|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
4-455 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 527.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 4 PLRLSQLTVALDARLIG-EDAVFSAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVaDAPLPQLLV 82
Cdd:COG0770 2 LLTLAEIAEATGGRLIGdPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 83 RDTRAALGRLGALNRRKFTGPLAAMTGSSGKTTVKEMLASILRTQAgdaeSVLATRGNLNNDLGVPLTLLQLAPQHRSAV 162
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKG----KVLATPGNFNNEIGVPLTLLRLPEDHEFAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 163 IELGASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRpL 242
Cdd:COG0770 157 LEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-V 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 243 LTFSLDrPQADFRAADLQRDARGcMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKG 322
Cdd:COG0770 236 LTFGLS-EDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 323 RAVAQLTASGLRVIDDSYNANPASMLAAIDILSGFS--GRTVLVLGDMGELGSWAEQAHREVGAYAAG-KVSALYAVGPL 399
Cdd:COG0770 314 RLEVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAElGIDRLFTVGEL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599612 400 MAHAVQAFGAT-GRHFADQASLIGALATE-QPTTTILIKGSRSAAMDKVVAALCGSSE 455
Cdd:COG0770 394 ARAIAEAAGGErAEHFEDKEELLAALKALlRPGDVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
30-450 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 514.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 30 TDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREV-ADAPLPQLLVRDTRAALGRLGALNRRKFTGPLAAMT 108
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 109 GSSGKTTVKEMLASILRTQAGdaesVLATRGNLNNDLGVPLTLLQLAPQHRSAVIELGASRIGEIAYTVELTRPHVAIIT 188
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYK----VFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVIT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 189 NAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRPLLTFSLDRpqADFRAADLQRDARGCMG 268
Cdd:TIGR01143 157 NIGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG--GDFVAKDISYSALGSTS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 269 FRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAVaQLTASGLRVIDDSYNANPASML 348
Cdd:TIGR01143 235 FTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 349 AAIDILSGFSGRTVLVLGDMGELGSWAEQAHREVGAYAAGK-VSALYAVGPLMAHAVQAFGATGRHFADQASLIGALATE 427
Cdd:TIGR01143 314 AALDALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLgIDLVFLVGEEAAVIYDSFGKQGKHFADKDELLAFLKTL 393
|
410 420
....*....|....*....|....
gi 15599612 428 Q-PTTTILIKGSRSAAMDKVVAAL 450
Cdd:TIGR01143 394 VrKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
4-450 |
7.00e-142 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 414.04 E-value: 7.00e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 4 PLRLSQLTVALDARLIGEDAVFSAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVaDAPLPQLLVR 83
Cdd:PRK10773 3 SVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPL-DIDLPQLVVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 84 DTRAALGRLGALNRRKFTGPLAAMTGSSGKTTVKEMLASILRtQAGdaeSVLATRGNLNNDLGVPLTLLQLAPQHRSAVI 163
Cdd:PRK10773 82 DTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILR-QCG---NTLYTAGNLNNDIGVPLTLLRLTPEHDYAVI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 164 ELGASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRPLL 243
Cdd:PRK10773 158 ELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 244 TFSLDR-PQADFRAADLQRDARGcMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKG 322
Cdd:PRK10773 238 RFSPNAaNSVDFTATNIHVTSHG-TEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 323 RAVAQLTASGLRVIDDSYNANPASMLAAIDILSGFSGRTVLVLGDMGELGSWAEQAHREVG-AYAAGKVSALYAVGPLMA 401
