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Conserved domains on  [gi|15599971|ref|NP_253465|]
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two-component regulator system signal sensor kinase PmrB [Pseudomonas aeruginosa PAO1]

Protein Classification

sensor histidine kinase family protein( domain architecture ID 1004179)

sensor histidine kinase family protein may be part of a two-component regulatory system and may function as a protein kinase that phosphorylates a target protein in response to various signals; similar to Haemophilus influenzae sensor protein QseC

Gene Ontology:  GO:0007165
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10337 super family cl32501
sensor protein QseC; Provisional
 1-434 1.62e-61

sensor protein QseC; Provisional


The actual alignment was detected with superfamily member PRK10337:

Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 207.19  E-value: 1.62e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971    1 MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFgeaALRLLDLatedqagedgSITEIIERS 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLF---AKRLSTL----------DLNELNAPD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   81 REAiQGLPLLRR----ESALGYALW-RDGQPLL----SSLNLPpeITAQGPGFSTVEAQGTH--WRVLQLNI-DG-FQIW 147
Cdd:PRK10337  68 RMA-QTPKKLKHghvdDDALAFAIFtRDGKMVLndgdNGEDIP--YSYQREGFADGQLVGDDdlWRFVWLTSpDGkYRIV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  148 ISENLIYRQHtMNLLLFYSLFPLLLALPLLGGLVWFG-VARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDEL 226
Cdd:PRK10337 145 VGQEWEYRED-MALAIVAGQLIPWLVALPIMLIILMVlLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEAL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  227 NLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVA-LRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDA 305
Cdd:PRK10337 224 NQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  306 LLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYVM--GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAq 383
Cdd:PRK10337 304 NLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIrtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN- 382

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15599971  384 havLRVRDNGPGVALEEQQAIFTRFYRSPATSSgEGSGLGLPIVKRIVELH 434
Cdd:PRK10337 383 ---FTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLH 429
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 1-434 1.62e-61

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 207.19  E-value: 1.62e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971    1 MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFgeaALRLLDLatedqagedgSITEIIERS 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLF---AKRLSTL----------DLNELNAPD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   81 REAiQGLPLLRR----ESALGYALW-RDGQPLL----SSLNLPpeITAQGPGFSTVEAQGTH--WRVLQLNI-DG-FQIW 147
Cdd:PRK10337  68 RMA-QTPKKLKHghvdDDALAFAIFtRDGKMVLndgdNGEDIP--YSYQREGFADGQLVGDDdlWRFVWLTSpDGkYRIV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  148 ISENLIYRQHtMNLLLFYSLFPLLLALPLLGGLVWFG-VARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDEL 226
Cdd:PRK10337 145 VGQEWEYRED-MALAIVAGQLIPWLVALPIMLIILMVlLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEAL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  227 NLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVA-LRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDA 305
Cdd:PRK10337 224 NQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  306 LLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYVM--GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAq 383
Cdd:PRK10337 304 NLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIrtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN- 382

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15599971  384 havLRVRDNGPGVALEEQQAIFTRFYRSPATSSgEGSGLGLPIVKRIVELH 434
Cdd:PRK10337 383 ---FTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLH 429
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
136-438 2.85e-60

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 200.52  E-value: 2.85e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 136 VLQLNIDGFQIWISENLIYRQHTMNLLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEAV 215
Cdd:COG0642   2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 216 PLEIRGLIDELNLLLERLRTALE----AERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHaRGLLQVSRSVERISTL 291
Cdd:COG0642  82 LLLLLLLLLLLLLLLLALLLLLEeaneAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR-EYLETILRSADRLLRL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 292 MEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGNALRYTP 369
Cdd:COG0642 161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599971 370 AGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG0642 241 EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTI 309
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 340-438 9.33e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 154.87  E-value: 9.33e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 340 HQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAqHAVLRVRDNGPGVALEEQQAIFTRFYRSPATsSGEG 419
Cdd:cd16940   1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYRSDGQ-NYGG 78

                        90
                ....*....|....*....
gi 15599971 420 SGLGLPIVKRIVELHFGSI 438
Cdd:cd16940  79 SGLGLSIVKRIVELHGGQI 97
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 182-438 1.16e-39

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 148.69  E-value: 1.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   182 WFGVARGLAPLREVQAEVQQRSARHL-QPIAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRT 260
Cdd:TIGR01386 182 WWITRLGLEPLRRLSAVAARISPESLdQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLG 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   261 HAQVALRSEDPKAHARGLLQVS-RSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSL 339
Cdd:TIGR01386 262 QTQVALSQPRTGEEYREVLESNlEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   340 HQETVyVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPA--TSSG 417
Cdd:TIGR01386 342 EGEGL-VRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDParSNSG 420

                         250       260
                  ....*....|....*....|.
gi 15599971   418 EGSGLGLPIVKRIVELHFGSI 438
Cdd:TIGR01386 421 EGTGLGLAIVRSIMEAHGGRA 441
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 348-438 5.38e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 110.05  E-value: 5.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971    348 GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR-SPATSSGEGSGLGLPI 426
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRtDKRSRKIGGTGLGLSI 80

                           90
                   ....*....|..
gi 15599971    427 VKRIVELHFGSI 438
Cdd:smart00387  81 VKKLVELHGGEI 92
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 348-438 2.47e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.05  E-value: 2.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   348 GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVEnRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSpATSSGEGSGLGLPIV 427
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTA-DKRGGGGTGLGLSIV 78

                          90
                  ....*....|.
gi 15599971   428 KRIVELHFGSI 438
Cdd:pfam02518  79 RKLVELLGGTI 89
AdeS_HK NF012226
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ...
 248-438 1.09e-14

two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.


