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Conserved domains on  [gi|15600532|ref|NP_254026|]
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hypothetical protein PA5339 [Pseudomonas aeruginosa PAO1]

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-125 2.33e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.06  E-value: 2.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532     3 KTVIHTDNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEG-FEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGdIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15600532    82 LSHFAKVNEIMGRYFTQPYPARAAIGVAALPKGAQVEMDAIVVL 125
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-125 2.33e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.06  E-value: 2.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532     3 KTVIHTDNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEG-FEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGdIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15600532    82 LSHFAKVNEIMGRYFTQPYPARAAIGVAALPKGAQVEMDAIVVL 125
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-126 1.81e-57

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 173.83  E-value: 1.81e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532   1 MTKTVIHTdNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLT 80
Cdd:COG0251   1 MTRELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15600532  81 DLSHFAKVNEIMGRYFTQPYPARAAIGVAALPKGAQVEMDAIVVLE 126
Cdd:COG0251  80 DMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-124 8.78e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 146.67  E-value: 8.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532    10 NAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEG-FEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKV 88
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGdVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 15600532    89 NEIMGRYFTQP-YPARAAIGVAALPKGAQVEMDAIVV 124
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-123 8.74e-46

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 143.85  E-value: 8.74e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKVNEIMGRYFT 97
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
gi 15600532  98 -QPYPARAAIGVAALPKGAQVEMDAIV 123
Cdd:cd00448  81 eGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
3-124 2.36e-30

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 105.53  E-value: 2.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532    3 KTVIHTDNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDL 82
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15600532   83 SHFAKVNEIMGRYFTQ---PYPARAAIGVAALPKGAQVEMDAIVV 124
Cdd:PRK11401  82 NDFATINEVYKQFFDEhqaTYPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-125 2.33e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.06  E-value: 2.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532     3 KTVIHTDNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEG-FEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGdIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15600532    82 LSHFAKVNEIMGRYFTQPYPARAAIGVAALPKGAQVEMDAIVVL 125
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-126 1.81e-57

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 173.83  E-value: 1.81e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532   1 MTKTVIHTdNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLT 80
Cdd:COG0251   1 MTRELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15600532  81 DLSHFAKVNEIMGRYFTQPYPARAAIGVAALPKGAQVEMDAIVVLE 126
Cdd:COG0251  80 DMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-124 8.78e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 146.67  E-value: 8.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532    10 NAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEG-FEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKV 88
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGdVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 15600532    89 NEIMGRYFTQP-YPARAAIGVAALPKGAQVEMDAIVV 124
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-123 8.74e-46

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 143.85  E-value: 8.74e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKVNEIMGRYFT 97
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
gi 15600532  98 -QPYPARAAIGVAALPKGAQVEMDAIV 123
Cdd:cd00448  81 eGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
3-124 2.36e-30

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 105.53  E-value: 2.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532    3 KTVIHTDNAPAAIGTYSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDL 82
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15600532   83 SHFAKVNEIMGRYFTQ---PYPARAAIGVAALPKGAQVEMDAIVV 124
Cdd:PRK11401  82 NDFATINEVYKQFFDEhqaTYPTRSCVQVARLPKDVKLEIEAIAV 126
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 18-125 6.29e-24

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 88.47  E-value: 6.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKtMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDL-SHFAKVNEIMGRYF 96
Cdd:cd02198   3 YSPAVRVGDTLFVSGQVGSDAD-GSVAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDEYF 81

                        90       100       110
                ....*....|....*....|....*....|
gi 15600532  97 TQPYPARAAIGVAAL-PKGAQVEMDAIVVL 125
Cdd:cd02198  82 KEPYPAWTAVGVAWLaRPGLLVEIKVVAVR 111
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-122 4.35e-22

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 84.14  E-value: 4.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKVNEIMGRYFT 97
Cdd:cd06154  13 YSRAVRVGNWVFVSGTTGYDYDGMVMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVFG 92

                        90       100
                ....*....|....*....|....*.
gi 15600532  98 QPYPARAAIGVAALPK-GAQVEMDAI 122
Cdd:cd06154  93 DIRPAATMVVVSLLVDpEMLVEIEVT 118
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-124 9.41e-15

