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Conserved domains on  [gi|16758014|ref|NP_445770|]
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hemopexin precursor [Rattus norvegicus]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-230 1.27e-48

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.18  E-value: 1.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014  52 DAWSFDATTMDhNGTMLFFKGEFVWRGHSGIRE----LISERWKNPVTSVDAAFRGP--DSVFLIKEDKVWVYPPEKKEN 125
Cdd:cd00094   5 DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 126 GYPKLFQEeSPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL- 194
Cdd:cd00094  84 GYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLd 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16758014 195 ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 230
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 269-458 1.03e-38

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 1.03e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 269 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 346
Cdd:cd00094  16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 347 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 420
Cdd:cd00094  92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 16758014 421 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-230 1.27e-48

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.18  E-value: 1.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014  52 DAWSFDATTMDhNGTMLFFKGEFVWRGHSGIRE----LISERWKNPVTSVDAAFRGP--DSVFLIKEDKVWVYPPEKKEN 125
Cdd:cd00094   5 DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 126 GYPKLFQEeSPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL- 194
Cdd:cd00094  84 GYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLd 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16758014 195 ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 230
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 269-458 1.03e-38

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 1.03e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 269 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 346
Cdd:cd00094  16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 347 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 420
Cdd:cd00094  92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 16758014 421 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 2.70e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.07  E-value: 2.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 16758014    261 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 304
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 2.94e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.07  E-value: 2.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 16758014     97 VDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEESPGIP 139
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 9.67e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.47  E-value: 9.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16758014    97 VDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEESPGIP 139
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 2.05e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16758014   261 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 304
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 52-230 1.27e-48

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 165.18  E-value: 1.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014  52 DAWSFDATTMDhNGTMLFFKGEFVWRGHSGIRE----LISERWKNPVTSVDAAFRGP--DSVFLIKEDKVWVYPPEKKEN 125
Cdd:cd00094   5 DPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPPgspfLISSFWPSLPSPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 126 GYPKLFQEeSPGIPYPP--DAAVECHRGEcqseGVLFFQGNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL- 194
Cdd:cd00094  84 GYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLd 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16758014 195 ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 230
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 269-458 1.03e-38

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 1.03e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 269 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 346
Cdd:cd00094  16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16758014 347 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 420
Cdd:cd00094  92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 16758014 421 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 458
Cdd:cd00094 159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 2.70e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.07  E-value: 2.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 16758014    261 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 304
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 2.94e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.07  E-value: 2.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 16758014     97 VDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEESPGIP 139
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 97-139 9.67e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.47  E-value: 9.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16758014    97 VDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEESPGIP 139
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-92 1.17e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.84  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 16758014     56 FDATTMDHNGTMLFFKGEFVWR-----GHSGIRELISERWKN 92
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRfdpkrVDPGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 261-304 2.05e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 16758014   261 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 304
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-77 3.55e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 35.23  E-value: 3.55e-03
                          10        20
                  ....*....|....*....|..
gi 16758014    56 FDATTMDHNGTMLFFKGEFVWR 77
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWR 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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