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Conserved domains on  [gi|90111685|ref|NP_418513|]
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DNA-binding transcriptional repressor AlsR [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11485319)

MurR/RpiR family transcriptional regulator similar to Escherichia coli HTH-type transcriptional regulator RpiR, a regulatory protein involved in rpiB gene repression and als operon repression

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AlsR NF040776
transcriptional repressor AlsR;
13-291 0e+00

transcriptional repressor AlsR;


:

Pssm-ID: 468733 [Multi-domain]  Cd Length: 279  Bit Score: 525.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   13 GIGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQ 92
Cdd:NF040776   1 GLALAPKIRMKLEGMTNTESRIVEWLLSPGNLNAKTAIKEVAEALGVSEAMIVKVSKLLGFSGFRELRSALVEYFSELEQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   93 VLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQA 172
Cdd:NF040776  81 VITAELSSDDSPQDVVNKVFNISLQTIMEGQSILDPDVIAEAARCFFKAKQRDLYGVGGSNTICADIEHKFLRIGIRCNA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  173 YPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNAS 252
Cdd:NF040776 161 YSDAHLMMMSASLLQEGDVVLVVSHSGRTSDLLKAVELAKKNGAKIICITHSDHSPIAQLADFVICSPAPETPLLGQNAS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 90111685  253 ARILQLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFFS 291
Cdd:NF040776 241 ARILQLTLLDAFFVSVAQQDIEQAEENLEKTSTIVAYFR 279
 
Name Accession Description Interval E-value
AlsR NF040776
transcriptional repressor AlsR;
13-291 0e+00

transcriptional repressor AlsR;


Pssm-ID: 468733 [Multi-domain]  Cd Length: 279  Bit Score: 525.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   13 GIGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQ 92
Cdd:NF040776   1 GLALAPKIRMKLEGMTNTESRIVEWLLSPGNLNAKTAIKEVAEALGVSEAMIVKVSKLLGFSGFRELRSALVEYFSELEQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   93 VLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQA 172
Cdd:NF040776  81 VITAELSSDDSPQDVVNKVFNISLQTIMEGQSILDPDVIAEAARCFFKAKQRDLYGVGGSNTICADIEHKFLRIGIRCNA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  173 YPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNAS 252
Cdd:NF040776 161 YSDAHLMMMSASLLQEGDVVLVVSHSGRTSDLLKAVELAKKNGAKIICITHSDHSPIAQLADFVICSPAPETPLLGQNAS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 90111685  253 ARILQLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFFS 291
Cdd:NF040776 241 ARILQLTLLDAFFVSVAQQDIEQAEENLEKTSTIVAYFR 279
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
2-293 1.30e-180

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 499.29  E-value: 1.30e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685    2 SQSEFDSALPNGIGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRS 81
Cdd:PRK11337   1 SQSEFDSALPNGIGLGPYIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   82 ALEDYFSQSEQVLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQH 161
Cdd:PRK11337  81 ALEDYFSQSEQVLHSELSFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  162 KFLRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPA 241
Cdd:PRK11337 161 KFLRIGVRCQAYDDAHIMLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTA 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 90111685  242 PETPLLGRNASARILQLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFFSPG 293
Cdd:PRK11337 241 QGSPLLGENAAARIAQLNILDAFFVSVAQLNIEQAEINLQKTGAAVDFFRPG 292
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
20-290 1.91e-68

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 214.41  E-value: 1.91e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  20 LRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQVLP--SE 97
Cdd:COG1737  11 IRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYErlRR 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  98 LAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYP-DA 176
Cdd:COG1737  91 LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDgDG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 177 HIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNASARIL 256
Cdd:COG1737 171 HLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVA 250
                       250       260       270
                ....*....|....*....|....*....|....
gi 90111685 257 QLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFF 290
Cdd:COG1737 251 QLALIDALAAAVAQRDGDKARERLERTEALLSEL 284
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
129-267 5.18e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 143.91  E-value: 5.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 129 DEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAV 208
Cdd:cd05013   1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 90111685 209 ELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNASARILQLTLLDAFFVS 267
Cdd:cd05013  81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
138-267 7.83e-34

