|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09694 |
PRK09694 |
CRISPR-associated helicase/endonuclease Cas3; |
1-883 |
0e+00 |
|
CRISPR-associated helicase/endonuclease Cas3;
Pssm-ID: 182031 [Multi-domain] Cd Length: 878 Bit Score: 1596.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 1 MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFD 80
Cdd:PRK09694 1 MESFKYYCRYWGKASKSLTKGNDYHLLPYHCLDVAAVADCWWDQSPVLRSQFSANEMLSKQQVRAWLLFFVALHDIGKFD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 81 IRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDffSFFDAAPHPYESWFPWVEAVTGHH 160
Cdd:PRK09694 81 IRFQYKAPEIWLKLNPAGPSISGPSTQMCRKYDHGAAGLLWFRQDFRSNQASDD--SFFDAAPHPYEAWFPWMEAVTGHH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 161 GFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTF 240
Cdd:PRK09694 159 GYILHSQDQDDSRWEMPASLASYAEQDKQAREEWIQALEALFLTPAGLSLNDIPPPCSPLLAGFCSVSDWLGSWTTTFTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 241 LFNedapSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGK 320
Cdd:PRK09694 239 LFN----SPILALRQYFQQRQQDAARVLELSGLVANKKPYGGVHALLDNGYQPRQLQTLVDALPLQPGLTIIEAPTGSGK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 321 TETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAW 400
Cdd:PRK09694 315 TEAALAYAWRLIDQGLADSIIFALPTQATANAMLSRLEALASKLFPSPNLILAHGNSRFNHLFQSLKSRAATEQGQEEAW 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 401 VQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVI 480
Cdd:PRK09694 395 VQCCEWLSQSNKRVFLGQIGVCTIDQVLISVLPVKHRFIRGFGLGRSVLIVDEVHAYDAYMYGLLEAVLKAQAQAGGSVI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 481 LLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERM 560
Cdd:PRK09694 475 LLSATLPATLKQKLLDTYGGH-DPVELSSAYPLITWRGVNGAQRFDLSAHPEQLPARFTIQLEPICLADMLPDLTLLQRM 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 561 IAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQ 640
Cdd:PRK09694 554 IAAANAGAQVCLICNLVDDAQKLYQRLKELNNTQVDIDLFHARFTLNDRREKEQRVIENFGKNGKRNQGRILVATQVVEQ 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 641 SLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGAS 720
Cdd:PRK09694 634 SLDLDFDWLITQLCPVDLLFQRLGRLHRHHRKYRPAGFEIPVATVLLPDGEGYGRSGYIYGNTRVLWRTEQLLEEHNAAS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 721 LFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPY 799
Cdd:PRK09694 714 LFFPDAYREWIESVYDEAEMDeEPEWVISGMDKFEDKECEKRYKARKMLKWAEETPLSDNDERVLALTRDGEMSLPVLPY 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 800 VQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQG-NSIVITYTGDEG 878
Cdd:PRK09694 794 VQTEHGKQLLDGQVLEQLDEEQQYEALALNRVNVPHTWKRSFLEVVDEDGLIWLEGHQDADGWCWQGkNDIVITYTEDEG 873
|
....*
gi 16130668 879 MTRVI 883
Cdd:PRK09694 874 MTRVI 878
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
309-716 |
3.32e-159 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 469.63 E-value: 3.32e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 309 LTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEAsashLFSSpNLILAHGNSRFnhlfqsiks 388
Cdd:TIGR01587 1 LLVIEAPTGYGKTEAALLWALHSIKSQKADRVIIALPTRATINAMYRRAKE----LFGS-ELVGLHHSSSF--------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 389 RAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLP-VKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEA 467
Cdd:TIGR01587 67 SRIKEMGDSEEFEHLFPLYIHSNDKLFLDPITVCTIDQVLKSVFGeFGHYEFTLASIANSLLIFDEVHFYDEYTLALILA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 468 VLKAQADVGGSVILLSATLPmkqkqKLLDTYGLHTDPVENNSAYPLINwrgvngaqrfdllahpeqlPPRFSIQPEPICL 547
Cdd:TIGR01587 147 VLEVLKDNDVPILLMSATLP-----KFLKEYAEKIGYVEFNEPLDLKE-------------------ERRFENHRFILIE 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 548 ADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQvDIDLFHARFTLNDRREKENRVISNFGKNgkrN 627
Cdd:TIGR01587 203 SDKVGEISSLERLLEFIKKGGSIAIIVNTVDRAQEFYQQLKEKAPEE-EIILYHSRFTEKDRAKKEAELLREMKKS---N 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 628 VGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRpAGFEIPVATILLPDGegygrheHIYSNVRVMW 707
Cdd:TIGR01587 279 EKFVIVATQVIEASLDISADVMITELAPIDSLIQRLGRLHRYGRKIG-ENFEVYIITIAPEGK-------LFPYPYELVE 350
|
....*....
