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Conserved domains on  [gi|16132188|ref|NP_418787|]
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ferric-siderophore reductase FhuF [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

siderophore-iron reductase FhuF( domain architecture ID 11484840)

siderophore-iron reductase FhuF is involved in the reduction of ferric iron in hydroxamate-type siderophores such as ferrioxamine B

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10647 PRK10647
ferric iron reductase involved in ferric hydroximate transport; Provisional
1-262 0e+00

ferric iron reductase involved in ferric hydroximate transport; Provisional


:

Pssm-ID: 182616  Cd Length: 262  Bit Score: 503.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    1 MAYRSAPLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLEFIRLDEPAPLNAMTLAQWSSPNVLSSLLAVYSDHIYRN 80
Cdd:PRK10647   1 MAYRSAPLYEDIIWRTHLQPSDAGLADAIRELIAKTREHLLDFIRLDEPAPLNAMTLAQWSSPNAFSSLLAVYSDHIYRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   81 QPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNATPHSPQHRMETL 160
Cdd:PRK10647  81 QPTLKRENKPLYSLWAQWYIGLMVPPLMLALLTQPQALDVSPEHFHVEFHETGRAACFWYDVHEDKNATPLSPQERMETL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188  161 ISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLWRTVVLRDGLLV 240
Cdd:PRK10647 161 ISQALIPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEALYESLRQALFFEKTLPNGQDNPLWRTVVLRDGLLV 240
                        250       260
                 ....*....|....*....|..
gi 16132188  241 RRTCCQRYRLPDVQQCGDCTLK 262
Cdd:PRK10647 241 RRTCCQRYRLPDVQQCGDCTLK 262
 
Name Accession Description Interval E-value
PRK10647 PRK10647
ferric iron reductase involved in ferric hydroximate transport; Provisional
1-262 0e+00

ferric iron reductase involved in ferric hydroximate transport; Provisional


Pssm-ID: 182616  Cd Length: 262  Bit Score: 503.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    1 MAYRSAPLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLEFIRLDEPAPLNAMTLAQWSSPNVLSSLLAVYSDHIYRN 80
Cdd:PRK10647   1 MAYRSAPLYEDIIWRTHLQPSDAGLADAIRELIAKTREHLLDFIRLDEPAPLNAMTLAQWSSPNAFSSLLAVYSDHIYRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   81 QPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNATPHSPQHRMETL 160
Cdd:PRK10647  81 QPTLKRENKPLYSLWAQWYIGLMVPPLMLALLTQPQALDVSPEHFHVEFHETGRAACFWYDVHEDKNATPLSPQERMETL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188  161 ISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLWRTVVLRDGLLV 240
Cdd:PRK10647 161 ISQALIPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEALYESLRQALFFEKTLPNGQDNPLWRTVVLRDGLLV 240
                        250       260
                 ....*....|....*....|..
gi 16132188  241 RRTCCQRYRLPDVQQCGDCTLK 262
Cdd:PRK10647 241 RRTCCQRYRLPDVQQCGDCTLK 262
Fe_III_red_FhuF TIGR03951
siderophore-iron reductase FhuF; Members of this protein family, including FhuF of E. coli, ...
87-262 3.82e-88

siderophore-iron reductase FhuF; Members of this protein family, including FhuF of E. coli, are siderophore ferric iron reductases that appear to play a role in iron removal from certain hydroxamate-type siderophores, including coprogen, ferrichrome, ferrioxamine B, and aerobactin. Genes occur in regularly in siderophore transport and/or biosynthesis clusters. The C-terminus includes four Cys residues in a C-C-10(X)-C-X-X-C motif that binds a 2Fe-2S cluster. Family TIGR03950 is similar, but especially in the C-terminal region, but likely acts on a different panel of siderophores. [Energy metabolism, Electron transport, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 274875 [Multi-domain]  Cd Length: 182  Bit Score: 259.59  E-value: 3.82e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    87 ENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNA-TPHSPQHRMETLISQAL 165
Cdd:TIGR03951   1 DARALLSLWSKYYFGLLIPPGMLALLVLGRALPLAPERLRVELHETGLPDAFYLPHEGDALLdTPPDPLQRFAGLLDDHL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   166 VPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLW---RTVVLRDGLL--V 240
Cdd:TIGR03951  81 QPVIEALAAYGGINPRLLWSNAGYYIDWYLGELAELLGPAPLAALGLALFFEPQLPDGRRNPLFgpvRTVVLRNGLLfrQ 160
                         170       180
                  ....*....|....*....|..
gi 16132188   241 RRTCCQRYRLPDVQQCGDCTLK 262
Cdd:TIGR03951 161 RRVCCLRYKLPGVGQCGDCPLL 182
FhuF COG4114
Ferric iron reductase protein FhuF, involved in iron transport [Inorganic ion transport and ...
89-262 6.57e-73

