|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
21-481 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 652.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 21 LTLDSRGVRPGDLFLAVPGGRQDGRAHIAdalakgaaavayEA----------EGAGELPPSDAPLIAVKGLAAQLSAVA 90
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIA------------QAiargavavvtEAPGALLAAGVPVIVVPDPRAALALLA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 91 GRFYGEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQATLATLKQAGAR 170
Cdd:COG0769 70 AAFYGHPSQKLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 171 AVAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPG-LRCRVINLDDDFGRRLAgEEQDSE 249
Cdd:COG0769 150 HVVMEVSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGpGGAAVINADDPYGRRLA-AAAPAR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 250 LITYSLtDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVG 329
Cdd:COG0769 229 VITYGL-KADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 330 RMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRTEAS 409
Cdd:COG0769 308 RMERVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDP 387
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599613 410 AAIIADIRKGFAAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSDIEQAERALAA 481
Cdd:COG0769 388 AAIIADILAGIPGAGKVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALAE 459
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
1-482 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 647.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 1 MPMSLNQLFPQAErdllIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAgelPPSDAPLIAVK 80
Cdd:PRK00139 2 ASMKLRDLLAPVE----ITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGE---AGTGVPVIIVP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 81 GLAAQLSAVAGRFYGEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQAT 160
Cdd:PRK00139 75 DLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 161 LATLKQAGARAVAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCrVINLDDDFGRR 240
Cdd:PRK00139 155 LAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLAA-VINADDEVGRR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 241 LAgeeqdSELITYSLTDSSAFLYCREARFGDAGIEAALVTPhgeglLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRT 320
Cdd:PRK00139 234 LL-----ALPDAYAVSMAGADLRATDVEYTDSGQTFTLVTE-----VESPLIGRFNVSNLLAALAALLALGVPLEDALAA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 321 LPQLQGPVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVT 400
Cdd:PRK00139 304 LAKLQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVT 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 401 DDNPRTEASAAIIADIRKGFAAAdkvtfLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSDIEQAERALA 480
Cdd:PRK00139 384 SDNPRSEDPAAIIADILAGIYDV-----IEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDDREVAREALA 458
|
..
gi 15599613 481 AW 482
Cdd:PRK00139 459 ER 460
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
15-471 |
0e+00 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 522.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 15 DLLIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAGELPPsdAPLIAVKGLAAQLSAVAGRFY 94
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAP--VPVIIVPDLRHALSSLAAAFY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 95 GEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESG---RHTTPDPLAVQATLATLKQAGARA 171
Cdd:TIGR01085 79 GHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIKnpaALTTPEALTLQSTLAEMVEAGAQY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 172 VAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCR-VINLDDDFGRRLAGEEQDS-- 248
Cdd:TIGR01085 159 AVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFaVINLDDEYGAQFVKRLPKDit 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 249 -ELITYSLTDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLG-YPLGDILRTLPQLQG 326
Cdd:TIGR01085 239 vSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 327 PVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRT 406
Cdd:TIGR01085 319 VPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDNPRG 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599613 407 EASAAIIADIRKGFAAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSD 471
Cdd:TIGR01085 399 EDPEQIIADILAGISEKEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDD 463
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
106-307 |
3.56e-66 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 211.78 E-value: 3.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 106 VTGTNGKTSVSQLVAQALDLLGercGIVGTLGTGfygaLESGRHTTPDPLAVQATLATLKQAGARAVAMEVSSHGLDQGR 185
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAG---GVIGTIGTY----IGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 186 VAAL-GFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCR-VINLDDDFGRRLAGE--EQDSELITYSLtDSSAF 261
Cdd:pfam08245 74 LSGLlKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIaVINADDPYGAFLIAKlkKAGVRVITYGI-EGEAD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15599613 262 LYCREARFGDAGIEAALV-TPHGEGLLRSPLLGRFNLSNLLAAVGAL 307
Cdd:pfam08245 153 LRAANIELSSDGTSFDLFtVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
104-345 |
1.15e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 41.16 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 104 IGVTGTNGKTSVSQLVAqalDLLGERCGIVGT-LGTGFY--GALESGRHTTPdplavqAT-LATLKQAGARAVAM----- 174
Cdd:NF033197 95 IEITGVKGKTTTAELLA---HILSDEYVLLHTsRGTERYpeGELSNKGSITP------ASiLNALELAEEIGIDDygfli 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 175 -EVSshgldqgrvaaLG----FDIAVFTNLSRDHLDYHGSMEAyAAAKAKLFAWPGLRCRVINLDDDFGRRLAGEEQDSE 249
Cdd:NF033197 166 fEVS-----------LGgtgaGDVGIITNILEDYPIAGGKRSA-SAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 250 LITYsltdssAFLYCREARFGDAGIEaalvtphgeglLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVG 329
Cdd:NF033197 234 GVEI------LSKYPLRFKYGNTEFE-----------FNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPG 296
|
250
....*....|....*...
