NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|26024221|ref|NP_445956|]
View 

neurotrypsin precursor [Rattus norvegicus]

Protein Classification

serine protease( domain architecture ID 10639018)

trypsin-like serine protease such as human plasminogen, the precursor of the widely distributed protease plasmin, or granzyme B, a human enzyme necessary for target cell lysis in cell-mediated immune responses

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 517-758 3.13e-87

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 274.54  E-value: 3.13e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 517 IIGGNNSLRGAWPWQASLRLKSthgdGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDYHTLVPEGFEQDIGVQ 596
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLQYTG----GRHFCGGSLISPRWVLTAAHCV--YSSAPSNYTVRLGSHDLSSNEGGGQVIKVK 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 597 QIVIHRNYRPDSSDYDIALVRLqgsgEQCARLSTHVLPACLPlWRERPQKTASNCHITGWGDT--GRAYSRTLQQAAVPL 674
Cdd:cd00190  75 KVIVHPNYNPSTYDNDIALLKL----KRPVTLSDNVRPICLP-SSGYNLPAGTTCTVSGWGRTseGGPLPDVLQEVNVPI 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 675 LPKRFCKERYKGLF--TGRMLCAGNLQEDnrVDSCQGDSGGPLMCEKPDeTWVVYGVTSWGYGCGIKDTPGVYTRVPAFV 752
Cdd:cd00190 150 VSNAECKRAYSYGGtiTDNMLCAGGLEGG--KDACQGDSGGPLVCNDNG-RGVLVGIVSWGSGCARPNYPGVYTRVSSYL 226


                ....*.
gi 26024221 753 PWIKSV 758
Cdd:cd00190 227 DWIQKT 232
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 166-265 1.03e-45

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 158.27  E-value: 1.03e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    166 IRLVGGKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQC 245
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    246 PKSSWGEHNCGHKEDAGVSC 265
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 386-485 1.47e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 155.19  E-value: 1.47e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    386 IRLMDGENKREGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    466 VKQDIGRHNCRHSEDAGVIC 485
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 273-372 3.71e-40

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 142.87  E-value: 3.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    273 IRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSV-NHFEGSSRPIWLDDVSCSGKEASFIQC 351
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 26024221    352 SRRQWGRHDCSHREDVGLTCY 372
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 83-159 1.98e-19

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


:

Pssm-ID: 214527  Cd Length: 83  Bit Score: 83.21  E-value: 1.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221     83 RRCGAGEP-----WGNATNLGVPCLHWDEVPPFLERSPPASWAELrGQPHNFCRSPDG-AGRPWCFYRNAQgkVDWGYCD 156
Cdd:smart00130   1 RECYAGNGesyrgTVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77


                   ....*.
gi 26024221    157 ---CGQ 159
Cdd:smart00130  78 ipqCEE 83
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 517-758 3.13e-87

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 274.54  E-value: 3.13e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 517 IIGGNNSLRGAWPWQASLRLKSthgdGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDYHTLVPEGFEQDIGVQ 596
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLQYTG----GRHFCGGSLISPRWVLTAAHCV--YSSAPSNYTVRLGSHDLSSNEGGGQVIKVK 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 597 QIVIHRNYRPDSSDYDIALVRLqgsgEQCARLSTHVLPACLPlWRERPQKTASNCHITGWGDT--GRAYSRTLQQAAVPL 674
Cdd:cd00190  75 KVIVHPNYNPSTYDNDIALLKL----KRPVTLSDNVRPICLP-SSGYNLPAGTTCTVSGWGRTseGGPLPDVLQEVNVPI 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 675 LPKRFCKERYKGLF--TGRMLCAGNLQEDnrVDSCQGDSGGPLMCEKPDeTWVVYGVTSWGYGCGIKDTPGVYTRVPAFV 752
Cdd:cd00190 150 VSNAECKRAYSYGGtiTDNMLCAGGLEGG--KDACQGDSGGPLVCNDNG-RGVLVGIVSWGSGCARPNYPGVYTRVSSYL 226


