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Concise Results
Standard Results
Full Results
protease 3 [Escherichia coli str. K-12 substr. MG1655]
Protein Classification
insulinase family protein ( domain architecture ID 11487641 )
insulinase family protein (peptidase M16) similar to pitrilysin is a zinc-dependent peptidase that cleaves small peptides close to a terminus, often including bonds on the amino side of basic residues such as arginine
List of domain hits
Name
Accession
Description
Interval
E-value
PRK15101
PRK15101 protease3; Provisional
1-960
0e+00
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 1992.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 1 MPRSTWFKALLLL V ALWAPLSQAETGWQP I QETIRKS D KD N RQYQAIRLDNGM V VLLVSDPQAVKSL S AL VV PVGSLEDP 80
Cdd:PRK15101 1 MPRSTWFKALLLL L ALWAPLSQAETGWQP L QETIRKS E KD P RQYQAIRLDNGM T VLLVSDPQAVKSL A AL AL PVGSLEDP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 81 E A Y QGLAHYLEHM S LMGSKKYPQ A DSLAE Y LK M HGGSHNASTA P YRTAFYLEVENDALP G AVDRLADAIAEPLLD K K Y A E 160
Cdd:PRK15101 81 D A Q QGLAHYLEHM V LMGSKKYPQ P DSLAE F LK K HGGSHNASTA S YRTAFYLEVENDALP P AVDRLADAIAEPLLD P K N A D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 161 RERNAVNAELTMAR T RDGMRMAQVSAETINPAHPGS K FSGGNLETLSDKPG NPV Q Q AL K DF HEK YYSANLMKAVIYSN K P 240
Cdd:PRK15101 161 RERNAVNAELTMAR S RDGMRMAQVSAETINPAHPGS R FSGGNLETLSDKPG SKL Q D AL V DF YQR YYSANLMKAVIYSN Q P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 241 LPELAK M AADTFGRVPNK ESKK PEITVPVVTDAQKGIIIHYVPA L PRKVLRVEFRIDNNSAKFRSKTDE L I T YLIGNRSP 320
Cdd:PRK15101 241 LPELAK L AADTFGRVPNK NASV PEITVPVVTDAQKGIIIHYVPA Q PRKVLRVEFRIDNNSAKFRSKTDE Y I S YLIGNRSP 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 321 GTLSDWLQKQGL V EGISA NS DP I V NG NSGV L AIS A SLTDKGLA N RDQVVAAIFSYLNLLREKGIDK Q YFDELA N VLD I DF 400
Cdd:PRK15101 321 GTLSDWLQKQGL A EGISA GA DP M V DR NSGV F AIS V SLTDKGLA Q RDQVVAAIFSYLNLLREKGIDK S YFDELA H VLD L DF 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 401 RYPSITRDMDY V EWLADTM I RVPVEHTLDA VN IADRYD A KA V K E RLA M MTPQNARIWYISP K EPHNKTAYFVDAPYQVDK 480
Cdd:PRK15101 401 RYPSITRDMDY I EWLADTM L RVPVEHTLDA PY IADRYD P KA I K A RLA E MTPQNARIWYISP Q EPHNKTAYFVDAPYQVDK 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 481 IS A QTFADWQ K KA AD IALSLPELNPYIPDDFSLIK SE K K Y D HPELIVDE SN LRVVY A PS R YFA S EPKAD V SL I LRNPKAM 560
Cdd:PRK15101 481 IS E QTFADWQ Q KA QN IALSLPELNPYIPDDFSLIK AD K A Y K HPELIVDE PG LRVVY M PS Q YFA D EPKAD I SL V LRNPKAM 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 561 DSARNQV M FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL F QALLEGYFS Y T A TE D QL E QAKSW 640
Cdd:PRK15101 561 DSARNQV L FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL L QALLEGYFS F T P TE E QL A QAKSW 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 641 Y NQMM DSAEKGKA F EQAIMPAQMLSQVPYF S RDERRK I LPSITLK E VLAYRDAL K SGA R PEF M V I GN M TE A Q A TTLARDV 720
Cdd:PRK15101 641 Y REQL DSAEKGKA Y EQAIMPAQMLSQVPYF E RDERRK L LPSITLK D VLAYRDAL L SGA T PEF L V V GN L TE E Q V TTLARDV 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 721 QKQLGADG S EW C R N KDVVVDKKQSV I FEKAG N STDSALAAV F VPTGYDEY T SSAYSSLLGQI V QPWFYNQLRTEEQLGYA 800
Cdd:PRK15101 721 QKQLGADG T EW W R G KDVVVDKKQSV N FEKAG S STDSALAAV Y VPTGYDEY Q SSAYSSLLGQI I QPWFYNQLRTEEQLGYA 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 801 VFAFPMSVGRQWGMGFLLQSNDKQP SF LW E RY K AFFP T AEAKLRAMKP D EFAQ I QQA V I T Q M LQAPQTLGEEAS K LSKDF 880
Cdd:PRK15101 801 VFAFPMSVGRQWGMGFLLQSNDKQP AY LW Q RY Q AFFP Q AEAKLRAMKP E EFAQ Y QQA L I N Q L LQAPQTLGEEAS R LSKDF 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 881 DRGNMRFDSRDKI V AQIKLLTPQKLADFFHQAV V EPQG M AILSQISGSQNGKA E Y V HP E GWK V WENVSALQQT M P L M SEK 960
Cdd:PRK15101 881 DRGNMRFDSRDKI I AQIKLLTPQKLADFFHQAV I EPQG L AILSQISGSQNGKA D Y A HP K GWK T WENVSALQQT L P V M EKN 960
Name
Accession
Description
Interval
E-value
PRK15101
PRK15101 protease3; Provisional
1-960
0e+00
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 1992.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 1 MPRSTWFKALLLL V ALWAPLSQAETGWQP I QETIRKS D KD N RQYQAIRLDNGM V VLLVSDPQAVKSL S AL VV PVGSLEDP 80
Cdd:PRK15101 1 MPRSTWFKALLLL L ALWAPLSQAETGWQP L QETIRKS E KD P RQYQAIRLDNGM T VLLVSDPQAVKSL A AL AL PVGSLEDP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 81 E A Y QGLAHYLEHM S LMGSKKYPQ A DSLAE Y LK M HGGSHNASTA P YRTAFYLEVENDALP G AVDRLADAIAEPLLD K K Y A E 160