gi 15599613 330 RMQ--RLGGgdkpLVVVD 345
Cdd:NF033197 297 RMAvkKEGG----VVIVD 310
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
21-481 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 652.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 21 LTLDSRGVRPGDLFLAVPGGRQDGRAHIAdalakgaaavayEA----------EGAGELPPSDAPLIAVKGLAAQLSAVA 90
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIA------------QAiargavavvtEAPGALLAAGVPVIVVPDPRAALALLA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 91 GRFYGEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQATLATLKQAGAR 170
Cdd:COG0769 70 AAFYGHPSQKLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 171 AVAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPG-LRCRVINLDDDFGRRLAgEEQDSE 249
Cdd:COG0769 150 HVVMEVSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGpGGAAVINADDPYGRRLA-AAAPAR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 250 LITYSLtDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVG 329
Cdd:COG0769 229 VITYGL-KADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 330 RMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRTEAS 409
Cdd:COG0769 308 RMERVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDP 387
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599613 410 AAIIADIRKGFAAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSDIEQAERALAA 481
Cdd:COG0769 388 AAIIADILAGIPGAGKVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALAE 459
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
1-482 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 647.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 1 MPMSLNQLFPQAErdllIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAgelPPSDAPLIAVK 80
Cdd:PRK00139 2 ASMKLRDLLAPVE----ITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGE---AGTGVPVIIVP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 81 GLAAQLSAVAGRFYGEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQAT 160
Cdd:PRK00139 75 DLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 161 LATLKQAGARAVAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCrVINLDDDFGRR 240
Cdd:PRK00139 155 LAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLAA-VINADDEVGRR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 241 LAgeeqdSELITYSLTDSSAFLYCREARFGDAGIEAALVTPhgeglLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRT 320
Cdd:PRK00139 234 LL-----ALPDAYAVSMAGADLRATDVEYTDSGQTFTLVTE-----VESPLIGRFNVSNLLAALAALLALGVPLEDALAA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 321 LPQLQGPVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVT 400
Cdd:PRK00139 304 LAKLQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVT 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 401 DDNPRTEASAAIIADIRKGFAAAdkvtfLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSDIEQAERALA 480
Cdd:PRK00139 384 SDNPRSEDPAAIIADILAGIYDV-----IEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDDREVAREALA 458
|
..
gi 15599613 481 AW 482
Cdd:PRK00139 459 ER 460
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
15-471 |
0e+00 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 522.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 15 DLLIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAGELPPsdAPLIAVKGLAAQLSAVAGRFY 94
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAP--VPVIIVPDLRHALSSLAAAFY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 95 GEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESG---RHTTPDPLAVQATLATLKQAGARA 171
Cdd:TIGR01085 79 GHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIKnpaALTTPEALTLQSTLAEMVEAGAQY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 172 VAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCR-VINLDDDFGRRLAGEEQDS-- 248
Cdd:TIGR01085 159 AVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFaVINLDDEYGAQFVKRLPKDit 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 249 -ELITYSLTDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLG-YPLGDILRTLPQLQG 326
Cdd:TIGR01085 239 vSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 327 PVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRT 406
Cdd:TIGR01085 319 VPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDNPRG 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599613 407 EASAAIIADIRKGFAAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSD 471
Cdd:TIGR01085 399 EDPEQIIADILAGISEKEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDD 463
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
17-482 |
7.79e-176 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 518.88 E-value: 7.79e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 17 LIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAGELPPSDAPLIAVKGLAAQLSAVAGRFYGE 96