Pssm-ID: 411090 [Multi-domain]  Cd Length: 353  Bit Score: 75.03  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  248 AHEIRTPLASLRTHAQVALR---SEDPKAHARGLLQvsrsVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLs 324
Cdd:NF012226 146 AHELRTPITILQGRLQGILDgvfEPDPALFKSLLNQ----VEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVL- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  325 ELARQAIDK---DIELSLHQETVY--VMGIDLWLKAmvgnLVGNALRYTPAgGQVEIRVENRAQHAVLRVRDNGPGVALE 399
Cdd:NF012226 221 KMFEDRLEQaqlTIVLNLTATPVFcdRRRIEQVLIA----LIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEE 295

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 15599971  400 EQQAIFTRFYRSPATSSGE--GSGLGLPIVKRIVELHFGSI 438
Cdd:NF012226 296 YQQDLFNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSI 336
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 236-432 7.18e-04

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 41.73  E-value: 7.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  236 ALEAERRLT------SDAAHEIRTPLAslrTHAQVAlrsedpKAHARGLLQVSRSVERISTLMEQ------IL-LLARL- 301
Cdd:NF033792 192 VLAREQHLSaldglaAAAAHELGTPLA---TIALVA------KELERELPDDPPLREDAELLRSQaercrdILrRLTSLg 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  302 -DGDALLEQfhpVNLATLAEDVLSELarQAIDKDIELSLHQETV---YVMGIDLWLKAMvGNLVGNALRYtpAGGQVEIR 377
Cdd:NF033792 263 eEGDAHLDR---LPLSALIEEAAAPH--RGFGKEIEVVVAGDPGeepVIRRNPEILYGL-GNLIENAVDF--ARSTVTVT 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599971  378 VENRAQHAVLRVRDNGPGVAleeqQAIFTRF---Y-----RSPATSSGEGSGLGLPIVKRIVE 432
Cdd:NF033792 335 ASWDAESVTITIEDDGPGFP----PDVLSRIgepYvttrrGEERRPGGGGLGLGLFIAKTLLE 393
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 1-434 1.62e-61

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 207.19  E-value: 1.62e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971    1 MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFgeaALRLLDLatedqagedgSITEIIERS 80
Cdd:PRK10337   1 MKFTQRLSLRVRLTLIFLILASITWLLSSFVAWKQTTDNVDELFDTQQMLF---AKRLSTL----------DLNELNAPD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   81 REAiQGLPLLRR----ESALGYALW-RDGQPLL----SSLNLPpeITAQGPGFSTVEAQGTH--WRVLQLNI-DG-FQIW 147
Cdd:PRK10337  68 RMA-QTPKKLKHghvdDDALAFAIFtRDGKMVLndgdNGEDIP--YSYQREGFADGQLVGDDdlWRFVWLTSpDGkYRIV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  148 ISENLIYRQHtMNLLLFYSLFPLLLALPLLGGLVWFG-VARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDEL 226
Cdd:PRK10337 145 VGQEWEYRED-MALAIVAGQLIPWLVALPIMLIILMVlLGRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEAL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  227 NLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVA-LRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDA 305
Cdd:PRK10337 224 NQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  306 LLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYVM--GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAq 383
Cdd:PRK10337 304 NLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIrtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN- 382

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15599971  384 havLRVRDNGPGVALEEQQAIFTRFYRSPATSSgEGSGLGLPIVKRIVELH 434
Cdd:PRK10337 383 ---FTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLH 429
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
136-438 2.85e-60

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 200.52  E-value: 2.85e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 136 VLQLNIDGFQIWISENLIYRQHTMNLLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEAV 215
Cdd:COG0642   2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 216 PLEIRGLIDELNLLLERLRTALE----AERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHaRGLLQVSRSVERISTL 291
Cdd:COG0642  82 LLLLLLLLLLLLLLLLALLLLLEeaneAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR-EYLETILRSADRLLRL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 292 MEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGNALRYTP 369
Cdd:COG0642 161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599971 370 AGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG0642 241 EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTI 309
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
236-438 2.47e-54

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 182.03  E-value: 2.47e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 236 ALEAERRLTSDAAHEIRTPLASLRTHAQVALRSED--PKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPV 313
Cdd:COG2205  12 LERLKSEFLANVSHELRTPLTSILGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPV 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 314 NLATLAEDVLSELARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRD 391
Cdd:COG2205  92 DLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSD 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15599971 392 NGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG2205 172 NGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTI 218
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
135-438 2.99e-54

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 186.68  E-value: 2.99e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 135 RVLQLNIDGFQIWISENLIYRQHTMNLLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEA 214
Cdd:COG5002  53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 215 VPLEIRGLIDELNLLLERLRTALEAERRL-------TSDAAHEIRTPLASLRTHAQVALRS--EDPKAHARGLLQVSRSV 285
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVERDITELERLeqmrrefVANVSHELRTPLTSIRGYLELLLDGaaDDPEERREYLEIILEEA 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 286 ERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGN 363
Cdd:COG5002 213 ERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDlpEDPLLVLGDPDRLEQVLTNLLDN 292

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599971 364 ALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPA--TSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG5002 293 AIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKsrSRETGGTGLGLAIVKHIVEAHGGRI 369
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 340-438 9.33e-46

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 154.87  E-value: 9.33e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 340 HQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAqHAVLRVRDNGPGVALEEQQAIFTRFYRSPATsSGEG 419
Cdd:cd16940   1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYRSDGQ-NYGG 78

                        90
                ....*....|....*....
gi 15599971 420 SGLGLPIVKRIVELHFGSI 438
Cdd:cd16940  79 SGLGLSIVKRIVELHGGQI 97
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 182-438 1.16e-39

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 148.69  E-value: 1.16e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   182 WFGVARGLAPLREVQAEVQQRSARHL-QPIAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRT 260
Cdd:TIGR01386 182 WWITRLGLEPLRRLSAVAARISPESLdQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLG 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   261 HAQVALRSEDPKAHARGLLQVS-RSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSL 339
Cdd:TIGR01386 262 QTQVALSQPRTGEEYREVLESNlEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   340 HQETVyVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPA--TSSG 417
Cdd:TIGR01386 342 EGEGL-VRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDParSNSG 420

                         250       260
                  ....*....|....*....|.
gi 15599971   418 EGSGLGLPIVKRIVELHFGSI 438
Cdd:TIGR01386 421 EGTGLGLAIVRSIMEAHGGRA 441
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
191-459 6.26e-36

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 136.25  E-value: 6.26e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  191 PLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVALRSed 270
Cdd:PRK10755  88 PLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQ-- 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  271 pkaharGLLQVSRSVERISTLM---EQILLLARLDGDALLEQFHPVNLA----TLAEDVLSELARQAiDKDIELSLHQET 343
Cdd:PRK10755 166 ------HHIDVAPLIARLDQMMhtvEQLLQLARAGQSFSSGHYQTVKLLedviLPSQDELSEMLEQR-QQTLLLPESAAD 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  344 VYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRspATSSGEGSGLG 423
Cdd:PRK10755 239 ITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVR--MDSRYGGIGLG 316

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 15599971  424 LPIVKRIVELHFGSIGLGKGLEGKGLEVQVFLPKTQ 459
Cdd:PRK10755 317 LSIVSRITQLHHGQFFLQNRQERSGTRAWVWLPKAQ 352
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 248-438 2.56e-32