                ....*.
gi 26024221 753 PWIKSV 758
Cdd:cd00190 227 DWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 516-755 5.68e-84

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 266.08  E-value: 5.68e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    516 RIIGGNNSLRGAWPWQASLRLksthGDGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDyHTLVPEGFEQDIGV 595
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQY----GGGRHFCGGSLISPRWVLTAAHCV--RGSDPSNIRVRLGS-HDLSSGEEGQVIKV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    596 QQIVIHRNYRPDSSDYDIALVRLQGSgeqcARLSTHVLPACLPlWRERPQKTASNCHITGWGDT---GRAYSRTLQQAAV 672
Cdd:smart00020  74 SKVIIHPNYNPSTYDNDIALLKLKEP----VTLSDNVRPICLP-SSNYNVPAGTTCTVSGWGRTsegAGSLPDTLQEVNV 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    673 PLLPKRFCKERYKGLF--TGRMLCAGNLQEDnrVDSCQGDSGGPLMCEkpDETWVVYGVTSWGYGCGIKDTPGVYTRVPA 750
Cdd:smart00020 149 PIVSNATCRRAYSGGGaiTDNMLCAGGLEGG--KDACQGDSGGPLVCN--DGRWVLVGIVSWGSGCARPGKPGVYTRVSS 224


                   ....*
gi 26024221    751 FVPWI 755
Cdd:smart00020 225 YLDWI 229
Trypsin pfam00089
Trypsin;
517-755 9.16e-67

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 220.01  E-value: 9.16e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   517 IIGGNNSLRGAWPWQASLRLKSthgdGRLLCGATLLSSCWVLTAAHCFTrygnNSRSYAVRVGDYHTLVPEGFEQDIGVQ 596
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSS----GKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGAHNIVLREGGEQKFDVE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   597 QIVIHRNYRPDSSDYDIALVRLQGSgeqcARLSTHVLPACLPLWRERPQKTASnCHITGWGDTGRA-YSRTLQQAAVPLL 675
Cdd:pfam00089  73 KIIVHPNYNPDTLDNDIALLKLESP----VTLGDTVRPICLPDASSDLPVGTT-CTVSGWGNTKTLgPSDTLQEVTVPVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   676 PKRFCKERYKGLFTGRMLCAGnlqeDNRVDSCQGDSGGPLMCEKPdetwVVYGVTSWGYGCGIKDTPGVYTRVPAFVPWI 755
Cdd:pfam00089 148 SRETCRSAYGGTVTDTMICAG----AGGKDACQGDSGGPLVCSDG----ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 514-759 1.73e-58

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 199.49  E-value: 1.73e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 514 QTRIIGGNNSLRGAWPWQASLRlkSTHGDGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDYHTLVPEGfeQDI 593
Cdd:COG5640  28 APAIVGGTPATVGEYPWMVALQ--SSNGPSGQFCGGTLIAPRWVLTAAHCV--DGDGPSDLRVVIGSTDLSTSGG--TVV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 594 GVQQIVIHRNYRPDSSDYDIALVRLqgsgeqcARLSTHVLPACLP--LWRERPQKTAsncHITGWGDTGR---AYSRTLQ 668
Cdd:COG5640 102 KVARIVVHPDYDPATPGNDIALLKL-------ATPVPGVAPAPLAtsADAAAPGTPA---TVAGWGRTSEgpgSQSGTLR 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 669 QAAVPLLPKRFCKeRYKGLFTGRMLCAGNlqEDNRVDSCQGDSGGPLMcEKPDETWVVYGVTSWGYGCGIKDTPGVYTRV 748
Cdd:COG5640 172 KADVPVVSDATCA-AYGGFDGGTMLCAGY--PEGGKDACQGDSGGPLV-VKDGGGWVLVGVVSWGGGPCAAGYPGVYTRV 247

                       250
                ....*....|.
gi 26024221 749 PAFVPWIKSVT 759
Cdd:COG5640 248 SAYRDWIKSTA 258
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 166-265 1.03e-45