Cdd:PRK11929 28 ATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADALVLPVADLRKALGELAARWYGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 97 PSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQATLATLKQAGARAVAMEV 176
Cdd:PRK11929 108 PSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLTTPDAIILHRILARMRAAGADAVAMEA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 177 SSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLF-AWPGLRCRVINLDDDFGRRLAGEEQDSELITYSL 255
Cdd:PRK11929 188 SSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFsKLPGLGAAVINADDPAAARLLAALPRGLKVGYSP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 256 TDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLG 335
Cdd:PRK11929 268 QNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERVG 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 336 ---GGDKPLVVVDYAHTPDALEKVLEALRPHAAA---RLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRTEAS 409
Cdd:PRK11929 348 ptaGAQGPLVVVDYAHTPDALAKALTALRPVAQArngRLVCVFGCGGDRDKGKRPEMGRIAAELADRVVVTSDNPRSEAP 427
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599613 410 AAIIADIRKGFAAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKGHEDYQEIDGVRHPFSDIEQAERALAAW 482
Cdd:PRK11929 428 EAIIDQILAGIPAGARVFVISDRAEAIRQAIWMAAPGDVILIAGKGHETYQEIGGRKLFFDDREWARRALLAR 500
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
3-479 |
1.10e-77 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 250.72 E-value: 1.10e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 3 MSLNQLFPQAERDLLIRE------------------LTLDSRGVRPGDLFLAVPGGRQdgraHIADALAKGAAAVAYEAE 64
Cdd:PRK14022 1 ITIETLLDILKKDHNFREiidqdhyhynysgvqfddISYDSRTADEGTLFFAKGAYFK----HKFLQNAITQGLKLYVSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 65 GAGELppsDAPLIAVKGLAAQLSAVAGRFYGEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLG-----TG 139
Cdd:PRK14022 77 KDYEV---GIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTtldgeTF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 140 FYGALesgrhTTPDPLAVQATLATLKQAGARAVAMEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDY--HGSMEAYAAAK 217
Cdd:PRK14022 154 FKSAL-----TTPESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 218 AKLFAwpGLRCRVINLDDDFGRRLAGEEQDSELITYSLTDSSAFLYCREARFGDAGieaalvTPHGEGLLRspLLGRFNL 297
Cdd:PRK14022 229 RLLME--NSKAVVVNSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATG------KLAGTYDIQ--LIGKFNQ 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 298 SNLLAAVGALLGLGYPLGDILRTLPQLQGPvGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGD 377
Cdd:PRK14022 299 ENAMAAGLACLRLGASLEDIQKGIAQTPVP-GRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGN 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 378 RDAGKRPLMAAIAERLAD-EVLVTDDNPRTEASAAIIADIRKGfaAADKVTFLPSRGEAIAHLIASAAV-DDVVLLAGKG 455
Cdd:PRK14022 378 KGESRRPDFGRVANRHPYlQVILTADDPNNEDPKMITQEIASH--ITHPVEIIDDRAEAIKHAMSITEGpGDAVIIAGKG 455
|
490 500
....*....|....*....|....*
gi 15599613 456 HEDYQEIDGVRHPFS-DIEQAERAL 479
Cdd:PRK14022 456 ADAYQIVPGHRDDYIgDEAAAKKYL 480
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
106-307 |
3.56e-66 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 211.78 E-value: 3.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 106 VTGTNGKTSVSQLVAQALDLLGercGIVGTLGTGfygaLESGRHTTPDPLAVQATLATLKQAGARAVAMEVSSHGLDQGR 185
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAG---GVIGTIGTY----IGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 186 VAAL-GFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLRCR-VINLDDDFGRRLAGE--EQDSELITYSLtDSSAF 261
Cdd:pfam08245 74 LSGLlKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIaVINADDPYGAFLIAKlkKAGVRVITYGI-EGEAD 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15599613 262 LYCREARFGDAGIEAALV-TPHGEGLLRSPLLGRFNLSNLLAAVGAL 307
Cdd:pfam08245 153 LRAANIELSSDGTSFDLFtVPGGELEIEIPLLGRHNVYNALAAIAAA 199
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
104-452 |
8.42e-39 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 146.38 E-value: 8.42e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 104 IGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALesgrhttpdplavqatlatLKQAGARAVAMEVSSHGLDq 183
Cdd:COG0771 108 IAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLL-------------------LEPEPPDVYVLELSSFQLE- 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 184 gRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAW--PGLRCrVINLDDDFGRRLAgEEQDSELITYSLTdssaf 261
Cdd:COG0771 168 -TTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANqtPDDYA-VLNADDPLTRALA-EEAKARVVPFSLK----- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 262 lycrEARFGDAGIEAALVTPHGEG--LLRS---PLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLG- 335
Cdd:COG0771 240 ----EPLEGGAGLEDGKLVDRASGeeLLPVddlRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAe 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 336 -GGdkplvvVDY-----AHTPDALEKVLEALRPHaaARLLclfgCGG-DRDAGKRPLMAAIAERLADEVLVTDDNPRtea 408