gi 16130668 708 RTQQHIEEL 716
Cdd:TIGR01587 351 RTIQKLEES 359
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
309-716 |
1.64e-157 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 464.98 E-value: 1.64e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 309 LTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSpnlilahgnsrfnhlFQSIKS 388
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQKADRVIIALPTRATINAMYRRAKEAFGETGLY---------------HSSILS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 389 RAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLP-VKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEA 467
Cdd:cd09639 66 SRIKEMGDSEEFEHLFPLYIHSNDTLFLDPITVCTIDQVLKSVFGeFGHYEFTLASIANSLLIFDEVHFYDEYTLALILA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 468 VLKAQADVGGSVILLSATLPmkqkqKLLDTYGLHTDPVENNSAYPLINWRGvngaqrfdllahpeqlpprfsiQPEPICL 547
Cdd:cd09639 146 VLEVLKDNDVPILLMSATLP-----KFLKEYAEKIGYVEENEPLDLKPNER----------------------APFIKIE 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 548 ADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNtQVDIDLFHARFTLNDRREKENRVISNFGKNGKrn 627
Cdd:cd09639 199 SDKVGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQLKEKGP-EEEIMLIHSRFTEKDRAKKEAELLLEFKKSEK-- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 628 vgRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRpagfEIPVATILLPDGEGygrheHIYSNVRVMW 707
Cdd:cd09639 276 --FVIVATQVIEASLDISVDVMITELAPIDSLIQRLGRLHRYGEKNG----EEVYIITDAPDGKG-----QKPYPYDLVE 344
|
....*....
gi 16130668 708 RTQQHIEEL 716
Cdd:cd09639 345 RTIELLEEG 353
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
144-756 |
1.90e-115 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 362.86 E-value: 1.90e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 144 HPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEW--ISVLEALFLTPAGLSINDIPPDCSSLL 221
Cdd:COG1203 5 AKEALLGALALAALLLLLLALLLAALLLLLLAALLLALLLALLLLAALELAllLLLLLLLLLLLLLLLLDLLLDDLAFLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 222 AGFCSLADWLGSWTTtntflfnEDAPSDINALRtyfqdrqqdasrvlelsglvsnkrcYEGVHALLDNGYQPR------Q 295
Cdd:COG1203 85 LLLLIDADWLDSANF-------DMARQALDHLL-------------------------AERLERLLPKKSKPRtpinplQ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 296 LQVLVDALPVA---PGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEAsashlFSSPNLIL 372
Cdd:COG1203 133 NEALELALEAAeeePGLFILTAPTGGGKTEAALLFALRLAAKHGGRRIIYALPFTSIINQTYDRLRD-----LFGEDVLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 373 AHGNSRFNHLfqsiksRAITEQGQEEAWvqccqwlSQSNKKVFLGQIGVCTIDQVLISVL-PVKHRFIRGLGIGRSVLIV 451
Cdd:COG1203 208 HHSLADLDLL------EEEEEYESEARW-------LKLLKELWDAPVVVTTIDQLFESLFsNRKGQERRLHNLANSVIIL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 452 DEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYplinwrgvngAQRFDllahp 531
Cdd:COG1203 275 DEVQAYPPYMLALLLRLLEWLKNLGGSVILMTATLPPLLREELLEAYELIPDEPEELPEY----------FRAFV----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 532 eqlPPRFSIQPEPICLADmlpdltMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNtQVDIDLFHARFTLNDRRE 611
Cdd:COG1203 340 ---RKRVELKEGPLSDEE------LAELILEALHKGKSVLVIVNTVKDAQELYEALKEKLP-DEEVYLLHSRFCPADRSE 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 612 KENRVISNFgkngKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKyrpagFEIPVATILLPDGE 691
Cdd:COG1203 410 IEKEIKERL----ERGKPCILVSTQVVEAGVDIDFDVVIRDLAPLDSLIQRAGRCNRHGRK-----EEEGNVYVFDPEDE 480
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130668 692 GYGRhehIYSNVRVmWRTQQHIEELNGaslFFPDAYRQWLDSIYDDAEMDEPEWvgngMDKFESA 756
Cdd:COG1203 481 GGGY---VYDKPLL-ERTRELLREHDE---ILPEDKRELIEEYYRELYELLPDE----LDSFKEI 534
|
|
| HD_6 |
pfam18019 |
HD domain; This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase ... |
11-236 |
7.12e-47 |
|
HD domain; This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase domain. This domain is sometimes found as a separate protein. It acts as a nuclease that cleaves ssDNA.