Cdd:PRK15101 81 D A Q QGLAHYLEHM V LMGSKKYPQ P DSLAE F LK K HGGSHNASTA S YRTAFYLEVENDALP P AVDRLADAIAEPLLD P K N A D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 161 RERNAVNAELTMAR T RDGMRMAQVSAETINPAHPGS K FSGGNLETLSDKPG NPV Q Q AL K DF HEK YYSANLMKAVIYSN K P 240
Cdd:PRK15101 161 RERNAVNAELTMAR S RDGMRMAQVSAETINPAHPGS R FSGGNLETLSDKPG SKL Q D AL V DF YQR YYSANLMKAVIYSN Q P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 241 LPELAK M AADTFGRVPNK ESKK PEITVPVVTDAQKGIIIHYVPA L PRKVLRVEFRIDNNSAKFRSKTDE L I T YLIGNRSP 320
Cdd:PRK15101 241 LPELAK L AADTFGRVPNK NASV PEITVPVVTDAQKGIIIHYVPA Q PRKVLRVEFRIDNNSAKFRSKTDE Y I S YLIGNRSP 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 321 GTLSDWLQKQGL V EGISA NS DP I V NG NSGV L AIS A SLTDKGLA N RDQVVAAIFSYLNLLREKGIDK Q YFDELA N VLD I DF 400
Cdd:PRK15101 321 GTLSDWLQKQGL A EGISA GA DP M V DR NSGV F AIS V SLTDKGLA Q RDQVVAAIFSYLNLLREKGIDK S YFDELA H VLD L DF 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 401 RYPSITRDMDY V EWLADTM I RVPVEHTLDA VN IADRYD A KA V K E RLA M MTPQNARIWYISP K EPHNKTAYFVDAPYQVDK 480
Cdd:PRK15101 401 RYPSITRDMDY I EWLADTM L RVPVEHTLDA PY IADRYD P KA I K A RLA E MTPQNARIWYISP Q EPHNKTAYFVDAPYQVDK 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 481 IS A QTFADWQ K KA AD IALSLPELNPYIPDDFSLIK SE K K Y D HPELIVDE SN LRVVY A PS R YFA S EPKAD V SL I LRNPKAM 560
Cdd:PRK15101 481 IS E QTFADWQ Q KA QN IALSLPELNPYIPDDFSLIK AD K A Y K HPELIVDE PG LRVVY M PS Q YFA D EPKAD I SL V LRNPKAM 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 561 DSARNQV M FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL F QALLEGYFS Y T A TE D QL E QAKSW 640
Cdd:PRK15101 561 DSARNQV L FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL L QALLEGYFS F T P TE E QL A QAKSW 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 641 Y NQMM DSAEKGKA F EQAIMPAQMLSQVPYF S RDERRK I LPSITLK E VLAYRDAL K SGA R PEF M V I GN M TE A Q A TTLARDV 720
Cdd:PRK15101 641 Y REQL DSAEKGKA Y EQAIMPAQMLSQVPYF E RDERRK L LPSITLK D VLAYRDAL L SGA T PEF L V V GN L TE E Q V TTLARDV 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 721 QKQLGADG S EW C R N KDVVVDKKQSV I FEKAG N STDSALAAV F VPTGYDEY T SSAYSSLLGQI V QPWFYNQLRTEEQLGYA 800
Cdd:PRK15101 721 QKQLGADG T EW W R G KDVVVDKKQSV N FEKAG S STDSALAAV Y VPTGYDEY Q SSAYSSLLGQI I QPWFYNQLRTEEQLGYA 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 801 VFAFPMSVGRQWGMGFLLQSNDKQP SF LW E RY K AFFP T AEAKLRAMKP D EFAQ I QQA V I T Q M LQAPQTLGEEAS K LSKDF 880
Cdd:PRK15101 801 VFAFPMSVGRQWGMGFLLQSNDKQP AY LW Q RY Q AFFP Q AEAKLRAMKP E EFAQ Y QQA L I N Q L LQAPQTLGEEAS R LSKDF 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 881 DRGNMRFDSRDKI V AQIKLLTPQKLADFFHQAV V EPQG M AILSQISGSQNGKA E Y V HP E GWK V WENVSALQQT M P L M SEK 960
Cdd:PRK15101 881 DRGNMRFDSRDKI I AQIKLLTPQKLADFFHQAV I EPQG L AILSQISGSQNGKA D Y A HP K GWK T WENVSALQQT L P V M EKN 960
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
1-958
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 1508.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 1 M PRS T - WFKA LLLL VALW AP LS QA ET GWQP IQ ETI R KS DK D N RQY Q AI R LDNG MV VLLVSDPQA V KS LS AL V VPVGS LE D 79
Cdd:COG1025 1 M KKL T l SLFF LLLL LLAA AP SA QA AQ GWQP LA ETI I KS PN D P RQY R AI T LDNG LK VLLVSDPQA D KS AA AL A VPVGS FD D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 80 P EAY QGLAH Y LEHM SLM G S KKYP QADSLA E YLKM HGGSHNASTA PY RT AF Y L EVENDAL PG A V DR L AD AI A E PL L D KK Y A 159
Cdd:COG1025 81 P DDQ QGLAH F LEHM LFL G T KKYP EPGEYQ E FISK HGGSHNASTA TE RT NY Y F EVENDAL EE A L DR F AD FF A A PL F D PE Y V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 160 E RERNAVNAE L T MA R TR DG M R MA QV SA ET I NPAHP G S K FS G GNLETLSDKPG NPVQQA L KD F HEK YYSANLMK A V I YSN K 239
Cdd:COG1025 161 D RERNAVNAE Y T LK R SD DG R R IY QV HK ET L NPAHP F S R FS V GNLETLSDKPG SKLRDE L LA F YQR YYSANLMK L V L YSN Q 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 240 P L P EL A K M A AD TFG RV PN KESKK P E ITVP VV T DA Q K GIIIH Y VP AL PR KV LR V EF R I D NN S A KF RSK TDEL I T YL I GN RS 319
Cdd:COG1025 241 S L D EL E K L A RQ TFG AI PN RNLSV P P ITVP LY T PE Q L GIIIH I VP LK PR RQ LR L EF P I P NN Q A YY RSK PLTY I S YL L GN EG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 320 P G T L S DWL Q KQGL V E GI SA NSD p I VNG N S G VLA IS A SLTDKGLA N RD QVV AA I F S Y LN L L R EK GI DKQ YFDE L A NV L DID 399