Cdd:COG0771 316 iNG------VRFindskATNPDATLAALESFDGP--VVLI----AGGlDKGADFSPLAPAVAERVKAVVLIGEDAEK--- 380
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15599613 409 saaIIADIRKgfaAADKVTFLPSRGEAIAHLIASAAVDDVVLLA 452
Cdd:COG0771 381 ---IAAALAG---AGVPVVIVETMEEAVAAAAELARPGDVVLLS 418
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
1-455 |
1.11e-36 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 140.62 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 1 MPMSLNQLF------PQAERDLLIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIAdalakgaaavayEAEGAG------- 67
Cdd:COG0770 1 ILLTLAEIAeatggrLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVA------------QALAKGaaaalvs 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 68 ELPPSDAPLIAVK-GLAA--QL-SAVAGRFygepsrGLDLIGVTGTNGKTSVSQLVAQALdllgERCGIVgtlgtgfyga 143
Cdd:COG0770 69 RPLPADLPLIVVDdTLKAlqQLaAAHRARF------NIPVIAITGSNGKTTTKEMLAAVL----STKGKV---------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 144 lesgrHTTPD--------PLavqaTLATLkQAGARAVAMEVS-SHgldQGRVAALGF----DIAVFTNLSRDHLDYHGSM 210
Cdd:COG0770 129 -----LATPGnfnneigvPL----TLLRL-PEDHEFAVLEMGmNH---PGEIAYLARiarpDIAVITNIGPAHLEGFGSL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 211 EAYAAAKAKLFAwpGLR---CRVINLDDDFGRRLAgEEQDSELITYSLtDSSAFLYCREARFGDAGIEAALVTPHGEGLL 287
Cdd:COG0770 196 EGIARAKGEIFE--GLPpggVAVLNADDPLLAALA-ERAKARVLTFGL-SEDADVRAEDIELDEDGTRFTLHTPGGELEV 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 288 RSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLGGGDKPLVVVD-YAHTPDALEKVLEAL--RPHA 364
Cdd:COG0770 272 TLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDsYNANPDSMKAALDVLaqLPGG 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 365 AARLLCLfgcgGD------------RDAGkrplmAAIAERLADEVLVTDDNprteasAAIIADirkgFAAADKVTFLPSR 432
Cdd:COG0770 352 GRRIAVL----GDmlelgeeseelhREVG-----ELAAELGIDRLFTVGEL------ARAIAE----AAGGERAEHFEDK 412
|
490 500
....*....|....*....|...
gi 15599613 433 GEAIAHLIASAAVDDVVLLagKG 455
Cdd:COG0770 413 EELLAALKALLRPGDVVLV--KG 433
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
95-455 |
1.04e-32 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 129.42 E-value: 1.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 95 GEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERC-----GIVGTLGTGFygalesgRHTTPDPLAVQA--------TL 161
Cdd:COG0773 98 AELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPtfligGILNNFGTNA-------RLGDGDYFVAEAdesdgsflHY 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 162 ATlkqagaravamevsshgldqgrvaalgfDIAVFTNLSRDHLDYHGSMEAYAAAKAKlFAW--PGLRCRVINLDDDFGR 239
Cdd:COG0773 171 SP----------------------------DIAVVTNIEADHLDIYGDLEAIKEAFHE-FARnvPFYGLLVLCADDPGLR 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 240 RLAgEEQDSELITYSLTDSSAFlYCREARFGDAGIEAALVTPHGE-GLLRSPLLGRFNLSNLLAAVGALLGLGYPLGDIL 318
Cdd:COG0773 222 ELL-PRCGRPVITYGFSEDADY-RAENIRIDGGGSTFDVLRRGEElGEVELNLPGRHNVLNALAAIAVALELGVDPEAIA 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 319 RTLPQLQGPVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRP-HAAARLLCLFgcggdrdagkRP--------LMAAI 389
Cdd:COG0773 300 EALASFKGVKRRFELKGEVGGVTVIDDYAHHPTEIAATLAAAREkYPDRRLVAVF----------QPhrysrtrdFLDEF 369
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599613 390 AE--RLADEVLVTDDNPRTEA------SAAIIADIRKgfaAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKG 455
Cdd:COG0773 370 AEalSLADEVILLDIYAAREKpipgvsSEDLAEAIRK---RGKDVVYVPDLDELVEALAEIARPGDVVLTMGAG 440
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
103-452 |
4.63e-28 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 115.90 E-value: 4.63e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 103 LIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTgfygalesgrhttpdplavqATLATLKQAGARAVAMEVSSHGLD 182
Cdd:TIGR01087 104 VVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGT--------------------PALEVLDQEGAELYVLELSSFQLE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 183 qgRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAwpGLRCR---VINLDDDfgrRLAGEEQDSELITYSLTDSS 259
Cdd:TIGR01087 164 --TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFA--RQTEGdvaVLNADDP---RFARLAQKSKAQVIWFSVEK 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 260 AFLYcrearfgDAGIEAALVTPHGEGLLrSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLGGGDK 339
Cdd:TIGR01087 237 DAER-------GLCIRDGGLYLKPNDLE-GSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNG 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 340 PLVVVDYAHT-PDALEKVLEALRPHAAarllcLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDnprteasAAIIADIRK 418
Cdd:TIGR01087 309 VHFYNDSKATnVHATLAALSAFDNPVI-----LIVGGDDKGADFSPLAPAAAGKVKAVLAIGED-------AAKIAPLLK 376
|
330 340 350
....*....|....*....|....*....|....