Pssm-ID: 436216 Cd Length: 212 Bit Score: 166.46 E-value: 7.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 11 WGKSSKslTKGNDIHLLIYHCLDVAAVADCWWDQSV--VLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSA 88
Cdd:pfam18019 1 WAKSDR--EGGGGWHPLVYHLLDVAAVAGALWDHWLapGVRDLLARLLGLDEEAARRLLAFLAALHDIGKASPAFQAKVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 89 ESWLKLNPATPSLNGPSTqmCRKFNHGAAGLYWFNQDslseqslgdffsFFDAAPHPYESWFPWVEAVTGHHGF-ILHSQ 167
Cdd:pfam18019 79 ELAEKLRDAGLPFPSSLD--ESRARHGLAGAALLREW------------LEDEAGWDRGVARALAAAVGGHHGRpPAEDL 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 168 DQDKSRWEMPASLASYA-AQDKQAREEWISVLEALFLTPAGlsinDIPPDCSSLLAGFCSLADWLGSWTT 236
Cdd:pfam18019 145 RLARPALRPAGGSWQEArRELLEAAAAFLGAAAVLLLPPAR----ELSQPAQVLLAGLVILADWIASNED 210
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
310-487 |
1.81e-13 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 70.21 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 310 TVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFssPNLILAHGNSRFNHLFQSIKSR 389
Cdd:smart00487 27 VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLG--LKVVGLYGGDSKREQLRKLESG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 390 AIteqgqeeawvqccqwlsqsnkkvflgQIGVCTIdQVLISVLPVKHRFIRGLgigrSVLIVDEVHAYDTYMNGLLEAVL 469
Cdd:smart00487 105 KT--------------------------DILVTTP-GRLLDLLENDKLSLSNV----DLVILDEAHRLLDGGFGDQLEKL 153
|
170
....*....|....*...
gi 16130668 470 KAQADVGGSVILLSATLP 487
Cdd:smart00487 154 LKLLPKNVQLLLLSATPP 171
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09694 |
PRK09694 |
CRISPR-associated helicase/endonuclease Cas3; |
1-883 |
0e+00 |
|
CRISPR-associated helicase/endonuclease Cas3;
Pssm-ID: 182031 [Multi-domain] Cd Length: 878 Bit Score: 1596.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 1 MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFD 80
Cdd:PRK09694 1 MESFKYYCRYWGKASKSLTKGNDYHLLPYHCLDVAAVADCWWDQSPVLRSQFSANEMLSKQQVRAWLLFFVALHDIGKFD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 81 IRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDffSFFDAAPHPYESWFPWVEAVTGHH 160
Cdd:PRK09694 81 IRFQYKAPEIWLKLNPAGPSISGPSTQMCRKYDHGAAGLLWFRQDFRSNQASDD--SFFDAAPHPYEAWFPWMEAVTGHH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 161 GFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTF 240
Cdd:PRK09694 159 GYILHSQDQDDSRWEMPASLASYAEQDKQAREEWIQALEALFLTPAGLSLNDIPPPCSPLLAGFCSVSDWLGSWTTTFTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 241 LFNedapSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGK 320
Cdd:PRK09694 239 LFN----SPILALRQYFQQRQQDAARVLELSGLVANKKPYGGVHALLDNGYQPRQLQTLVDALPLQPGLTIIEAPTGSGK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 321 TETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAW 400
Cdd:PRK09694 315 TEAALAYAWRLIDQGLADSIIFALPTQATANAMLSRLEALASKLFPSPNLILAHGNSRFNHLFQSLKSRAATEQGQEEAW 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 401 VQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVI 480
Cdd:PRK09694 395 VQCCEWLSQSNKRVFLGQIGVCTIDQVLISVLPVKHRFIRGFGLGRSVLIVDEVHAYDAYMYGLLEAVLKAQAQAGGSVI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 481 LLSATLPMKQKQKLLDTYGLHtDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERM 560
Cdd:PRK09694 475 LLSATLPATLKQKLLDTYGGH-DPVELSSAYPLITWRGVNGAQRFDLSAHPEQLPARFTIQLEPICLADMLPDLTLLQRM 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 561 IAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQ 640
Cdd:PRK09694 554 IAAANAGAQVCLICNLVDDAQKLYQRLKELNNTQVDIDLFHARFTLNDRREKEQRVIENFGKNGKRNQGRILVATQVVEQ 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 641 SLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGAS 720
