|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
9-374 |
1.64e-137 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 397.59 E-value: 1.64e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 9 TRWLTLIGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGL 88
Cdd:TIGR00890 1 RWWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 89 GFFLTAHSDNLMMLWLSAGvLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTF 168
Cdd:TIGR00890 81 GFTFYAIADSLAALYLTYG-LASAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 169 VIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAhLD 248
Cdd:TIGR00890 160 IYMGIIFLLVIVLGAFLIGYPPGQLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLG-LS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 249 VVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAP-LNAVTFFAAIACVAFNFGGTITVFPS 327
Cdd:TIGR00890 239 DGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPmLNDVLFLATVALVFFTWGGTISLFPS 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 16131418 328 LVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF---GGFYVTFYVIF 374
Cdd:TIGR00890 319 LVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHAlteIGFEYTFIVTG 368
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
10-373 |
5.90e-113 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 335.73 E-value: 5.90e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 10 RWLTLIGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 170 IWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEK-------DYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQ 242
Cdd:cd17353 162 ILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANnaensprDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 243 SLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTI 322
Cdd:cd17353 242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGF 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 16131418 323 TVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF---GGFYVTFYVI 373
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlytGGYNAAFIIA 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-374 |
2.72e-57 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 192.40 E-value: 2.72e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 8 RTRWLTL-IGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:COG2223 1 SGRWRVLlLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 87 GLGFFLTAHSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLE 165
Cdd:COG2223 81 GIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 166 KTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEkdyTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLA 245
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 246 HLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVF 325
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 16131418 326 PSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIAS----LFGGFYVTFYVIF 374
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGalldATGSYTAAFLVFA 369
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
10-363 |
3.07e-35 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 133.69 E-value: 3.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 10 RWLTLIGTIITQFAL-GSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGL 88
Cdd:cd17314 1 RWFVLYVSFLLSAMStGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 89 GFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTF 168
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 169 VIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLD 248
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 249 VVSAANAVTVISIANLSGRLVLGILSD-KIARIRVITIGQVISLVGMAALLFA-PLNAVTFFAAIACVAFNFGGTITVFP 326
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLlKMTPVGLVLTGSLLGFSYGGLFTVYP 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 16131418 327 SLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF 363
Cdd:cd17314 321 ATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKF 357
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
11-363 |
1.17e-31 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 123.92 E-value: 1.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQF-ALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17355 2 WVVLAVTFLILIlSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYL-LTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTF 168
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAvAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 169 VIWGAIALLMIVFGATLMKDAP---KQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSgLYVIGVAKDIAQSLA 245
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFA-VVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 246 HLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVF 325
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 16131418 326 PSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF 363
Cdd:cd17355 321 AALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-373 |
1.52e-26 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 109.18 E-value: 1.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQF-ALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17352 2 WVVVFASFLVNFfTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 170 IWGAIALLMIVFGATLmkdapkqevktsngvvekdytlaESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLaHLDV 249
Cdd:cd17352 162 ILGGLCLNLCVCGLLL-----------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 250 VSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACV-AFNFGGTITVFPSL 328
Cdd:cd17352 218 SDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLfGFCSGSYSSLTPVI 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 16131418 329 VSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF----GGFYVTFYVI 373
Cdd:cd17352 298 LADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrdytGDYDAAFYFC 346
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-373 |
2.71e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 108.81 E-value: 2.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 8 RTRWLTLIGTIITQFALG-SVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRpAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 87 GLGFFLTAHSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEK 166
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 167 TFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVvekdyTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSlAH 246
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-----SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 247 LDVVSAANAVTVISIANLSGRLVLGILSDKIARIR-VITIGQVISLVGMAALLFAPLNAvtFFAAIACVAFNFGGTITVF 325
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSL--PWLWAVLLGLGQGGLFPLA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 16131418 326 PSLVSEFFG-LNNLAKNYGVI----YLGFGIGSICGSIIASLFGGFYVTFYVI 373
Cdd:COG2807 325 LTLIGLRARtPAEAAALSGMAqsvgYLLAALGPLLVGALHDATGSWTAALLLL 377
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
10-371 |
6.40e-25 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 105.03 E-value: 6.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 10 RWLTLIGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSfGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17354 2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLL-SVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAG------VLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLgfkfIDTQLLETVG 163
Cdd:cd17354 81 YGVLWLVVTGLISDLSFWlmclcfFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGA----IGSQLYKALF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 164 LEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSngvvekdytlaESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQS 243
Cdd:cd17354 157 FHDSARVFLFLAVLPAVVGLLAWFSVRIVSIEEG-----------EFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 244 LAHLDVVSaaNAVTVISIANLSGRLVLGILSD------KIARIRVITIGQVISLVGMAALLFAPLNAvTFFAAIACVAFN 317
Cdd:cd17354 226 LTGPSNTS--TLVSLFSIFSFLGRLLSGLLSDlfvrkfRLPRPSRMVLLLLILSLGHLLQAFGLPSG-ALYVASALIGFG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 16131418 318 FGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSIcgsiiasLFGGFYVTFY 371
Cdd:cd17354 303 YGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSL-------IFSVIYAGVY 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-373 |
1.39e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 100.71 E-value: 1.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 6 YQRTRWLTLIGTIITQFALGSV-YTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGI 84
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 85 LLGLGFFLTAHSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDTQLLETVG 163
Cdd:COG2271 84 LWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 164 LEKTFVIWGAIALLMIVFgatlmkdapkqevktsngvvekdytlaesmrkpQYWMLAVMFLTACMSGLYVIGVAKDIAQS 243
Cdd:COG2271 163 WRAAFLILGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 244 LAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIR--VITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGT 321
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGA 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 16131418 322 ITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF---GGFYVTFYVI 373
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLldaTGYQAAFLLL 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-353 |
4.13e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 4.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 8 RTRWLTLIGTIITQFALG-SVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:COG2814 6 RRRWLALLALALGAFLSGlGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 87 GLGFFLTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLE 165
Cdd:COG2814 86 ALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 166 KTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGvvekdyTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLA 245
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRG------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 246 HLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVF 325
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLL 317
|
330 340
....*....|....*....|....*...