gi 15599613 419 gfAAADKVTFLPSRGEAIAHLIASAAVDDVVLLA 452
Cdd:TIGR01087 377 --EAGLSVYLVESLEEAVQAAREVASPGDVVLLS 408
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
329-413 |
1.34e-27 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 105.50 E-value: 1.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 329 GRMQRLGGGDKPLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADEVLVTDDNPRTEA 408
Cdd:pfam02875 3 GRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYPRAED 82
|
....*
gi 15599613 409 SAAII 413
Cdd:pfam02875 83 PGAII 87
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
10-453 |
1.84e-25 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 110.56 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 10 PQAERDLLIRELTLDSRGVRPGDLFLAVPGGRQDGRAHIAdalakgaaavayEAEGAG--------ELPPSDAPLIAVKG 81
Cdd:PRK11929 518 LQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLP------------QAFAAGacaavverQVADVDLPQIVVDD 585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 82 LAAQLSAVAGRFYGEPSrgLDLIGVTGTNGKTSVSQLVAQAldlLGERCGivgtlgtgfygalESGRHTTP----DPLAV 157
Cdd:PRK11929 586 TRAALGRLATAWRARFS--LPVVAITGSNGKTTTKEMIAAI---LAAWQG-------------EDRVLATEgnfnNEIGV 647
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 158 QATLATLKqAGARAVAMEVSSHGLDQ-GRVAALGF-DIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAwpGLR---CRVIN 232
Cdd:PRK11929 648 PLTLLRLR-AQHRAAVFELGMNHPGEiAYLAAIAApTVALVTNAQREHQEFMHSVEAVARAKGEIIA--ALPedgVAVVN 724
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 233 LDDDFG---RRLAGEEQDSELITYSLTDSSAFLYCREARFGDAG-IEAALVTPHGEGLLRSPLLGRFNLSNLLAAVGALL 308
Cdd:PRK11929 725 GDDPYTaiwAKLAGARRVLRFGLQPGADVYAEKIAKDISVGEAGgTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACAL 804
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 309 GLGYPLGDILRTLPQLQGPVGRMQRLGGGDKPLVVVD-YAHTPDALEKVLEAL-RPHAAARLLCLFGCGGDRDAGKRplM 386
Cdd:PRK11929 805 AAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLaELPNGPRALVLGDMLELGDNGPA--M 882
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599613 387 AAIAERLADEVLVTDDNPRTEASAAIIADIRKGFAAAdkvtfLPSRGEAIAHLIASAAVDDVVLLAG 453
Cdd:PRK11929 883 HREVGKYARQLGIDALITLGEAARDAAAAFGAGARGV-----CASVDEIIAALRGALPEGDSVLIKG 944
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
23-371 |
2.73e-24 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 104.66 E-value: 2.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 23 LDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEgagELPPSDAPLIAV----KGLAAQLSAVAGRFYGEps 98
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDRE---VGPDNGLPQILVddtlEALQALARAKRAKFSGK-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 99 rgldLIGVTGTNGKTSVSQLVAQALDLLGercgivgtlgtgfygalesGRHTTPDPLAVQATLA-TLKQAGARA----VA 173
Cdd:TIGR01143 76 ----VIGITGSSGKTTTKEMLAAILSHKY-------------------KVFATPGNFNNEIGLPlTLLRAPGDHdyavLE 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 174 MEVSSHGLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAwpGLRCR---VINLDDDFGRRLAGEEQDSEL 250
Cdd:TIGR01143 133 MGASHPGEIAYLAEIAKPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQ--GLKENgiaVINADDPAFADLAKRLPNRNI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 251 ITYSLTDSSafLYCREARFGDAGIEAA-LVTPHGEGLLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVG 329
Cdd:TIGR01143 211 LSFGFEGGD--FVAKDISYSALGSTSFtLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKG 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15599613 330 RMQRLGGGDkpLVVVD--YAHTPDALEKVLEALRPHAAARLLCL 371
Cdd:TIGR01143 289 RFEVQTKNG--LTLIDdtYNANPDSMRAALDALARFPGKKILVL 330
|
|
| cya_phycin_syn |
TIGR02068 |
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and ... |
103-451 |
2.18e-22 |
|
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and energy, found in most Cyanobacteria. The polymer has a backbone of L-aspartic acid, with most Asp side chain carboxyl groups attached to L-arginine. The polymer is made by this enzyme, cyanophycin synthetase, and degraded by cyanophycinase. Heterologously expressed cyanophycin synthetase in E. coli produces a closely related, water-soluble polymer with some Arg replaced by Lys. It is unclear whether enzymes that produce soluble cyanophycin-like polymers in vivo in non-Cyanobacterial species should be designated as cyanophycin synthetase itself or as a related enzyme. This model makes the designation as cyanophycin synthetase. Cyanophycin synthesis is analogous to polyhydroxyalkanoic acid (PHA) biosynthesis, except that PHA polymers lack nitrogen and may be made under nitrogen-limiting conditions. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 273950 [Multi-domain] Cd Length: 864 Bit Score: 101.01 E-value: 2.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 103 LIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGT--GFYgALESGRHTTPdplavQATLATLKQAGARAVAMEVSSHG 180