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 120.10  E-value: 7.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   138 FYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIMMMS-ASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGA 216
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGvLALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90111685   217 KIICITHSYHSPIAKLADYIICSPAPETPLLGrNASARILQLTLLDAFFVS 267
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYINAGPETGVA-STKSITAQLAALDALAVA 131
 
Name Accession Description Interval E-value
AlsR NF040776
transcriptional repressor AlsR;
13-291 0e+00

transcriptional repressor AlsR;


Pssm-ID: 468733 [Multi-domain]  Cd Length: 279  Bit Score: 525.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   13 GIGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQ 92
Cdd:NF040776   1 GLALAPKIRMKLEGMTNTESRIVEWLLSPGNLNAKTAIKEVAEALGVSEAMIVKVSKLLGFSGFRELRSALVEYFSELEQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   93 VLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQA 172
Cdd:NF040776  81 VITAELSSDDSPQDVVNKVFNISLQTIMEGQSILDPDVIAEAARCFFKAKQRDLYGVGGSNTICADIEHKFLRIGIRCNA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  173 YPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNAS 252
Cdd:NF040776 161 YSDAHLMMMSASLLQEGDVVLVVSHSGRTSDLLKAVELAKKNGAKIICITHSDHSPIAQLADFVICSPAPETPLLGQNAS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 90111685  253 ARILQLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFFS 291
Cdd:NF040776 241 ARILQLTLLDAFFVSVAQQDIEQAEENLEKTSTIVAYFR 279
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
2-293 1.30e-180

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 499.29  E-value: 1.30e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685    2 SQSEFDSALPNGIGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRS 81
Cdd:PRK11337   1 SQSEFDSALPNGIGLGPYIRMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   82 ALEDYFSQSEQVLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQH 161
Cdd:PRK11337  81 ALEDYFSQSEQVLHSELSFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  162 KFLRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPA 241
Cdd:PRK11337 161 KFLRIGVRCQAYDDAHIMLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTA 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 90111685  242 PETPLLGRNASARILQLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFFSPG 293
Cdd:PRK11337 241 QGSPLLGENAAARIAQLNILDAFFVSVAQLNIEQAEINLQKTGAAVDFFRPG 292
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
20-290 1.91e-68

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 214.41  E-value: 1.91e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  20 LRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQVLP--SE 97
Cdd:COG1737  11 IRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYErlRR 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  98 LAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYP-DA 176
Cdd:COG1737  91 LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDgDG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 177 HIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNASARIL 256
Cdd:COG1737 171 HLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVA 250
                       250       260       270
                ....*....|....*....|....*....|....
gi 90111685 257 QLTLLDAFFVSVAQLNIEQANINMQKTGAIVDFF 290
Cdd:COG1737 251 QLALIDALAAAVAQRDGDKARERLERTEALLSEL 284
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
129-267 5.18e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 143.91  E-value: 5.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 129 DEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAV 208
Cdd:cd05013   1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 90111685 209 ELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNASARILQLTLLDAFFVS 267
Cdd:cd05013  81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
138-267 7.83e-34

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 120.10  E-value: 7.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   138 FYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIMMMS-ASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGA 216
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGvLALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90111685   217 KIICITHSYHSPIAKLADYIICSPAPETPLLGrNASARILQLTLLDAFFVS 267
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYINAGPETGVA-STKSITAQLAALDALAVA 131
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
20-272 1.94e-32

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 120.96  E-value: 1.94e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   20 LRMKQEGMTENESRIVEWLL-KPGNLSCAPAiKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSAL-EDYFSQSEQV---- 93
Cdd:PRK15482   7 IRNAESEFTENEQKIADFLRaNVSELKSVSS-RKMAKQLGISQSSIVKFAQKLGAQGFTELRMALiGEYSASREKTnata 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   94 --LPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQ 171
Cdd:PRK15482  86 lhLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  172 AYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNA 251
Cdd:PRK15482 166 CEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSM 245
                        250       260
                 ....*....|....*....|.
gi 90111685  252 SARILQLTLLDAFFVSVAQLN 272
Cdd:PRK15482 246 STRTAQNSVTDLLFVGLVQLN 266
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
20-287 9.87e-31