gi 16131418 326 PSLVSEFFGLNNLAKNYGVIYLGFGIGS 353
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-354 |
1.14e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 22 FALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMM 101
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 102 LWLsAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIV 180
Cdd:pfam07690 88 LLV-LRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 181 FGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMsGLYVIGVAKDIAQSLAHLDVVSAANAVTVIS 260
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF-AFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 261 IANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPL--NAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNL 338
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*.
gi 16131418 339 AKNYGVIYLGFGIGSI 354
Cdd:pfam07690 326 GTASGLYNTAGSLGGA 341
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-366 |
3.98e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.21 E-value: 3.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 1 MTPSNYQRTRWLTLIGTIITQFALGSvytWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTM 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 81 ASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLL- 159
Cdd:COG0738 78 LGLLLMALGLLLFALAPSYPLL-LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIl 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 160 ETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDyTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKD 239
Cdd:COG0738 157 LGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA-SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 240 IAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPlnaVTFFAAIACVAFNFG 319
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP---GPWLALIGLALVGLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 16131418 320 GTItVFPSLVSefFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGF 366
Cdd:COG0738 313 LSL-MFPTIFS--LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-373 |
3.24e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.54 E-value: 3.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 39 AKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADGAGY 118
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL-LLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 119 LLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTS 197
Cdd:cd17325 103 PAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 198 NGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKI 277
Cdd:cd17325 183 VSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 278 ARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGS 357
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
|
330
....*....|....*....
gi 16131418 358 IIASL---FGGFYVTFYVI 373
Cdd:cd17325 342 LLGGFlydAFGFATPFLAA 360
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
56-372 |
3.08e-13 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 70.50 E-value: 3.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 56 SLGLAI---SSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPER 132
Cdd:cd17423 45 SIGLAVqqlASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRR 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 133 KGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDA-PKQEVKTSNGVvekdYTLAESM 211
Cdd:cd17423 125 RSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPCGALLRPLAlPGDPPAPPRSL----SAAFGLS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 212 RKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAH-LDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVIS 290
Cdd:cd17423 201 LLTHRAFLRYALATTLINTGYFIPYVHLVAHARALgLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 291 LVGMAALLFAPLNAVTFFAAIAcVAFNF--GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF----G 364
Cdd:cd17423 281 LTGLSLLLLPLAKVYGSLLALA-VAYGFcaGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLrditG 359
|
....*...
gi 16131418 365 GFYVTFYV 372
Cdd:cd17423 360 DYTASFLV 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
46-374 |
3.16e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.53 E-value: 3.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 46 SQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNC 125
Cdd:cd06174 31 SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFLLGLGSGLIDPAVLALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 126 VKWFPERK-----GLISAFAIGSYGLGSLGFKFIDTQLleTVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGV 200
Cdd:cd06174 110 ADLFPERErgralGLLQAFGSVGGILGPLLGGILASSL--GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 201 VEKDYT--LAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIA 278
Cdd:cd06174 188 SSKSVLklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 279 RIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSI 358
Cdd:cd06174 268 GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347
|
330
....*....|....*.
gi 16131418 359 IASLFGGFYVTFYVIF 374
Cdd:cd06174 348 LAGFLLAATFGLTGAF 363
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
42-364 |
4.78e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 70.04 E-value: 4.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 42 DAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADGAGYLLT 121
Cdd:cd17333 27 NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLF-VVLMFLAGLGAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 122 LSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKT-FVIWGAIALL--MIVFGATLMKDAPKQEVKTSN 198
Cdd:cd17333 106 NTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWaYLIIGLIYLLlaILILLTLFPELPSARNPQQSV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 199 GvvEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIA 278
Cdd:cd17333 186 G--AFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIK 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 279 RIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNlAKNYGVIYLGFGIGSICGSI 358
Cdd:cd17333 264 PHTLLVLSGSGALLGLLILLLAP-TLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPF 341
|
....*.