Cdd:COG1025 321 E G S L L DWL K KQGL A E SL SA GGG - I SGR N F G DFS IS V SLTDKGLA H RD EII AA V F A Y IE L I R QQ GI QEW YFDE Q A QL L ELA 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 400 FR YPSI TR D MDYV E WL A D T M I R V PVE HT LDA VNIA D RY D AK A VKE RLA MM TP Q NARIW Y ISP KE P HN KTAY FV D A PY Q VD 479
Cdd:COG1025 400 FR FQEK TR P MDYV S WL S D N M L R Y PVE DV LDA DYLM D GF D PA A IRA RLA QL TP E NARIW L ISP DV P TD KTAY WY D T PY S VD 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 480 K I SAQTF A D WQ KKAADI ALSLPELNPYIPDDFSLIK SE K KYDH PEL I VDE SN LR VV Y A P SR YFA s EPKAD VS L I LRNP K A 559
Cdd:COG1025 480 P I TQEQL A K WQ QASQNP ALSLPELNPYIPDDFSLIK LD K ESAK PEL L VDE PG LR LW Y M P DQ YFA - EPKAD IY L S LRNP Q A 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 560 M DSARNQV MFA L N DYL AGL AL DQ LS N QASV G G I S F S TN A - NN GL MVN A N G Y TQ RL P Q L FQ ALL EGYF S YTA TE DQLE QAK 638
Cdd:COG1025 559 V DSARNQV LTR L L DYL LND AL NE LS Y QASV A G L S Y S LY A h QG GL TLS A S G F TQ KQ P K L LE ALL DQLA S FEP TE ERFA QAK 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 639 S WYNQMM D S AEK G K AFE Q AIM P AQM L S Q V PYF S R D E RRKI L P SITL KEVL A Y R DA L KSGARP E FM V I GN MT E A QA TT LA R 718
Cdd:COG1025 639 S QLLRQL D N AEK A K PYS Q LFS P LSR L L Q P PYF E R E E LLAA L E SITL QDLR A F R EQ L LQQLHL E ML V V GN LS E E QA KQ LA D 718
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 719 DVQ KQL GAD G S - E WC R NKD V VV DK KQ S VIF EKA GNS TDSAL AAVF v PT GYD EYT S S A Y SSLLGQI VQ PWF Y NQLRTEEQL 797
Cdd:COG1025 719 SLK KQL APN G T g E EP R RQV V DL DK SG S LNL EKA CDH TDSAL LIYY - QS GYD SLA S M A L SSLLGQI IS PWF F NQLRTEEQL 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 798 GY A V F A FP M SV GRQ W G M GF LL QS NDKQ P SF L W ER YKA F FPTA E AK L R A MKPD EFAQ IQ Q AV I T Q M L QAP Q T L G EEA SK L S 877
Cdd:COG1025 798 GY V V G A GY M PL GRQ P G L GF YV QS PVAS P AY L L ER IDD F LKQF E ER L L A LSEE EFAQ YK Q GL I N Q L L EPD Q N L S EEA QR L W 877
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 878 K D FDR G NMR FD S R D K IV A QI K L LT PQK L A DFF H QAV VE PQG MAI LSQ IS G SQNG KA E yv HPE GWK VWENV SA L Q Q T M P LM 957
Cdd:COG1025 878 V D IGN G DFE FD T R E K LI A AV K K LT RAD L I DFF Q QAV IA PQG LRL LSQ SQ G TKHS KA D -- ELK GWK TITDI SA F Q K T L P VK 955
.
gi 16130725 958 S 958
Cdd:COG1025 956 E 956
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
400-677
9.36e-58
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 200.10
E-value: 9.36e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 400 FR YPSITRDM DYV EW LA DT M IRV P V E HT L DAVNIADR YD AKAVK E R L AMM TP Q NARI WYI S PKEP -- HNKTAYFVDAP Y Q 477
Cdd:pfam16187 1 FR FQEKSPPS DYV SS LA SN M QPY P P E DI L SGDYLLRE YD PELIQ E L L DYL TP E NARI TLV S KEFE ge TDQKEPWYGTE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 478 V DK I SAQTFAD W QKKAADIA - L S LPE L NP Y IP D DF S L I K S E K K YD -- H P E LI V D ESNL R VV Y APSRY F a SE PKA DVS L I L 554
Cdd:pfam16187 81 V EP I PEELLKK W KNAPEPNP e L H LPE P NP F IP T DF D L K K K E V K EP ak Y P V LI R D TPLS R LW Y KKDDT F - WV PKA NIY L S L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 555 R N P K A MD S A RN Q V MFA L NDY L AGLA L DQLSNQ A SVG G I S F S - TNANN GL MVNAN GY TQR LP Q L FQAL LE GYFSYTATE D Q 633
Cdd:pfam16187 160 R S P L A YS S P RN A V LTR L YVE L LKDS L NEYAYD A ELA G L S Y S l SATER GL TLSVS GY NDK LP V L LEKI LE KLRDFEIDP D R 239
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 16130725 634 L E QA K SWYNQMMDSAEKGKAFE QA IMPAQM L SQVPYFSRD E RRK 677
Cdd:pfam16187 240 F E II K EQLLRSYKNFALEQPYQ QA FDYLLY L LEERSWTPE E KLE 283
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
45-835
1.54e-50
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 190.47
E-value: 1.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 45 QA I R L D NG MV V L L VSD P Q A VKSLSA L V V PV GS LED P E A YQ GLAH Y LEH MSLM G SKKYPQA D S L AEYLKMH GG SH NA S T AP 124
Cdd:TIGR02110 1 RR I T L P NG LR V H L YHQ P D A KRAAAL L R V AA GS HDE P S A WP GLAH F LEH LLFL G GERFQGD D R L MPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 125 YR TAF YL E VEND AL PGAVD RL A D AI A E PLL DKKYAE RER NAVN AE L t M A RTR D GMRMAQVS - AETINPA HP GSK F SG G NL 203