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 121.18  E-value: 9.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   20 LRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQVLPSELA 99
Cdd:PRK14101 347 IRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQVH 426
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  100 FDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIM 179
Cdd:PRK14101 427 LGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQ 506
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  180 MMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSyHSPIAKLADYIICSPAPETPLLGRNASARILQLT 259
Cdd:PRK14101 507 AASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSS-NTPLAKRATVALETDHIEMRESQLSMISRILHLV 585
                        250       260
                 ....*....|....*....|....*...
gi 90111685  260 LLDAFFVSVAqlnIEQANINMQKTGAIV 287
Cdd:PRK14101 586 MIDILAVGVA---IRRAAPNAELAEAVA 610
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
14-90 1.16e-28

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 104.72  E-value: 1.16e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111685    14 IGLAPYLRMKQEGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQS 90
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
50-263 5.44e-25

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 101.22  E-value: 5.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   50 IKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQVLPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVD 129
Cdd:PRK11302  37 IATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYVNRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  130 EIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTsdvKAAVE 209
Cdd:PRK11302 117 AINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYFDDIVMQRMSCMNSSDGDVVVLISHTGRT---KSLVE 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111685  210 ---LAKKNGAKIICIThSYHSPIAKLADYIICSPAPE-----TPLlgrnaSARILQLTLLDA 263
Cdd:PRK11302 194 laqLARENGATVIAIT-SAGSPLAREATLALTLDVPEdtdiyMPM-----VSRIAQLTVIDV 249
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
20-287 3.35e-19

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 85.20  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   20 LRMKQ--EGMTENESRIVEWLLKPGNLSCAPAIKDVAEALAVSEAMIVKVSKLLGFSGFRNLRSALEDYFSQSEQV---- 93
Cdd:PRK11557   1 LRIRQryPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPEPpsvp 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   94 LPSELAFDEAPQDVVNKVFNITLRTIMEGQSIVNVDEIHRAARFFYQARQRDLYGAGGSNAICADVQHKFLRIGVRCQAY 173
Cdd:PRK11557  81 VHNQIRGDDPLRLVGEKLIKENTAAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  174 PDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPLLGRNASA 253
Cdd:PRK11557 161 RDMHALLATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCLYTIAEEQATRSAAISS 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 90111685  254 RILQLTLLDAFFVSVAQLNIEQANINMQKTGAIV 287
Cdd:PRK11557 241 THAQGMLTDLLFMALIQQDLERAPERIRHSEALV 274
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
146-223 8.99e-16

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 70.87  E-value: 8.99e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 146 LYGAGGSNAICADVQHKFLRI-GVRCQAYPDAHIMMMS-ASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITH 223
Cdd:cd04795   3 VIGIGGSGAIAAYFALELLELtGIEVVALIATELEHASlLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAITD 82
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
186-243 8.98e-15

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 70.68  E-value: 8.98e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 90111685 186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPE 243
Cdd:cd05005  73 IGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAAT 130
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
185-263 1.92e-12

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 62.95  E-value: 1.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 185 LLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADY-IICSPAPETPLLGRNASAR-ILQLTLLD 262
Cdd:cd05014  44 MVTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVvLDLPVEEEACPLGLAPTTStTAMLALGD 123

                .
gi 90111685 263 A 263
Cdd:cd05014 124 A 124
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
185-243 6.34e-11

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 58.66  E-value: 6.34e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 185 LLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPA-PE 243
Cdd:cd05008  43 LLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITNVVGSTLAREADYVLYLRAgPE 102
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
127-245 1.37e-10