Cdd:PRK10773 317 RLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGeAAKAAGIDKVLSVGKLSH 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 15599612 402 HAVQAFGaTGRHFADQASLIGALAT---EQPTTTILIKGSRSAAMDKVVAAL 450
Cdd:PRK10773 397 AISEASG-VGEHFADKTALIARLKAllaEHQVITILVKGSRSAAMEEVVRAL 447
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
26-450 |
4.30e-129 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 396.77 E-value: 4.30e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 26 SAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVADAPLPQLLVRDTRAALGRLGALNRRKFTGPLA 105
Cdd:PRK11929 527 GAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVV 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 106 AMTGSSGKTTVKEMLASILRTQAGDAeSVLATRGNLNNDLGVPLTLLQLAPQHRSAVIELGASRIGEIAYTVELTRPHVA 185
Cdd:PRK11929 607 AITGSNGKTTTKEMIAAILAAWQGED-RVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVA 685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 186 IITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRPLLTFSLdRPQADFRA----ADLQR 261
Cdd:PRK11929 686 LVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGL-QPGADVYAekiaKDISV 764
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 262 DARGCMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAVAQLTASGLRVIDDSYN 341
Cdd:PRK11929 765 GEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTYN 844
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 342 ANPASMLAAIDILSGF-SGRTVLVLGDMGELGSWAEQAHREVGAYAAGK-VSALYAVGPLMAHAVQAFGATGR-HFADQA 418
Cdd:PRK11929 845 ANPDSMRAAIDVLAELpNGPRALVLGDMLELGDNGPAMHREVGKYARQLgIDALITLGEAARDAAAAFGAGARgVCASVD 924
|
410 420 430
....*....|....*....|....*....|...
gi 15599612 419 SLIGALATEQP-TTTILIKGSRSAAMDKVVAAL 450
Cdd:PRK11929 925 EIIAALRGALPeGDSVLIKGSRFMRLERVVDAL 957
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
22-450 |
5.35e-62 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 208.86 E-value: 5.35e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 22 DAVFsAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVERE-----VADAPLpqLLVRDTRAALGRLGALN 96
Cdd:PRK14093 26 RDVT-GISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAqrdkfAADAPL--LVVDDVLAALRDLGRAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 97 RRKFTGPLAAMTGSSGKTTVKEMLASILRTQAGDAESVlatrGNLNNDLGVPLTLLQLAPQHRSAVIELGASRIGEIAYT 176
Cdd:PRK14093 103 RARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASV----ASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 177 VELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGR---PLLTFSLDrPQAD 253
Cdd:PRK14093 179 VKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAgiaRIVSFGAD-EKAD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 254 FRAADLQRDARgCMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAVA---QLTA 330
Cdd:PRK14093 258 ARLLDVALHAD-CSAVHADILGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRGVRhtlEVGG 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 331 SGLRVIDDSYNANPASMLAAIDILS----GFSGRTVLVLGDMGELGSWAEQAHREV-GAYAAGKVSALYAVGPLMAHAVQ 405
Cdd:PRK14093 337 GEATLIDESYNANPASMAAALGVLGrapvGPQGRRIAVLGDMLELGPRGPELHRGLaEAIRANAIDLVFCCGPLMRNLWD 416
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 15599612 406 AF--GATGRHFADQASLIGAL-ATEQPTTTILIKGSRSAAMDKVVAAL 450
Cdd:PRK14093 417 ALssGKRGGYAEDAAALESQVvAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
7-456 |
1.38e-50 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 183.62 E-value: 1.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 7 LSQLTVALDARLIGE-DAVFSAVSTDSRAI--GPGQLFIALSGPRFDGHDYLAEVAAKGAVAALV-EREVADAPLPQ--- 79
Cdd:PRK11930 5 LESISGILGAEGLGDkDAIIDQILTDSRSLsfPENTLFFALKGERNDGHRYIQELYEKGVRNFVVsEEKHPEESYPDanf 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 80 LLVRDTRAALGRLGALNRRKFTGPLAAMTGSSGKTTVKEMLASILRTQagdaESVLATRGNLNNDLGVPLTLLQLAPQHR 159
