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Conserved domains on  [gi|1939872583|ref|NP_445843|]
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heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor [Rattus norvegicus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
59-296 1.54e-40

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 141.71  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583  59 LPQTIIIGVRKGGTRALLEMLSLHPDVAAAEN--EVHFFDWEeHYSQGLGWYLTQMPF---SSPHQLTVEKTPAYFTS-- 131
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNH-NRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKThl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 132 PKVPERIHSMNPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPYPPIEDLLMRDGRLNvdykalnRSLYHAHMLNWLRF 211
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN-------CGSYFDHVKGWWKL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 212 FPLGHIHIVDGDRLIRDPFPEIQKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS--------GKDRCLHESKgra 278
Cdd:pfam00685 153 RPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpkevspFFRKGLVGDW--- 229

                         250
                  ....*....|....*...
gi 1939872583 279 HPQVDPKLLDKLHEYFHE 296
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
59-296 1.54e-40

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 141.71  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583  59 LPQTIIIGVRKGGTRALLEMLSLHPDVAAAEN--EVHFFDWEeHYSQGLGWYLTQMPF---SSPHQLTVEKTPAYFTS-- 131
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNH-NRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKThl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 132 PKVPERIHSMNPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPYPPIEDLLMRDGRLNvdykalnRSLYHAHMLNWLRF 211
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN-------CGSYFDHVKGWWKL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 212 FPLGHIHIVDGDRLIRDPFPEIQKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS--------GKDRCLHESKgra 278
Cdd:pfam00685 153 RPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpkevspFFRKGLVGDW--- 229

                         250
                  ....*....|....*...
gi 1939872583 279 HPQVDPKLLDKLHEYFHE 296
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
59-296 1.54e-40

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 141.71  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583  59 LPQTIIIGVRKGGTRALLEMLSLHPDVAAAEN--EVHFFDWEeHYSQGLGWYLTQMPF---SSPHQLTVEKTPAYFTS-- 131
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNH-NRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKThl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 132 PKVPERIHSMNPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPYPPIEDLLMRDGRLNvdykalnRSLYHAHMLNWLRF 211
Cdd:pfam00685  80 PLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVN-------CGSYFDHVKGWWKL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 212 FPLGHIHIVDGDRLIRDPFPEIQKVERFLKLSP-----QINASNFYFNKTKGFYCLRDS--------GKDRCLHESKgra 278
Cdd:pfam00685 153 RPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSklpkevspFFRKGLVGDW--- 229

                         250
                  ....*....|....*...
gi 1939872583 279 HPQVDPKLLDKLHEYFHE 296
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
63-242 6.56e-16

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 74.25  E-value: 6.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583  63 IIIGVRKGGTRALLEMLSLHPDVAAAENEVHFF-DWEEHYSQGLGWYLTQMPFSSPHQLTVEKTPAYFTSPkvpERIHSM 141
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIpRILALLQAWGKSLEALARVPSYARWLCDKSPSHLFHL---DLLLKA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939872583 142 NPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPyppiEDLLMRDGRLNVDYKALNRslYHAHmlnWLRFFPlGHIHIVD 221
Cdd:pfam13469  79 FPDAKFIHLHRDPVDTVISSYCSLFGFTLSSYST----AFLRDIGLALARWSRAYER--LMAA---RARVPP-GRFLDVR 148

                         170       180
                  ....*....|....*....|.
gi 1939872583 222 GDRLIRDPFPEIQKVERFLKL 242
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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