Cdd:PRK09694 634 SLDLDFDWLITQLCPVDLLFQRLGRLHRHHRKYRPAGFEIPVATVLLPDGEGYGRSGYIYGNTRVLWRTEQLLEEHNAAS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 721 LFFPDAYRQWLDSIYDDAEMD-EPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPY 799
Cdd:PRK09694 714 LFFPDAYREWIESVYDEAEMDeEPEWVISGMDKFEDKECEKRYKARKMLKWAEETPLSDNDERVLALTRDGEMSLPVLPY 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 800 VQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQG-NSIVITYTGDEG 878
Cdd:PRK09694 794 VQTEHGKQLLDGQVLEQLDEEQQYEALALNRVNVPHTWKRSFLEVVDEDGLIWLEGHQDADGWCWQGkNDIVITYTEDEG 873
|
....*
gi 16130668 879 MTRVI 883
Cdd:PRK09694 874 MTRVI 878
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
309-716 |
3.32e-159 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 469.63 E-value: 3.32e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 309 LTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEAsashLFSSpNLILAHGNSRFnhlfqsiks 388
Cdd:TIGR01587 1 LLVIEAPTGYGKTEAALLWALHSIKSQKADRVIIALPTRATINAMYRRAKE----LFGS-ELVGLHHSSSF--------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 389 RAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLP-VKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEA 467
Cdd:TIGR01587 67 SRIKEMGDSEEFEHLFPLYIHSNDKLFLDPITVCTIDQVLKSVFGeFGHYEFTLASIANSLLIFDEVHFYDEYTLALILA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 468 VLKAQADVGGSVILLSATLPmkqkqKLLDTYGLHTDPVENNSAYPLINwrgvngaqrfdllahpeqlPPRFSIQPEPICL 547
Cdd:TIGR01587 147 VLEVLKDNDVPILLMSATLP-----KFLKEYAEKIGYVEFNEPLDLKE-------------------ERRFENHRFILIE 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 548 ADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQvDIDLFHARFTLNDRREKENRVISNFGKNgkrN 627
Cdd:TIGR01587 203 SDKVGEISSLERLLEFIKKGGSIAIIVNTVDRAQEFYQQLKEKAPEE-EIILYHSRFTEKDRAKKEAELLREMKKS---N 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 628 VGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRpAGFEIPVATILLPDGegygrheHIYSNVRVMW 707
Cdd:TIGR01587 279 EKFVIVATQVIEASLDISADVMITELAPIDSLIQRLGRLHRYGRKIG-ENFEVYIITIAPEGK-------LFPYPYELVE 350
|
....*....
gi 16130668 708 RTQQHIEEL 716
Cdd:TIGR01587 351 RTIQKLEES 359
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
309-716 |
1.64e-157 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 464.98 E-value: 1.64e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 309 LTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSpnlilahgnsrfnhlFQSIKS 388
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQKADRVIIALPTRATINAMYRRAKEAFGETGLY---------------HSSILS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 389 RAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLP-VKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEA 467
Cdd:cd09639 66 SRIKEMGDSEEFEHLFPLYIHSNDTLFLDPITVCTIDQVLKSVFGeFGHYEFTLASIANSLLIFDEVHFYDEYTLALILA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 468 VLKAQADVGGSVILLSATLPmkqkqKLLDTYGLHTDPVENNSAYPLINWRGvngaqrfdllahpeqlpprfsiQPEPICL 547
Cdd:cd09639 146 VLEVLKDNDVPILLMSATLP-----KFLKEYAEKIGYVEENEPLDLKPNER----------------------APFIKIE 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 548 ADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNtQVDIDLFHARFTLNDRREKENRVISNFGKNGKrn 627
Cdd:cd09639 199 SDKVGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQLKEKGP-EEEIMLIHSRFTEKDRAKKEAELLLEFKKSEK-- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 628 vgRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRpagfEIPVATILLPDGEGygrheHIYSNVRVMW 707
Cdd:cd09639 276 --FVIVATQVIEASLDISVDVMITELAPIDSLIQRLGRLHRYGEKNG----EEVYIITDAPDGKG-----QKPYPYDLVE 344
|
....*....