Ferric iron reductase protein FhuF, involved in iron transport [Inorganic ion transport and metabolism];


Pssm-ID: 443290 [Multi-domain]  Cd Length: 187  Bit Score: 221.04  E-value: 6.57e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188  89 KPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVcEDKNATPHSPQHRMETLISQALVPV 168
Cdd:COG4114   1 RAAASLWSKRYFGLLTPPVLYALLVLDRALDLSLENVRLELHEDGRPWAFYLPD-EGLPLPGLSPEERIESLLADHLAPL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188 169 VQALEATGEINGKLIWSNTGYLINWYLTEMKQLLG-EATVESLRHALFFEKTLTNGEDNPLWRTV-----VLRDGLLVRR 242
Cdd:COG4114  80 IEALAAVTGISPRLLWENAAVYIYWLLEELLELLGdAARAAADAQALLDEATLPDGRRNPLYRFVrpktpDAGAPVRVRR 159
                       170       180
                ....*....|....*....|
gi 16132188 243 TCCQRYRLPDVQQCGDCTLK 262
Cdd:COG4114 160 TCCLRYRLPGVGYCGTCPLL 179
FhuF pfam06276
Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric ...
93-239 2.22e-20

Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This family also includes the IucA and IucC proteins.


Pssm-ID: 428860 [Multi-domain]  Cd Length: 163  Bit Score: 85.14  E-value: 2.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    93 SLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHEtGRVACFWVDVCEDK--------NATPHSPQ---------- 154
Cdd:pfam06276   1 SAWFKRYLGLLLPPLLHLLLRYGIALEAHGQNILLVLDD-GLPVRLYLRDFGEGvrlrdellPELPGLPEevkrlytddp 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   155 ----HRMETLISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEatvesLRHALFFEKTLTNgEDNPL-W 229
Cdd:pfam06276  80 awlrFIFYYLFVNHLRPLIAALAAAGGLSERLLWSNVADVLEWYQAELPELADR-----FAQFLLFAPTLPD-KANLLrV 153
                         170
                  ....*....|
gi 16132188   230 RTVVLRDGLL 239
Cdd:pfam06276 154 RLADNAEATL 163
 
Name Accession Description Interval E-value
PRK10647 PRK10647
ferric iron reductase involved in ferric hydroximate transport; Provisional
1-262 0e+00

ferric iron reductase involved in ferric hydroximate transport; Provisional


Pssm-ID: 182616  Cd Length: 262  Bit Score: 503.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    1 MAYRSAPLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLEFIRLDEPAPLNAMTLAQWSSPNVLSSLLAVYSDHIYRN 80
Cdd:PRK10647   1 MAYRSAPLYEDIIWRTHLQPSDAGLADAIRELIAKTREHLLDFIRLDEPAPLNAMTLAQWSSPNAFSSLLAVYSDHIYRN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   81 QPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNATPHSPQHRMETL 160
Cdd:PRK10647  81 QPTLKRENKPLYSLWAQWYIGLMVPPLMLALLTQPQALDVSPEHFHVEFHETGRAACFWYDVHEDKNATPLSPQERMETL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188  161 ISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLWRTVVLRDGLLV 240
Cdd:PRK10647 161 ISQALIPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEALYESLRQALFFEKTLPNGQDNPLWRTVVLRDGLLV 240
                        250       260
                 ....*....|....*....|..
gi 16132188  241 RRTCCQRYRLPDVQQCGDCTLK 262
Cdd:PRK10647 241 RRTCCQRYRLPDVQQCGDCTLK 262
Fe_III_red_FhuF TIGR03951
siderophore-iron reductase FhuF; Members of this protein family, including FhuF of E. coli, ...
87-262 3.82e-88

