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Conserved domains on  [gi|15600262|ref|NP_253756|]
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sec-independent translocase [Pseudomonas aeruginosa PAO1]

Protein Classification

Sec-independent protein translocase family protein( domain architecture ID 241)

Sec-independent protein translocase family protein such as Sec-independent protein translocase proteins TatA and TatB, which are part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes

Gene Ontology:  GO:0033281|GO:0043953

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TatA_B_E super family cl00788
mttA/Hcf106 family; Members of this protein family are involved in a sec independent ...
 2-72 4.51e-15

mttA/Hcf106 family; Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.


The actual alignment was detected with superfamily member TIGR01410:

Pssm-ID: 445098 [Multi-domain]  Cd Length: 80  Bit Score: 65.41  E-value: 4.51e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600262     2 FGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSME 72
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFL 71
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-72 4.51e-15

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 65.41  E-value: 4.51e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600262     2 FGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSME 72
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFL 71
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-76 6.65e-14

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 65.60  E-value: 6.65e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15600262    1 MFGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSMEREAQ 76
Cdd:PRK04654   1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSLQDVQASLREAEDQ 76
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 22-62 1.62e-07

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 45.70  E-value: 1.62e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15600262  22 PERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQ 62
Cdd:COG1826  22 PKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKS 62
 
Name Accession Description Interval E-value
tatB TIGR01410
twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a ...
 2-72 4.51e-15

twin arginine-targeting protein translocase TatB; This model represents the TatB protein of a Sec-independent system for transporting folded proteins, often with a bound redox cofactor, across the bacterial inner membrane. TatC is the multiple membrane spanning component. TatB, like the related TatA/E proteins, appears to span the membrane one time. The tat system recognizes proteins with an elongated signal sequence containing a conserved R-R in a motif approximated by RRxFLK N-terminal to the transmembrane helix. TIGRFAMs model TIGR01409 describes this twin-Arg signal sequence. A similar system, termed Delta-pH-dependent transport, operates on chloroplast-encoded proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130477 [Multi-domain]  Cd Length: 80  Bit Score: 65.41  E-value: 4.51e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15600262     2 FGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSME 72
Cdd:TIGR01410   1 FDIGFSELLLIAVVALVVLGPERLPVAIRTVGGFVRALRGMASDVKNELDEELKLQELDDQLKKAQQARFL 71
PRK04654 PRK04654
sec-independent translocase; Provisional
 1-76 6.65e-14

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 65.60  E-value: 6.65e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15600262    1 MFGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSMEREAQ 76
Cdd:PRK04654   1 MFDIGVGELTLIAVVALVVLGPERLPKAARFAGLWVRRARMQWDSVKQELERELEAEELKRSLQDVQASLREAEDQ 76
TatA COG1826
Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, ...
 22-62 1.62e-07

Twin-arginine protein secretion pathway components TatA and TatB [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441431 [Multi-domain]  Cd Length: 72  Bit Score: 45.70  E-value: 1.62e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15600262  22 PERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQ 62
Cdd:COG1826  22 PKKLPELARSLGKAIREFKKAANEVKEELDEELKEEELRKS 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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