Cdd:PRK11930 85 LKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPD----YNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 160 SAVIELGASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKgeiLEGLAADGTAVLNLDDKAFDT-WKARAS 238
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEK---LKLFKDCDVIIYNGDNELISScITKSNL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 239 GRPLLTFSLDRPQADFR--AADLQRDARgcmGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQA 316
Cdd:PRK11930 238 TLKLISWSRKDPEAPLYipFVEKKEDHT---VISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMAR 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 317 LQPVKGRAVAQLTASGLRVIDDSYNANPASMLAAIDILS--GFSGRTVLVLGDMGELGSWAEQAHREVGAYA-AGKVSAL 393
Cdd:PRK11930 315 LEPVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNrrSQSKKKTLILSDILQSGQSPEELYRKVAQLIsKRGIDRL 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599612 394 YAVGPLMAHAVQAFGATG-RHFADQASLIGALA-TEQPTTTILIKGSRSAAMDKVVAALCGSSEE 456
Cdd:PRK11930 395 IGIGEEISSEASKFEGTEkEFFKTTEAFLKSFAfLKFRNELILVKGARKFEFEQITELLEQKVHE 459
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
108-287 |
2.80e-46 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 159.01 E-value: 2.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 108 TGSSGKTTVKEMLASILRTQAGdaesVLATRG--------NLNNDLGVPLTLLQLAPQ-HRSAVIELGASRIGEiAYTVE 178
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSLAGG----VIGTIGtyigksgnTTNNAIGLPLTLAEMVEAgAEYAVLEVSSHGLGE-GRLSG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 179 LTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRP--LLTFSLDrPQADFRA 256
Cdd:pfam08245 77 LLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGIE-GEADLRA 155
|
170 180 190
....*....|....*....|....*....|.
gi 15599612 257 ADLQRDARGCMGFRLQGVAGEAQVQLNLLGR 287
Cdd:pfam08245 156 ANIELSSDGTSFDLFTVPGGELEIEIPLLGR 186
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
28-366 |
1.43e-43 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 159.09 E-value: 1.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 28 VSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVA--DAPLPQLLVRDTRAALGRLGAL----NRRKFT 101
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGAllAAGVPVIVVPDPRAALALLAAAfyghPSQKLK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 102 gpLAAMTGSSGKTTVKEMLASILRtQAGDAESVLATRGNLNNDLGVPLTL-----LQLapQH----------RSAVIElg 166
Cdd:COG0769 82 --LIGVTGTNGKTTTTYLLAQILR-ALGKKTGLIGTVGNGIGGELIPSSLttpeaLDL--QRllaemvdagvTHVVME-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 167 AS-------RIGEIAYtveltrpHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASG 239
Cdd:COG0769 155 VSshaldqgRVDGVRF-------DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 240 RpLLTFSLDrPQADFRAADLQRDARGcMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQP 319
Cdd:COG0769 228 R-VITYGLK-ADADLRATDIELSADG-TRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15599612 320 VKGRAVAQLTASGLRVIDDsYNANPASMLAAIDILSGF-SGRTVLVLG 366
Cdd:COG0769 305 VPGRMERVDGGQGPTVIVD-YAHTPDALENVLEALRPHtKGRLIVVFG 351
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
15-370 |
1.65e-32 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 131.36 E-value: 1.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 15 DARLIGEDAVFSAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVAD----APLPQLLVRDTRAALG 90
Cdd:PRK11929 19 LAWLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDqvaaADALVLPVADLRKALG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 91 RLGAlnrRKFTGP-----LAAMTGSSGKTTVKEMLASILrTQAGDAESVLATRGNLNND--LGVPLT----------LLQ 153
Cdd:PRK11929 99 ELAA---RWYGRPseqlsLVAVTGTNGKTSCAQLLAQLL-TRLGKPCGSIGTLGARLDGrlIPGSLTtpdaiilhriLAR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 154 LAPQHRSAVIeLGASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTW 233