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 158.27  E-value: 1.03e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    166 IRLVGGKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQC 245
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    246 PKSSWGEHNCGHKEDAGVSC 265
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 386-485 1.47e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 155.19  E-value: 1.47e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    386 IRLMDGENKREGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    466 VKQDIGRHNCRHSEDAGVIC 485
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 273-372 3.71e-40

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 142.87  E-value: 3.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    273 IRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSV-NHFEGSSRPIWLDDVSCSGKEASFIQC 351
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 26024221    352 SRRQWGRHDCSHREDVGLTCY 372
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 171-266 4.47e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 136.74  E-value: 4.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   171 GKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAW-HQAHFGEG-SGPILLDEVRCTGNELSIEQCPKS 248
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 26024221   249 SWGEHNCGHKEDAGVSCA 266
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 391-485 1.39e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 127.11  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   391 GENKREGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARA-RTMAYFGEG-KGPIHMDNVKCTGNEKALADCVKQ 468
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSApSGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 26024221   469 DIGRHNCRHSEDAGVIC 485
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 278-371 6.82e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 124.80  E-value: 6.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   278 GKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVNH---FEGSSRPIWLDDVSCSGKEASFIQCSRR 354
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCsyfGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 26024221   355 QWGRHDCSHREDVGLTC 371
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 83-159 1.98e-19

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 83.21  E-value: 1.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221     83 RRCGAGEP-----WGNATNLGVPCLHWDEVPPFLERSPPASWAELrGQPHNFCRSPDG-AGRPWCFYRNAQgkVDWGYCD 156
Cdd:smart00130   1 RECYAGNGesyrgTVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77


                   ....*.
gi 26024221    157 ---CGQ 159
Cdd:smart00130  78 ipqCEE 83
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 98-156 3.35e-09

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 54.31  E-value: 3.35e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221  98 GVPCLHWDEVPPFLERSPPASWAELRGQpHNFCRSPDGA-GRPWCFYRNaqGKVDWGYCD 156
Cdd:cd00108  22 GKPCQRWNSQLPHQHKFNPERFPEGLLE-ENYCRNPDGDpEGPWCYTTD--PNVRWEYCD 78
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 95-156 1.05e-07

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 49.61  E-value: 1.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26024221    95 TNLGVPCLHWDEVPPFLERSPPAS---WAELRGqphNFCRSPDGAGRPWCFYRNaqGKVDWGYCD 156
Cdd:pfam00051  16 TESGRPCQAWDSQTPHRHSKYTPEnfpAKGLGE---NYCRNPDGDERPWCYTTD--PRVRWEYCD 75
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 517-758 3.13e-87

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 274.54  E-value: 3.13e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 517 IIGGNNSLRGAWPWQASLRLKSthgdGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDYHTLVPEGFEQDIGVQ 596
Cdd:cd00190   1 IVGGSEAKIGSFPWQVSLQYTG----GRHFCGGSLISPRWVLTAAHCV--YSSAPSNYTVRLGSHDLSSNEGGGQVIKVK 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 597 QIVIHRNYRPDSSDYDIALVRLqgsgEQCARLSTHVLPACLPlWRERPQKTASNCHITGWGDT--GRAYSRTLQQAAVPL 674
Cdd:cd00190  75 KVIVHPNYNPSTYDNDIALLKL----KRPVTLSDNVRPICLP-SSGYNLPAGTTCTVSGWGRTseGGPLPDVLQEVNVPI 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 675 LPKRFCKERYKGLF--TGRMLCAGNLQEDnrVDSCQGDSGGPLMCEKPDeTWVVYGVTSWGYGCGIKDTPGVYTRVPAFV 752
Cdd:cd00190 150 VSNAECKRAYSYGGtiTDNMLCAGGLEGG--KDACQGDSGGPLVCNDNG-RGVLVGIVSWGSGCARPNYPGVYTRVSSYL 226


                ....*.
gi 26024221 753 PWIKSV 758
Cdd:cd00190 227 DWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 516-755 5.68e-84