Cdd:TIGR02110 81 RT TAF FF E LPAA AL AAGLA RL C D ML A R PLL TAEDQQ RER EVLE AE Y - I A WQN D ADTLREAA l LDALQAG HP LRR F HA G SR 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 204 ET L SD k P GNPV QQAL K DFH EKY Y S A NL M KAVIYSNKP L P EL AKM AA DTFGRVPNKESKKPEITV P VVTDAQKGIIIHYV P 283
Cdd:TIGR02110 160 DS L AL - P NTAF QQAL R DFH RRH Y Q A GN M QLWLQGPQS L D EL EQL AA RFGASLAAGGECAQAPPA P LLRFDRLTLAGGSE P 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 284 A L PRK vlrve F RIDNNS A KF R SKTDE L ITY L i GNRS PG T L SDW L QKQ GL V E GIS A N sd PIV - NGNSGV LA ISA S LTDKGL 362
Cdd:TIGR02110 239 R L WLL ----- F ALAGLP A TA R DNVTL L CEF L - QDEA PG G L LAQ L RER GL A E SVA A T -- WLY q DAGQAL LA LEF S ARCISA 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 363 A NRD Q VVAAIFSY L NL L R E KG idkqyfdelanvldidfr YPSITR dm D Y VE w LA DTMIRVPVEHT L davnia DRYDAK A V 442
Cdd:TIGR02110 311 A AAQ Q IEQLLTQW L GA L A E QT ------------------ WAEQLE -- H Y AQ - LA QRRFQTLALSP L ------ AQLRGR A L 363
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 443 KER L AMMT P QN ariwyispkephnktay FV D APYQVDKISAQTFA - DW Q KKA A DI A L S LPEL npyi P DD f S L IKSEKKYD 521
Cdd:TIGR02110 364 GFA L GCAL P DA ----------------- LT D FLAALQDCPRTRLL t QQ Q IPG A PF A H S GLHA ---- P VA - R L ARAVVQAR 421
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 522 HPE L IVDE S NLRVVYA P S R YFASE ---- P K ADVS L I LR N -- P KAMDSARNQ vmf AL NDY L AG L a L DQL s NQ A S V G G ISFS 595
Cdd:TIGR02110 422 SVS L TLAA S RCSAPKS P T R CAFLA alps D K TERA L A LR W gf P SHPPEELAL --- AL QRQ L RP L - L ADA - RH A G V N G SWQA 496
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 596 T N A NNG L MV na NG YTQRLPQL F --- Q ALL E gyfsy T A TEDQLEQ A KS wynqmmdsaekg K A FEQA I MPA Q M L SQ vpyfsr 672
Cdd:TIGR02110 497 T G A SWQ L LL -- NG PRSPMRAV F sva L ALL A ----- L A APMLAQP A AN ------------ R A SAPS I PIR Q L L AA ------ 551
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 673 derrki LP SIT LK EVL A YR D ALKS g AR pefm VIGNMTE AQ ATT L ardv Q KQL G ADGSEWCR nkd VVVDKKQSVIFEK A GN 752
Cdd:TIGR02110 552 ------ LP ERL LK SLP A QQ D DWLA - AR ---- WGAATQL AQ RVA L ---- Q LSP G TADLARPT --- PLPARLGRGWVPL A CD 613
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 753 STDS AL a AV F V P TGYDEYT S S A YSS LL G Q IVQ P W F YNQ LR T E E QLGY A VF AFPMS V GRQW G MG F L LQS N D KQPSF L WERY 832
Cdd:TIGR02110 614 GGEQ AL - LL F C P LPTADVA S E A AWR LL A Q LLE P P F FQR LR V E L QLGY V VF CRYRR V ADRD G LL F A LQS P D ASARE L LQHI 692
...
gi 16130725 833 K A F 835
Cdd:TIGR02110 693 K R F 695
Name
Accession
Description
Interval
E-value
PRK15101
PRK15101 protease3; Provisional
1-960
0e+00
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 1992.54
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 1 MPRSTWFKALLLL V ALWAPLSQAETGWQP I QETIRKS D KD N RQYQAIRLDNGM V VLLVSDPQAVKSL S AL VV PVGSLEDP 80
Cdd:PRK15101 1 MPRSTWFKALLLL L ALWAPLSQAETGWQP L QETIRKS E KD P RQYQAIRLDNGM T VLLVSDPQAVKSL A AL AL PVGSLEDP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 81 E A Y QGLAHYLEHM S LMGSKKYPQ A DSLAE Y LK M HGGSHNASTA P YRTAFYLEVENDALP G AVDRLADAIAEPLLD K K Y A E 160
Cdd:PRK15101 81 D A Q QGLAHYLEHM V LMGSKKYPQ P DSLAE F LK K HGGSHNASTA S YRTAFYLEVENDALP P AVDRLADAIAEPLLD P K N A D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 161 RERNAVNAELTMAR T RDGMRMAQVSAETINPAHPGS K FSGGNLETLSDKPG NPV Q Q AL K DF HEK YYSANLMKAVIYSN K P 240
Cdd:PRK15101 161 RERNAVNAELTMAR S RDGMRMAQVSAETINPAHPGS R FSGGNLETLSDKPG SKL Q D AL V DF YQR YYSANLMKAVIYSN Q P 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 241 LPELAK M AADTFGRVPNK ESKK PEITVPVVTDAQKGIIIHYVPA L PRKVLRVEFRIDNNSAKFRSKTDE L I T YLIGNRSP 320
Cdd:PRK15101 241 LPELAK L AADTFGRVPNK NASV PEITVPVVTDAQKGIIIHYVPA Q PRKVLRVEFRIDNNSAKFRSKTDE Y I S YLIGNRSP 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 321 GTLSDWLQKQGL V EGISA NS DP I V NG NSGV L AIS A SLTDKGLA N RDQVVAAIFSYLNLLREKGIDK Q YFDELA N VLD I DF 400
Cdd:PRK15101 321 GTLSDWLQKQGL A EGISA GA DP M V DR NSGV F AIS V SLTDKGLA Q RDQVVAAIFSYLNLLREKGIDK S YFDELA H VLD L DF 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 401 RYPSITRDMDY V EWLADTM I RVPVEHTLDA VN IADRYD A KA V K E RLA M MTPQNARIWYISP K EPHNKTAYFVDAPYQVDK 480