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 128.42  E-value: 2.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  248 AHEIRTPLASLRTHAQVaLRSEDPKAHARGLL-QVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSEL 326
Cdd:PRK11100 264 THELKSPLAAIRGAAEL-LQEDPPPEDRARFTgNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  327 ARQAIDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGV---ALEEqqa 403
Cdd:PRK11100 343 EAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIpdyALPR--- 419

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15599971  404 IFTRFYRSPATSSGE-GSGLGLPIVKRIVELHFGSI 438
Cdd:PRK11100 420 IFERFYSLPRPANGRkSTGLGLAFVREVARLHGGEV 455
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 1-438 5.48e-32

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 127.98  E-value: 5.48e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   1 MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFGEAALRLLDLATEDQAGEDGSITEIIERS 80
Cdd:COG4251  26 LVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  81 REAIQGLPLLRRESALGYALWRDGQPLLSSLNLPPEITAQGPGFSTVEAQGTHWRVLQLNIDGFQIWISENLIYRQHTMN 160
Cdd:COG4251 106 LLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLL 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 161 LLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDELNLLLERLRTALEAE 240
Cdd:COG4251 186 LVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELE 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 241 RRL-----------------TSDAAHEIRTPLASLRTHAQVALRSEDPK--AHARGLLQ-VSRSVERISTLMEQILLLAR 300
Cdd:COG4251 266 EELeertaelersneeleqfAYVASHDLREPLRKISGFSQLLEEDYGDKldEEGREYLErIRDAAERMQALIDDLLAYSR 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 301 LDGDALleQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVyVMGIDLWLKAMVGNLVGNALRYTPAG--GQVEIRV 378
Cdd:COG4251 346 VGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT-VRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGA 422

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 379 ENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG4251 423 EREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRI 482
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 353-438 2.66e-30

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 113.47  E-value: 2.66e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVE 432
Cdd:cd00075   1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80


                ....*.
gi 15599971 433 LHFGSI 438
Cdd:cd00075  81 AHGGRI 86
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 241-438 4.36e-30

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 121.22  E-value: 4.36e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 241 RRLtsdaAHEIRTPLASLRTHAQVALR------SEDPKAHARGLLQVSRSVERISTLMEQILLLARLDgdalLEQFHPVN 314
Cdd:COG5000 206 RRI----AHEIKNPLTPIQLSAERLRRkladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVD 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 315 LATLAEDVLSELARQAIDKDIEL--SLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDN 392
Cdd:COG5000 278 LNELLREVLALYEPALKEKDIRLelDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDN 357

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 15599971 393 GPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG5000 358 GPGIPEEVLERIFEPFF----TTKPKGTGLGLAIVKKIVEEHGGTI 399
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
236-438 2.39e-29

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 118.03  E-value: 2.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 236 ALEAERRLTSDAAHEIRTPLASLRTHAQVaLRSEDPKAHARGLLQVS-RSVERISTLMEQILLLARLDgdalLEQFHPVN 314
Cdd:COG3852 131 KLAAVGELAAGLAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIiEEADRLNNLVDRLLSFSRPR----PPEREPVN 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 315 LATLAEDVLsELARQAIDKDIELSLHQETvyvmgiDLW--------LKAMVGNLVGNALRYTPAGGQVEIRVENRAQ--- 383
Cdd:COG3852 206 LHEVLERVL-ELLRAEAPKNIRIVRDYDP------SLPevlgdpdqLIQVLLNLVRNAAEAMPEGGTITIRTRVERQvtl 278

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599971 384 -------HAVLRVRDNGPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG3852 279 gglrprlYVRIEVIDNGPGIPEEILDRIFEPFF----TTKEKGTGLGLAIVQKIVEQHGGTI 336
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 348-438 5.38e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 110.05  E-value: 5.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971    348 GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR-SPATSSGEGSGLGLPI 426
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRtDKRSRKIGGTGLGLSI 80

                           90
                   ....*....|..
gi 15599971    427 VKRIVELHFGSI 438
Cdd:smart00387  81 VKKLVELHGGEI 92
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 242-438 7.52e-28

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 114.13  E-value: 7.52e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 242 RLTSDAAHEIRTPLASLRTHAQVALR----SEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGdallEQFHPVNLAT 317
Cdd:COG4191 144 ELAAGIAHEINNPLAAILGNAELLRRrledEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNE 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 318 LAEDVLSELARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGNALRYTP--AGGQVEIRVENRAQHAVLRVRDNG 393
Cdd:COG4191 220 LIDEALELLRPRLKARGIEVELDlpPDLPPVLGDPGQLEQVLLNLLINAIDAMEegEGGRITISTRREGDYVVISVRDNG 299

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 15599971 394 PGVALEEQQAIFTRFYrspaT--SSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG4191 300 PGIPPEVLERIFEPFF----TtkPVGKGTGLGLSISYGIVEKHGGRI 342
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
181-438 3.72e-27

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 113.71  E-value: 3.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  181 VWFGVARGLAPLREVQAEVQQRSARHLQP-IAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLR 259
Cdd:PRK09835 202 VLLAVHKGHAPIRSVSRQIQNITSKDLDVrLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLI 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  260 THAQVAL-RSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELS 338
Cdd:PRK09835 282 TQTEIALsQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELR 361

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  339 LHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR-SPATS-S 416
Cdd:PRK09835 362 FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRvDPSRQrK 441

                        250       260
                 ....*....|....*....|..
gi 15599971  417 GEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK09835 442 GEGSGIGLAIVKSIVVAHKGTV 463
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
241-438 9.01e-25

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 106.64  E-value: 9.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  241 RRLTSDAAHEIRTPLASLRTH---AQVALRSEDPKAHARglLQVSrsVERISTLMEQILLLARLDGDALLEQFHPVNLAT 317
Cdd:PRK10549 241 RDFMADISHELRTPLAVLRGEleaIQDGVRKFTPESVAS--LQAE--VGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVP 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  318 LAEDVLSELARQAIDKDIELSLH-QETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGV 396
Cdd:PRK10549 317 LLEVAGGAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGV 396

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15599971  397 ALEEQQAIFTRFYRSPAT---SSGeGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK10549 397 SDEQLQKLFERFYRTEGSrnrASG-GSGLGLAICLNIVEAHNGRI 440
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 248-438 1.43e-24

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 106.21  E-value: 1.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 248 AHEIRTPLASLRTHAQVaLRSEDPKAHARgLLQVSRS-VERISTLMEQILLLARLDGdallEQFHPVNLATLAEDVLSEL 326
Cdd:COG5809 278 AHEIRNPLTSLKGFIQL-LKDTIDEEQKT-YLDIMLSeLDRIESIISEFLVLAKPQA----IKYEPKDLNTLIEEVIPLL 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 327 ARQAIDKDIELSLH--QETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAV-LRVRDNGPGVALEEQQA 403
Cdd:COG5809 352 QPQALLKNVQIELEleDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVvISVTDEGCGIPEERLKK 431

                       170       180       190
                ....*....|....*....|....*....|....*
gi 15599971 404 IFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG5809 432 LGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKI 462
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 348-438 2.47e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.05  E-value: 2.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   348 GIDLWLKAMVGNLVGNALRYTPAGGQVEIRVEnRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSpATSSGEGSGLGLPIV 427
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTA-DKRGGGGTGLGLSIV 78

                          90
                  ....*....|.
gi 15599971   428 KRIVELHFGSI 438
Cdd:pfam02518  79 RKLVELLGGTI 89
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
239-438 1.31e-23

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 103.89  E-value: 1.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  239 AER-----RLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARldgdALLEQFHPV 313
Cdd:PRK11360 384 QERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPV 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  314 NLATLAEDVLsELARQAIDKD---IELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQ-HAVLRV 389
Cdd:PRK11360 460 SLNALVEEVL-QLFQTAGVQArvdFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSI 538

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 15599971  390 RDNGPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFF----TTKAKGTGLGLALSQRIINAHGGDI 583
PRK10604 PRK10604
sensor protein RstB; Provisional
 236-438 7.02e-22

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 97.75  E-value: 7.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  236 ALEAERRLTSDA-AHEIRTPLASLRTHAQValrSEDPKAHARGLLQvsRSVERISTLMEQILLLARLDGDALLEQFHPVN 314
Cdd:PRK10604 207 ALIASKKQLIDGiAHELRTPLVRLRYRLEM---SDNLSAAESQALN--RDIGQLEALIEELLTYARLDRPQNELHLSEPD 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  315 LATLAEDVLSELARQAIDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYtpAGGQVEIRVENRAQHAVLRVRDNGP 394
Cdd:PRK10604 282 LPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGP 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 15599971  395 GVALEEQQAIFTRFYR---SPATSSGeGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK10604 360 GIPPEERERVFEPFVRldpSRDRATG-GCGLGLAIVHSIALAMGGSV 405
PRK09303 PRK09303
histidine kinase;
237-438 2.76e-21

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 95.40  E-value: 2.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRLTSDAAHEIRTPLaslrTHAQVALRS----------EDPKAHARGLLQVSRS-VERISTLMEQILLLARLDGDA 305
Cdd:PRK09303 148 LKFKDRVLAMLAHDLRTPL----TAASLALETlelgqidedtELKPALIEQLQDQARRqLEEIERLITDLLEVGRTRWEA 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  306 LleQFHP--VNLATLAEDVLSELA------RQAIDKDIELSLhqETVYVMGiDLWLKAMVgNLVGNALRYTPAGGQVEIR 377
Cdd:PRK09303 224 L--RFNPqkLDLGSLCQEVILELEkrwlakSLEIQTDIPSDL--PSVYADQ-ERIRQVLL-NLLDNAIKYTPEGGTITLS 297

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599971  378 VENRAQHAV-LRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK09303 298 MLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQI 359
envZ PRK09467
osmolarity sensor protein; Provisional
 237-438 9.47e-20

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 91.13  E-value: 9.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRL-TSDAAHEIRTPLASLRThAQVALRSEDpkaharGLLQVS--RSVERISTLMEQILLLARLDGDallEQFHPV 313
Cdd:PRK09467 225 LEDDRTLlMAGVSHDLRTPLTRIRL-ATEMMSEED------GYLAESinKDIEECNAIIEQFIDYLRTGQE---MPMEMA 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  314 NLATLAEDVLSelARQAIDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTpaGGQVEIRVENRAQHAVLRVRDNG 393
Cdd:PRK09467 295 DLNALLGEVIA--AESGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDG 370

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15599971  394 PGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK09467 371 PGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKV 415
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
237-434 2.18e-19

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 90.07  E-value: 2.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERR-LTSDAAHEIRTPLASLR-----THAQVALRSEDPKAHarGLLQvsRSVERISTLMEQILLLARLDGDALLEQF 310
Cdd:PRK11006 200 LEGARRnFFANVSHELRTPLTVLQgylemMQDQPLEGALREKAL--HTMR--EQTQRMEGLVKQLLTLSKIEAAPTIDLN 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  311 HPVNLATLAEDV------LSElARQAIDKDIELSLHqetvyVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQH 384
Cdd:PRK11006 276 EKVDVPMMLRVLereaqtLSQ-GKHTITFEVDNSLK-----VFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQG 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15599971  385 AVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGE--GSGLGLPIVKRIVELH 434
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQtgGSGLGLAIVKHALSHH 401
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 353-438 6.47e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 81.77  E-value: 6.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAGgQVEIRV---ENRAQHAVLR--VRDNGPGVALEEQQAIFTRFYR--SPATSSGEGSGLGLP 425
Cdd:cd16922   1 LRQILLNLLGNAIKFTEEG-EVTLRVsleEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQadSSTTRKYGGTGLGLA 79

                        90
                ....*....|...
gi 15599971 426 IVKRIVELHFGSI 438
Cdd:cd16922  80 ISKKLVELMGGDI 92
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 1.21e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 80.83  E-value: 1.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYTPagGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR--SPATSSGEGSGLGLPIVKRIVELHFG 436
Cdd:cd16949   7 NVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRvdSARDRESGGTGLGLAIAERAIEQHGG 84


                ..
gi 15599971 437 SI 438
Cdd:cd16949  85 KI 86
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 248-438 1.40e-18

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 88.25  E-value: 1.40e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 248 AHEIRTPLASLRTHAQVALRSEDPKAHargLLQVSRS-VERISTLMEQILLLARLDGDalleQFHPVNLATLAEDVLSEL 326
Cdd:COG5805 295 AHEIRNPLTSIKGFLQLLQPGIEDKEE---YFDIMLSeLDRIESIISEFLALAKPQAV----NKEKENINELIQDVVTLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 327 ARQAIDKDIELSLHQ--ETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAI 404
Cdd:COG5805 368 ETEAILHNIQIRLELldEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447

                       170       180       190
                ....*....|....*....|....*....|....
gi 15599971 405 FTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG5805 448 GEPFF----TTKEKGTGLGLMVSYKIIENHNGTI 477
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-438 5.33e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 79.43  E-value: 5.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR---SPATSSGeGSGLGLPIVKR 429
Cdd:cd16946   5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRvesSRNRASG-GSGLGLAICHN 83