gi 16131418 359 IASLFG 364
Cdd:cd17333 342 IMGFIA 347
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
61-374 |
9.91e-12 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 65.61 E-value: 9.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 61 ISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFA 140
Cdd:cd17428 53 IASPVCSACVSSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 141 IGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGAtlmkdapkqevktsngvvekdytLAESMRKPQYWMLA 220
Cdd:cd17428 133 STGSSVGLFIYAALQRELIELYGLDGCLLIVGALALNLLACGS-----------------------LMRLFKNRVFSALF 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 221 VMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDkIARIRVITIgQVISLVGM-AALLF 299
Cdd:cd17428 190 IAILLFDIGAFPPSLLMEDVARSENIIEEIALIPLVSIIGITTAIGKLILGVLAD-FKWVNSLYL-YVLTLIGMgAALLA 267
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16131418 300 APLNAVTFFAAIACVAFNF-GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFYVTFYVIF 374
Cdd:cd17428 268 IPFAKSYLTLAVLSAILGFlSGNWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAF 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
46-373 |
4.55e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 46 SQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNC 125
Cdd:cd17319 38 TQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 126 VKWFPER-KGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGAtlmkdapkqevktsngvvekd 204
Cdd:cd17319 117 AEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 205 ytlaesMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVIT 284
Cdd:cd17319 176 ------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 285 IGQVISLVGMAALLFAPLNAVTFFAAIA-CVA-FNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIA-- 360
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYLTTSPVVAVILlSLAgFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIgy 329
|
330
....*....|....*
gi 16131418 361 --SLFGGFYVTFYVI 373
Cdd:cd17319 330 lvDATGSYTAAFLFL 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-362 |
7.58e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.80 E-value: 7.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 37 LSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAgVLVGLADGA 116
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 117 GYLLTLSNCVKWFPERKGL-ISAFAIGsyglGSLGFKF---IDTQLLETVGLEKTFvIWGAIALLMIVFGATLMKDAPKQ 192
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLaMSIFSVG----GNLGFALgplIAAALVALFGGLGLL-ILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 193 EVKTSNGVVEKDYTLaESMRKPQYWMLAVMFLTAcmsgLYVIGVAKDIAQSLAH--LDVVSAANAVTVISIANLSGRLVL 270
Cdd:cd17478 176 EAKKAAAKSSARSTL-KGVWRALLLLLIIVFLRS----WVLSSLTTFLPFYLVQrgYSLVFAGLLLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 271 GILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACvaFNFGGTITVFPSLVSEFFGlNNLAKNYGVIY-LGF 349
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAG--FLLFASFPVTVVLAQELLP-GNVGLASGLMMgLSF 327
|
330
....*....|...
gi 16131418 350 GIGSICGSIIASL 362
Cdd:cd17478 328 GLGGIGAPVLGAL 340
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
36-365 |
3.74e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.51 E-value: 3.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 36 ALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLsAGVLVGLADG 115
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 116 AgyllTLSNCVKWFPE-----RKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIAL-LMIVFGATLmkda 189
Cdd:cd17365 103 A----AMPNAITLVSEyaparRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLiLLPLLRGTL---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 190 pkqevktsngvvekdytlaesmrkpqywMLAVMFLtACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLV 269
Cdd:cd17365 175 ----------------------------LLWVTFF-MGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 270 LGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGviyLGF 349
Cdd:cd17365 226 LGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVG---WAL 302
|
330
....*....|....*.
gi 16131418 350 GIGSIcGSIIASLFGG 365
Cdd:cd17365 303 GVGRL-GAILGPLLGG 317
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
217-367 |
6.25e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 6.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 217 WMLAVMFLTACMSGLYVIGVAKDIAQSLaHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAA 296
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131418 297 LLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFY 367
Cdd:COG2814 92 CALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
22-319 |
9.27e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.78 E-value: 9.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 22 FALGSVYTWSLFngaLSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMM 101
Cdd:cd17475 10 LVAQGIPALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 102 LwLSAGVLVGLADGAGYLLTLSNCVKWFPERKgliSAFAIG--------SYGLGSLGFKFIDTQLletvGLEKTFVIWGA 173
Cdd:cd17475 87 L-LVLLFLVGAGYGSVQPGGGRAIMRWFPPRE---RGLAMGirqtgvplGGALAAALLPPLALHY----GWRAAFVVAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 174 IALLMIVFGATLMKDAPKQEVKTSNGVVEKDyTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAA 253
Cdd:cd17475 159 VSILAAVLFWLFYREPPAASAATESASTLLR-SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAG 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16131418 254 NAVTVISIANLSGRLVLGILSDKI-ARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFG 319
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLG 304
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
11-185 |
1.40e-07 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 52.85 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQ-FALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17425 2 WVVLLATMIVQgLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:cd17425 82 MVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFL 161
|
170
....*....|....*.