Cdd:TIGR02068 481 IVSVTGTNGKTTTTRLVAHILKQTGKVVGMTTTDGVyiGKY-LVEKGDNTGP-----ASARRILMDPTVDAAVLETARGG 554
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 181 -LDQGrvaaLGFD---IAVFTNLSRDHL--DYHGSMEAYAAAKAKL--FAWPGlRCRVINLDDDFGRRLAgEEQDSELIT 252
Cdd:TIGR02068 555 iLREG----LAFDrcdVGVVTNIAGDHLgiGDINTIEDLADVKRVVveVVLPD-GYAVLNADDPMVAAMA-EKCKGKIAY 628
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 253 YSLTDSSAFLYCREARFGDAGI--EAALVTPHGEGLLR------SPLL--GR--FNLSNLLAAVGALLGLGYPLGDI--- 317
Cdd:TIGR02068 629 FSMDPNNPTVAAHIADGGRAVYyeNGYIVIARGGDEVAiariaaIPLTmgGRvaFQIENALAAVAAAWALGVPIELIrag 708
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 318 LRTL-PQLQGPVGRMQRLGGGDKpLVVVDYAHTPDALEKVLEALRPHAAARLLCLFGCGGDRDAGKRPLMAAIAERLADE 396
Cdd:TIGR02068 709 IRTFdADAAQAPGRFNLFNLGGA-HVLVDYGHNPAAIEAVGAAIRNWPARRRIGVIGGPGDRRDEDLVEQGELLGGAFDQ 787
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 397 VLVTDDN-----PRTEASAAIIADIRKGFAAADKVTFLpSRGEAIAHLIASAAVDDVVLL 451
Cdd:TIGR02068 788 IILKEDDdvrgrPRGEAAALLRQGLRQSARKAAIEDIL-DETEAIAAALDDLRAGDLVVI 846
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
95-455 |
1.02e-19 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 91.60 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 95 GEPSRGLDLIGVTGTNGKTSVSQLVAQALDLLGERC-----GIVGTLGTGfygalesGRHTTPDPLAVQATlatlkqaga 169
Cdd:TIGR01082 93 AELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPtvvvgGLVKEAGTN-------ARLGSGEYLVAEAD--------- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 170 ravamEVSSHGLDqgrvaaLGFDIAVFTNLSRDHLD-YHGSMEAYAAAKAKLFAWPGLRCR-VINLDDDFGRRLAGEEQD 247
Cdd:TIGR01082 157 -----ESDASFLH------LQPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYGLaVICADDPVLRELVPKATE 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 248 SeLITYSLTDSSAFLYCREARFGDAGIEAALVTPHGEGL-LRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQG 326
Cdd:TIGR01082 226 Q-VITYGGSGEDADYRAENIQQSGAEGKFSVRGKGKLYLeFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQG 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 327 PVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALR-------------PHAAARLlclfgcggdrdagkRPLMAAIAERL 393
Cdd:TIGR01082 305 VKRRFEILGEFGGVLLIDDYAHHPTEIKATLKAARqgypdkrivvvfqPHRYSRT--------------RDLFDDFAKVL 370
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 394 --ADEVLVTD-----DNPRTEASAAIIAD-IRKGfaAADKVTFLPSRGEAIAHLIASAAVDDVVLLAGKG 455
Cdd:TIGR01082 371 sdADELILLDiyaagEEPINGIDGKSLARkITQL--GKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAG 438
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
104-451 |
3.60e-17 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 83.48 E-value: 3.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 104 IGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFYGALESgrhTTPDPLAVqatlatlkqagaravaMEVSSHGLDQ 183
Cdd:PRK14106 111 VAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIDAVEE---YGEDDIIV----------------AEVSSFQLET 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 184 grVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPGLR-CRVINLDDDFGRRLAGEEQdSELITYS---LTDSS 259
Cdd:PRK14106 172 --IKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSdYTVLNYDDPRTRSLAKKAK-ARVIFFSrksLLEEG 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 260 AFLycrearfgDAGIEAALVTPHGEGLLRS---PLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLGG 336
Cdd:PRK14106 249 VFV--------KNGKIVISLGGKEEEVIDIdeiFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAE 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 337 GDKPLVVVDYAHT-PDALEKVLEAL-RPhaaarlLCLFGCGGDRDAGKRPLMAAIAERLADEVLVtddnprTEASAAIIA 414
Cdd:PRK14106 321 INGVKFINDSKGTnPDAAIKALEAYeTP------IVLIAGGYDKGSDFDEFAKAFKEKVKKLILL------GETAQEIAE 388
|
330 340 350
....*....|....*....|....*....|....*...