                ....*....
gi 15599971 430 IVELHFGSI 438
Cdd:cd16946  84 IALAHGGTI 92
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-438 7.94e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 78.64  E-value: 7.94e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYtpAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVE 432
Cdd:cd16950   1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78


                ....*.
gi 15599971 433 LHFGSI 438
Cdd:cd16950  79 AHGGSL 84
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
237-438 2.23e-16

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 81.13  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRLTSDAAHEIRTPLASLRTHAQVALR--SEDPKahargLLQVSRSVERISTLMEQILLLARLDGD-ALLEQFHPV 313
Cdd:PRK09470 240 MTSQQRLLSDISHELRTPLTRLQLATALLRRrqGESKE-----LERIETEAQRLDSMINDLLVLSRNQQKnHLERETFKA 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  314 NlaTLAEDVLSELARQA--IDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENraQHAVLRVRD 391
Cdd:PRK09470 315 N--SLWSEVLEDAKFEAeqMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDK--DGLTITVDD 390

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 15599971  392 NGPGVALEEQQAIFTRFYRSPAT---SSGeGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK09470 391 DGPGVPEEEREQIFRPFYRVDEArdrESG-GTGLGLAIVENAIQQHRGWV 439
PRK10490 PRK10490
sensor protein KdpD; Provisional
 237-438 2.63e-16

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 82.01  E-value: 2.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERR-----LTSDAAHEIRTPLASLRTHAQV---ALRSEDPKaHARGLLQVSRSVERISTLMEQILLLARL--DGDAL 306
Cdd:PRK10490 656 LASEREqlrnaLLAALSHDLRTPLTVLFGQAEIltlDLASEGSP-HARQASEIRQQVLNTTRLVNNLLDMARIqsGGFNL 734

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  307 LEQFHPvnLATLAEDVLSELARQAIDKDIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAV 386
Cdd:PRK10490 735 RKEWLT--LEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQ 812

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15599971  387 LRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK10490 813 LDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTI 864
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 352-438 4.86e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 73.65  E-value: 4.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 352 WLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGS-GLGLPIVKRI 430
Cdd:cd16945   4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKStGLGLAFVQEV 83


                ....*...
gi 15599971 431 VELHFGSI 438
Cdd:cd16945  84 AQLHGGRI 91
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 356-438 1.22e-15

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 72.91  E-value: 1.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 356 MVGNLVGNALRYTPAGGQVEIRVE-NRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGE--GSGLGLPIVKRIVE 432
Cdd:cd16925   8 VVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAhgGTGLGLSIVKEFVE 87


                ....*.
gi 15599971 433 LHFGSI 438
Cdd:cd16925  88 LHGGTV 93
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
237-438 3.75e-15

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 78.18  E-value: 3.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHA-RGLLQVSRSVERISTLMEQILLLARlDGDALLEqfhPVNL 315
Cdd:PRK13837 447 LEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAaRYIDEIISAGARARLIIDQILAFGR-KGERNTK---PFDL 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  316 ATLAEDVLSELaRQAIDKDIELSLHQ--ETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEI---RVENRAQ------- 383
Cdd:PRK13837 523 SELVTEIAPLL-RVSLPPGVELDFDQdqEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIslsRAKLRAPkvlshgv 601

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  384 -----HAVLRVRDNGPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK13837 602 lppgrYVLLRVSDTGAGIDEAVLPHIFEPFF----TTRAGGTGLGLATVHGIVSAHAGYI 657
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 358-438 7.89e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 70.05  E-value: 7.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 358 GNLVGNALRYTPAG--GQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHF 435
Cdd:cd16921   6 TNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIERHG 85


                ...
gi 15599971 436 GSI 438
Cdd:cd16921  86 GRI 88
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
243-438 8.26e-15

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 76.36  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  243 LTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQV-SRSVERISTLMEQILLLARLDGDALleqfHPVNLATLAED 321
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVmAKEADRLNRVVSELLELVKPTHLAL----QAVDLNDLINH 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  322 VLSELARQAIDKDIELSLH-QETVYVMGIDL-WLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALE 399
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTaNDTLPEIQADPdRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAAD 395

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 15599971  400 EQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK10364 396 QLEAIFTPYF----TTKAEGTGLGLAVVHNIVEQHGGTI 430
TMAO_torS TIGR02956
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ...
 248-438 8.32e-15

TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]


Pssm-ID: 274362 [Multi-domain]  Cd Length: 968  Bit Score: 77.13  E-value: 8.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   248 AHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELA 327
Cdd:TIGR02956 472 SHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMV 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   328 RQAIDKDIELSLH---QETVYVMGIDLWLKAMVGNLVGNALRYTPAgGQVEIRVENRAQHAVL-RVRDNGPGVALEEQQA 403
Cdd:TIGR02956 552 SRAQLKGIQLRLNipeQLPNWWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSSLLfEVEDTGCGIAEEEQAT 630

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 15599971   404 IFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:TIGR02956 631 LFDAFTQADGRRRSGGTGLGLAISQRLVEAMDGEL 665
AdeS_HK NF012226
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ...
 248-438 1.09e-14

two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.


Pssm-ID: 411090 [Multi-domain]  Cd Length: 353  Bit Score: 75.03  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  248 AHEIRTPLASLRTHAQVALR---SEDPKAHARGLLQvsrsVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLs 324
Cdd:NF012226 146 AHELRTPITILQGRLQGILDgvfEPDPALFKSLLNQ----VEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVL- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  325 ELARQAIDK---DIELSLHQETVY--VMGIDLWLKAmvgnLVGNALRYTPAgGQVEIRVENRAQHAVLRVRDNGPGVALE 399
Cdd:NF012226 221 KMFEDRLEQaqlTIVLNLTATPVFcdRRRIEQVLIA----LIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEE 295

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 15599971  400 EQQAIFTRFYRSPATSSGE--GSGLGLPIVKRIVELHFGSI 438
Cdd:NF012226 296 YQQDLFNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSI 336
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 276-438 1.43e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 75.27  E-value: 1.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 276 RGLLQVSRsVERISTLMEQILLLARLDGDALLEQFHPVNLATLaedvLSELARQAIDKDIELSLHQETvYVMGIDLW--- 352
Cdd:COG3290 208 SGLLQLGE-YDEALEYIDEISEELQELIDSLLSRIGNPVLAAL----LLGKAARARERGIDLTIDIDS-DLPDLPLSdtd 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAG----GQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRspaTSSGEGSGLGLPIVK 428
Cdd:COG3290 282 LVTILGNLLDNAIEAVEKLpeeeRRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS---TKLGEGRGLGLALVK 358

