 17865341    237 VEDVQDTAP 245
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-575 1.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    496 TAVDPDTGPWGKVQYSI-YGTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVND 572
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 17865341    573 HYP 575
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 2.90e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNitpsgeyswsLQVQ 658
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdREEQSSYT----------LTVT 73

                        90       100
                ....*....|....*....|.
gi 17865341 659 AKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 1.25e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKSLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 17865341 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 2.50e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    270 VAIDGDRGKPNHILYRLLNESD-GLFEINETSGAISVLqspAQLRRE---VYELHVQVTEvnsSGSPAAQSTVPVIIRIV 345
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATD---GGGPPLSSTATVTITVL 74


                   ....*..
gi 17865341    346 DLNNHPP 352
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
252-344 3.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   252 YYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLN-ESDGLFEINETSGAISVLQspaQLRREV---YELHVQVTevn 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTK---PLDRESigeYELTVEAT--- 74

                          90
                  ....*....|....*..
gi 17865341   328 SSGSPAAQSTVPVIIRI 344
Cdd:pfam00028  75 DSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.61e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 17865341 119 E---KVVIVVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-679 4.12e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    596 ATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNitpsgeyswsLQVQAKDRGSPSFSTTALLK 674
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdREEQPEYT----------LTVEATDGGGPPLSSTATVT 70


                   ....*
gi 17865341    675 IDITD 679
Cdd:smart00112  71 ITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-471 2.61e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341    384 TVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKfSSTADIVI 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 17865341    462 QLLDTNDNVP 471
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 2.35e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17865341   590 TPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKnsiRSLEALHNitpsGEYswSLQVQAKDRGSPSFST 669
Cdd:pfam00028  14 EVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDRESI----GEY--ELTVEATDSGGPPLSS 83


                  ....*....
gi 17865341   670 TALLKIDIT 678
Cdd:pfam00028  84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 7.85e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 7.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17865341    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPNFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 1.56e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.56e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17865341     61 DPEGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVIVVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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