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Conserved domains on  [gi|151101369|ref|NP_444269|]
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COMM domain-containing protein 7 isoform 1 [Homo sapiens]

Protein Classification

COMM domain-containing protein 7( domain architecture ID 10140835)

COMM domain-containing protein 7 (COMMD7) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and associates with the NF-kappa-B complex and suppresses its transcriptional activity

Gene Symbol:  COMMD7
Gene Ontology:  GO:0051059|GO:0006355
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-198 5.33e-111

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240103  Cd Length: 180  Bit Score: 314.77  E-value: 5.33e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  19 MQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 98
Cdd:cd04755    1 IQNLNQLSEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  99 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELT 178
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                        170       180
                 ....*....|....*....|
gi 151101369 179 LPQFYSFLHEMERVRTSMEC 198
Cdd:cd04755  161 LPQFYSFLHEMERAKASLEC 180
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-198 5.33e-111

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 314.77  E-value: 5.33e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  19 MQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 98
Cdd:cd04755    1 IQNLNQLSEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  99 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELT 178
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                        170       180
                 ....*....|....*....|
gi 151101369 179 LPQFYSFLHEMERVRTSMEC 198
Cdd:cd04755  161 LPQFYSFLHEMERAKASLEC 180
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 130-192 8.15e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.03  E-value: 8.15e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151101369  130 MINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQ-TENVYIELTLPQFYSFLHEMERV 192
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGsSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-198 5.33e-111

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 314.77  E-value: 5.33e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  19 MQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFIT 98
Cdd:cd04755    1 IQNLNQLSEQQFSRLTEILFEFLLEPKESERLLNQLDEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  99 LGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELT 178
Cdd:cd04755   81 LGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRKGNQTENVYMELT 160

                        170       180
                 ....*....|....*....|
gi 151101369 179 LPQFYSFLHEMERVRTSMEC 198
Cdd:cd04755  161 LPQFYSFLHEMERAKASLEC 180
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 127-196 5.60e-17

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 72.34  E-value: 5.60e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 151101369 127 QTLMINQLIDMEWKFGVTSGSSELEKVG--SIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSM 196
Cdd:cd04748   16 QSLSLPQLVDFDWRLDVQISSSSLAKVKqpTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 130-192 8.15e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.03  E-value: 8.15e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151101369  130 MINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQ-TENVYIELTLPQFYSFLHEMERV 192
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGsSEEVTFELSKEQLQDLLNELEEA 64
Commd6 cd04754
COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of ...
 127-197 7.59e-06

COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240102  Cd Length: 86  Bit Score: 42.60  E-value: 7.59e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 151101369 127 QTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKL-VVKKGNQTENVYIELTLPQFYSFLHEMERVRTSME 197
Cdd:cd04754   15 QVLNIGQLVDFKWKLGMAVSSDTCRSLNSPYVAVTLkVADPSGQVVTKSFEMTIPEFQNFSRQFKEMAAVLE 86
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 66-197 1.05e-05

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 43.96  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101369  66 GSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTS 145
Cdd:cd04752   39 GDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYIL 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 151101369 146 GSSELEKVGSIFLQLKLVVK--KGNQTENVYIELTLPQFYSFLHEMERVRTSME 197
Cdd:cd04752  119 SSSELQEVNEPLVQLRLKVRnaDTGEITPHPFSVSADKFRVLLAELKQAQTLME 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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