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Conserved domains on  [gi|15830610|ref|NP_309383|]
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tellurium resistance protein TerE [Escherichia coli O157:H7 str. Sakai]

Protein Classification

TerD family protein( domain architecture ID 10492220)

TerD family protein similar to stress response proteins such as Bacillus subtilis general stress protein 16U and tellurium resistance proteins TerD, TerE, and TerX

CATH:  2.60.60.30
Gene Ontology:  GO:0006950
SCOP:  4006781

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TerD pfam02342
TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, ...
 1-187 3.93e-120

TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.


:

Pssm-ID: 426730  Cd Length: 187  Bit Score: 337.55  E-value: 3.93e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610     1 MAVSLVKGGNVSLTKEAPTMNVAMVGLGWDARVTDGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNR 80
Cdd:pfam02342   1 MAISLQKGQNISLTKEAPGLTKVMVGLGWDVNKTGGADFDLDASAFLLGANGKVRSDEDFVFYNNLKSPDGSVRHLGDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610    81 TGEGDGDDEQVKIDLTKVSADIKKLVFAVTIYDAEARKQNFGMVSNSFMRVYNNDNGTEIARFDLSEDASTETAMVFGEL 160
Cdd:pfam02342  81 TGEGDGDDEQIEVDLSKVPADVEKIVFVVTIYDAEARRQNFGQVRNAYIRVVDAATGEELARYDLSEDFSGETALIFGEL 160

                         170       180
                  ....*....|....*....|....*..
gi 15830610   161 YRHGTEWKFKAVGQGFAGGLSALASQH 187
Cdd:pfam02342 161 YRHGGEWKFRAVGQGYAGGLAGLATDY 187
 
Name Accession Description Interval E-value
TerD pfam02342
TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, ...
 1-187 3.93e-120

TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.


Pssm-ID: 426730  Cd Length: 187  Bit Score: 337.55  E-value: 3.93e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610     1 MAVSLVKGGNVSLTKEAPTMNVAMVGLGWDARVTDGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNR 80
Cdd:pfam02342   1 MAISLQKGQNISLTKEAPGLTKVMVGLGWDVNKTGGADFDLDASAFLLGANGKVRSDEDFVFYNNLKSPDGSVRHLGDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610    81 TGEGDGDDEQVKIDLTKVSADIKKLVFAVTIYDAEARKQNFGMVSNSFMRVYNNDNGTEIARFDLSEDASTETAMVFGEL 160
Cdd:pfam02342  81 TGEGDGDDEQIEVDLSKVPADVEKIVFVVTIYDAEARRQNFGQVRNAYIRVVDAATGEELARYDLSEDFSGETALIFGEL 160

                         170       180
                  ....*....|....*....|....*..
gi 15830610   161 YRHGTEWKFKAVGQGFAGGLSALASQH 187
Cdd:pfam02342 161 YRHGGEWKFRAVGQGYAGGLAGLATDY 187
TerZ COG2310
Stress response protein SCP2 [Signal transduction mechanisms];
1-187 8.91e-116

Stress response protein SCP2 [Signal transduction mechanisms];


Pssm-ID: 441884  Cd Length: 187  Bit Score: 326.36  E-value: 8.91e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610   1 MAVSLVKGGNVSLTKEAPTMNVAMVGLGWDARVTDGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNR 80
Cdd:COG2310   1 MAISLQKGQNISLTKEAPGLTKVRVGLGWDPAKTDGGDFDLDASAFLLDANGKVRSDEDFVFYNNLKSPDGSVRHTGDNR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610  81 TGEGDGDDEQVKIDLTKVSADIKKLVFAVTIYDAEARKQNFGMVSNSFMRVYNNDNGTEIARFDLSEDASTETAMVFGEL 160
Cdd:COG2310  81 TGEGDGDDEQITVDLSKVPADVEKIVFVVTIYDAEARGQNFGQVSNAFIRVVDAATGEELARYDLSEDFSGETAMVFGEL 160

                       170       180
                ....*....|....*....|....*..
gi 15830610 161 YRHGTEWKFKAVGQGFAGGLSALASQH 187
Cdd:COG2310 161 YRHGGEWKFRAVGQGYNGGLAGLATDY 187
TerD_like cd06974
Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; ...
 24-188 1.66e-67

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.


Pssm-ID: 132992  Cd Length: 162  Bit Score: 203.30  E-value: 1.66e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610  24 MVGLGWDARVTdGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNRTGeGDGDDEQVKIDLTKVSADIK 103
Cdd:cd06974   5 RVGLGWDPGST-GGGIDLDLSAFLLDADGKVRGDADVVFYNQLSSPDGAVRLSGDNRTG-GDGDDETITVDLDRLPPDIR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610 104 KLVFAVTIYDAearkQNFGMVSNSFMRVYNNDNGTEIARFDLSEDaSTETAMVFGELYRHGTEWKFKAVGQGFAGGLSAL 183
Cdd:cd06974  83 RIVFTVTIYEG----QPFGQVENAFVRLVDAGGNTELARYDLTED-SGETALILAELYRRNGEWKFRAVGQGFNGGLAAL 157


                ....*
gi 15830610 184 ASQHG 188
Cdd:cd06974 158 ATHYG 162
 
Name Accession Description Interval E-value
TerD pfam02342
TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, ...
 1-187 3.93e-120

TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.