Cdd:PRK15101 401 RYPSITRDMDY I EWLADTM L RVPVEHTLDA PY IADRYD P KA I K A RLA E MTPQNARIWYISP Q EPHNKTAYFVDAPYQVDK 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 481 IS A QTFADWQ K KA AD IALSLPELNPYIPDDFSLIK SE K K Y D HPELIVDE SN LRVVY A PS R YFA S EPKAD V SL I LRNPKAM 560
Cdd:PRK15101 481 IS E QTFADWQ Q KA QN IALSLPELNPYIPDDFSLIK AD K A Y K HPELIVDE PG LRVVY M PS Q YFA D EPKAD I SL V LRNPKAM 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 561 DSARNQV M FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL F QALLEGYFS Y T A TE D QL E QAKSW 640
Cdd:PRK15101 561 DSARNQV L FALNDYLAGLALDQLSNQASVGGISFSTNANNGLMVNANGYTQRLPQL L QALLEGYFS F T P TE E QL A QAKSW 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 641 Y NQMM DSAEKGKA F EQAIMPAQMLSQVPYF S RDERRK I LPSITLK E VLAYRDAL K SGA R PEF M V I GN M TE A Q A TTLARDV 720
Cdd:PRK15101 641 Y REQL DSAEKGKA Y EQAIMPAQMLSQVPYF E RDERRK L LPSITLK D VLAYRDAL L SGA T PEF L V V GN L TE E Q V TTLARDV 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 721 QKQLGADG S EW C R N KDVVVDKKQSV I FEKAG N STDSALAAV F VPTGYDEY T SSAYSSLLGQI V QPWFYNQLRTEEQLGYA 800
Cdd:PRK15101 721 QKQLGADG T EW W R G KDVVVDKKQSV N FEKAG S STDSALAAV Y VPTGYDEY Q SSAYSSLLGQI I QPWFYNQLRTEEQLGYA 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 801 VFAFPMSVGRQWGMGFLLQSNDKQP SF LW E RY K AFFP T AEAKLRAMKP D EFAQ I QQA V I T Q M LQAPQTLGEEAS K LSKDF 880
Cdd:PRK15101 801 VFAFPMSVGRQWGMGFLLQSNDKQP AY LW Q RY Q AFFP Q AEAKLRAMKP E EFAQ Y QQA L I N Q L LQAPQTLGEEAS R LSKDF 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 881 DRGNMRFDSRDKI V AQIKLLTPQKLADFFHQAV V EPQG M AILSQISGSQNGKA E Y V HP E GWK V WENVSALQQT M P L M SEK 960
Cdd:PRK15101 881 DRGNMRFDSRDKI I AQIKLLTPQKLADFFHQAV I EPQG L AILSQISGSQNGKA D Y A HP K GWK T WENVSALQQT L P V M EKN 960
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
1-958
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 1508.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 1 M PRS T - WFKA LLLL VALW AP LS QA ET GWQP IQ ETI R KS DK D N RQY Q AI R LDNG MV VLLVSDPQA V KS LS AL V VPVGS LE D 79
Cdd:COG1025 1 M KKL T l SLFF LLLL LLAA AP SA QA AQ GWQP LA ETI I KS PN D P RQY R AI T LDNG LK VLLVSDPQA D KS AA AL A VPVGS FD D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 80 P EAY QGLAH Y LEHM SLM G S KKYP QADSLA E YLKM HGGSHNASTA PY RT AF Y L EVENDAL PG A V DR L AD AI A E PL L D KK Y A 159
Cdd:COG1025 81 P DDQ QGLAH F LEHM LFL G T KKYP EPGEYQ E FISK HGGSHNASTA TE RT NY Y F EVENDAL EE A L DR F AD FF A A PL F D PE Y V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 160 E RERNAVNAE L T MA R TR DG M R MA QV SA ET I NPAHP G S K FS G GNLETLSDKPG NPVQQA L KD F HEK YYSANLMK A V I YSN K 239
Cdd:COG1025 161 D RERNAVNAE Y T LK R SD DG R R IY QV HK ET L NPAHP F S R FS V GNLETLSDKPG SKLRDE L LA F YQR YYSANLMK L V L YSN Q 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 240 P L P EL A K M A AD TFG RV PN KESKK P E ITVP VV T DA Q K GIIIH Y VP AL PR KV LR V EF R I D NN S A KF RSK TDEL I T YL I GN RS 319
Cdd:COG1025 241 S L D EL E K L A RQ TFG AI PN RNLSV P P ITVP LY T PE Q L GIIIH I VP LK PR RQ LR L EF P I P NN Q A YY RSK PLTY I S YL L GN EG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 320 P G T L S DWL Q KQGL V E GI SA NSD p I VNG N S G VLA IS A SLTDKGLA N RD QVV AA I F S Y LN L L R EK GI DKQ YFDE L A NV L DID 399
Cdd:COG1025 321 E G S L L DWL K KQGL A E SL SA GGG - I SGR N F G DFS IS V SLTDKGLA H RD EII AA V F A Y IE L I R QQ GI QEW YFDE Q A QL L ELA 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 400 FR YPSI TR D MDYV E WL A D T M I R V PVE HT LDA VNIA D RY D AK A VKE RLA MM TP Q NARIW Y ISP KE P HN KTAY FV D A PY Q VD 479
Cdd:COG1025 400 FR FQEK TR P MDYV S WL S D N M L R Y PVE DV LDA DYLM D GF D PA A IRA RLA QL TP E NARIW L ISP DV P TD KTAY WY D T PY S VD 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 480 K I SAQTF A D WQ KKAADI ALSLPELNPYIPDDFSLIK SE K KYDH PEL I VDE SN LR VV Y A P SR YFA s EPKAD VS L I LRNP K A 559
Cdd:COG1025 480 P I TQEQL A K WQ QASQNP ALSLPELNPYIPDDFSLIK LD K ESAK PEL L VDE PG LR LW Y M P DQ YFA - EPKAD IY L S LRNP Q A 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 560 M DSARNQV MFA L N DYL AGL AL DQ LS N QASV G G I S F S TN A - NN GL MVN A N G Y TQ RL P Q L FQ ALL EGYF S YTA TE DQLE QAK 638
Cdd:COG1025 559 V DSARNQV LTR L L DYL LND AL NE LS Y QASV A G L S Y S LY A h QG GL TLS A S G F TQ KQ P K L LE ALL DQLA S FEP TE ERFA QAK 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 639 S WYNQMM D S AEK G K AFE Q AIM P AQM L S Q V PYF S R D E RRKI L P SITL KEVL A Y R DA L KSGARP E FM V I GN MT E A QA TT LA R 718
