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Conserved domains on  [gi|309319787|ref|NP_445792|]
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opioid growth factor receptor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
76-283 1.71e-149

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


:

Pssm-ID: 461383  Cd Length: 208  Bit Score: 427.90  E-value: 1.71e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787   76 DCNGDMCNLSFYKNEICFQPNGALIEDILQNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLKEVEAFKSSKEVRE 155
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787  156 RLVRAYELMLGFYGIHLEDRGTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKSLGELGLEHYQAPLVRFFLEETLVQHK 235
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 309319787  236 LPSVRQSALDYFLFAVRCRHQRRELVYFAWEHFKPRREFVWGPRDKLR 283
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
287-570 5.09e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 287 PQTIPQPLTGPGQADKDEGSRDPSQEAGTQGRTCGSGRDLSGDSGTAEDPSlLNTKPSDGGTLDGNQRDEAKSLSPKESK 366
Cdd:PTZ00449 514 PEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPA-KEHKPSKIPTLSKKPEFPKDPKHPKDPE 592
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 367 K-RKLEGNRQEQVPGEADPQGVSEVEKIALNLEEcALSPISqePREAEPPcpvarvanevrKRRKVEEGAEGDGVVSNTQ 445
Cdd:PTZ00449 593 EpKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKR-PESPKS--PKRPPPP-----------QRPSSPERPEGPKIIKSPK 658
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 446 MQASALPPTPSECPE------AQKDGNGPEDSNSQVGAEDSKS---QVGPEDPNSQVGLEDPNSQVGPEDPNSQVGP-ED 515
Cdd:PTZ00449 659 PPKSPKPPFDPKFKEkfyddyLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFEPiGD 738
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 309319787 516 PNSQvgPEDPNSQVVGPEQAAS---KSPVEDPDSDTMGTSVDESEELARIEASAEPPK 570
Cdd:PTZ00449 739 PDAE--QPDDIEFFTPPEEERTffhETPADTPLPDILAEEFKEEDIHAETGEPDEAMK 794
 
Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
76-283 1.71e-149

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


Pssm-ID: 461383  Cd Length: 208  Bit Score: 427.90  E-value: 1.71e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787   76 DCNGDMCNLSFYKNEICFQPNGALIEDILQNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLKEVEAFKSSKEVRE 155
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787  156 RLVRAYELMLGFYGIHLEDRGTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKSLGELGLEHYQAPLVRFFLEETLVQHK 235
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 309319787  236 LPSVRQSALDYFLFAVRCRHQRRELVYFAWEHFKPRREFVWGPRDKLR 283
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
287-570 5.09e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 287 PQTIPQPLTGPGQADKDEGSRDPSQEAGTQGRTCGSGRDLSGDSGTAEDPSlLNTKPSDGGTLDGNQRDEAKSLSPKESK 366
Cdd:PTZ00449 514 PEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPA-KEHKPSKIPTLSKKPEFPKDPKHPKDPE 592
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 367 K-RKLEGNRQEQVPGEADPQGVSEVEKIALNLEEcALSPISqePREAEPPcpvarvanevrKRRKVEEGAEGDGVVSNTQ 445
Cdd:PTZ00449 593 EpKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKR-PESPKS--PKRPPPP-----------QRPSSPERPEGPKIIKSPK 658
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 446 MQASALPPTPSECPE------AQKDGNGPEDSNSQVGAEDSKS---QVGPEDPNSQVGLEDPNSQVGPEDPNSQVGP-ED 515
Cdd:PTZ00449 659 PPKSPKPPFDPKFKEkfyddyLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFEPiGD 738
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 309319787 516 PNSQvgPEDPNSQVVGPEQAAS---KSPVEDPDSDTMGTSVDESEELARIEASAEPPK 570
Cdd:PTZ00449 739 PDAE--QPDDIEFFTPPEEERTffhETPADTPLPDILAEEFKEEDIHAETGEPDEAMK 794
Herpes_LMP1 pfam05297
Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane ...
465-569 5.36e-03

Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high lymphoma rates in immunosuppressed monkeys


Pssm-ID: 283060  Cd Length: 386  Bit Score: 39.24  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787  465 GNGPEDSNSQVGAEDSKSQVGPEDPNS--QVGLEDPNS--QVGPEDPNsqvgPEDPNS--QVGPEDP-NSQVVGPEQAAS 537
Cdd:pfam05297 232 GDGPPLCSQNLGAPGGGPDNGPQDPDNtdDNGPQDPDNtdDNGPHDPL----PQDPDNtdDNGPQDPdNTADNGPHDPLP 307
                          90       100       110
                  ....*....|....*....|....*....|..
gi 309319787  538 KSPVEDPDSDtmGTSVDESEELARIEASAEPP 569
Cdd:pfam05297 308 HNPSDSAGND--GGPPNLTEEVENKGGDQGPP 337
 
Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
76-283 1.71e-149

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


Pssm-ID: 461383  Cd Length: 208  Bit Score: 427.90  E-value: 1.71e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787   76 DCNGDMCNLSFYKNEICFQPNGALIEDILQNWKDNYDLLEENHSYIQWLFPLREPGVNWHAKPLTLKEVEAFKSSKEVRE 155
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787  156 RLVRAYELMLGFYGIHLEDRGTGAVCRAQNFQPRFHNLNSHSHNNLRITRILKSLGELGLEHYQAPLVRFFLEETLVQHK 235
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 309319787  236 LPSVRQSALDYFLFAVRCRHQRRELVYFAWEHFKPRREFVWGPRDKLR 283
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
287-570 5.09e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 287 PQTIPQPLTGPGQADKDEGSRDPSQEAGTQGRTCGSGRDLSGDSGTAEDPSlLNTKPSDGGTLDGNQRDEAKSLSPKESK 366
Cdd:PTZ00449 514 PEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPA-KEHKPSKIPTLSKKPEFPKDPKHPKDPE 592
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 367 K-RKLEGNRQEQVPGEADPQGVSEVEKIALNLEEcALSPISqePREAEPPcpvarvanevrKRRKVEEGAEGDGVVSNTQ 445
Cdd:PTZ00449 593 EpKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKR-PESPKS--PKRPPPP-----------QRPSSPERPEGPKIIKSPK 658
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787 446 MQASALPPTPSECPE------AQKDGNGPEDSNSQVGAEDSKS---QVGPEDPNSQVGLEDPNSQVGPEDPNSQVGP-ED 515
Cdd:PTZ00449 659 PPKSPKPPFDPKFKEkfyddyLDAAAKSKETKTTVVLDESFESilkETLPETPGTPFTTPRPLPPKLPRDEEFPFEPiGD 738
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 309319787 516 PNSQvgPEDPNSQVVGPEQAAS---KSPVEDPDSDTMGTSVDESEELARIEASAEPPK 570
Cdd:PTZ00449 739 PDAE--QPDDIEFFTPPEEERTffhETPADTPLPDILAEEFKEEDIHAETGEPDEAMK 794
Herpes_LMP1 pfam05297
Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane ...
465-569 5.36e-03

Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high lymphoma rates in immunosuppressed monkeys


Pssm-ID: 283060  Cd Length: 386  Bit Score: 39.24  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309319787  465 GNGPEDSNSQVGAEDSKSQVGPEDPNS--QVGLEDPNS--QVGPEDPNsqvgPEDPNS--QVGPEDP-NSQVVGPEQAAS 537
Cdd:pfam05297 232 GDGPPLCSQNLGAPGGGPDNGPQDPDNtdDNGPQDPDNtdDNGPHDPL----PQDPDNtdDNGPQDPdNTADNGPHDPLP 307
                          90       100       110
                  ....*....|....*....|....*....|..
gi 309319787  538 KSPVEDPDSDtmGTSVDESEELARIEASAEPP 569
Cdd:pfam05297 308 HNPSDSAGND--GGPPNLTEEVENKGGDQGPP 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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