gi 16130668 708 RTQQHIEEL 716
Cdd:cd09639 345 RTIELLEEG 353
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
144-756 |
1.90e-115 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 362.86 E-value: 1.90e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 144 HPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEW--ISVLEALFLTPAGLSINDIPPDCSSLL 221
Cdd:COG1203 5 AKEALLGALALAALLLLLLALLLAALLLLLLAALLLALLLALLLLAALELAllLLLLLLLLLLLLLLLLDLLLDDLAFLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 222 AGFCSLADWLGSWTTtntflfnEDAPSDINALRtyfqdrqqdasrvlelsglvsnkrcYEGVHALLDNGYQPR------Q 295
Cdd:COG1203 85 LLLLIDADWLDSANF-------DMARQALDHLL-------------------------AERLERLLPKKSKPRtpinplQ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 296 LQVLVDALPVA---PGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEAsashlFSSPNLIL 372
Cdd:COG1203 133 NEALELALEAAeeePGLFILTAPTGGGKTEAALLFALRLAAKHGGRRIIYALPFTSIINQTYDRLRD-----LFGEDVLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 373 AHGNSRFNHLfqsiksRAITEQGQEEAWvqccqwlSQSNKKVFLGQIGVCTIDQVLISVL-PVKHRFIRGLGIGRSVLIV 451
Cdd:COG1203 208 HHSLADLDLL------EEEEEYESEARW-------LKLLKELWDAPVVVTTIDQLFESLFsNRKGQERRLHNLANSVIIL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 452 DEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYplinwrgvngAQRFDllahp 531
Cdd:COG1203 275 DEVQAYPPYMLALLLRLLEWLKNLGGSVILMTATLPPLLREELLEAYELIPDEPEELPEY----------FRAFV----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 532 eqlPPRFSIQPEPICLADmlpdltMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNtQVDIDLFHARFTLNDRRE 611
Cdd:COG1203 340 ---RKRVELKEGPLSDEE------LAELILEALHKGKSVLVIVNTVKDAQELYEALKEKLP-DEEVYLLHSRFCPADRSE 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 612 KENRVISNFgkngKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKyrpagFEIPVATILLPDGE 691
Cdd:COG1203 410 IEKEIKERL----ERGKPCILVSTQVVEAGVDIDFDVVIRDLAPLDSLIQRAGRCNRHGRK-----EEEGNVYVFDPEDE 480
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130668 692 GYGRhehIYSNVRVmWRTQQHIEELNGaslFFPDAYRQWLDSIYDDAEMDEPEWvgngMDKFESA 756
Cdd:COG1203 481 GGGY---VYDKPLL-ERTRELLREHDE---ILPEDKRELIEEYYRELYELLPDE----LDSFKEI 534
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
307-499 |
1.05e-63 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 212.54 E-value: 1.05e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 307 PGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSI 386
Cdd:cd17930 1 PGLVILEAPTGSGKTEAALLWALKLAARGGKRRIIYALPTRATINQMYERIREILGRLDDEDKVLLLHSKAALELLESDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 387 KsraiteqgqEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYD-TYMNGLL 465
Cdd:cd17930 81 E---------PDDDPVEAVDWALLLKRSWLAPIVVTTIDQLLESLLKYKHFERRLHGLANSVVVLDEVQAYDpEYMALLL 151
|
170 180 190
....*....|....*....|....*....|....
gi 16130668 466 EAVLKAQADVGGSVILLSATLPMKQKQKLLDTYG 499
Cdd:cd17930 152 KALLELLGELGGPVVLMTATLPALLRDELLEALL 185
|
|
| HD_6 |
pfam18019 |
HD domain; This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase ... |
11-236 |
7.12e-47 |
|
HD domain; This HD domain is found at the N-terminus of Cas3 enzymes fused to a helicase domain. This domain is sometimes found as a separate protein. It acts as a nuclease that cleaves ssDNA.