gi 16131418 170 IWGAIALLMIVFGATL 185
Cdd:cd17425 162 VFGGVLLNCCVCGAVM 177
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
218-373 |
2.35e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 2.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 218 MLAVMFLTACMSGLYVIGVAKDIAQSLaHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAAL 297
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16131418 298 LFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF---GGFYVTFYVI 373
Cdd:pfam07690 80 LFAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaslFGWRAAFLIL 157
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
53-356 |
2.73e-07 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 52.14 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 53 GLLSLGLA-ISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPE 131
Cdd:cd17429 44 SSLSMGITlIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 132 RKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVktsngvvekdytlaesm 211
Cdd:cd17429 124 RRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMRLFTNKVFV----------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 212 rkpqywmlAVMFLTACMSGLYVIGVAKdiAQSLAHLDVVSAANAV----TVISIANLSGRLVLGILSDkIARIRVITIGQ 287
Cdd:cd17429 187 --------AFIFWALFAYCSFVIPFIH--LPEIVKLYGLSEQNDKfpltSIIAIVHIFGKVILGIICD-LPCISVWNVFI 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 288 VISLVGMAALLFAPLNAVTFFAAIACVAFNF-GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICG 356
Cdd:cd17429 256 LANFTLGVCILILPLMHTYTGLAIVCALIGFsSGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLG 325
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
13-365 |
3.99e-07 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 51.58 E-value: 3.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 13 TLIGTIITQFALG-SVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFF 91
Cdd:cd17396 1 TALGLYFNYFVHGmGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 92 LTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDT-QLLETVGLEKTFVI 170
Cdd:cd17396 81 GILFSPNLIIAYV-FALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAfLAANNLWYGWSFIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 171 WGAIALLMIVFGATLMkdAPKQEVKTSNGVVEkdyTLAESMRKPQYWM---LAVMFLTACMSGLYVIGV-AKDIAQSLAH 246
Cdd:cd17396 160 PAAVLVLNALLLLKLS--FPPQTVTAANTKQK---EIPVKREKPKFLIegiALILIGFTSTATFYLFSQwMPKYGSAVAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 247 LDVVSAANAVTVISIANLSGRLVLGILSDKIAR-IRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVF 325
Cdd:cd17396 235 MGEAESLKLISYYSMGSLVCVFITAVLLKRYVRpIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 16131418 326 PSLVSEFFGLNNlAKNYGVIYLGFGIGSICGSIIASLFGG 365
Cdd:cd17396 315 LTLMAEFFPKGK-GKVTGIYMIASSLANFVIPLITGIIAS 353
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
11-197 |
6.25e-07 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 51.28 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQ-FALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:TIGR00892 18 WVVLGATFVSIgFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:TIGR00892 98 MILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFL 177
|
170 180
....*....|....*....|....*...
gi 16131418 170 IWGAIALLMIVFGATLMKDAPKQEVKTS 197
Cdd:TIGR00892 178 ILGGLLLHCCVCGALMRPVGPSQRVSKS 205
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
80-364 |
6.37e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 6.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 80 MASGILLGLGFFLTAHSDNLMMLWLSAGVLVG-LADGAGYLLTLSNCVKWFPE------RKGLISAFAIGSYGLGSLGFK 152
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLSPTGKLIYALVTyLLLGLAYTLVNIPYSALGAEltpdyeERTRLSSWRFAFAGLGGLLAS 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 153 FIDTQLLETVGLEK------TFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVekdyTLAESMRKPQYWMLAVMFLTA 226
Cdd:COG2211 165 VLPPPLVAAFGGDAalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE----SLKALLKNRPFLLLLLAYLLF 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 227 CMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFA-PLNAV 305
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLW 320
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16131418 306 TFFAAIACVAFNFGGTITVFPSLVSE----------------FFGLNNLAknygvIYLGFGIGSICGSIIASLFG 364
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADvvdydewktgrrreglYFGIFTFA-----IKLGQALAGALAGLLLALFG 390
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
57-367 |
1.97e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 49.54 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 57 LGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPER-KGL 135
Cdd:PRK12307 64 IGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSR-FIVGMGMAGEYACASTYAVESWPKHlKSK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 136 ISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSN-------GVVEKDYTLA 208
Cdd:PRK12307 143 ASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGkgkhsqsAWSVFSLSMK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 209 ESMRKPQYWMLAVMFLTaCMSglyVIGVAKDIAQSLAH------LDVVSAANAVTVISIANLSGRLVLGILSDKIARIRV 282
Cdd:PRK12307 223 GLFNRAQFPLTLCVFIV-LFS---IFGANWPIFGLLPTylagegFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKT 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 283 ITIGQVISLVGMAALLFAPL-NAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIAS 361
Cdd:PRK12307 299 FSIGLLMSFLFIFPLFRIPQdNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAAT 378
|
....*.