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 64.87  E-value: 9.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKtmelvEGFEEQTVQVFENLKAVIEASGGylhDVAKL---NIFLTDLSHFAKVNEIMGR 94
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVADDTS-----ADITGQTRQVLAKIDALLAEAGS---DKSRIlsaTIWLADMADFAAMNAVWDA 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 15600532  95 YFTQPY-PARAAIGVAALPKGAQVEMDAIVV 124
Cdd:cd06150  75 WVPPGHaPARACVEAKLADPGYLVEIVVTAA 105
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-112 1.15e-14

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 65.02  E-value: 1.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKTMELVEGFEEQTVQVFENLKAVIEASGGY-LHDVAKLNIFLTDLSHfAKVNEIMGRYF 96
Cdd:cd06152   3 YSQAVRIGDRIEISGQGGWDPDTGKIPEDLEEEIDQAFDNVELALKAAGGKgWEQVYKVNSYHVDIKN-EEAFGLMVENF 81

                        90       100
                ....*....|....*....|
gi 15600532  97 TQPYPARA----AIGVAALP 112
Cdd:cd06152  82 KKWMPNHQpiwtCVGVTALG 101
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 22-123 5.41e-14

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 62.66  E-value: 5.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  22 IKAGNTVYVSGQipldpKTMELVEGFEEQTVQVFENLKAVIEASGGYLHDVAKLNIFLTDLSHFAKVNEIMGRYFTQPYP 101
Cdd:cd06155   4 NRTGGLLWISNV-----TASESDETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNP 78

                        90       100
                ....*....|....*....|...
gi 15600532 102 -ARAAIGvAALPKGAQVEMDAIV 123
Cdd:cd06155  79 pSRVCVE-CGLPEGCDVQLSCVA 100
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 18-118 2.46e-11

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 56.57  E-value: 2.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  18 YSQAIKAGNTVYVSGQIPLDPKTMELVE-GFEEQTVQVFENLKAVIEASGgyLHDVAKLNIFLTDLSH-------FAKVN 89
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLIPATMTLLEgGITLQAVLSLQHLERVAKAMN--VQWVLAAVCYVTDESSvpiarsaWSKYC 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15600532  90 EIMGRYFTQPYPARAAIG------VAALPKGAQVE 118
Cdd:cd06156  79 SELDLEDESRNESDDVNPplvivvVPELPRGALVE 113
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 11-123 6.42e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 53.23  E-value: 6.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  11 APAAIGTYSQAIKAGNTVYVSGQIPLD----------PKTMELVEGFEEqTVQVFENLKAVIEASGGYLHDVA---KLNI 77
Cdd:cd02199   9 APAPVGNYVPAVRTGNLLYVSGQLPRVdgklvytgkvGADLSVEEGQEA-ARLCALNALAALKAALGDLDRVKrvvRLTG 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15600532  78 FLTDLSHF---AKV--------NEIMGRyftQPYPARAAIGVAALPKGAQVEMDAIV 123
Cdd:cd02199  88 FVNSAPDFteqPKVangasdllVEVFGE---AGRHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 27-122 7.09e-05

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 39.61  E-value: 7.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  27 TVYVSGQIP--LDPK-TMELVEGF---EEQTVQVFENLKAVIEASGGYLHDVAKLNIFL------TDLSHFAKVNEIMGR 94
Cdd:cd06151  13 TIYLSGTVPavVNASaPKGSPARYgdtETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGKMDFAGFMKAYRQ 92

                        90       100       110
                ....*....|....*....|....*....|...
gi 15600532  95 YF---TQP-YPARAAIGVAALPK-GAQVEMDAI 122
Cdd:cd06151  93 FFgtaEQPnKPARSTLQVAGLVNpGWLVEIEVV 125
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 21-102 6.24e-03

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 34.15  E-value: 6.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15600532  21 AIKAGNTVYVSGQIPLDPKTmELVEG-FEEQTVQVFENLKAVIEA-----SGGYLHDVAKLNIFLTDLSHFAKVNEIMGR 94
Cdd:cd06153   8 AAGGRTHLFISGTASIVGHG-TVHPGdVEAQTRETLENIEALLEAagrggGAQFLADLLRLKVYLRDREDLPAVRAILAA 86


                ....*...
gi 15600532  95 YFTQPYPA 102
Cdd:cd06153  87 RLGPAVPA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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