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 61.07  E-value: 1.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 127 NVDEIHRAARFFYQARQRDLY--GAGGSNAICADVQHKF-LRIGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSD 203
Cdd:COG2222  18 LAAAIAALLARLRAKPPRRVVlvGAGSSDHAAQAAAYLLeRLLGIPVAALAPSELVVYPAYLKLEGTLVVAISRSGNSPE 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 90111685 204 VKAAVELAKKNGAKIICITHSYHSPIAKLADYIIcsPAPETP 245
Cdd:COG2222  98 VVAALELAKARGARTLAITNNPDSPLAEAADRVL--PLPAGP 137
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
186-263 1.67e-09

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 57.68  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPE--TPL-LGRNASArILQLTLLD 262
Cdd:COG0794  89 ITPGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPVEReaCPLnLAPTTST-TATLALGD 167

                .
gi 90111685 263 A 263
Cdd:COG0794 168 A 168
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
148-237 1.89e-09

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 54.50  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 148 GAGGSNAICADVQHkFLR--IGVRCQAYPDAHIMMMSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSY 225
Cdd:cd05710   6 GCGGSLADMYPAKY-FLKkeSKLPVFVYNAAEFLHTGPKRLTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDE 84
                        90
                ....*....|..
gi 90111685 226 HSPIAKLADYII 237
Cdd:cd05710  85 DSPLAKLADYVI 96
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
129-246 1.06e-08

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 53.67  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 129 DEIHRAARFFYQARQRD----LYGAGGSNAICadvQH---------KFLRIGVRCQAyPDAHIMMMSA------------ 183
Cdd:cd05006  17 EAIEQAAQLLAEALLNGgkilICGNGGSAADA---QHfaaelvkrfEKERPGLPAIA-LTTDTSILTAiandygyeevfs 92
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111685 184 ----SLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPL 246
Cdd:cd05006  93 rqveALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRDGGKLLELADIEIHVPSDDTPR 159
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
186-238 2.80e-08

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 54.02  E-value: 2.80e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 90111685  186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIIC 238
Cdd:PRK05441 129 LTAKDVVVGIAASGRTPYVIGALEYARERGALTIGISCNPGSPLSKEADIAIE 181
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
186-245 8.58e-08

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 52.14  E-value: 8.58e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICspaPETP 245
Cdd:cd05007 116 LTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLLQLADIAIA---LITG 172
MurQ COG2103
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis] ...
186-238 1.17e-07

N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441706 [Multi-domain]  Cd Length: 301  Bit Score: 52.02  E-value: 1.17e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 90111685 186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIIC 238
Cdd:COG2103 130 LGPGDVVVGIAASGRTPYVIGALEYARARGALTVAIACNPGSPLSAAADIAIE 182
GlmS COG0449
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ...
115-237 1.24e-07

Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440218 [Multi-domain]  Cd Length: 610  Bit Score: 52.71  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685 115 TLRTIMEGQSIVNVDEIHRAARFFYQARQRDL------YGAG--GSNAIcadvqHKFLRIGVrcqaypDAHImmmsAS-- 184
Cdd:COG0449 268 TLRGRLDEDGRVVLDELNLAAEDLRNIDRIYIvacgtsYHAGlvGKYLI-----EELARIPV------EVEI----ASef 332
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 90111685 185 -----LLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYII 237
Cdd:COG0449 333 ryrdpVVDPGTLVIAISQSGETADTLAALREAKEKGAKVLAICNVVGSTIARESDAVL 390
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
184-246 1.09e-06

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 47.93  E-value: 1.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111685  184 SLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPETPL 246
Cdd:PRK13937 102 ALGRPGDVLIGISTSGNSPNVLAALEKARELGMKTIGLTGRDGGKMKELCDHLLIVPSDDTPR 164
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
127-222 3.44e-06