gi 16131418 362 LFGGFY 367
Cdd:PRK12307 379 WLGITM 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-363 |
2.40e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 56 SLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMmLWLSAGVLVGLADGAGYLLTLSNCVKWFPERK-- 133
Cdd:cd17477 41 YLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFVVSESWLNALATNENrg 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 134 ---GLISAFAIGSYGLGSLGFKFIDTQLLETvglektFVIWGAIALLMIVFGATLMKDAPKQEVktsngvvekdytlAES 210
Cdd:cd17477 120 rvlGLYSTVLGLGFALGPLLLALVGTAGALP------FLIAAVLLLLALVPLLLTRRAAPEIEE-------------AES 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 211 MRKPQYWMLAVMFLTACmsglYVIGVAKDIAQSL-------AHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVI 283
Cdd:cd17477 181 ISLRRLLRIAPLALLGA----FVAGFLEGAFYSLlplyglrLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 284 TIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF 363
Cdd:cd17477 257 LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-370 |
2.63e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.08 E-value: 2.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 36 ALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADG 115
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 116 AGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEV 194
Cdd:cd17324 103 GFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 195 KTSNGVveKDYTLAESMRKPQYWMLAVMFLTACMSGLY-VIGVakdIAQSLAHLDVVSAANAVTVISIANLSGRLVLGIL 273
Cdd:cd17324 183 GSLGLL--SSLLLLLRNPRLRLAYLITFLLFGGFFALYtYLAP---FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 274 SDKIARiRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNN---LAKNYGVIYLGFG 350
Cdd:cd17324 258 ADRGGR-RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARglaSSLYLAAYNLGGA 336
|
330 340
....*....|....*....|
gi 16131418 351 IGSICGSIIASLFGGFYVTF 370
Cdd:cd17324 337 LGAALGGLVLDHGGWAGVGW 356
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-316 |
3.24e-06 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 48.59 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 18 IITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSD 97
Cdd:cd17422 10 FVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFAS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 98 NLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALL 177
Cdd:cd17422 90 SIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 178 MIVFGAtlmkdapkqevktsngvvekdytLAESMRKPQYWMLAVMFLTACMS----GLYVIGVAKDIAqslahLDVVSAA 253
Cdd:cd17422 170 IVVCGA-----------------------LLRVLKEPGFICYALFGLFATLGffapQLYIIPLSLSLG-----IDQDWAA 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16131418 254 NAVTVISIANLSGRLVLGILSDK--IARIRVITIgqVISLVGMAALLFAplNAVTFFAAIACVAF 316
Cdd:cd17422 222 YMLSAMAIAELFGRISAGWVLNKcpIRKIYIELI--CVILLCVVLLLFP--FAYGFWSLLVCSIF 282
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-374 |
6.69e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.60 E-value: 6.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 40 KLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADGAGYL 119
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 120 LTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDapkqevktsn 198
Cdd:cd17316 109 GASTYVAEFAPSKRrGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRR---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 199 gvvekdytlaesmrkpqywMLAVMFLTACMSGLY--VIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDK 276
Cdd:cd17316 179 -------------------TLLLILLWFFISFGYygLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 277 IARIRVITIGQVISLVGMAALLFAP-LNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY----LGFGI 351
Cdd:cd17316 240 IGRKKTLVIGLILSGILALPLFYLLsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYnlgrLGGGG 319
|
330 340
....*....|....*....|...
gi 16131418 352 GSICGSIIASLFGGFYVTFYVIF 374
Cdd:cd17316 320 APPLIALLLASTGGTGVPALILA 342
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
172-360 |
8.78e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 172 GAIALLMIVFGATLMKDAPKQEVKTSNGVVEKdytlaesmRKPQYWM--LAVMFLTACMS--GLYVIGVAK-DIAQSLAH 246
Cdd:cd17370 166 ALLALLILLFVVKEYPRPPKLRKKSKKTSLKK--------LPKAFWLylLAVALFALGNFsfAFLILRAQElGLSAALIP 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 247 LdVVSAANAVTVISIanlsgrLVLGILSDKIARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFP 326
Cdd:cd17370 238 L-LYALFNLVYALAA------YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-SLWLLLLGFILWGLYMGAQESIER 309
|
170 180 190
....*....|....*....|....*....|....
gi 16131418 327 SLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIA 360
Cdd:cd17370 310 AAVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
28-319 |
1.73e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 28 YTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAG 107
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 108 VLVGLAdGAGYLLTLSNCVKWFPERKglISAFAIGSYGLGSLG----------FKFIDTQLLETVGLEKTFVIWGAIALL 177
Cdd:cd17341 96 FLLGFA-GANFASGQPWASFWFPKEK--IGGAAGGIAGAGNMGvavsqllaplIAGAIVFDGGFVGWRNAFFVPGILLAI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 178 MIVFGATLMKDAPKQEVKTSNGVVEKDYTLaesmRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVT 257
Cdd:cd17341 173 AAVLVLLFGDDLPTGKASALEFLKVQLAVL----KNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16131418 258 VISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFG 319
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALG 310
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
208-362 |
2.16e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 208 AESMRKPQYWMLAVMFLTACMSGL--YVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITI 285
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLdrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16131418 286 GQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASL 362
Cdd:COG2271 81 GLLLWGLATLLFGFAT-SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-365 |
2.44e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 36 ALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLsAGVLVGLADG 115
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI-ARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 116 AGYLLTLSNCVKWFPERK-----GLISAFAIGSYGLGSLgfkfIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKD-A 189
Cdd:cd17320 103 AGSVVARAIVRDLYSGAElakifSLLMMILAIAPALAPL----LGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPEtL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 190 PKQEVKTSNGVVEKDYtlAESMRKPQYWMLAVMfLTACMSGLYV-IGVAKDIAQSLAHLDV-----VSAANAVTVISIAN 263
Cdd:cd17320 179 PEEKRKPLLSSLLRAY--KRVLKNRRFLGYALA-LGLSFAGLFAyLAAAPFIYIEQLGLSPaqfglLFALNAIALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 264 LSGRLVLGILSDKIarIRVITIGQVISLVGMAAL-LFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGlnNLAKNY 342
Cdd:cd17320 256 LNGRLVRRFGPRRL--LRLGLLLLLAAALVLLLAaLLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP--HVAGTA 331
|
330 340
....*....|....*....|....*
gi 16131418 343 GVIY--LGFGIGSICGSIIASLFGG 365
Cdd:cd17320 332 SALLgfLQFLIGALAGALVGLLPNG 356
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-374 |
3.41e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 56 SLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWF--PERK 133
Cdd:cd17473 45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGVAGIMTLATALIGDYFegEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 134 ---GLISAFAigsyGLGSLGFKFIdTQLLETVGLEKTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVekdyTLAES 210
Cdd:cd17473 124 kmlGLQSAAM----SLGGVVFLLL-GGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAA----TAAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 211 MRKPQYWMLAVMFLTacMSGLYVIGVAkdIAQSLAHLDVVSAANAVTVISIANLSGRLV---LGILSDKIARIRVITIGQ 287
Cdd:cd17473 195 PWKRVLPIYFLAFLA--MLLFYVIPIQ--LPFLLQERGGGSAALIGLALAIASLAGAIGallFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 288 VISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFY 367
Cdd:cd17473 271 ALMALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
....*..