Cdd:PRK11929 175 MRAAGADAVA-MEASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 234 KARASGRPLLTFSLDRPQADFRAADLQRDARGCMgFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAG 313
Cdd:PRK11929 254 LAALPRGLKVGYSPQNAGADVQARDLRATAHGQV-FTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599612 314 LQALQPVKGR--AVAQLTASGLRVIDDSYNANPASMLAAIDILSGF----SGRTVLVLGDMGE 370
Cdd:PRK11929 333 LAAVSPVPGRmeRVGPTAGAQGPLVVVDYAHTPDALAKALTALRPVaqarNGRLVCVFGCGGD 395
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
22-365 |
1.87e-31 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 125.51 E-value: 1.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 22 DAVFSAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREV--ADAPLPQLLVRDTRAALGRLGAL---- 95
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVdfYVAPVPVIIVPDLRHALSSLAAAfygh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 96 --NRRKFTGplaaMTGSSGKTTVKEMLASILRtQAGDAESVLATRGN--LNNDL---------GVPLTLLQLAPQHRS-- 160
Cdd:TIGR01085 81 psKKLKVIG----VTGTNGKTTTTSLIAQLLR-LLGKKTGLIGTIGYrlGGNDLiknpaalttPEALTLQSTLAEMVEag 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 161 ---AVIElgASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARA 237
Cdd:TIGR01085 156 aqyAVME--VSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 238 SGRplLTFSLDRPQADFRAADLQRDARGCMG----FRLQGVAGEAQVQLNLLGR-HNVANALAAAAAAHALGVPLDGIVA 312
Cdd:TIGR01085 234 PKD--ITVSAITQPADGRAQDIKITDSGYSFegqqFTFETPAGEGHLHTPLIGRfNVYNLLAALATLLHLGGIDLEDIVA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15599612 313 GLQALQPVKGRAVAQLTASGLRVIDDsYNANPASMLAAIDILSGFSGRTVLVL 365
Cdd:TIGR01085 312 ALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
22-366 |
4.89e-30 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 121.39 E-value: 4.89e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 22 DAVFSAVSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVEREVADAP-LPQLLVRDTRAALGRLGAL--NRR 98
Cdd:PRK00139 12 PVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAGTgVPVIIVPDLRKALALLAAAfyGHP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 99 KFTGPLAAMTGSSGKTTVKEMLASILRtQAGDAESVLATRGN-LNNDL-------GVPLTLL----QLAPQH-RSAVIEl 165
Cdd:PRK00139 92 SDKLKLIGVTGTNGKTTTAYLLAQILR-LLGEKTALIGTLGNgIGGELipsglttPDALDLQrllaELVDAGvTYAAME- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 166 gASRIGEIAYTVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLaaDGTAVLNLDDKAFDTWKARAsgrplLTF 245
Cdd:PRK00139 170 -VSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSEL--GLAAVINADDEVGRRLLALP-----DAY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 246 SLDRPQADFRAADLQRDARGcMGFRLQGvageaQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGR-A 324
Cdd:PRK00139 242 AVSMAGADLRATDVEYTDSG-QTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRmE 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599612 325 VAQLTASGLRVIDdsYNANPASMLAAIDILSGF-SGRTVLVLG 366
Cdd:PRK00139 316 RVDAGQGPLVIVD--YAHTPDALEKVLEALRPHaKGRLICVFG 356
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
98-397 |
5.98e-16 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 79.69 E-value: 5.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 98 RKFTGPLAAMTGSSGKTTVKEMLASILRTQAGDAesVLAtrGNLnndlGVPLtlLQLAPQHRSAVIELGASRIgEIAYTV 177
Cdd:TIGR01087 98 RLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKA--FLG--GNI----GTPA--LEVLDQEGAELYVLELSSF-QLETTE 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 178 ELtRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFdTWKARASGRPLLTFSLDRPqADFRAA 257
Cdd:TIGR01087 167 SL-RPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRF-ARLAQKSKAQVIWFSVEKD-AERGLC 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 258 DLQrDARGCMGFRLQGvageaqvqlNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAVAQLTASGLRVID 337
Cdd:TIGR01087 244 IRD-GGLYLKPNDLEG---------SLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYN 313