Cdd:COG1025 639 S QLLRQL D N AEK A K PYS Q LFS P LSR L L Q P PYF E R E E LLAA L E SITL QDLR A F R EQ L LQQLHL E ML V V GN LS E E QA KQ LA D 718
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 719 DVQ KQL GAD G S - E WC R NKD V VV DK KQ S VIF EKA GNS TDSAL AAVF v PT GYD EYT S S A Y SSLLGQI VQ PWF Y NQLRTEEQL 797
Cdd:COG1025 719 SLK KQL APN G T g E EP R RQV V DL DK SG S LNL EKA CDH TDSAL LIYY - QS GYD SLA S M A L SSLLGQI IS PWF F NQLRTEEQL 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 798 GY A V F A FP M SV GRQ W G M GF LL QS NDKQ P SF L W ER YKA F FPTA E AK L R A MKPD EFAQ IQ Q AV I T Q M L QAP Q T L G EEA SK L S 877
Cdd:COG1025 798 GY V V G A GY M PL GRQ P G L GF YV QS PVAS P AY L L ER IDD F LKQF E ER L L A LSEE EFAQ YK Q GL I N Q L L EPD Q N L S EEA QR L W 877
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 878 K D FDR G NMR FD S R D K IV A QI K L LT PQK L A DFF H QAV VE PQG MAI LSQ IS G SQNG KA E yv HPE GWK VWENV SA L Q Q T M P LM 957
Cdd:COG1025 878 V D IGN G DFE FD T R E K LI A AV K K LT RAD L I DFF Q QAV IA PQG LRL LSQ SQ G TKHS KA D -- ELK GWK TITDI SA F Q K T L P VK 955
.
gi 16130725 958 S 958
Cdd:COG1025 956 E 956
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
400-677
9.36e-58
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 200.10
E-value: 9.36e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 400 FR YPSITRDM DYV EW LA DT M IRV P V E HT L DAVNIADR YD AKAVK E R L AMM TP Q NARI WYI S PKEP -- HNKTAYFVDAP Y Q 477
Cdd:pfam16187 1 FR FQEKSPPS DYV SS LA SN M QPY P P E DI L SGDYLLRE YD PELIQ E L L DYL TP E NARI TLV S KEFE ge TDQKEPWYGTE Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 478 V DK I SAQTFAD W QKKAADIA - L S LPE L NP Y IP D DF S L I K S E K K YD -- H P E LI V D ESNL R VV Y APSRY F a SE PKA DVS L I L 554
Cdd:pfam16187 81 V EP I PEELLKK W KNAPEPNP e L H LPE P NP F IP T DF D L K K K E V K EP ak Y P V LI R D TPLS R LW Y KKDDT F - WV PKA NIY L S L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 555 R N P K A MD S A RN Q V MFA L NDY L AGLA L DQLSNQ A SVG G I S F S - TNANN GL MVNAN GY TQR LP Q L FQAL LE GYFSYTATE D Q 633
Cdd:pfam16187 160 R S P L A YS S P RN A V LTR L YVE L LKDS L NEYAYD A ELA G L S Y S l SATER GL TLSVS GY NDK LP V L LEKI LE KLRDFEIDP D R 239
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 16130725 634 L E QA K SWYNQMMDSAEKGKAFE QA IMPAQM L SQVPYFSRD E RRK 677
Cdd:pfam16187 240 F E II K EQLLRSYKNFALEQPYQ QA FDYLLY L LEERSWTPE E KLE 283
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
45-835
1.54e-50
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 190.47
E-value: 1.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 45 QA I R L D NG MV V L L VSD P Q A VKSLSA L V V PV GS LED P E A YQ GLAH Y LEH MSLM G SKKYPQA D S L AEYLKMH GG SH NA S T AP 124
Cdd:TIGR02110 1 RR I T L P NG LR V H L YHQ P D A KRAAAL L R V AA GS HDE P S A WP GLAH F LEH LLFL G GERFQGD D R L MPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 125 YR TAF YL E VEND AL PGAVD RL A D AI A E PLL DKKYAE RER NAVN AE L t M A RTR D GMRMAQVS - AETINPA HP GSK F SG G NL 203
Cdd:TIGR02110 81 RT TAF FF E LPAA AL AAGLA RL C D ML A R PLL TAEDQQ RER EVLE AE Y - I A WQN D ADTLREAA l LDALQAG HP LRR F HA G SR 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 204 ET L SD k P GNPV QQAL K DFH EKY Y S A NL M KAVIYSNKP L P EL AKM AA DTFGRVPNKESKKPEITV P VVTDAQKGIIIHYV P 283
Cdd:TIGR02110 160 DS L AL - P NTAF QQAL R DFH RRH Y Q A GN M QLWLQGPQS L D EL EQL AA RFGASLAAGGECAQAPPA P LLRFDRLTLAGGSE P 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 284 A L PRK vlrve F RIDNNS A KF R SKTDE L ITY L i GNRS PG T L SDW L QKQ GL V E GIS A N sd PIV - NGNSGV LA ISA S LTDKGL 362
Cdd:TIGR02110 239 R L WLL ----- F ALAGLP A TA R DNVTL L CEF L - QDEA PG G L LAQ L RER GL A E SVA A T -- WLY q DAGQAL LA LEF S ARCISA 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 363 A NRD Q VVAAIFSY L NL L R E KG idkqyfdelanvldidfr YPSITR dm D Y VE w LA DTMIRVPVEHT L davnia DRYDAK A V 442
Cdd:TIGR02110 311 A AAQ Q IEQLLTQW L GA L A E QT ------------------ WAEQLE -- H Y AQ - LA QRRFQTLALSP L ------ AQLRGR A L 363
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 443 KER L AMMT P QN ariwyispkephnktay FV D APYQVDKISAQTFA - DW Q KKA A DI A L S LPEL npyi P DD f S L IKSEKKYD 521
Cdd:TIGR02110 364 GFA L GCAL P DA ----------------- LT D FLAALQDCPRTRLL t QQ Q IPG A PF A H S GLHA ---- P VA - R L ARAVVQAR 421