                       170
                ....*....|
gi 15599971 429 RIVELHFGSI 438
Cdd:COG3290 359 QIVEKYGGTI 368
PRK15347 PRK15347
two component system sensor kinase;
236-438 1.86e-14

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 76.22  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  236 ALEAERR----LTSdAAHEIRTPLASLrTHAQVALRSEDPKAHARGLL----QVSRSVERIstlMEQILLLARLDGDALL 307
Cdd:PRK15347 391 AEQANKRksehLTT-ISHEIRTPLNGV-LGALELLQNTPLTAEQMDLAdtarQCTLSLLAI---INNLLDFSRIESGQMT 465

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  308 EQFHPVNLATLAEDVLSELARQAIDKDIELS--LHQETVYVMGID-LWLKAMVGNLVGNALRYTPAGGqVEIRVENRAQH 384
Cdd:PRK15347 466 LSLEETALLPLLDQAMLTIQGPAQSKSLTLRtfVGAHVPLYLHLDsLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQ 544

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15599971  385 AVLRVRDNGPGVALEEQQAIFTRFYRSPATSSgeGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK15347 545 LCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGEL 596
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-434 6.19e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 68.00  E-value: 6.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR--SPATSSGEGSGLGLPIVKRI 430
Cdd:cd16952   1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRvdIERCRNTGGTGLGLAIVKHV 80


                ....
gi 15599971 431 VELH 434
Cdd:cd16952  81 MSRH 84
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-438 9.28e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 67.31  E-value: 9.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNAL----RYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYrspATSSGEGSGLGLPIVK 428
Cdd:cd16915   1 LITIVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV---STKGQGERGIGLALVR 77

                        90
                ....*....|
gi 15599971 429 RIVELHFGSI 438
Cdd:cd16915  78 QSVERLGGSI 87
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
218-432 6.70e-13

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 71.30  E-value: 6.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   218 EIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSV-ERISTLMEQIL 296
Cdd:PRK09959  690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATgQSLLGLIGEIL 769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971   297 LLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQE--TVYVMGID-LWLKAMVGNLVGNALRYTPAGGq 373
Cdd:PRK09959  770 DVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDpQAFKQVLSNLLSNALKFTTEGA- 848

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599971   374 VEIR---VENRAQHAVLR--VRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVE 432
Cdd:PRK09959  849 VKITtslGHIDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIK 912
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-438 1.30e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 64.13  E-value: 1.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAG-GQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFY--RSPATSSGEGSGLGLPIVKR 429
Cdd:cd16953   1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQ 80


                ....*....
gi 15599971 430 IVELHFGSI 438
Cdd:cd16953  81 IIEAHGGIS 89
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 352-430 3.19e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 63.07  E-value: 3.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 352 WLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSP-ATSSGEGSGLGLPIVKRI 430
Cdd:cd16948   5 WLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEnGRNFQESTGMGLYLVKKL 84
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-438 6.54e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 62.05  E-value: 6.54e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATssGEGSGLGLPIVKRIVE 432
Cdd:cd16943   4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPV--GEGTGLGLSLSYRIIQ 81


                ....*.
gi 15599971 433 LHFGSI 438
Cdd:cd16943  82 KHGGTI 87
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 1.14e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 61.29  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYtpAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR---SPATSSGeGSGLGLPIVKRIVELHF 435
Cdd:cd16939   7 NLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldpSRDRATG-GFGLGLAIVHRVALWHG 83


                ...
gi 15599971 436 GSI 438
Cdd:cd16939  84 GHV 86
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 237-300 1.81e-11

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 59.53  E-value: 1.81e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599971 237 LEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQ-VSRSVERISTLMEQILLLAR 300
Cdd:cd00082   1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLErIREEAERLLRLINDLLDLSR 65
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 2.20e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 60.48  E-value: 2.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:cd16923   7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELHGGSA 86
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 353-436 7.87e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 58.62  E-value: 7.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 353 LKAMVGNLVGNALRytpAGGQVE---IRVENRAQ--HAVLRVRDNGPGVALEEQQAIFTRFYRSPATssGEGSGLGLPIV 427
Cdd:cd16976   1 IQQVLMNLLQNALD---AMGKVEnprIRIAARRLggRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV--GKGTGLGLSIS 75


                ....*....
gi 15599971 428 KRIVELHFG 436
Cdd:cd16976  76 YGIVEEHGG 84
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 239-302 9.23e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 57.58  E-value: 9.23e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599971    239 AERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLD 302
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 248-438 1.25e-10

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 63.55  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 248 AHEIRTPLASLRTHAQVALRSedpkAHARGLLQVSRSVERISTLMEQILLLARLdgdalLEQF--------HPVNLATLA 319
Cdd:COG4192 441 AHELNQPLNAMSMYLFSAKKA----LEQENYAQLPTSLDKIEGLIERMDKIIKS-----LRQFsrksdtplQPVDLRQVI 511

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 320 EDVLSELARQAIDKDIELSLHQETVyVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALE 399
Cdd:COG4192 512 EQAWELVESRAKPQQITLHIPDDLM-VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLV 590

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15599971 400 EQqaIFTRFYrspaTSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:COG4192 591 DK--LFTPFT----TTKEVGLGLGLSICRSIMQQFGGDL 623
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 320-432 1.25e-10

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 63.71  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  320 EDVLSELARQAIDKDIELSLH-QETV--YVMGIDLWLKAMVGNLVGNALRYTPAGgQVEIRVENRAQ---HAVLR--VRD 391
Cdd:PRK11107 373 DEVVTLLAHSAHEKGLELTLNiDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESG-NIDILVELRALsntKVQLEvqIRD 451

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15599971  392 NGPGVAlEEQQA-IFTRFyrSPATSS-----GeGSGLGLPIVKRIVE 432
Cdd:PRK11107 452 TGIGIS-ERQQSqLFQAF--RQADASisrrhG-GTGLGLVITQKLVN 494
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 239-302 3.99e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 55.68  E-value: 3.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599971   239 AERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLD 302
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 334-438 4.59e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 57.14  E-value: 4.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 334 DIELSLHQETVYVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFY--RS 411
Cdd:cd16947   2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYtlED 81

                        90       100
                ....*....|....*....|....*..
gi 15599971 412 PATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:cd16947  82 SRNSAKQGNGLGLTITKRLAESMGGSI 108
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 5.70e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 56.32  E-value: 5.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR-SPATSSGEGSGLGLPIVKRIVELHFGS 437
Cdd:cd16975  11 NIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRdDTSRRSGGHYGMGLYIAKNLVEKHGGS 90