Pssm-ID: 436216 Cd Length: 212 Bit Score: 166.46 E-value: 7.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 11 WGKSSKslTKGNDIHLLIYHCLDVAAVADCWWDQSV--VLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSA 88
Cdd:pfam18019 1 WAKSDR--EGGGGWHPLVYHLLDVAAVAGALWDHWLapGVRDLLARLLGLDEEAARRLLAFLAALHDIGKASPAFQAKVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 89 ESWLKLNPATPSLNGPSTqmCRKFNHGAAGLYWFNQDslseqslgdffsFFDAAPHPYESWFPWVEAVTGHHGF-ILHSQ 167
Cdd:pfam18019 79 ELAEKLRDAGLPFPSSLD--ESRARHGLAGAALLREW------------LEDEAGWDRGVARALAAAVGGHHGRpPAEDL 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 168 DQDKSRWEMPASLASYA-AQDKQAREEWISVLEALFLTPAGlsinDIPPDCSSLLAGFCSLADWLGSWTT 236
Cdd:pfam18019 145 RLARPALRPAGGSWQEArRELLEAAAAFLGAAAVLLLPPAR----ELSQPAQVLLAGLVILADWIASNED 210
|
|
| Cas3''_I |
cd09641 |
CRISPR/Cas system-associated protein Cas3''; CRISPR (Clustered Regularly Interspaced Short ... |
20-233 |
5.38e-21 |
|
CRISPR/Cas system-associated protein Cas3''; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; HD-like nuclease, specifically digesting double-stranded oligonucleotides and preferably cleaving at G:C pairs; signature gene for Type I
Pssm-ID: 193608 [Multi-domain] Cd Length: 200 Bit Score: 91.95 E-value: 5.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 20 KGNDIHLLIYHCLDVAAVAdcwwdqsVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKsaesWLKLNPATP 99
Cdd:cd09641 2 KSGPWQPLLEHLLDVAAWD-------AELAEEFARKLGLELGLSRELLALAGLLHDLGKATPAFQKY----LRGGKEALR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 100 SLNGpstqmcRKFNHGAAGLYWFNQdslseqslgdffsFFDAAPHPYESWFPWVEAVTGHHGFI--LHSQDQDKSRWEMP 177
Cdd:cd09641 71 EGKR------KEVRHSLLGALLLYE-------------LLKELGLDEELALLLAYAIAGHHGGLpdVLLLLDEDDESALK 131
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130668 178 ASLASYA------AQDKQAREEWISVLEALFLTPAGLSINDIPPDC-SSLLAGFCSLADWLGS 233
Cdd:cd09641 132 ERLEELDeeklllELWEEELEELLDELLKELLLLLLPELLSFELYLlLRLLFSLLVDADWLAS 194
|
|
| cas3_HD |
TIGR01596 |
CRISPR-associated endonuclease Cas3-HD; CRISPR/Cas systems are widespread, mobile systems for ... |
27-233 |
4.97e-16 |
|
CRISPR-associated endonuclease Cas3-HD; CRISPR/Cas systems are widespread, mobile systems for host defense against invasive elements such as phage. In these systems, Cas3 designates one of the core proteins shared widely by multiple types of CRISPR/Cas system. This model represents an HD-like endonuclease that occurs either separately or as the N-terminal region of Cas3, the helicase-containing CRISPR-associated protein.
Pssm-ID: 273711 [Multi-domain] Cd Length: 176 Bit Score: 76.86 E-value: 4.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 27 LIYHCLDVAAVADcwwdqsvVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQyksaeSWLKLNPATPSlngpst 106
Cdd:TIGR01596 1 LKEHLLDVAAVAE-------ALPALRPRLAEKLGLELRELLKLAGLLHDLGKASPAFQ-----KKLRKAEERGD------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 107 qmCRKFNHGAAGLYWFNQdslseqslgdffsFFDAAPHPYESWFPWVEAVTGHHGFILhsqDQDKSRWEMPASLASYAAQ 186
Cdd:TIGR01596 63 --RGEVRHSTLSAALLYD-------------LLEELGLEEELALLLALAIAGHHGGLI---DDDDLEELLELLERELEEA 124
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 16130668 187 DKQAREEWISVLEALFLT-PAGLSINDIPPDCSS----LLAGFCSLADWLGS 233
Cdd:TIGR01596 125 LGELLEELEELLDEVLKAlPLRLLLDKEEPIELYllarLLFGLLVDADWLAS 176
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
310-485 |
6.63e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 69.74 E-value: 6.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 310 TVIEAPTGSGKTETALAYAWKLIDQQiADSVIFALPTQATANAMLTRMEASASHlfsSPNLILAHGNSRFNHLFQSIKSR 389
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKK-GKKVLVLVPTKALALQTAERLRELFGP---GIRVAVLVGGSSAEEREKNKLGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 390 AiteqgqeeawvqccqwlsqsnkkvflgQIGVCTIDQVLISVLPVKHRFIRGLgigrSVLIVDEVHAYDT---YMNGLLE 466
Cdd:cd00046 80 A---------------------------DIIIATPDMLLNLLLREDRLFLKDL----KLIIVDEAHALLIdsrGALILDL 128
|
170
....*....|....*....