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 522 HPE L IVDE S NLRVVYA P S R YFASE ---- P K ADVS L I LR N -- P KAMDSARNQ vmf AL NDY L AG L a L DQL s NQ A S V G G ISFS 595
Cdd:TIGR02110 422 SVS L TLAA S RCSAPKS P T R CAFLA alps D K TERA L A LR W gf P SHPPEELAL --- AL QRQ L RP L - L ADA - RH A G V N G SWQA 496
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 596 T N A NNG L MV na NG YTQRLPQL F --- Q ALL E gyfsy T A TEDQLEQ A KS wynqmmdsaekg K A FEQA I MPA Q M L SQ vpyfsr 672
Cdd:TIGR02110 497 T G A SWQ L LL -- NG PRSPMRAV F sva L ALL A ----- L A APMLAQP A AN ------------ R A SAPS I PIR Q L L AA ------ 551
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 673 derrki LP SIT LK EVL A YR D ALKS g AR pefm VIGNMTE AQ ATT L ardv Q KQL G ADGSEWCR nkd VVVDKKQSVIFEK A GN 752
Cdd:TIGR02110 552 ------ LP ERL LK SLP A QQ D DWLA - AR ---- WGAATQL AQ RVA L ---- Q LSP G TADLARPT --- PLPARLGRGWVPL A CD 613
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 753 STDS AL a AV F V P TGYDEYT S S A YSS LL G Q IVQ P W F YNQ LR T E E QLGY A VF AFPMS V GRQW G MG F L LQS N D KQPSF L WERY 832
Cdd:TIGR02110 614 GGEQ AL - LL F C P LPTADVA S E A AWR LL A Q LLE P P F FQR LR V E L QLGY V VF CRYRR V ADRD G LL F A LQS P D ASARE L LQHI 692
...
gi 16130725 833 K A F 835
Cdd:TIGR02110 693 K R F 695
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
54-191
4.22e-42
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 150.53
E-value: 4.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 54 V V LLV SDP Q A VK S LSA L VVPV GS LED P EAYQ GLAH Y LEHM SLM G S KKYP Q a DS L A E Y L KMH GGS H NA S T APYR T AF Y L EV 133
Cdd:pfam00675 1 R V ASE SDP P A DT S TVG L WIDA GS RYE P DNNN GLAH F LEHM AFK G T KKYP S - NE L E E E L EKL GGS L NA F T SREN T VY Y A EV 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130725 134 E ND A LP G AVDRLAD AIAE PL LDKKYA ER ------- E RN AV NA E ---- LTMARTRDGM R MAQVSAETIN P 191
Cdd:pfam00675 80 L ND D LP K AVDRLAD FFRN PL FTESEI ER erlvvly E VE AV DS E pqlv VLENLHAAAY R NTPLGRSLLG P 148
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
43-395
2.10e-41
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 157.78
E-value: 2.10e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 43 QYQAIR L D NG MV V L LV S DP Q A - V K S LS a L V V P VGS LED P EAYQ GLAH Y LEHM SLM G S KK YP q A DSL AE Y L KMH GGS H NA S 121
Cdd:COG0612 14 DVEEFT L P NG LR V I LV P DP E A p V V S VR - L W V R VGS RDE P PGKT GLAH F LEHM LFK G T KK RS - A GEI AE E L EAL GGS L NA F 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 122 T APYR T AF YL E V ENDA L PG A VDR LAD AIAE P LL D KKYA ERER NA V NA E LTMARTRDGMRMAQVSAETINPA HP GSKFSG G 201
Cdd:COG0612 92 T SFDY T VY YL S V LSED L EL A LEL LAD RLLN P TF D EEEL ERER GV V LE E IRRYEDDPDGLAFEALLAALYGD HP YGRPII G 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 202 NL E TLS dkpg NPVQQA L KD F HEK YY SA N LMKA V IYSNKPLP E LAKMAADT FG RV P NKESKKPEITVPVVTDAQK g IIIHY 281
Cdd:COG0612 172 TE E SIE ---- AITRED L RA F YKR YY RP N NAVL V VVGDVDPE E VLALVEKY FG DL P AGPAPPRPDPAEPPQTGPR - RVVVD 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 282 V P ALPRKVLRVEFR - IDNNSAKFR sk TDELITYLI G nrsp G TL S DW L ----- Q K Q GL VEGISANSD P iv NGNS G VLA I S A 355
Cdd:COG0612 247 D P DAEQAHILLGYP g PARDDPDYY -- ALDVLNEIL G ---- G GF S SR L fqelr E K K GL AYSVGSSFS P -- YRDA G LFT I Y A 318
330 340 350 360
....*....|....*....|....*....|....*....|
gi 16130725 356 S l T DKG la NRDQVV AAI FSY L NL L REK G IDK qyf D EL ANV 395
Cdd:COG0612 319 G - T APD -- KLEEAL AAI LEE L ER L AKE G VTE --- E EL ERA 352
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
216-396
5.02e-23
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 97.08
E-value: 5.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 216 QA L K DF HE K Y YS ANL M KA VI YSNKPLP EL AKM A ADT FG RV P NKE sk K PEITV P VVTD A QKGIIIHY VP ALPRKVLRVE -- 293
Cdd:pfam05193 5 ED L R DF YK K H YS PDN M VL VI VGDVDHE EL LDL A EKY FG DL P ASP -- K GKPRP P PLEP A KLKGREVV VP KKDEPQAHLA la 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 294 F RIDNNSAKFR S KTDELITY L I G NRSPGT L SDW L Q - K Q GL VEGI S ANS D P iv NGN SG VLA I S A SLTDK gla N R D Q V VAA I 372
Cdd:pfam05193 83 F PGPPLNNDED S LALDVLNE L L G GGMSSR L FQE L R e K E GL AYSV S SFN D S -- YSD SG LFG I Y A TVDPE --- N V D E V IEL I 157
170 180
....*....|....*....|....