gi 16131418 368 VTFYVIF 374
Cdd:cd17473 350 GGLSGAF 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-181 |
6.01e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 6.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQFALGSVYTwsLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGF 90
Cdd:cd17325 202 LALFLAIFVLAFAFGALEP--FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 91 FLTAHSDNLMMLWLSAgVLVGLADG---AGYLLTLSNCVKwfPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKT 167
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGlvfPATLALLADIVP--PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....
gi 16131418 168 FVIWGAIALLMIVF 181
Cdd:cd17325 357 FLAAAALLLLAAVL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
36-327 |
7.00e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 7.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 36 ALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwLSAGVLVGLADG 115
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 116 AGYLLTLSNCVKWFPERK-----GLISAFAIGSYGLGSL--GFkfidtqLLETVGLEKTFVIWGAIALLMIVFGATlmkd 188
Cdd:cd17321 100 AIMPASLALIAATFPGERrgralGLWGAVVGIGAALGPLlgGL------LLELFGWRWIFLINVPIGLVALLLART---- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 189 apkqevktsngvvekdYTLAesmrkpqywMLAVMFLTACMSGLYVIGVAkdIAQSLAHLDVVSAANAVTVISIANLSGRL 268
Cdd:cd17321 170 ----------------FSGA---------VLAAFLLGAALGGLLFLLPL--YLQGVLGYSPLQAGLALLPLALAMLVAAP 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 16131418 269 VLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPS 327
Cdd:cd17321 223 LAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPL 281
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
35-373 |
7.64e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 7.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 35 GALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDN---LMMLWLSAGVLVG 111
Cdd:cd17371 23 PALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNywqLLILRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 112 LADGAGYLLTLSncvKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLE---KTFVIWGAIALLMIVFGATLMKD 188
Cdd:cd17371 103 GEWAAGAALMAE---YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawRVLFLLGALPALLVLFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 189 APK-QEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLA---HLDVVSAANAVTVISIANL 264
Cdd:cd17371 180 PPQwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTgerGLSFEGSAGYLVVTILGGF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 265 SGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGV 344
Cdd:cd17371 260 LGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGF 339
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 16131418 345 IYLG---------FGIGSICGS----IIASLFGGFYVTFYVI 373
Cdd:cd17371 340 CYNVgriigalfpFLVGFLATSgslgTAIAVFAAVYYIAGLV 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-181 |
7.69e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 7.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQFALGSVYTW-SLFngaLSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYlAPF---LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAhSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:cd17324 278 LLLTL-LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|..
gi 16131418 170 IWGAIALLMIVF 181
Cdd:cd17324 357 VGAALLLLALLL 368
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
30-199 |
9.37e-05 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 44.44 E-value: 9.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 30 WSLFNGALSAKLDAPVSQVAFSFGLLSLGLA-ISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGV 108
Cdd:cd17420 26 HSLLLERLTKLGDPEASFKAAWVGALAMGMIfFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 109 LVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKD 188
Cdd:cd17420 106 MFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPL 185
|
170
....*....|.