gi 15599613 415 DIRK-GFaaaDKVTFLPSRGEAIAHLIASAAVDDVVLL 451
Cdd:PRK14106 389 AARKyGF---DNILFAETLEEAVKKAYEIAKPGDVVLL 423
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
2-331 |
3.16e-12 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 68.52 E-value: 3.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 2 PMSLNQLFP--QAER---DLLIRELTLDSRGVRPGDLFLAVPGGRQDgrAHIADALAKgaaavayeAEGAGEL-----PP 71
Cdd:PRK10773 3 SVTLSQLADilNGELqgaDITIDAVTTDTRKVTPGCLFVALKGERFD--AHDFADDAK--------AAGAGALlvsrpLD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 72 SDAPLIAVKGLAAQLSAVAGRFYGE-PSRgldLIGVTGTNGKTSVSQLVAQALDLLGErcgivgTLGTGfyGALEsgrht 150
Cdd:PRK10773 73 IDLPQLVVKDTRLAFGQLAAWVRQQvPAR---VVALTGSSGKTSVKEMTAAILRQCGN------TLYTA--GNLN----- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 151 tpDPLAVQATLATLKQAGARAVAMEVSSHgldQGRVA---ALGF-DIAVFTNLSRDHLDYHGSMEAYAAAKAKLFA-WPG 225
Cdd:PRK10773 137 --NDIGVPLTLLRLTPEHDYAVIELGANH---QGEIAytvSLTRpEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSgLPE 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 226 LRCRVINLDDDFGRRLAGEEQDSELITYSL--TDSSAFlYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLSNLLAA 303
Cdd:PRK10773 212 NGIAIMNADSNDWLNWQSVIGSKTVWRFSPnaANSVDF-TATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAA 290
|
330 340
....*....|....*....|....*...
gi 15599613 304 VGALLGLGYPLGDILRTLPQLQGPVGRM 331
Cdd:PRK10773 291 AALAMSVGATLDAVKAGLANLKAVPGRL 318
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
1-328 |
2.84e-10 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 62.67 E-value: 2.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 1 MPMSLNQLFP------QAERDLLIRELTLDSRGVR--PGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAGELPPS 72
Cdd:PRK11930 1 MSYTLESISGilgaegLGDKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESYP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 73 DAPLIAVKGLAAQLSAVAGRFYGEpsrgLDL--IGVTGTNGKTSVSQLVAQaldLLGERCGIVGT-------LGTgfyga 143
Cdd:PRK11930 81 DANFLKVKDPLKALQELAAYHRSQ----FDIpvIGITGSNGKTIVKEWLYQ---LLSPDYNIVRSprsynsqIGV----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 144 lesgrhttpdPLAV-----QATLATLkQAGAravamevsSHGLDQGRVAAL-GFDIAVFTNLSRDHLDYHGSMEAYAAAK 217
Cdd:PRK11930 149 ----------PLSVwqlneEHELGIF-EAGI--------SQPGEMEALQKIiKPTIGILTNIGGAHQENFRSIKQKIMEK 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 218 AKLFawpgLRCRVI--NLDDDFG-RRLAGEEQDSELITYSLTDSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGR 294
Cdd:PRK11930 210 LKLF----KDCDVIiyNGDNELIsSCITKSNLTLKLISWSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDD 285
|
330 340 350
....*....|....*....|....*....|....