siderophore-iron reductase FhuF; Members of this protein family, including FhuF of E. coli, are siderophore ferric iron reductases that appear to play a role in iron removal from certain hydroxamate-type siderophores, including coprogen, ferrichrome, ferrioxamine B, and aerobactin. Genes occur in regularly in siderophore transport and/or biosynthesis clusters. The C-terminus includes four Cys residues in a C-C-10(X)-C-X-X-C motif that binds a 2Fe-2S cluster. Family TIGR03950 is similar, but especially in the C-terminal region, but likely acts on a different panel of siderophores. [Energy metabolism, Electron transport, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 274875 [Multi-domain]  Cd Length: 182  Bit Score: 259.59  E-value: 3.82e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    87 ENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVCEDKNA-TPHSPQHRMETLISQAL 165
Cdd:TIGR03951   1 DARALLSLWSKYYFGLLIPPGMLALLVLGRALPLAPERLRVELHETGLPDAFYLPHEGDALLdTPPDPLQRFAGLLDDHL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   166 VPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLW---RTVVLRDGLL--V 240
Cdd:TIGR03951  81 QPVIEALAAYGGINPRLLWSNAGYYIDWYLGELAELLGPAPLAALGLALFFEPQLPDGRRNPLFgpvRTVVLRNGLLfrQ 160
                         170       180
                  ....*....|....*....|..
gi 16132188   241 RRTCCQRYRLPDVQQCGDCTLK 262
Cdd:TIGR03951 161 RRVCCLRYKLPGVGQCGDCPLL 182
FhuF COG4114
Ferric iron reductase protein FhuF, involved in iron transport [Inorganic ion transport and ...
89-262 6.57e-73

Ferric iron reductase protein FhuF, involved in iron transport [Inorganic ion transport and metabolism];


Pssm-ID: 443290 [Multi-domain]  Cd Length: 187  Bit Score: 221.04  E-value: 6.57e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188  89 KPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHETGRVACFWVDVcEDKNATPHSPQHRMETLISQALVPV 168
Cdd:COG4114   1 RAAASLWSKRYFGLLTPPVLYALLVLDRALDLSLENVRLELHEDGRPWAFYLPD-EGLPLPGLSPEERIESLLADHLAPL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188 169 VQALEATGEINGKLIWSNTGYLINWYLTEMKQLLG-EATVESLRHALFFEKTLTNGEDNPLWRTV-----VLRDGLLVRR 242
Cdd:COG4114  80 IEALAAVTGISPRLLWENAAVYIYWLLEELLELLGdAARAAADAQALLDEATLPDGRRNPLYRFVrpktpDAGAPVRVRR 159
                       170       180
                ....*....|....*....|
gi 16132188 243 TCCQRYRLPDVQQCGDCTLK 262
Cdd:COG4114 160 TCCLRYRLPGVGYCGTCPLL 179
FhuF pfam06276
Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric ...
93-239 2.22e-20

Ferric iron reductase FhuF-like transporter; This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This family also includes the IucA and IucC proteins.


Pssm-ID: 428860 [Multi-domain]  Cd Length: 163  Bit Score: 85.14  E-value: 2.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188    93 SLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHAEFHEtGRVACFWVDVCEDK--------NATPHSPQ---------- 154
Cdd:pfam06276   1 SAWFKRYLGLLLPPLLHLLLRYGIALEAHGQNILLVLDD-GLPVRLYLRDFGEGvrlrdellPELPGLPEevkrlytddp 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132188   155 ----HRMETLISQALVPVVQALEATGEINGKLIWSNTGYLINWYLTEMKQLLGEatvesLRHALFFEKTLTNgEDNPL-W 229
Cdd:pfam06276  80 awlrFIFYYLFVNHLRPLIAALAAAGGLSERLLWSNVADVLEWYQAELPELADR-----FAQFLLFAPTLPD-KANLLrV 153
                         170
                  ....*....|
gi 16132188   230 RTVVLRDGLL 239
Cdd:pfam06276 154 RLADNAEATL 163
FhuF_C pfam11575
FhuF 2Fe-2S C-terminal domain; This family consists of several bacterial ferric iron reductase ...
241-261 3.54e-06

FhuF 2Fe-2S C-terminal domain; This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.


Pssm-ID: 431941 [Multi-domain]  Cd Length: 21  Bit Score: 42.41  E-value: 3.54e-06
                          10        20
                  ....*....|....*....|.
gi 16132188   241 RRTCCQRYRLPDVQQCGDCTL 261
Cdd:pfam11575   1 RRSCCLYYRLPGGEYCGTCPL 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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