gi 16130725 373 FSY L NL L REK G IDKQYFDELA N V L 396
Cdd:pfam05193 158 LEE L EK L AQE G VTEEELERAK N Q L 181
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
681-857
7.27e-16
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 76.66
E-value: 7.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 681 S I T LKEVLAYRDALK S GARPEFMVI G NMTEAQATT LA RDVQKQ L G A -- D G SEWCRNKDVVVD K KQS V IF - E K AGNSTDS A 757
Cdd:pfam05193 1 S L T REDLRDFYKKHY S PDNMVLVIV G DVDHEELLD LA EKYFGD L P A sp K G KPRPPPLEPAKL K GRE V VV p K K DEPQAHL A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 758 LA AVFV P TG -- Y D EYTSSAYSS LLG QIVQPWFYNQ LR TE E Q L G Y A V FA F PM S VG -- RQW G MGFLLQSNDKQ psflw E RYK 833
Cdd:pfam05193 81 LA FPGP P LN nd E D SLALDVLNE LLG GGMSSRLFQE LR EK E G L A Y S V SS F ND S YS ds GLF G IYATVDPENVD ----- E VIE 155
170 180
....*....|....*....|....*
gi 16130725 834 AFFPTA E AKLRA - MKPD E FAQIQQA 857
Cdd:pfam05193 156 LILEEL E KLAQE g VTEE E LERAKNQ 180
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
652-922
1.33e-04
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 45.30
E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 652 K A FEQ A IMPAQMLSQVPYFSRDE rrki LPS IT LKEVL A YRDALKSGARPEFM V I G NMTEAQATT L ARDVQKQ L G A DGS - E 730
Cdd:COG0612 153 E A LLA A LYGDHPYGRPIIGTEES ---- IEA IT REDLR A FYKRYYRPNNAVLV V V G DVDPEEVLA L VEKYFGD L P A GPA p P 228
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 731 WCRNKDVVVDKKQS V IFEKAGNSTDSA L AAVFV P TGY D E -- Y TSSAYSSL LG QIVQPWFYNQ LR TEEQ L G Y A V FAF p M S V 808
Cdd:COG0612 229 RPDPAEPPQTGPRR V VVDDPDAEQAHI L LGYPG P ARD D P dy Y ALDVLNEI LG GGFSSRLFQE LR EKKG L A Y S V GSS - F S P 307
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 809 G R QW G M g F LLQ --- SN DK QPSF L ------ W ER YKAFFP T A E aklramkpd E FAQIQQAVITQMLQAPQTLGEE AS K L SKD 879
Cdd:COG0612 308 Y R DA G L - F TIY agt AP DK LEEA L aailee L ER LAKEGV T E E --------- E LERAKNQLLGSLALSLESNSGL AS Q L GRY 377
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 16130725 880 FDR G n MRF D SRDKIVAQ I KLL T PQKLADFF h QAVVE P QGMAIL 922
Cdd:COG0612 378 ELY G - GDL D YLEEYLER I EAV T AEDVQAVA - RKYLD P DNLVVV 418
Cym1
COG1026 Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
85-236
2.03e-04
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440649 [Multi-domain]
Cd Length: 974
Bit Score: 45.18
E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 85 G L AH Y LEH MS L M GS K KYP QA D -------- SL AEY L kmhggsh NA S T APYR TA FYLEVE N DA ---- L pga V D RLA DA IAE P 152
Cdd:COG1026 64 G V AH I LEH SV L C GS R KYP VK D pffellkg SL NTF L ------- NA M T YSDK TA YPVASR N EK dfyn L --- M D VYL DA VFF P 133
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 153 L LD KKYAER E -- R --- NAVNAE LT MA rtrd G ----- M RM A QV S AETIN --------- P AHPGSKF SGG NL E --- T L S dkp 210
Cdd:COG1026 134 N LD PLIFAQ E gw R yel EEPDSP LT YK ---- G vvyne M KG A MS S PDSVL wralqkslf P DTTYGYN SGG DP E vip D L T --- 206
170 180
....*....|....*....|....*..
gi 16130725 211 gnpv QQALKD FH E KYY S - A N lmk A V IY 236
Cdd:COG1026 207 ---- YEQFLA FH K KYY H p S N --- A Y IY 226
PTZ00432
PTZ00432 falcilysin; Provisional
54-136
6.01e-03
falcilysin; Provisional
Pssm-ID: 240416 [Multi-domain]
Cd Length: 1119
Bit Score: 40.55
E-value: 6.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130725 54 V VL L VS - D PQAVKSLSALV VP VGSLE D peay Q G LA H Y LEH MS L M GSKKY PQA DS L ae Y L KMH GG SH --- NA S T APY RT AF 129
Cdd:PTZ00432 103 V IS L KT n D SSGKEMCFDFY VP TPPHN D ---- K G IP H I LEH SV L S GSKKY NYK DS F -- S L LVQ GG FN sfl NA Y T FKD RT SY 176
....*..
gi 16130725 130 YLEVE N D 136
Cdd:PTZ00432 177 LFAST N E 183
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