gi 16131418 189 APKQEVKTSNG 199
Cdd:cd17420 186 HPSPEDPKSKP 196
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
61-360 |
1.17e-04 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 44.03 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 61 ISSSVAGKLQERFGVkrvtMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFA 140
Cdd:cd17424 57 LGSLISNHLSCQVGI----ILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 141 IGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGAtlmkdapkqevktsngvvekdytLAESMRKPQYWMLA 220
Cdd:cd17424 133 MSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGA-----------------------LMRFLLMPDFLVLA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 221 V--MFLTACMSGLYVIGVAKDIAQSLAHLDvvsAANAVTVISIANLSGRLVLGILSDK--IARIRVITIGQVISLVGMAA 296
Cdd:cd17424 190 VsvLFLAYGCSPPFVYLVPYALSVGVSHQQ---AAFLMSILGVIDIIGNITFGWLTDRrcLKKYRYFCYLFAVGMDGLCC 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16131418 297 LLFAPLNAVTFFAAIACVAFNFGGT-ITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIA 360
Cdd:cd17424 267 LFLPILKTFPLLVPFSFTFGYFDGAyVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIA 331
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
255-375 |
1.91e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.33 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 255 AVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFG 334
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT-SYWQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 16131418 335 LNNLAKNYGVIYLGFGIGSICGSIIASL---FGGFYVTFYVIFA 375
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLladALGYRAPFLVCAA 158
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-366 |
2.23e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 50 FSFGLLslGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDN---LMMLWLSAGVLVGLADGAGYLLTLSNCV 126
Cdd:TIGR00895 58 FSAGLI--GMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNvtqLLILRFLAGLGLGGLMPNLNALVSEYAP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 127 KWFpeRKGLISAFAIGsYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGAT--------LMKDAPKQEVKTSN 198
Cdd:TIGR00895 136 KRF--RGTAVGLMFCG-YPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRflpesidfLVSKRPETVRRIVN 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 199 GVV-----EKDYTLAESMRKPQYW---------------MLAVMFLTACMS-GLYVIGVAKDIAQSLAHLDVVSAANAVT 257
Cdd:TIGR00895 213 AIApqmqaEAQSALPEQKSTQGTKrsvfkalfqgktariTVLLWLLYFMLLvGVYFLTNWLPKLMVELGFSLSLAATGGA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 258 VISIANLSGRLVLGILSDKIaRIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNN 337
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRL-GPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI 371
|
330 340
....*....|....*....|....*....
gi 16131418 338 LAKNYGViylGFGIGSIcGSIIASLFGGF 366
Cdd:TIGR00895 372 RATGVGW---AIGIGRL-GAIIGPILAGY 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
255-370 |
2.82e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 255 AVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFG 334
Cdd:cd17329 40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-SPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110
....*....|....*....|....*....|....*.
gi 16131418 335 LNNLAKNYGVIYLGFGIGSICGSIIASLFGGFYVTF 370
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL 154
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
217-402 |
3.14e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 217 WMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAA 296
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 297 LLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASL----FGGFYVTFYV 372
Cdd:COG2223 87 LALAV-SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLliaaFGWRNAFLIL 165
|
170 180 190
....*....|....*....|....*....|
gi 16131418 373 IFALLILSLALSTTIRQPEQKMLREAHGSL 402
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASL 195
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
206-367 |
3.46e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.11 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 206 TLAESMRKPQYWMLAVMFLTACMSGL--YVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVI 283
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLdfTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 284 TIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLF 363
Cdd:COG0477 83 LIGLLLFGLASLLCGLAP-SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
....
gi 16131418 364 GGFY 367
Cdd:COG0477 162 VAAL 165
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
219-363 |
4.85e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 219 LAVMFLTACMSGLYVIGVAKDI--AQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVgMAA 296
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALsyATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL-FAF 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131418 297 LLFAPL----NAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNnlaknygVIYLGFGIGSICGSIIASLF 363
Cdd:cd17369 310 PFFWLLdtgsTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTR-------VRYTGASLGYQLGAILGGGF 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
11-185 |
6.36e-04 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 41.64 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGT-IITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLG 89
Cdd:cd17430 2 WAVLFGCfVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 90 FFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFV 169
Cdd:cd17430 82 MILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFL 161
|
170
....*....|....*.
gi 16131418 170 IWGAIALLMIVFGATL 185
Cdd:cd17430 162 ILGGLLLNCCTCGAVM 177
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
269-374 |
7.31e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 7.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 269 VLGILSDKIARIRVITIGQVISLVGMaaLLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLG 348
Cdd:cd17330 53 LWGRLSDRYGRKPVLLLSLAGSAVSY--VLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAA 130
|
90 100
....*....|....*....|....*....
gi 16131418 349 FGIGSICGSIIASLFG---GFYVTFYVIF 374
Cdd:cd17330 131 FGLGFILGPALGGFLStpyGYALPFLVAA 159
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
168-363 |
7.81e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.47 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 168 FVIWGAIALLMIVFGATLMKDAP-------KQE-------VKTSNGVVE----KDYTLAESMRKPQYWMLAVMFlTACMS 229
Cdd:cd17327 169 FIIEGLITIIIGLVIFFWLPDNPskawfltEEEkelaverLRANQTGKGdqkfKWKQIKEAFKDPRTWLLFLFF-FCSQI 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 230 GLYVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIA-RIRVITIGQVISLVGMAALLFAPLNAVTFF 308
Cdd:cd17327 248 TNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKkRGLFAIFACVLALVGSIILLAAPNPPGAYF 327
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 16131418 309 AAIACvAFNFGGTITVFPSLVSEFfgLNNLAKNYGVIYLGFGIGSICGSIIASLF 363
Cdd:cd17327 328 AAYIL-GGGSYAGFPILLSWISSN--CAGYTKRATVLAIMLIFYNVGNIVAPQIF 379
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-185 |
1.62e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.18 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 2 TPSNYQRTRWLTLIGTIITQFALGsvYTWSLFNGAL---SAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRV 78
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEG--LDFTIVNVALpsiAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 79 TMASGILLGLGFFLTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDTQ 157
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180
....*....|....*....|....*...