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599612 338 DSYNANPASMLAAidiLSGFSGRTVLVLGDMG---ELGSWAEqahrevgaYAAGKVSALYAVG 397
Cdd:TIGR01087 314 DSKATNVHATLAA---LSAFDNPVILIVGGDDkgaDFSPLAP--------AAAGKVKAVLAIG 365
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
98-408 |
3.45e-14 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 74.35 E-value: 3.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 98 RKFTGPLAAMTGSSGKTTVKEMLASILRtQAGdAESVLAtrGNLnndlGVP-LTLLQLAPQHRSAVIEL------GASRI 170
Cdd:COG0771 101 RLSPAPIIAITGTNGKTTTTTLIGHILK-AAG-LRVAVG--GNI----GTPlLDLLLEPEPPDVYVLELssfqleTTPSL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 171 geiaytveltRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRpLLTFSLDRP 250
Cdd:COG0771 173 ----------RPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKAR-VVPFSLKEP 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 251 QADfraadlqrdargcmGFRLQG----VAGEAQV-----QLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVK 321
Cdd:COG0771 242 LEG--------------GAGLEDgklvDRASGEEllpvdDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLP 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 322 GRA--VAqlTASGLRVIDDSYNANPASMLAAidiLSGFSGRTVLVLG------DMGELgswaeqahrevGAYAAGKVSAL 393
Cdd:COG0771 308 HRLefVA--EINGVRFINDSKATNPDATLAA---LESFDGPVVLIAGgldkgaDFSPL-----------APAVAERVKAV 371
|
330
....*....|....*...
gi 15599612 394 YAVG---PLMAHAVQAFG 408
Cdd:COG0771 372 VLIGedaEKIAAALAGAG 389
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
25-372 |
1.49e-12 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 69.30 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 25 FSAVSTDSRAIGPGQLFIAlSGPRFDgHDYLAEVAAKGAVAALVEREVaDAPLPQLLVRDTRAALgrlgALNRRKFTG-P 103
Cdd:PRK14022 34 FDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLKLYVSEKDY-EVGIPQVIVPDIKKAM----SLIAMEFYDnP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 104 -----LAAMTGSSGKTTVKEMLASILRTQAGDAeSVLATRGNLNND------LGVPLTlLQLAPQHRSAVIELGASRIGE 172
Cdd:PRK14022 107 qhklkLLAFTGTKGKTTAAYFAYHILKQLHKPA-MLSTMNTTLDGEtffksaLTTPES-LDLFKMMAEAVDNGMTHLIME 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 173 I---AYTVELTRP---HVAIITNAGTAHVG--EFGGPEKIVEAKGEILEGLAAdgtAVLNLDDKAFDTWKARASGRPLLT 244
Cdd:PRK14022 185 VssqAYLVGRVYGltfDVGVFLNITPDHIGpiEHPTFEDYFYHKRLLMENSKA---VVVNSDMDHFSELLEQVTPQEHDF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 245 FSLDRpqadfraaDLQRDARGCMGFRLQG-VAGEAQVQlnLLGRHNVANALAAAAAAHALGVPLDGIVAGLQAlQPVKGR 323
Cdd:PRK14022 262 YGIDS--------ENQIMASNAFSFEATGkLAGTYDIQ--LIGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TPVPGR 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15599612 324 aVAQLTAS-GLRVIDDsYNANPASMLAAIDILSGF-SGRTVLVLGDMGELG 372
Cdd:PRK14022 331 -MEVLTQSnGAKVFID-YAHNGDSLNKLIDVVEEHqKGKLILLLGAAGNKG 379
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
92-351 |
3.35e-11 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 65.02 E-value: 3.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 92 LGALNRRKFTgplAAMTGSSGKTTVKEMLASILrTQAGDAESVL----ATRGNLNNDLGvpltllqlapQHRSAVIELGA 167
Cdd:TIGR01082 92 LAELMRFRHS---IAVAGTHGKTTTTAMIAVIL-KEAGLDPTVVvgglVKEAGTNARLG----------SGEYLVAEADE 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 168 SRIGEIAYTveltrPHVAIITNAGTAHVGEFGGP-EKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASgRPLLTFS 246
Cdd:TIGR01082 158 SDASFLHLQ-----PNVAIVTNIEPDHLDTYGSSfERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKAT-EQVITYG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 247 LDRPQADFRAADL-QRDARGCMGFRLQGVAGEAqVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAV 325
Cdd:TIGR01082 232 GSGEDADYRAENIqQSGAEGKFSVRGKGKLYLE-FTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFE 310
|
250 260
....*....|....*....|....*.