                .
gi 15599971 438 I 438
Cdd:cd16975  91 L 91
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
245-438 1.20e-09

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 60.42  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  245 SDAAHEIRTPLA-------SLRTHAQVALRSEDPKAhargLLQVSrsveRISTLMEQILLLA--RLDGDALLEQFHPVnl 315
Cdd:PRK10815 271 TDLTHSLKTPLAvlqstlrSLRSGKQMSVEQAEPIM----LEQIS----RISQQIGYYLHRAsmRSEHNLLSRELHSV-- 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  316 ATLAEDVLSELAR--QAIDKDIELSLHQETVYVMGIDLWLKAMvGNLVGNALRYTPAGgqVEIRVENRAQHAVLRVRDNG 393
Cdd:PRK10815 341 APLLDNLTSALNKvyQRKGVNITLDISPEITFVGEKNDFMEVM-GNVLDNACKYCLEF--VEISARQTDEHLHIVVEDDG 417

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 15599971  394 PGVALEEQQAIFTRFYRSPATSSGEgsGLGLPIVKRIVELHFGSI 438
Cdd:PRK10815 418 PGIPESKRELIFDRGQRADTLRPGQ--GLGLSVAREITEQYEGKI 460
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 1.34e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 55.48  E-value: 1.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALR----YTPAGGQVEIRVENRAQHAV-LRVRDNGPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVEL 433
Cdd:cd16920   7 NLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSICRSIIEA 82


                ....*
gi 15599971 434 HFGSI 438
Cdd:cd16920  83 HGGRL 87
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 317-438 3.06e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 55.33  E-value: 3.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 317 TLAEDVLSELARQAIDKDIELSLHQETVYVMGIDLW-LKAMVGNLVGNALRYtpAGGQVEIRVENRAQHAVLRVRDNGPG 395
Cdd:cd16954   1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNdLMELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPG 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15599971 396 VALEEQQAIFTRFYRspATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:cd16954  79 VPESQRSKIFQRGQR--LDEQRPGQGLGLAIAKEIVEQYGGEL 119
PRK13557 PRK13557
histidine kinase; Provisional
 237-427 5.49e-09

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 58.14  E-value: 5.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRLTSDAAHEIRTPLASLRTHA---QVALRSEDPKA--HARGLLQVSRSVERISTLMEQILLLAR---LDGdalle 308
Cdd:PRK13557 160 MEALGQLTGGIAHDFNNLLQVMSGYLdviQAALSHPDADRgrMARSVENIRAAAERAATLTQQLLAFARkqrLEG----- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  309 qfHPVNLATLAEDvLSELARQAIDKDIELslhqetVYVMGIDLW------LKAMVG--NLVGNALRYTPAGGQVEIRVEN 380
Cdd:PRK13557 235 --RVLNLNGLVSG-MGELAERTLGDAVTI------ETDLAPDLWncridpTQAEVAllNVLINARDAMPEGGRVTIRTRN 305

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599971  381 R---------------AQHAVLRVRDNGPGVALEEQQAIFTRFYRSpaTSSGEGSGLGLPIV 427
Cdd:PRK13557 306 VeiededlamyhglppGRYVSIAVTDTGSGMPPEILARVMDPFFTT--KEEGKGTGLGLSMV 365
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 372-438 1.23e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 52.54  E-value: 1.23e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599971 372 GQVEIRVE-NRAQHAVLRVRDNGPGVALEEQQaiftRFYRSPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:cd16944  28 GEVRIRVEaDQDGRIVLIVCDNGKGFPREMRH----RATEPYVTTRPKGTGLGLAIVKKIMEEHGGRI 91
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 312-438 1.77e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 56.87  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  312 PVNLATLAEDVLSELARQAIDKDIELSLHQET---VYVMGIDLWLKAMVGNLVGNALRYTPAGGqVEIRVEnRAQHAVLR 388
Cdd:PRK11091 355 PIDFTDFLADLENLSGLQAEQKGLRFDLEPLLplpHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVR-YEEGDMLT 432

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15599971  389 --VRDNGPGVALEEQQAIFTRFYR---SPATSSGEGSGLGLPIVKRIVELHFGSI 438
Cdd:PRK11091 433 feVEDSGIGIPEDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGGDI 487
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 359-438 2.28e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 52.02  E-value: 2.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYTPaGGQVEIRVENRAQHAV------------LRVRDNGPGVALEEQQAIFTRFyrspATSSGEGSGLGLPI 426
Cdd:cd16918   7 NLVRNAAQALA-GSGGEIILRTRTQRQVtlghprhrlalrVSVIDNGPGIPPDLQDTIFYPM----VSGRENGTGLGLAI 81

                        90
                ....*....|..
gi 15599971 427 VKRIVELHFGSI 438
Cdd:cd16918  82 AQNIVSQHGGVI 93
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
360-437 1.99e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 53.10  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 360 LVGNALRY----TPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFyrspaTSSGEGSGLGLPIVKRIVELHF 435
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYY 418


                ..
gi 15599971 436 GS 437
Cdd:COG2972 419 GE 420
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
360-431 2.81e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 46.44  E-value: 2.81e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599971 360 LVGNALRYT---PAGGQVEIRVENRAQHAVLRVRDNGPGVALEEqqaiftrfyRSPATSSGEGSGLGLPIVKRIV 431
Cdd:COG2172  42 AVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPED---------LPDPYSTLAEGGRGLFLIRRLM 107
glnL PRK11073
nitrogen regulation protein NR(II);
239-438 3.97e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 48.92  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  239 AERRLTSDAAHEIRTPLASLRTHAQVALRS-EDPKAHargllqvsrsvERISTLMEQI----LLLARLDGDALLEQFHPV 313
Cdd:PRK11073 129 AARDLVRGLAHEIKNPLGGLRGAAQLLSKAlPDPALT-----------EYTKVIIEQAdrlrNLVDRLLGPQRPGTHVTE 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  314 NLATLAEDV--LSELARQA---IDKDIELSLHQETVYVMGIDlwlKAMVgNLVGNALR-YTPAGGQVEIRVENRAQ---H 384
Cdd:PRK11073 198 SIHKVAERVvqLVSLELPDnvrLIRDYDPSLPELAHDPDQIE---QVLL-NIVRNALQaLGPEGGTITLRTRTAFQltlH 273