Pssm-ID: 426730  Cd Length: 187  Bit Score: 337.55  E-value: 3.93e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610     1 MAVSLVKGGNVSLTKEAPTMNVAMVGLGWDARVTDGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNR 80
Cdd:pfam02342   1 MAISLQKGQNISLTKEAPGLTKVMVGLGWDVNKTGGADFDLDASAFLLGANGKVRSDEDFVFYNNLKSPDGSVRHLGDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610    81 TGEGDGDDEQVKIDLTKVSADIKKLVFAVTIYDAEARKQNFGMVSNSFMRVYNNDNGTEIARFDLSEDASTETAMVFGEL 160
Cdd:pfam02342  81 TGEGDGDDEQIEVDLSKVPADVEKIVFVVTIYDAEARRQNFGQVRNAYIRVVDAATGEELARYDLSEDFSGETALIFGEL 160

                         170       180
                  ....*....|....*....|....*..
gi 15830610   161 YRHGTEWKFKAVGQGFAGGLSALASQH 187
Cdd:pfam02342 161 YRHGGEWKFRAVGQGYAGGLAGLATDY 187
TerZ COG2310
Stress response protein SCP2 [Signal transduction mechanisms];
1-187 8.91e-116

Stress response protein SCP2 [Signal transduction mechanisms];


Pssm-ID: 441884  Cd Length: 187  Bit Score: 326.36  E-value: 8.91e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610   1 MAVSLVKGGNVSLTKEAPTMNVAMVGLGWDARVTDGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNR 80
Cdd:COG2310   1 MAISLQKGQNISLTKEAPGLTKVRVGLGWDPAKTDGGDFDLDASAFLLDANGKVRSDEDFVFYNNLKSPDGSVRHTGDNR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610  81 TGEGDGDDEQVKIDLTKVSADIKKLVFAVTIYDAEARKQNFGMVSNSFMRVYNNDNGTEIARFDLSEDASTETAMVFGEL 160
Cdd:COG2310  81 TGEGDGDDEQITVDLSKVPADVEKIVFVVTIYDAEARGQNFGQVSNAFIRVVDAATGEELARYDLSEDFSGETAMVFGEL 160

                       170       180
                ....*....|....*....|....*..
gi 15830610 161 YRHGTEWKFKAVGQGFAGGLSALASQH 187
Cdd:COG2310 161 YRHGGEWKFRAVGQGYNGGLAGLATDY 187
TerD_like cd06974
Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; ...
 24-188 1.66e-67

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.


Pssm-ID: 132992  Cd Length: 162  Bit Score: 203.30  E-value: 1.66e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610  24 MVGLGWDARVTdGQGFDLDASVFAVGEDGKVLSDAHFIFFNNKTSPDGAVEHQGDNRTGeGDGDDEQVKIDLTKVSADIK 103
Cdd:cd06974   5 RVGLGWDPGST-GGGIDLDLSAFLLDADGKVRGDADVVFYNQLSSPDGAVRLSGDNRTG-GDGDDETITVDLDRLPPDIR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610 104 KLVFAVTIYDAearkQNFGMVSNSFMRVYNNDNGTEIARFDLSEDaSTETAMVFGELYRHGTEWKFKAVGQGFAGGLSAL 183
Cdd:cd06974  83 RIVFTVTIYEG----QPFGQVENAFVRLVDAGGNTELARYDLTED-SGETALILAELYRRNGEWKFRAVGQGFNGGLAAL 157


                ....*
gi 15830610 184 ASQHG 188
Cdd:cd06974 158 ATHYG 162
TerA COG4110
Tellurium resistance protein TerA/TerD [Defense mechanisms];
3-113 3.36e-03

Tellurium resistance protein TerA/TerD [Defense mechanisms];


Pssm-ID: 443286 [Multi-domain]  Cd Length: 385  Bit Score: 37.43  E-value: 3.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15830610   3 VSLVKGGN-VSLTKEAPTMNVAMVGLGWDARVTDGQGF-----------DLDASVFAVGEDG-KVLSDAhfiFFNNKTSP 69
Cdd:COG4110 187 ITLTKAGPsISLTKQGAGFGEIRVNLNWNQRPKQKKGFlgkllggnkgiDLDLGCLYELKDGsKGVIQA---LGNAFGSL 263

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15830610  70 DGA--VEHQGDNRTGEGDGdDEQVKIDLTKvSADIKKLVFAVTIYD 113
Cdd:COG4110 264 NRPpyIQLDGDDRTGAVSG-GENLHINGDH-WDEIKRILIFAFIYE 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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