gi 16131418 158 LLETVGLEKTFVIWGAIALLMIVFGATL 185
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-124 |
2.99e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 8 RTRWLTLIGTIITQFALGSVYTWSLFngALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLG 87
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPL--YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245
|
90 100 110
....*....|....*....|....*....|....*..
gi 16131418 88 LGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSN 124
Cdd:cd17321 246 VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLT 282
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
269-372 |
3.20e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 269 VLGILSDKIARIRVITIGQVISLVGMAALLFAPlNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGV---- 344
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAP-NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVfyfa 131
|
90 100
....*....|....*....|....*...
gi 16131418 345 IYLGFGIGSICGSIIASLFGGFYVTFYV 372
Cdd:cd17328 132 IPLGSGLGYVVGGLVAQATGGWRWAFRV 159
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
256-374 |
3.40e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.41 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 256 VTVISIANLSGRLVLGILSDKIARIRVIT-IGQVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTIT-------VFPS 327
Cdd:cd17337 250 WGIIFLVNIFFNLIFGILGDKIGWRRTVRwFGGVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAgfvplsaLMPS 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 16131418 328 LVSEFFGLNNLAKNygviyLGFGIGSICGSIIASLFGGFYVTFYVIF 374
Cdd:cd17337 330 LAPEHKGAAMSILN-----LGAGLSNFVGPAIVTLFLGSFGAGGVVW 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-192 |
3.46e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQFALGSVYTWslFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGF 90
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDW--LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 91 FLTAHSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVI 170
Cdd:COG0738 291 LLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
|
170 180
....*....|....*....|..
gi 16131418 171 WGAIALLMIVFGATLMKDAPKQ 192
Cdd:COG0738 370 PLVCYLLILLLALALKRKRRKK 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
210-372 |
3.60e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 210 SMRKPQYWMLAVMFLTACMSG--LYVIG-VAKDIAQSLAhLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIG 286
Cdd:TIGR00895 10 PLSRYQWRAIILSFLIMLMDGydLAAMGfAAPAISAEWG-LDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 287 QVISLVGMAALLFA----PLNAVTFFAAIAcvafnFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASL 362
Cdd:TIGR00895 89 ILLFSVFTLLCALAtnvtQLLILRFLAGLG-----LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
|
170
....*....|...
gi 16131418 363 FG---GFYVTFYV 372
Cdd:TIGR00895 164 LIpvfGWRSLFYV 176
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-191 |
3.88e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.08 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 11 WLTLIGTIITQFALGSVYTWslFNGALSAKLDAPVSQVAFSFGLLSLGLAISSSVAGKLQERFG--VKRVTMASGILLGL 88
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTW--LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 89 GFFLTAHSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKT 167
Cdd:COG2271 261 ALLLLALLPSPALAIA-LLFLAGFGLGGAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 16131418 168 FVIWGAIALLMIVFGATLMKDAPK 191
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
269-366 |
3.91e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.16 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 269 VLGILSDKIARIRVItigqVISLVGMAA----LLFAPLNAVTFFAAIacVAFNFGGTITVFPSLVSEFFGLNNLAKNYGV 344
Cdd:cd17388 57 ILGALSDRFGRRPVL----LLSLAGAALdyllMAFAPTLWWLYLGRI--IAGITGATGAVAAAYIADVTPPEQRARNFGL 130
|
90 100
....*....|....*....|..
gi 16131418 345 IYLGFGIGSICGSIIASLFGGF 366
Cdd:cd17388 131 LGAAFGLGFIAGPALGGLLGEI 152
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-364 |
5.77e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 53 GLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLwlsagVLVGLADGAGYLLTLSNCVKWF--- 129
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL-----LVLRLIHGIGWGAFTTAAATLVadi 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 130 --PERKG-LISAFAIGSYGLGSLGfKFIDTQLLETVGLekTFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDYT 206
Cdd:cd17489 113 ipPSRRGeGIGYYGLATTLAMALG-PALGLFLYQHLGF--AVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 207 laeSMRKPQYWMLAVMFLTACMSglyVIGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIG 286
Cdd:cd17489 190 ---RLVEKKVLPPALILFLASIA---YGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 287 QVISLVGMAALLFAPLNAVTFFAAIACVAfnfgGTITVFPSLVSEFFGL---NNLAKNYGVIY----LGFGIGSICGSII 359
Cdd:cd17489 264 LLLLALGLLLLSFAGSPWMLLLAAVLYGL----GFGLLFPALQALAVDLvppHRRGAANGTFFiffdLGIGLGGLLLGLV 339
|
....*
gi 16131418 360 ASLFG 364
Cdd:cd17489 340 AELFG 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
167-371 |
8.99e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 37.97 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 167 TFVIWGAIALLMIVFGATLMKDAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTAC----MSGLYVIgVAKDIAQ 242
Cdd:cd17332 175 TALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLafniVNTVLVY-YFKYVLG 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131418 243 SLAHLdvvsaANAVTVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAP-LNAVTFFAAIACVAFNFGGT 321
Cdd:cd17332 254 GRAEL-----VLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAVLAGIGYGGA 328
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 16131418 322 ITVFPSLVS---EFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFYVTFY 371
Cdd:cd17332 329 NLLPWAMLAdviDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
|
| |