gi 16130668 467 AVLKAQADvGGSVILLSAT 485
Cdd:cd00046 129 AVRKAGLK-NAQVILLSAT 146
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
310-487 |
1.81e-13 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 70.21 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 310 TVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFssPNLILAHGNSRFNHLFQSIKSR 389
Cdd:smart00487 27 VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLG--LKVVGLYGGDSKREQLRKLESG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 390 AIteqgqeeawvqccqwlsqsnkkvflgQIGVCTIdQVLISVLPVKHRFIRGLgigrSVLIVDEVHAYDTYMNGLLEAVL 469
Cdd:smart00487 105 KT--------------------------DILVTTP-GRLLDLLENDKLSLSNV----DLVILDEAHRLLDGGFGDQLEKL 153
|
170
....*....|....*...
gi 16130668 470 KAQADVGGSVILLSATLP 487
Cdd:smart00487 154 LKLLPKNVQLLLLSATPP 171
|
|
| Cas3_Cas2_I-F |
cd09673 |
CRISPR/Cas system-associated protein Cas3/Cas2; CRISPR (Clustered Regularly Interspaced Short ... |
296-681 |
4.79e-10 |
|
CRISPR/Cas system-associated protein Cas3/Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas3/Cas2 fusion; This protein includes both DEAH and HD motifs for helicase and N-terminal domain corresponding to Cas2 RNAse; signature gene for Type I and subtype I-F
Pssm-ID: 187804 [Multi-domain] Cd Length: 1106 Bit Score: 63.74 E-value: 4.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 296 LQVLVDALPVAPGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALP----TQATANAMLTRMeasasHLfSSPNLI 371
Cdd:cd09673 416 AQKLRQKSPEQGAFGVNMASTGCGKTLANARAMYALRDDKQGARFAIALGlrslTLQTGHALKTRL-----NL-SDDDLA 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 372 LAHGNSRFNHLFQSIKSRA--ITEQGQEEA-----WVQCC---------------QWLS--QSNKKVFLGQIGVCTIDQV 427
Cdd:cd09673 490 VLIGGTAVQTLFDLSKEKIeqVDEDGSESApiflaEGQDCnlpdwdgpldtiellGRLSldDKEKTLLAAPVLVCTIDHL 569
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 428 LISVLPVK--HRFIRGLGIGRSVLIVDEVHAYDtyMNGL--LEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTD 503
Cdd:cd09673 570 IPATESHRggHHIAPMLRLMSSDLILDEPDDYE--PEDLpaLLRLVQLAGLLGSRVLLSSATLPPALVKTLFRAYEAGRQ 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 504 PVENNSAYP------LINW------RGVNGAQRFDLLAH--------PEQL---PPR-----FSIQPEPICLADMLPDL- 554
Cdd:cd09673 648 MYQALYGQPkkplniCCAWvdepqvWQADCNQKSEFIQRhqdflrdrAVQLakkPVRrlaelLSLSSLKPRNESTYLALa 727
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 555 -TMLERMIAAANAGAQ---------------VCLICNLVDVAQVCYQRLKElNNTQVDIDLFHARFTLNDRREKENR--- 615
Cdd:cd09673 728 qSLLEGALRLHQAHAQtdpksekkvsvglirVANIDPLIRLAQFLYALLAE-EKFAIHLCCYHAQDPLLLRSYIERRldq 806
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 616 ---------------VISNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHH-RKYRPAGFE 679
Cdd:cd09673 807 lltrhkpeqlfqddeIIDLMQNSPALNHLFIVLATPVEEVGRDHDYDWAIADPSSMRSIIQLAGRVNRHRlEKVQQPNIV 886
|
..
gi 16130668 680 IP 681
Cdd:cd09673 887 IL 888
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
584-670 |
1.42e-06 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 46.82 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 584 YQRLKELNntqVDIDLFHARFTLNDRREKENRVisnfgKNGKRnvgRILVATQVVEQSLDV-DFDWLITQHCPAD--LLF 660
Cdd:smart00490 4 AELLKELG---IKVARLHGGLSQEEREEILDKF-----NNGKI---KVLVATDVAERGLDLpGVDLVIIYDLPWSpaSYI 72
|
90
....*....|
gi 16130668 661 QRLGRLHRHH 670
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
311-487 |
6.17e-06 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 47.24 E-value: 6.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 311 VIEAPTGSGKTETALAYAWKLIDQQIADS-VIFALPTQATANAMLTRMEASASHLfsSPNLILAHGNSRFNHLFQSIKSr 389
Cdd:pfam00270 18 LVQAPTGSGKTLAFLLPALEALDKLDNGPqALVLAPTRELAEQIYEELKKLGKGL--GLKVASLLGGDSRKEQLEKLKG- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 390 aiteqgqeeawvqcCQWLsqsnkkvflgqigVCTIDQvLISVLPVKHRFiRGLGIgrsvLIVDEVHAYDTYMNG-LLEAV 468
Cdd:pfam00270 95 --------------PDIL-------------VGTPGR-LLDLLQERKLL-KNLKL----LVLDEAHRLLDMGFGpDLEEI 141
|
170
....*....|....*....