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 45.66  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685   127 NVDEIHRAARFFYQARQRD----LYGAGGSNAicaDVQHKFLRIGVRCQAYP------------DAHIMM---------- 180
Cdd:pfam13580  17 QADAIEKAADLIAASLANGgkvyAFGTGHSAA---PAEELFARAGGLAGFEPillpalalhtdaSATISTalerdegyar 93
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 90111685   181 --MSASLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICIT 222
Cdd:pfam13580  94 qiLALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
PRK12570 PRK12570
N-acetylmuramic acid-6-phosphate etherase; Reviewed
186-243 1.28e-05

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 237142 [Multi-domain]  Cd Length: 296  Bit Score: 45.84  E-value: 1.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIIcSP--APE 243
Cdd:PRK12570 125 LTADDVVVGIAASGRTPYVIGALEYAKQIGATTIALSCNPDSPIAKIADIAI-SPvvGPE 183
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
184-237 2.12e-05

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 45.80  E-value: 2.12e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 90111685  184 SLLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYII 237
Cdd:PRK00331 332 PVLSPKTLVIAISQSGETADTLAALRLAKELGAKTLAICNVPGSTIARESDAVL 385
gmhA PRK00414
D-sedoheptulose 7-phosphate isomerase;
187-240 5.91e-05

D-sedoheptulose 7-phosphate isomerase;


Pssm-ID: 179012 [Multi-domain]  Cd Length: 192  Bit Score: 43.19  E-value: 5.91e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 90111685  187 QEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSP 240
Cdd:PRK00414 110 REGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTGKDGGKMAGLADIEIRVP 163
PRK02947 PRK02947
sugar isomerase domain-containing protein;
116-240 1.08e-04

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 42.93  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  116 LRTIMEGQSivnvDEIHRAARFFYQARQRD----LYGAGGSNAICADVqhkFLRIG-------------------VRCQA 172
Cdd:PRK02947  15 LERVRETQA----EAIEKAADLIADSIRNGgliyVFGTGHSHILAEEV---FYRAGglapvnpilepslmlhegaVASSY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111685  173 Y---PD-AHIMMMSASLlQEGDVVLVVTHSGRTSdvkAAVELA---KKNGAKIICIT-----------HSYHSPIAKLAD 234
Cdd:PRK02947  88 LervEGyAKAILDRYDI-RPGDVLIVVSNSGRNP---VPIEMAleaKERGAKVIAVTslaysasvasrHSSGKRLAEVAD 163

                 ....*...
gi 90111685  235 YII--CSP 240
Cdd:PRK02947 164 VVLdnGAP 171
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
188-222 2.02e-04

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 40.33  E-value: 2.02e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 90111685 188 EGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICIT 222
Cdd:cd05017  43 RKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAIT 77
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
188-222 2.13e-04

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 42.28  E-value: 2.13e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 90111685  188 EGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICIT 222
Cdd:PRK08674  78 EKTLVIAVSYSGNTEETLSAVEQALKRGAKIIAIT 112
PTZ00394 PTZ00394
glucosamine-fructose-6-phosphate aminotransferase; Provisional
186-237 2.73e-03

glucosamine-fructose-6-phosphate aminotransferase; Provisional


Pssm-ID: 173585 [Multi-domain]  Cd Length: 670  Bit Score: 39.09  E-value: 2.73e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 90111685  186 LQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYII 237
Cdd:PTZ00394 399 IQRDDVCFFVSQSGETADTLMALQLCKEAGAMCVGITNVVGSSISRLTHYAI 450
PRK10892 PRK10892
arabinose-5-phosphate isomerase KdsD;
185-243 5.13e-03

arabinose-5-phosphate isomerase KdsD;


Pssm-ID: 182814 [Multi-domain]  Cd Length: 326  Bit Score: 37.78  E-value: 5.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 90111685  185 LLQEGDVVLVVTHSGRTSDVKAAVELAKKNGAKIICITHSYHSPIAKLADYIICSPAPE 243
Cdd:PRK10892  91 MVTPQDVVIAISNSGESSEILALIPVLKRLHVPLICITGRPESSMARAADIHLCVKVPK 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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