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599971  385 -------AVLRVRDNGPGVALEEQQaifTRFYrsPATSSGEG-SGLGLPIVKRIVELHFGSI 438
Cdd:PRK11073 274 geryrlaARIDIEDNGPGIPPHLQD---TLFY--PMVSGREGgTGLGLSIARNLIDQHSGKI 330
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 357-438 5.46e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 48.76  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  357 VGNLVGNALRYTPAGGQVEIRVENRAQHAVL--RVRDNGPGVALEEQQAIFTRFYrspaTSSGEGSGLGLPIVKRIVELH 434
Cdd:PRK11086 438 LGNLIENALEAVGGEEGGEISVSLHYRNGWLhcEVSDDGPGIAPDEIDAIFDKGY----STKGSNRGVGLYLVKQSVENL 513


                 ....
gi 15599971  435 FGSI 438
Cdd:PRK11086 514 GGSI 517
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 205-438 7.47e-06

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 48.75  E-value: 7.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  205 RHLQPIA--VEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVaLRSEDPKAHARGLLQ-V 281
Cdd:PRK11466 407 RHREQLAaqVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQL-LADNPALNAQRDDLRaI 485

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  282 SRSVERISTLMEQILLLARLDGDALL-----EQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYVMGIDLWLKAM 356
Cdd:PRK11466 486 TDSGESLLTILNDILDYSAIEAGGKNvsvsdEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALMGDPRRIRQV 565

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  357 VGNLVGNALRYTPAGgQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRspATSSGEGSGLGLPIVKRIVELHFG 436
Cdd:PRK11466 566 ITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQ--VSGKRGGTGLGLTISSRLAQAMGG 642


                 ..
gi 15599971  437 SI 438
Cdd:PRK11466 643 EL 644
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 237-422 1.31e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 44.54  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  237 LEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLA 316
Cdd:PRK10618 447 QQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQ 526

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  317 TLAEDVLSELARQAIDKDIEL----SLHQETVYVMGIDLwLKAMVGNLVGNALRYTpAGGQVEIRVENRAQHA---VLRV 389
Cdd:PRK10618 527 DLIDEVLPEVLPAIKRKGLQLlihnHLKAEQLRIGDRDA-LRKILLLLLNYAITTT-AYGKITLEVDQDESSPdrlTIRI 604

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 15599971  390 RDNGPGVALEEQQAIftRF-YRSPATSS--GEGSGL 422
Cdd:PRK10618 605 LDTGAGVSIKELDNL--HFpFLNQTQGDryGKASGL 638
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 308-432 3.17e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 42.97  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 308 EQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVYV---MGIDLwlkAMVGN-LVGNALRY---TPAGGQVEIRVEN 380
Cdd:COG3920 354 EDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELpadAAVPL---GLILNeLVTNALKHaflSGEGGRIRVSWRR 430

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15599971 381 RAQHAVLRVRDNGPGValeeqqaiftrfyrSPATSSGEGSGLGLPIVKRIVE 432
Cdd:COG3920 431 EDGRLRLTVSDNGVGL--------------PEDVDPPARKGLGLRLIRALVR 468
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 236-432 7.18e-04

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 41.73  E-value: 7.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  236 ALEAERRLT------SDAAHEIRTPLAslrTHAQVAlrsedpKAHARGLLQVSRSVERISTLMEQ------IL-LLARL- 301
Cdd:NF033792 192 VLAREQHLSaldglaAAAAHELGTPLA---TIALVA------KELERELPDDPPLREDAELLRSQaercrdILrRLTSLg 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  302 -DGDALLEQfhpVNLATLAEDVLSELarQAIDKDIELSLHQETV---YVMGIDLWLKAMvGNLVGNALRYtpAGGQVEIR 377
Cdd:NF033792 263 eEGDAHLDR---LPLSALIEEAAAPH--RGFGKEIEVVVAGDPGeepVIRRNPEILYGL-GNLIENAVDF--ARSTVTVT 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599971  378 VENRAQHAVLRVRDNGPGVAleeqQAIFTRF---Y-----RSPATSSGEGSGLGLPIVKRIVE 432
Cdd:NF033792 335 ASWDAESVTITIEDDGPGFP----PDVLSRIgepYvttrrGEERRPGGGGLGLGLFIAKTLLE 393
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 357-432 8.63e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 38.40  E-value: 8.63e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599971 357 VGNLVGNALRYTPA---GGQVEIRVENRAQHAVLRVRDNGPGVALEEQqaiftrfyRSPATSSGEGsGLGLPIVKRIVE 432
Cdd:cd16936   5 VSEAVTNAVRHAYRhdgPGPVRLELDLDPDRLRVEVTDSGPGFDPLRP--------ADPDAGLREG-GRGLALIRALMD 74
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 359-432 9.01e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 38.90  E-value: 9.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 359 NLVGNALRYTPAGGQVEIRVENR---------------AQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATssGEGSGLG 423
Cdd:cd16919   7 NLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEV--GKGTGLG 84


                ....*....
gi 15599971 424 LPIVKRIVE 432
Cdd:cd16919  85 LSMVYGFVK 93
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 353-461 1.04e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 41.36  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  353 LKAMVGNLVGNA----LRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEgSGLGLPIVK 428
Cdd:PRK15053 433 FAAIVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGE-HGIGLYLIA 511

                         90       100       110
                 ....*....|....*....|....*....|...
gi 15599971  429 RIVELHFGSIgLGKGLEGKGLEVQVFLPKTQPD 461
Cdd:PRK15053 512 SYVTRCGGVI-TLEDNDPCGTLFSIFIPKVKPN 543
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
344-438 1.99e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 40.73  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971  344 VYVMGIDLWLKAMVGNLVGNALRYTPAGGQVeIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYR--SPATSSGEGSG 421
Cdd:PRK10841 554 VALNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvgTGVQRNFQGTG 632

                         90
                 ....*....|....*..
gi 15599971  422 LGLPIVKRIVELHFGSI 438
Cdd:PRK10841 633 LGLAICEKLINMMDGDI 649
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 351-436 7.66e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 35.88  E-value: 7.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 351 LWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRfyrspatssgEGSGLGLPIV-KR 429
Cdd:cd16956   4 LTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIR----------SSNGLGLNLVdKR 73


                ....*..
gi 15599971 430 IVELhFG 436
Cdd:cd16956  74 LRQA-FG 79
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-422 8.27e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.61  E-value: 8.27e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599971 363 NALRYTPAGgQVEIRVENRAQHAVLRVRDNGPGValeeqqaiftrfyRSPATSSGEGSGL 422
Cdd:cd16917  11 NALKHAGAS-RVRVTLSYTADELTLTVVDDGVGF-------------DGPAPPGGGGFGL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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