gi 16130668 469 LKaQADVGGSVILLSATLP 487
Cdd:pfam00270 142 LR-RLPKKRQILLLSATLP 159
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
311-460 |
1.03e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 46.51 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 311 VIEAPTGSGKTETALAYAWKLIDQQIADSVIFalptqatanamltrmeasashlfsspnliLAHGNSRFNHLFQSIKSRA 390
Cdd:pfam04851 27 LIVMATGSGKTLTAAKLIARLFKKGPIKKVLF-----------------------------LVPRKDLLEQALEEFKKFL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16130668 391 ITEQGQEEAWVQCCQWLSQSNKKVFlgqigVCTIDQVLISVLPVKHRFIRGlgiGRSVLIVDEVH--AYDTY 460
Cdd:pfam04851 78 PNYVEIGEIISGDKKDESVDDNKIV-----VTTIQSLYKALELASLELLPD---FFDVIIIDEAHrsGASSY 141
|
|
| Cas3_I |
cd09696 |
CRISPR/Cas system-associated protein Cas3; Distinct Cas3 family with HD domain fused to ... |
547-718 |
3.12e-05 |
|
CRISPR/Cas system-associated protein Cas3; Distinct Cas3 family with HD domain fused to C-termus of Helicase domain; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DNA helicase Cas3; This protein includes both DEAH and HD motifs; signature gene for Type I
Pssm-ID: 187827 [Multi-domain] Cd Length: 843 Bit Score: 47.71 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 547 LADMLPDLTMLErmiaaANAGAQVCLICNLVDVAQVCYQRLKelnntQVDIDLFHARFTLNDRRE-KENRVISNF---GK 622
Cdd:cd09696 256 LSTMVKELNLLM-----KDSGGAILVFCRTVKHVRKVFAKLP-----KEKFELLTGTLRGAERDDlVKKEIFNRFlpqML 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 623 NGKRNVGR----ILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGfeipvATILLPDGEGYGRHEH 698
Cdd:cd09696 326 SGSRARPQqgtvYLVCTSAGEVGVNISADHLVCDLAPFESMQQRFGRVNRFGELQACQI-----AVVHLDLGKDQDFDVY 400
|
170 180
....*....|....*....|
gi 16130668 699 IYSNVRVMWRTQQHIEELNG 718
Cdd:cd09696 401 GKKIDKSTWSTLKKLQQLKG 420
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
291-393 |
3.99e-04 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 42.80 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 291 YQPRQLQVLVDALpvAPGLTVIEAPTGSGKTETALayawklidqQIADSVIFALPTQATanamltrmeasashlfsspnL 370
Cdd:cd17935 6 FTPTQIEAIRSGM--QPGLTMVVGPPGTGKTDVAV---------QIISNLYHNFPNQRT--------------------L 54
|
90 100
....*....|....*....|...
gi 16130668 371 ILAHGNSRFNHLFQSIKSRAITE 393
Cdd:cd17935 55 IVTHSNQALNQLFEKIMALDIDE 77
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
554-669 |
6.10e-04 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 40.27 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 554 LTMLERMIAAANaGAQVCLICNLVDVAQVCYqrLKELNNtqVDIDLFHARFTLNDRREkenrVISNFgKNGKRNVgriLV 633
Cdd:pfam00271 3 LEALLELLKKER-GGKVLIFSQTKKTLEAEL--LLEKEG--IKVARLHGDLSQEEREE----ILEDF-RKGKIDV---LV 69
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 16130668 634 ATQVVEQSLDV---------DFDWlitqhCPADLLfQRLGRLHRH 669
Cdd:pfam00271 70 ATDVAERGLDLpdvdlvinyDLPW-----NPASYI-QRIGRAGRA 108
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
556-644 |
3.14e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 39.25 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130668 556 MLERMIAAANAGAQVCLICNLVD--------VAQVCYQRLKELNNTQVDIDLFHARFTlndRREKEnRVISNFgkngKRN 627
Cdd:cd18811 15 VYEFVREEIAKGRQAYVIYPLIEesekldlkAAVAMYEYLKERFRPELNVGLLHGRLK---SDEKD-AVMAEF----REG 86
|
90
....*....|....*..
gi 16130668 628 VGRILVATQVVEQSLDV 644
Cdd:cd18811 87 EVDILVSTTVIEVGVDV 103
|
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