gi 15599612 326 AQLTASGLRVIDDsYNANPASMLAAI 351
Cdd:TIGR01082 311 ILGEFGGVLLIDD-YAHHPTEIKATL 335
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
28-94 |
6.60e-11 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 58.40 E-value: 6.60e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599612 28 VSTDSRAIGPGQLFIALSGPRFDGHDYLAEVAAKGAVAALVER----------EVADAPLPQLLVRDTRAALGRLGA 94
Cdd:pfam01225 5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDaannispdnpELEAAKVPGIPVIDRREALAELAA 81
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
92-338 |
1.06e-08 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 57.00 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 92 LGALNRRKFTgplAAMTGSSGKTTVKEMLASILRtQAGdaesvlatrgnlnndlgvpltllqLAPqhrSAVI-----ELG 166
Cdd:COG0773 97 LAELMRGKRS---IAVAGTHGKTTTTSMLAHILE-EAG------------------------LDP---TFLIggilnNFG 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 167 AS-RIGEIAYTV----E------LTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKA 235
Cdd:COG0773 146 TNaRLGDGDYFVaeadEsdgsflHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLP 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 236 RAsGRPLLTFSLDrPQADFRAADLQRDARGcMGFRLQgVAGE--AQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAG 313
Cdd:COG0773 226 RC-GRPVITYGFS-EDADYRAENIRIDGGG-STFDVL-RRGEelGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEA 301
|
250 260
....*....|....*....|....*
gi 15599612 314 LQALQPVKGRAVAQLTASGLRVIDD 338
Cdd:COG0773 302 LASFKGVKRRFELKGEVGGVTVIDD 326
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
320-387 |
4.59e-07 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 47.72 E-value: 4.59e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599612 320 VKGRAVAQLTASGLRVIDDsYNANPASMLAAIDIL-SGFSGRTVLVLGDMGELGswaEQAHREVGAYAA 387
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrNLFPGRLILVFGGMGDRD---AEFHALLGRLAA 65
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
103-249 |
1.37e-06 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 50.93 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 103 PLAAMTGSSGKTTVKEMLASIL--------------------RTQAGD------AESVLatrgnLNNDLGVpltllqlap 156
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILklsgkrvgmtttdgvyidgrLIDKGDctgpksARRVL-----MNPDVEA--------- 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 157 qhrsAVIELGAsriGEI-----AYTveltRPHVAIITNAGTAHVGEFG--GPEKIVEAKGEILEGLAADGTAVLNLDDKA 229
Cdd:PRK14016 547 ----AVLETAR---GGIlreglAYD----RCDVGVVTNIGEDHLGLGGinTLEDLAKVKRVVVEAVKPDGYAVLNADDPM 615
|
170 180
....*....|....*....|
gi 15599612 230 FDTWKARASGRPLLtFSLDR 249
Cdd:PRK14016 616 VAAMAERCKGKVIF-FSMDP 634
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
102-246 |
1.76e-06 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 49.97 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599612 102 GPLAAMTGSSGKTTVKEMLASILRtQAGDAESVLatrGNLnndlGVPLTllqlapqhrSAVIELGASRI--GEIAY---- 175
Cdd:PRK14106 108 APIVAITGTNGKTTTTTLLGEIFK-NAGRKTLVA---GNI----GYPLI---------DAVEEYGEDDIivAEVSSfqle 170
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599612 176 TVELTRPHVAIITNAGTAHVGEFGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRpLLTFS 246
Cdd:PRK14106 171 TIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKAR-VIFFS 240
|
|
| |