gi 15599613 295 FNLSNLLAAVGALLGLGYPLGDILRTLPQLQgPV 328
Cdd:PRK11930 286 ASIENLIHCIAVLLYLGYSADQIQERMARLE-PV 318
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
95-332 |
2.51e-09 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 59.78 E-value: 2.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 95 GEPSRgLDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLG-------------TGFygalESGRHTTPDPlAVQAtl 161
Cdd:PRK14016 475 GDDGR-IPIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGvyidgrlidkgdcTGP----KSARRVLMNP-DVEA-- 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 162 atlkqagarAVaMEVSSHG-LDQGrvaaLGFD---IAVFTNLSRDHLDYHG--SMEAYA--------AAKAKLFAwpglr 227
Cdd:PRK14016 547 ---------AV-LETARGGiLREG----LAYDrcdVGVVTNIGEDHLGLGGinTLEDLAkvkrvvveAVKPDGYA----- 607
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 228 crVINLDDDFGRRLAgEEQDSELITYSLTDSSAF------------------LYCREARFGDAGIEAALVTPHGEGLLrs 289
Cdd:PRK14016 608 --VLNADDPMVAAMA-ERCKGKVIFFSMDPDNPViaehraqggravyvegdyIVLAEGGWEIRIISLADIPLTLGGKA-- 682
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15599613 290 pllgRFNLSNLLAAVGALLGLGYPLGDI---LRT-LPQLQGPVGRMQ 332
Cdd:PRK14016 683 ----GFNIENALAAIAAAWALGIDIELIragLRTfVSDAAQAPGRFN 725
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
291-455 |
4.72e-07 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 52.51 E-value: 4.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 291 LLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVGRMQRLGGGDKPLVVVDYAHTPDALEKVLEALR--------- 361
Cdd:PRK14573 267 LVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFLFLEDYAHHPSEISCTLRAVRdavglrrii 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 362 ----PHAAARLLCLFGCggdrdagkrpLMAAIAErlADEVLVTD-----DNPRTEASAAIIAD-IRKgfAAADKVTFLPs 431
Cdd:PRK14573 347 aicqPHRFSRLRECLDS----------FPSAFQD--ADEVILTDvysagEEPEDSISYQKLAEaISQ--SSIVKCTYVP- 411
|
170 180
....*....|....*....|....
gi 15599613 432 RGEAIAHLIASAAVDDVVLLAGKG 455
Cdd:PRK14573 412 FHEIQRYLEQSIRVHDVCVSLGAG 435
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
21-360 |
5.62e-07 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 51.70 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 21 LTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAGELPPsDAPLIAVKGLAAQLSAVagrfyGEPSRG 100
Cdd:PRK14093 31 ISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKFAA-DAPLLVVDDVLAALRDL-----GRAARA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 101 ---LDLIGVTGTNGKTSVSQLVAQALDLLGERCGIVGTLGTGFygalesgrhttpdplAVQATLATLKQAGARAVAMEVS 177
Cdd:PRK14093 105 rleAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHW---------------GVPLSLARCPADARFAVFEIGM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 178 SH-GLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAwpGLR---CRVINLDDDFGRRLAGEEQD---SEL 250
Cdd:PRK14093 170 NHaGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFT--GLEpggAAVLNRDNPQFDRLAASARAagiARI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 251 ITYSlTDSSAflycrEARFGDAGIEAALVTPHGEGL-----LRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQ 325
Cdd:PRK14093 248 VSFG-ADEKA-----DARLLDVALHADCSAVHADILghdvtYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQ 321
|
330 340 350
....*....|....*....|....*....|....*....
gi 15599613 326 GPVGRMQR----LGGGDKPLVVVDYAHTPDALEKVLEAL 360
Cdd:PRK14093 322 PAAGRGVRhtleVGGGEATLIDESYNANPASMAAALGVL 360
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
18-94 |
2.61e-05 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 42.61 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 18 IRELTLDSRGVRPGDLFLAVPGGRQDGRAHIADALAKGAAAVAYEAEGAG------ELPPSDAPLIAVKGLAAQLSAVAG 91
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNispdnpELEAAKVPGIPVIDRREALAELAA 81
|
...
gi 15599613 92 RFY 94
Cdd:pfam01225 82 AFY 84
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
104-345 |
1.15e-03 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 41.16 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 104 IGVTGTNGKTSVSQLVAqalDLLGERCGIVGT-LGTGFY--GALESGRHTTPdplavqAT-LATLKQAGARAVAM----- 174
Cdd:NF033197 95 IEITGVKGKTTTAELLA---HILSDEYVLLHTsRGTERYpeGELSNKGSITP------ASiLNALELAEEIGIDDygfli 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 175 -EVSshgldqgrvaaLG----FDIAVFTNLSRDHLDYHGSMEAyAAAKAKLFAWPGLRCRVINLDDDFGRRLAGEEQDSE 249
Cdd:NF033197 166 fEVS-----------LGgtgaGDVGIITNILEDYPIAGGKRSA-SAAKLQSLKNAKVGSINVADLGIYINGKNKLVITVA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599613 250 LITYsltdssAFLYCREARFGDAGIEaalvtphgeglLRSPLLGRFNLSNLLAAVGALLGLGYPLGDILRTLPQLQGPVG 329
Cdd:NF033197 234 GVEI------LSKYPLRFKYGNTEFE-----------FNPLLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKGLPG 296
|
250
....*....|....*...
gi 15599613 330 RMQ--RLGGgdkpLVVVD 345
Cdd:NF033197 297 RMAvkKEGG----VVIVD 310
|
|
| |