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 266.08  E-value: 5.68e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    516 RIIGGNNSLRGAWPWQASLRLksthGDGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDyHTLVPEGFEQDIGV 595
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQY----GGGRHFCGGSLISPRWVLTAAHCV--RGSDPSNIRVRLGS-HDLSSGEEGQVIKV 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    596 QQIVIHRNYRPDSSDYDIALVRLQGSgeqcARLSTHVLPACLPlWRERPQKTASNCHITGWGDT---GRAYSRTLQQAAV 672
Cdd:smart00020  74 SKVIIHPNYNPSTYDNDIALLKLKEP----VTLSDNVRPICLP-SSNYNVPAGTTCTVSGWGRTsegAGSLPDTLQEVNV 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    673 PLLPKRFCKERYKGLF--TGRMLCAGNLQEDnrVDSCQGDSGGPLMCEkpDETWVVYGVTSWGYGCGIKDTPGVYTRVPA 750
Cdd:smart00020 149 PIVSNATCRRAYSGGGaiTDNMLCAGGLEGG--KDACQGDSGGPLVCN--DGRWVLVGIVSWGSGCARPGKPGVYTRVSS 224


                   ....*
gi 26024221    751 FVPWI 755
Cdd:smart00020 225 YLDWI 229
Trypsin pfam00089
Trypsin;
517-755 9.16e-67

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 220.01  E-value: 9.16e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   517 IIGGNNSLRGAWPWQASLRLKSthgdGRLLCGATLLSSCWVLTAAHCFTrygnNSRSYAVRVGDYHTLVPEGFEQDIGVQ 596
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSS----GKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGAHNIVLREGGEQKFDVE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   597 QIVIHRNYRPDSSDYDIALVRLQGSgeqcARLSTHVLPACLPLWRERPQKTASnCHITGWGDTGRA-YSRTLQQAAVPLL 675
Cdd:pfam00089  73 KIIVHPNYNPDTLDNDIALLKLESP----VTLGDTVRPICLPDASSDLPVGTT-CTVSGWGNTKTLgPSDTLQEVTVPVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   676 PKRFCKERYKGLFTGRMLCAGnlqeDNRVDSCQGDSGGPLMCEKPdetwVVYGVTSWGYGCGIKDTPGVYTRVPAFVPWI 755
Cdd:pfam00089 148 SRETCRSAYGGTVTDTMICAG----AGGKDACQGDSGGPLVCSDG----ELIGIVSWGYGCASGNYPGVYTPVSSYLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 514-759 1.73e-58

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 199.49  E-value: 1.73e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 514 QTRIIGGNNSLRGAWPWQASLRlkSTHGDGRLLCGATLLSSCWVLTAAHCFtrYGNNSRSYAVRVGDYHTLVPEGfeQDI 593
Cdd:COG5640  28 APAIVGGTPATVGEYPWMVALQ--SSNGPSGQFCGGTLIAPRWVLTAAHCV--DGDGPSDLRVVIGSTDLSTSGG--TVV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 594 GVQQIVIHRNYRPDSSDYDIALVRLqgsgeqcARLSTHVLPACLP--LWRERPQKTAsncHITGWGDTGR---AYSRTLQ 668
Cdd:COG5640 102 KVARIVVHPDYDPATPGNDIALLKL-------ATPVPGVAPAPLAtsADAAAPGTPA---TVAGWGRTSEgpgSQSGTLR 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 669 QAAVPLLPKRFCKeRYKGLFTGRMLCAGNlqEDNRVDSCQGDSGGPLMcEKPDETWVVYGVTSWGYGCGIKDTPGVYTRV 748
Cdd:COG5640 172 KADVPVVSDATCA-AYGGFDGGTMLCAGY--PEGGKDACQGDSGGPLV-VKDGGGWVLVGVVSWGGGPCAAGYPGVYTRV 247

                       250
                ....*....|.
gi 26024221 749 PAFVPWIKSVT 759
Cdd:COG5640 248 SAYRDWIKSTA 258
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 166-265 1.03e-45

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 158.27  E-value: 1.03e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    166 IRLVGGKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAWHQAHFGEGSGPILLDEVRCTGNELSIEQC 245
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    246 PKSSWGEHNCGHKEDAGVSC 265
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 386-485 1.47e-44

