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Conserved domains on  [gi|16258809|ref|NP_434685|]
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zinc finger protein 354A isoform a [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.53e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 1.53e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16258809     14 VTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASMaGFLFTKPKVISLLQQGEDPW 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-567 4.41e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 170 KKQISYLSNPPGITPDKR-YKCSMCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYVC 246
Cdd:COG5048  15 VLSSTPKSTLKSLSNAPRpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 247 K----------------ECGKAFTLSTSLYKHLRTHTVEKS----------YRCKECGKSFGQRSGLFIHQKIHARENPH 300
Cdd:COG5048  95 SkslplsnskasssslsSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 301 RYNPGRKASASLSGCQRAHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKP 380
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 381 YRCGECGKGFTSISRLNRHRIIHTGE-------KLYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFR 447
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFS 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 448 QSSALIQHQRMHTGERPYKC-------------NECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSALIQHRRi 514
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS- 413

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 16258809 515 hTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKlFNYRSSLTNH 567
Cdd:COG5048 414 -FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.53e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 1.53e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16258809     14 VTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASMaGFLFTKPKVISLLQQGEDPW 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 7.94e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.94e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16258809    13 SVTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASM 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 2.17e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.17e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 16258809  14 VTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASM 53
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-567 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 170 KKQISYLSNPPGITPDKR-YKCSMCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYVC 246
Cdd:COG5048  15 VLSSTPKSTLKSLSNAPRpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 247 K----------------ECGKAFTLSTSLYKHLRTHTVEKS----------YRCKECGKSFGQRSGLFIHQKIHARENPH 300
Cdd:COG5048  95 SkslplsnskasssslsSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 301 RYNPGRKASASLSGCQRAHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKP 380
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 381 YRCGECGKGFTSISRLNRHRIIHTGE-------KLYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFR 447
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFS 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 448 QSSALIQHQRMHTGERPYKC-------------NECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSALIQHRRi 514
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS- 413

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 16258809 515 hTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKlFNYRSSLTNH 567
Cdd:COG5048 414 -FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 435-487 5.26e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 5.26e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 16258809 435 KPcKCKVCGKAFRQSSALIQHQRMHTgerpYKCNECGKTFRCNSSLSNH-QRIH 487
Cdd:cd20908   1 KP-WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 16258809   339 SLRYHQRIHTGEKPFRCSECGRAFSQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 492-539 5.83e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 16258809  492 PYQCIECGMSFGQSSALIQHRRIHTGEKpfKCNTCGKTFRQSSSRIAH 539
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.53e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.46  E-value: 1.53e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16258809     14 VTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASMaGFLFTKPKVISLLQQGEDPW 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 7.94e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.94e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16258809    13 SVTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASM 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 2.17e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.17e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 16258809  14 VTFEDVAVLFTRDEWKKLDLSQRSLYREVMLENYSNLASM 53
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-567 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 170 KKQISYLSNPPGITPDKR-YKCSMCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYVC 246
Cdd:COG5048  15 VLSSTPKSTLKSLSNAPRpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 247 K----------------ECGKAFTLSTSLYKHLRTHTVEKS----------YRCKECGKSFGQRSGLFIHQKIHARENPH 300
Cdd:COG5048  95 SkslplsnskasssslsSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 301 RYNPGRKASASLSGCQRAHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFSQSASLIQHERIHTGEKP 380
Cdd:COG5048 175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 381 YRCGECGKGFTSISRLNRHRIIHTGE-------KLYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFR 447
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFS 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 448 QSSALIQHQRMHTGERPYKC-------------NECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSALIQHRRi 514
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS- 413

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 16258809 515 hTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKlFNYRSSLTNH 567
Cdd:COG5048 414 -FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 435-487 5.26e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 5.26e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 16258809 435 KPcKCKVCGKAFRQSSALIQHQRMHTgerpYKCNECGKTFRCNSSLSNH-QRIH 487
Cdd:cd20908   1 KP-WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-573 5.29e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 322 KKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRA--FSQSASLIQHERIHTGEKPYRC---------------- 383
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 384 -----------GECGKGFTSISRLNRHRIIHTGEKLYNC------------------------NECGKALSSHSTLIIHE 428
Cdd:COG5048 111 sssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 429 RIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYQCIECGMSFGQSSAL 508
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16258809 509 IQHRRIHTGE-------KPFKCNTCGKTFRQSSSRIAHQR--IHTGE--KPYEC--NTCGKLFNYRSSLTNHYKIHVD 573
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 16258809   339 SLRYHQRIHTGEKPFRCSECGRAFSQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 119-267 3.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 119 FEPLNMKSENLFIHEGKLEEKWDKNTLTVERSHKNNEFSPKSHREKRSS-ECKKQISYLSNPPGITPDKRYKCSM--CEK 195
Cdd:COG5189 280 FEESSLGFDYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAhGGERNIDTPSRMLKVKDGKPYKCPVegCNK 359

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16258809 196 TFINTSSLRKHEKNhsgeklfkcKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLSTSLYKHlRTHT 267
Cdd:COG5189 360 KYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-476 3.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 16258809   451 ALIQHQRMHTGERPYKCNECGKTFRC 476
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-532 6.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 16258809   507 ALIQHRRIHTGEKPFKCNTCGKTFRQ 532
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
479-502 9.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.31e-04
                          10        20
                  ....*....|....*....|....
gi 16258809   479 SLSNHQRIHTGEKPYQCIECGMSF 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 9.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 16258809   367 SLIQHERIHTGEKPYRCGECGKGFTS 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-281 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....
gi 16258809   258 SLYKHLRTHTVEKSYRCKECGKSF 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 1.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|....*
gi 16258809   230 ALIQHQITHTGEKPYVCKECGKAFT 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 323-400 2.25e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16258809 323 KTYLCN--ECGNTFKSSSSLRYHqRIHtgekpfrcSECGRAFSQSASLIQHERIHTGEKPYRCGECGKGFTSISRLNRHR 400
Cdd:COG5189 348 KPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 16258809   202 SLRKHEKNHSGEKLFKCKECSKAFSQ 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 351-399 4.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 4.68e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 16258809 351 KPFrCSECGRAFSQSASLIQHERIHTgekpYRCGECGKGFTSISRLNRH 399
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
PHA00733 PHA00733
hypothetical protein
 492-539 5.83e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 16258809  492 PYQCIECGMSFGQSSALIQHRRIHTGEKpfKCNTCGKTFRQSSSRIAH 539
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-560 5.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.96e-03
                          10        20
                  ....*....|....*....|..
gi 16258809   539 HQRIHTGEKPYECNTCGKLFNY 560
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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