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 155.19  E-value: 1.47e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    386 IRLMDGENKREGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|
gi 26024221    466 VKQDIGRHNCRHSEDAGVIC 485
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVC 100
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 273-372 3.71e-40

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 142.87  E-value: 3.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221    273 IRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSV-NHFEGSSRPIWLDDVSCSGKEASFIQC 351
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 26024221    352 SRRQWGRHDCSHREDVGLTCY 372
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 171-266 4.47e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 136.74  E-value: 4.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   171 GKSGHEGRVELYHAGQWGTICDDQWDDADAEVICRQLGLSGIAKAW-HQAHFGEG-SGPILLDEVRCTGNELSIEQCPKS 248
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 26024221   249 SWGEHNCGHKEDAGVSCA 266
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 391-485 1.39e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 127.11  E-value: 1.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   391 GENKREGRVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARA-RTMAYFGEG-KGPIHMDNVKCTGNEKALADCVKQ 468
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSApSGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 26024221   469 DIGRHNCRHSEDAGVIC 485
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 278-371 6.82e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 124.80  E-value: 6.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221   278 GKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVNH---FEGSSRPIWLDDVSCSGKEASFIQCSRR 354
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCsyfGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 26024221   355 QWGRHDCSHREDVGLTC 371
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 83-159 1.98e-19

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 83.21  E-value: 1.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221     83 RRCGAGEP-----WGNATNLGVPCLHWDEVPPFLERSPPASWAELrGQPHNFCRSPDG-AGRPWCFYRNAQgkVDWGYCD 156
Cdd:smart00130   1 RECYAGNGesyrgTVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77


                   ....*.
gi 26024221    157 ---CGQ 159
Cdd:smart00130  78 ipqCEE 83
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 541-757 2.41e-09

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 57.76  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 541 GDGRLLCGATLLSSCWVLTAAHCFTRYGNNSRSYAVRVG-DYHTLVPEGFeqdiGVQQIVIHRNYRPD-SSDYDIALVRL 618
Cdd:COG3591   8 DGGGGVCTGTLIGPNLVLTAGHCVYDGAGGGWATNIVFVpGYNGGPYGTA----TATRFRVPPGWVASgDAGYDYALLRL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 619 QgsgeqcARLSTHVLPacLPLWRERPQKTASNCHITGWGDtGRAYSRTLQQAavpllpkrfCKERYKGLFTGRMLCagnl 698
Cdd:COG3591  84 D------EPLGDTTGW--LGLAFNDAPLAGEPVTIIGYPG-DRPKDLSLDCS---------GRVTGVQGNRLSYDC---- 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221 699 qednrvDSCQGDSGGPLMCEKpDETWVVYGVTSWGYGcgikDTPGVYTRV-PAFVPWIKS 757
Cdd:COG3591 142 ------DTTGGSSGSPVLDDS-DGGGRVVGVHSAGGA----DRANTGVRLtSAIVAALRA 190
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 98-156 3.35e-09

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 54.31  E-value: 3.35e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024221  98 GVPCLHWDEVPPFLERSPPASWAELRGQpHNFCRSPDGA-GRPWCFYRNaqGKVDWGYCD 156
Cdd:cd00108  22 GKPCQRWNSQLPHQHKFNPERFPEGLLE-ENYCRNPDGDpEGPWCYTTD--PNVRWEYCD 78
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 95-156 1.05e-07

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 49.61  E-value: 1.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26024221    95 TNLGVPCLHWDEVPPFLERSPPAS---WAELRGqphNFCRSPDGAGRPWCFYRNaqGKVDWGYCD 156
Cdd:pfam00051  16 TESGRPCQAWDSQTPHRHSKYTPEnfpAKGLGE---NYCRNPDGDERPWCYTTD--PRVRWEYCD 75
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 400-429 1.20e-04

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 41.55  E-value: 1.20e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 26024221   400 EVFV--NGQWGTICDDGWTDKHAAVICRQLGY 429
Cdd:pfam15494   7 QVYSsaRPSWLPVCSDDWNPAYGRAACQQLGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH