|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
20-393 |
7.84e-140 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 405.83 E-value: 7.84e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMAL 179
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 180 VGLLLILFFVPQPDHMTQHRESSVARQALLptLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGlPKEQHWWVYLT 259
Cdd:cd17472 161 VSLLILLFFVPDPPKIVQISEKEKKKLKKL--LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGG-GKGQLWKVYLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 260 ALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGG 339
Cdd:cd17472 238 AILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEY 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599429 340 KGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMR 393
Cdd:cd17472 318 RGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-393 |
7.13e-48 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 168.52 E-value: 7.13e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGM 177
Cdd:cd17325 80 FATSYWQLLLARFLQGLASaaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLILFFVPQPDHMTQHRESSVA--RQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWW 255
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAArlRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 256 VYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLAceLFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVS 335
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA--LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599429 336 PAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMR 393
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-352 |
1.45e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 156.29 E-value: 1.45e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGlgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 173 FTAGMALVGLLLILFFVPQPDHMTQHREssvaRQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQ 252
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARL----RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 253 HWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLAceLFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVS 332
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG--LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|
gi 15599429 333 KVSPAGGKGTAMGVYSTSQF 352
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFF 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-392 |
2.35e-34 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 131.92 E-value: 2.35e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAFrmLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGA 95
Cdd:cd17474 2 YAVFFATLLAV--LGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 96 ALAANADSIWGVIAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIGMSIGvsfaVAMVLGPVLTHLFGLHG---L 170
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAagLGPLALTLIGDLFEGGERAKAMGLYEAALG----LGIAVGPLLGGLLAAISwryP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 171 FWFTAGMALVGLLLILFFVPqPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPK 250
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLP-EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 251 EQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACeLFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSL 330
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS-LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599429 331 VSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTM 392
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-388 |
4.53e-33 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 128.48 E-value: 4.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGM 177
Cdd:cd17489 80 LATSVALLLVLRLIHGIGwgAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLILF--FVPQPDHMTQHRESSVARQALLPTLkhgdllRLDAGILILHAILMASFVA-LPLALVHEGGlpkeQHW 254
Cdd:cd17489 160 ALLALLLVFLvkDPPPVAAEEAEAGTRAFRRLVEKKV------LPPALILFLASIAYGAISTfLPLYAAERGI----SNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 255 WVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAvATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKV 334
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPG-LLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15599429 335 SPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAI 388
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-352 |
8.68e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.76 E-value: 8.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGM 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGlgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLILFFVPQPDHMTQHRESSVARQALLPT--LKHGDLLRLDAGILILHAILMASFVALPLALVHEgGLPKEQHWW 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 256 VYLTALLVGFFGMVPFIIYAEKKRRMKR-VLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKV 334
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330
....*....|....*...
gi 15599429 335 SPAGGKGTAMGVYSTSQF 352
Cdd:pfam07690 320 APKEERGTASGLYNTAGS 337
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-392 |
1.92e-30 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 121.53 E-value: 1.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17320 4 LALLVALGPLAIDMYLPALPAIARDL-GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAGAISAAVM--ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGM 177
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLILFFVPQ-PDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWV 256
Cdd:cd17320 163 GLLLLLLVLLFLPEtLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 257 YLtALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVF----GHSLAMLVVGTVVFFTAFNLLEASLPSLVS 332
Cdd:cd17320 243 FA-LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallgGLSLWPLVAPLFLIFFGFGLIFPNATSLAL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 333 KVSPaGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVfIGCAVLAALWLAIAVTM 392
Cdd:cd17320 322 EPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMG-LLILVLGLLALLLLILL 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-390 |
5.32e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 117.14 E-value: 5.32e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLT--HLFGLHGLFWFTA 175
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSglIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 176 GMALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLKH----GDLLRLDAGILILHAILMASFVALPLALVHEGGLPKE 251
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 252 QHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLpSLV 331
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF-ALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 332 SKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMF-QHGGLSMVFIGCAVLAALWLAIAV 390
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
31-389 |
8.52e-29 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 116.49 E-value: 8.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 31 MFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAG 110
Cdd:cd17324 15 EYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 111 RVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFF 188
Cdd:cd17324 94 RALAGlaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 189 VPQPDHMTQHRESSVARQALLptLKHGDLLRldagILILHAILMASFVA----LPLALVHEGGLPKEQHWWVYLTALLVG 264
Cdd:cd17324 174 LPSLPPKKPGSLGLLSSLLLL--LRNPRLRL----AYLITFLLFGGFFAlytyLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 265 FFGMVPFIIYAekKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAgGKGTAM 344
Cdd:cd17324 248 VVGSPLAGRLA--DRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLAS 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15599429 345 GVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIA 389
Cdd:cd17324 325 SLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-393 |
1.10e-27 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 113.48 E-value: 1.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLThLFGLHGLFWFTAGM 177
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGglFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVY 257
Cdd:cd17329 163 FLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 258 LTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVatLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPA 337
Cdd:cd17329 243 ALNALLIVLLQFPVARLVERFRLRKILMIGIL--LFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15599429 338 GGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMR 393
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-189 |
2.87e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.51 E-value: 2.87e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGlgLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 15599429 173 FTAGMALVGLLLILFFV 189
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-396 |
3.51e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.81 E-value: 3.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAFrmlGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGA 95
Cdd:COG2223 8 LLATLAFFLAF---GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 96 ALAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWF 173
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGigGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 174 TAGMALVGLLLILFFVPQPDHMTQHRESSVARqALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQH 253
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAAKASLR-DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 254 WWVYLTALLVGFFGMVPFIIYAEKKRRmKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSK 333
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGG-RRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599429 334 VSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQH-GGLSMVFIGCAVLAALWLAIAVTMREPP 396
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-389 |
3.90e-24 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 103.04 E-value: 3.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLA--GATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWG 106
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 107 VIAGRVLQGA-GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLI 185
Cdd:cd17330 90 LFLARFLDGLtGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 186 LFFVPqpdhmtqhressvarqallptlkhgdLLRLDAGILILHAILMASF-VALPLALVHEGGLPKEQHWWVYLtalLVG 264
Cdd:cd17330 170 LFFLP--------------------------PLRRLLLVYFLIALAFAGLeSVFSLFLKDRFGFSPSQIGLLLA---LVG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 265 FFGMVPFIIYAEKKRRM---KRVLTGAVAtLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKG 341
Cdd:cd17330 221 IAGILAQLLLIPRLAKRlgeRKLLRLGLL-LAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQG 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15599429 342 TAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIA 389
Cdd:cd17330 300 KAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-393 |
4.70e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 103.03 E-value: 4.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGeaGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 173 FTAGMALVGLLLilffvpqpdhmtqhressvarqallptlkhgDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQ 252
Cdd:COG2271 169 ILGLPGLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 253 HWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVS 332
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599429 333 KVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMR 393
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
36-347 |
2.23e-22 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 98.06 E-value: 2.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 36 PVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRR-PVIVVGLLIFAAGAALAANADSIWGVIAGRVLQ 114
Cdd:cd17490 17 PFLSPYAESL-GASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 115 GAGAISAAV-MALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPD 193
Cdd:cd17490 96 GIAAATWVSfTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 194 HmtqHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFII 273
Cdd:cd17490 176 E---KKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGT 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599429 274 YAEKKRRMKR-VLTGAVATLLACELFFLVFghSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVY 347
Cdd:cd17490 253 LFYKKLGERNtIIIGFLLLGAYCFLIPFAP--NLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFF 325
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-389 |
2.28e-21 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 95.33 E-value: 2.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 18 VGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAAL 97
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 98 AANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLThLFGLHGLFWFTa 175
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGvaGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVY- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 176 GMALVGLLLILFFVPQPdhMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQhww 255
Cdd:cd17473 160 LLALPVLILVLLFLPEP--ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAL--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 256 VYLTALLVGFFGMVPFIIYAEKKRRM-KRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKV 334
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLgKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599429 335 SPAGGKGTAMGVYSTS----QFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIA 389
Cdd:cd17473 315 VPPELRGRAMGIVTSAfflgQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-275 |
7.04e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 92.57 E-value: 7.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGigAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 173 FTAGMALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQ 252
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260
....*....|....*....|...
gi 15599429 253 HWWVYLTALLVGFFGMVPFIIYA 275
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALL 275
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
33-384 |
1.14e-20 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 92.99 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRR-PVIVVGLLIFAAGAALAANADSIWGVIAGR 111
Cdd:cd17370 17 MARSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 112 VLQ--GAGAISAAVMALLSDLTREQHRTK------AMAMIGMSIGVSFAVAMVLGpvltHLFGLHGLFWFTAGMALVGLL 183
Cdd:cd17370 96 ILErlGKGIRTPPRDALLADATPPSGRGKafglhrALDTLGAVLGPLLAALLLYL----LGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 184 LILFFVPQPDHmtqhresSVARQALLPTLKHGDLLRLDAGILILHAILMASFV--ALPLALVHEGGLPKEQHWWVYLTAL 261
Cdd:cd17370 172 ILLFVVKEYPR-------PPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFsfAFLILRAQELGLSAALIPLLYALFN 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 262 LVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFflVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKG 341
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF--ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599429 342 TAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAAL 384
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
20-350 |
6.27e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 91.10 E-value: 6.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFrMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17504 2 ALAALAV-MLVETMLSPALPTIQREF-GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGAG-AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMA 178
Cdd:cd17504 80 FAPNLPVLIAGRALQGIGgAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 179 LVGLLLILFFVPQpdhmtqhressvarqallpTLKHGDLLRLDAGILILHAILMASFVALPLAL----VHEGGLPKEQHW 254
Cdd:cd17504 160 VLLAALVPLIDLR-------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLqlptPTGFGLGITEAG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 255 WVYLTALLVGFFGmVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKV 334
Cdd:cd17504 221 LLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVES 299
|
330
....*....|....*.
gi 15599429 335 SPAGGKGTAMGVYSTS 350
Cdd:cd17504 300 VPPDRTGIATGMNTVL 315
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-351 |
2.41e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 86.88 E-value: 2.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 18 VGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIG-----RRPVIVVG----- 87
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGaipla 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 88 -LLIFAAGAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQH-RTKAMAMIGMSIGVSFAVAMVLGPVLTH 163
Cdd:COG2211 93 lSFVLLFTAPDLSPTGKLIYALVTYLLLGLAytLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 164 LF------GLHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRESsvARQALLPTLKHGDLLRLDAGILILHAILMASFVA 237
Cdd:COG2211 173 AFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS--LKESLKALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 238 LPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFF 317
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG 330
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15599429 318 TAFNLLEASLPSLVSKVSPAGGK-------GTAMGVYSTSQ 351
Cdd:COG2211 331 IGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAI 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-353 |
7.29e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 84.92 E-value: 7.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGV 107
Cdd:cd17321 9 ALDVTIVNVALPTIARDL-GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 108 IAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLI 185
Cdd:cd17321 88 IAARALQGIGAaaIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 186 LFFVPqpdhmtqhreSSVArqallptlkhgdllrldagILILHAILMASFVALPLALVHEGGLPkEQHWWVYLTALLVGF 265
Cdd:cd17321 168 RTFSG----------AVLA-------------------AFLLGAALGGLLFLLPLYLQGVLGYS-PLQAGLALLPLALAM 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 266 FGMVPFIIYAEKKRRMKRVLTG--AVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTA 343
Cdd:cd17321 218 LVAAPLAGRLADRFGPRLVLVAglLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAA 297
|
330
....*....|
gi 15599429 344 MGVYSTSQFL 353
Cdd:cd17321 298 SGILNTARQL 307
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
54-190 |
9.65e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 76.92 E-value: 9.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 54 GLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLT 131
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfgAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599429 132 REQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
29-232 |
1.60e-16 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 81.14 E-value: 1.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLAGATPAL---IGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIW 105
Cdd:cd17388 13 MGIGLIMPVLPTLLREFVGDSADAathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 106 GVIAGRVLQG-AGAISAAVMALLSDLTREQHRTKAMAMigmsIGVSFAVAMVLGPVLTHLFGLHGL---FWFTAGMALVG 181
Cdd:cd17388 93 WLYLGRIIAGiTGATGAVAAAYIADVTPPEQRARNFGL----LGAAFGLGFIAGPALGGLLGEISPrapFLVAAGLNGLN 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15599429 182 LLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILM 232
Cdd:cd17388 169 FLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQ 219
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
33-191 |
2.08e-16 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 80.72 E-value: 2.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDLAGATPALIGLaIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRV 112
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAV-MAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 113 LQGAGAISAAVMA--LLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:PRK11652 105 IQGLGTGVGGVMArtLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184
|
.
gi 15599429 191 Q 191
Cdd:PRK11652 185 E 185
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-191 |
5.87e-16 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 79.19 E-value: 5.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVI 108
Cdd:PRK11102 5 LAIDMYLPALPVIAADF-GVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 109 AGRVLQGAGAISAAVM--ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLIL 186
Cdd:PRK11102 84 YMRFLHGLAAAAASVVinALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
....*
gi 15599429 187 FFVPQ 191
Cdd:PRK11102 164 FFIPE 168
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
17-316 |
5.98e-16 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 79.35 E-value: 5.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 17 AVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAA 96
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADL-STPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 97 LAANADSIWGVIAGRVLQGAGAISAAVM--ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFT 174
Cdd:TIGR00710 86 GLALSNNIETLLVLRFVQAFGASAGSVIsqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 175 AGMALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHW 254
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFG 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 255 WVYLT---ALLVGFFGMVPFI--IYAEKKRRMKRVLTGAVATLLAcelFFLVFGHSLAMLVVGTVVF 316
Cdd:TIGR00710 246 LLFALniiAMIFGGFLNGRFIkkWGAKSLLRMGLILFAVSAVLLE---ITAILGLGSWAMIIGPMMF 309
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
15-186 |
2.13e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 74.50 E-value: 2.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVlPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSF-AFLILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGAG-AISAAVM-ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYmGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|....
gi 15599429 173 FTAGMALVGLLLIL 186
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-384 |
2.39e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.19 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFMVLPVLATYGQDLAGAtPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVV-----GLLIFAAGAALAANAD 102
Cdd:cd06173 12 ALGDWIFTVALPWLVLQLTGS-ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 103 SIWGVIAGRVLQGAGAI--SAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALV 180
Cdd:cd06173 91 SLWLLLVLAFLLGIASAffGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 181 GLLLILFFVPQPDHMTQHRESSVARQAL--LPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVYL 258
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLRegLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 259 TALLVGFFGMVPFIIYAEKKRRMKRVLTGAVAtLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAG 338
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGAL-LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 15599429 339 GKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAAL 384
Cdd:cd06173 330 LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-392 |
3.77e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 73.37 E-value: 3.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 34 VLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVL 113
Cdd:cd17319 21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 114 QGA--GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQ 191
Cdd:cd17319 101 LGVaeAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 192 pdhmtqhressvarqallptlkhgdLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPF 271
Cdd:cd17319 181 -------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 272 IIYAEKKRRMKRVLTGAVATLL-ACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTS 350
Cdd:cd17319 236 GRLSDRLLRGARRLVIIIGLLLaAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599429 351 QFLGAALGGILGGWMFQH-GGLSMVFIGCAVLAALWLAIAVTM 392
Cdd:cd17319 316 GNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
20-384 |
5.48e-14 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 73.01 E-value: 5.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDL-AGATPALIGLAIGAYGLTQAILQIPFGTISDRIG-RRPVIVVGLLIFAA---- 93
Cdd:cd17326 4 MYLTMFLSSLQFSIVLTSIWPYLQKIdPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVgnil 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 94 -GAALAANADSIWGVIAGRVLQGAGAISAAVM-ALLSDLTREQHRTKAMAMIGMSigvsFAVAMVLGPVLTHLF---GLH 168
Cdd:cd17326 84 yALAEYFPSNRKYVMLVARFLIGVGAGNVAVLrAYVAAASTLKDRTRAMAVISAA----QALGFIVGPALQAAFtpiGYP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 169 GL--------------FWFTAGMALVGLLLILFFvpqpdhmtqhressvarqallptLKHGDLLRLDAGILILHAILMAS 234
Cdd:cd17326 160 GYvigiklrfnmytapAWLMAILGIINIILILFF-----------------------FKEVVCIFLFFVVLFIFANLETI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 235 fvALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRmkrVLTGAVATLLACELFFLVFGHSLAMLVVGTV 314
Cdd:cd17326 217 --GTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLG---LIDERKILLGGLILFFLGFVVTLPWGITGVI 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 315 VFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAAL 384
Cdd:cd17326 292 LFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLL 361
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
55-190 |
2.85e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 71.07 E-value: 2.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 55 LAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGAGaiSAAVMAL----LSDL 130
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF--GSSPLAIgagtIADL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 131 TREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:cd17323 116 FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
29-312 |
9.00e-13 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 69.67 E-value: 9.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVI 108
Cdd:PRK10473 17 AGIDMYLVGLPRIAADL-NASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 109 AGRVLQGAGAISAAVM--ALLSDLTREQHRTKAMAMIGmsiGVSfAVAMVLGPVLTHLFGLH----GLFWFTAGMALVGL 182
Cdd:PRK10473 96 AGRFLQGIGAGCCYVVafAILRDTLDDRRRAKVLSLLN---GIT-CIIPVLAPVLGHLIMLKfpwqSLFYTMAAMGILVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 183 LLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILmaSFV-ALPLALVHEGGLPKEQHWWVY-LTA 260
Cdd:PRK10473 172 LLSLFILKETRPARAPAASSKPRENSESLLNRFFLSRLVITTLSVTVIL--TFVnTSPVLLMEQMGFSRGEYAIIMaLTA 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 15599429 261 L---LVGFfgMVPFIIYAEKKRRMkrVLTGAVatLLACELFFLVFGHSLAMLVVG 312
Cdd:PRK10473 250 GvsmTVSF--STPFALGIFKPRTL--MLTSQV--LFLAAGITLALSPSHAVSLFG 298
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-390 |
1.10e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.17 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 31 MFMVLPVLATYGQDlaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAG 110
Cdd:cd17316 18 IGFVAPVLAAEFSL--GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 111 RVLQGA--GAISAAVMALLSDLTREQHRTKAMAMI--GMSIGVSFA--VAMVLGPVLTHLFGLHGLFWFTAGMALVGLLL 184
Cdd:cd17316 96 RFLQGIgiGGEYPGASTYVAEFAPSKRRGFALGLLqsGWALGALLAalVASLLIPLLSGDWGWRILFLIGALPALLALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 185 ilffvpqpdhmtqhressvarqallptlkHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVG 264
Cdd:cd17316 176 -----------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 265 FFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAM 344
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15599429 345 GV-YSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAV 390
Cdd:cd17316 307 GLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
28-192 |
1.32e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 69.15 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMF---MVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSI 104
Cdd:PRK11043 16 MLGFLatdMYLPAFKAIQADL-QTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 105 WGVIAGRVLQGAGAISAAVM--ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGL 182
Cdd:PRK11043 95 AQLLVLRFVQAVGVCSAAVIwqALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLI 174
|
170
....*....|
gi 15599429 183 LLILFFVPQP 192
Cdd:PRK11043 175 LPTLRLKPSK 184
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
51-208 |
1.80e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 68.54 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 51 ALIGLAIGAygltqailqIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQ--GAGAISAAVMALLS 128
Cdd:TIGR00895 61 GLIGMAFGA---------LFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAglGLGGLMPNLNALVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 129 DLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRESSVARQAL 208
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIV 211
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-310 |
2.42e-12 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 67.96 E-value: 2.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIG-RRPVIVVGLLIFAAGAALA 98
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 99 ANADSIWGV-IAGRVLQGAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGP----VLTHLFGLHGLFWF 173
Cdd:cd17471 81 AFLRNYWVLlLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPplafLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 174 TAGMALVGLLLILFFVPQPDHMTQHRESSVARQallPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQH 253
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKATPASSLV---KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599429 254 WWVY-LTALLvgffgMVPFIIYA---EKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLV 310
Cdd:cd17471 238 GLLFgLAAAL-----EIPIMLLAgllAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIA 293
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-187 |
3.28e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 67.59 E-value: 3.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFM-------VLPVLATYGQDLAGAtpALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAAN 100
Cdd:cd17502 2 MLALFLaaldqtiVATALPTIVAEFGGL--SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 101 ADSIWGVIAGRVLQ--GAGAISAAVMALLSDLTREQHRTKAMAMigmsIGVSFAVAMVLGP----VLTHLFGLHGLFWF- 173
Cdd:cd17502 80 APNMTMLIVGRAIQgiGGGGLMSLAFIIIADLVPPRERGKYQGY----IGAVFGIASVAGPliggAFTDHLSWRWCFYIn 155
|
170
....*....|....*.
gi 15599429 174 --TAGMALVGLLLILF 187
Cdd:cd17502 156 lpIGGLALALLRTILL 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-311 |
8.18e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.82 E-value: 8.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGA 95
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADL-GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 96 ALAANADSIWGVIAGRVLQGAGaISAAVMALLSDLTRE--QHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWF 173
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 174 TAGMALVGLLLILFFVPqpdHMTQHRESSVARQALLPTLKHGDLLRLdAGILILHAILMASFVALPLALVHEGGLPKEQH 253
Cdd:COG2807 177 WALLALLALLLWLPLLR---RRPAAAAAAPAAASLRSLWRSPLAWLL-TLFFGLQSLLYYAVVAWLPPILRDAGLSAATA 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599429 254 WWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVV 311
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA 310
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-390 |
8.24e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.43 E-value: 8.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 34 VLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVL 113
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 114 QGAG--AISAAVMALLSDLTREQhRTKAMA--MIGMSIGvsFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFV 189
Cdd:cd17478 94 AGIGsaAFHPEGARLASQAAGGR-RGLAMSifSVGGNLG--FALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 190 PQPDHMTQHRESSVARQALLPTLKHGdLLRLDAGILILHAILMASFVALPLALVHEGGlpKEQHWWVYLTALLvgFFGMV 269
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRA-LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGY--SLVFAGLLLSLFL--FAGAI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 270 PFII--YAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLleASLPSLVSKVSPaGGKGTAMGVY 347
Cdd:cd17478 246 GTLIggPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF--PVTVVLAQELLP-GNVGLASGLM 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15599429 348 STSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAV 390
Cdd:cd17478 323 MGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-154 |
2.16e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.00 E-value: 2.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599429 95 AALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVA 154
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGfgLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-323 |
2.79e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 65.34 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 18 VGLSLVFAFRMLGMFMVLPVLATYGQDLAGATpaLIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAAL 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSS--NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 98 AANADSIWGVIAGRVLQGAG-AISAAVMALLSDLTREQHRTKAMAMI--GMSIGVSFAVAMVLGPVLTHLFGLHGLFWFT 174
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGaGTQGLGAAVASELVPNKYRGLVQGVVnlVASPGSALGPLIAGALVEANAAGWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 175 AGMALVGLLLILFFVPQPDHMTQHRESSvaRQAllptlkhgdLLRLDAGILILhaiLMASFVALPLALVHEGGlpkeQHW 254
Cdd:cd06179 159 AIFNALALILLFFFYHPPPRPQLHGSST--RQK---------LKRLDWVGLFL---LIAGLVLFLLGLSWGGN----PYP 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599429 255 WV---YLTALLVGFFGMVPFIIYAEKkrrmkrvltGAVATLLACELFFLVFGHSLAMLV--VGTVVFFTAFNLL 323
Cdd:cd06179 221 WSsahVIAPLVIGGVLLIAFGLYEWK---------GTKDGLLPPRLLFRGRNFALILIVafVEGMIFYSLNIFW 285
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-352 |
7.12e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.80 E-value: 7.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 35 LPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQ 114
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 115 GAGAISA------AVMALLsdltREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALV-GLLLILF 187
Cdd:cd17475 95 GAGYGSVqpgggrAIMRWF----PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILaAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 188 FVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVGFFG 267
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 268 MVPFIIYAEK--KRRMKRVL--TGAVATLLACELFFLVFGHSLAmLVVGTVVFFTAFNLLEASLP-SLVSKVSPAGGKGT 342
Cdd:cd17475 251 RIGLGRVSDRvfGGRRRPVLviTAAIAAAALLVLSLLSPGTPLW-LLVLLLILLGLFAIGWNGLYlTLVAESAGPEQAGT 329
|
330
....*....|
gi 15599429 343 AMGVYSTSQF 352
Cdd:cd17475 330 ALGLANTINF 339
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-322 |
1.33e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 34 VLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVL 113
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 114 QGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLF-GLHGLFWFTAGMALVGLLLILFFV- 189
Cdd:cd17328 97 VGIGeaSYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVr 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 190 -PQPDHMTQHRESSVARQALLPTLKhgDLLRLDAGILILHAILMASFVALPLAL--------VHEGGLPKEQHWWVYLTA 260
Cdd:cd17328 177 ePPRGAAEGGVMAKSTATSFLADLK--ALAKNPSFILSTLGFTAVSFVTGALAFwaptfflrAFGVGDLSSADVGLIFGA 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599429 261 L--LVGFFGMVPFIIYAEKKRRMK---RVLTGAVATLLACELFFL-VFGHSLAMLVVGTVVFFTAFNL 322
Cdd:cd17328 255 ItcIAGVLGVLLGGILADRLRRKTpraDPLVCAVGLLAAAPFLFLaLVLALSNLLLAWVLLFLGEFLL 322
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-188 |
3.28e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 61.82 E-value: 3.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 14 TRAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPV-IVVGLLIFA 92
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVlLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 93 AGAALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAMAMIGMSIGV-SFAVAMVLGPVLTHLFGLHG 169
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLLGLalGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATGSYTA 363
|
170
....*....|....*....
gi 15599429 170 LFWFTAGMALVGLLLILFF 188
Cdd:COG2223 364 AFLVFAVLALVALVLTLLL 382
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
29-186 |
5.72e-10 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 60.70 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVI 108
Cdd:cd17390 10 FGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 109 AGRVLQGA-GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFavamVLGPVL-THLFGLHGLFWFTAgmALVGLLLIL 186
Cdd:cd17390 89 LSRIPLGIfKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGF----ILGPVVgGHLAETDGGFYYVA--LLCSAIFIL 162
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
16-346 |
6.35e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 60.78 E-value: 6.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSL-VFAFRMLGmFMVLPVLATYGQDLAGA----TPALIGLAIGAygltqailqIPFGTISDRIGRRPVIVVGLLI 90
Cdd:cd17371 4 AFLGWALdGFDLLLLG-LVLPALIAEFGLDEAEAgllgTVTLAGGAIGG---------ILGGILADRFGRVRVLVITILL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 91 FAAGAALAANADSIWGVIAGRVLQ--GAGAISAAVMALLSDLTREQHRTKAMAMI--GMSIGVSFAVAM--VLGPVLTHL 164
Cdd:cd17371 74 FAVFTLLCGFAQNYWQLLILRALAglGFGGEWAAGAALMAEYVPARHRGKALGYVqsGWAVGWLLATLLaaLLFPLLPPE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 165 FGLHGLFWFTAGMALVgLLLILFFVPQPDHMTQHRE--SSVARQALLPTLKHGDLLRLDAGILILHAILMASFVA----L 238
Cdd:cd17371 154 IAWRVLFLLGALPALL-VLFIRRFVKEPPQWQAARAarRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGittwL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 239 PLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFT 318
Cdd:cd17371 233 PSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFF 312
|
330 340
....*....|....*....|....*...
gi 15599429 319 AFNLLeASLPSLVSKVSPAGGKGTAMGV 346
Cdd:cd17371 313 ASGPF-SGMGAYLTELFPTAVRATAQGF 339
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
71-391 |
1.60e-09 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 59.54 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 71 FGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVS 150
Cdd:cd17331 55 FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIG 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 151 FAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRE----SSVARQALLPTLKHGDLLRLDAGILI 226
Cdd:cd17331 135 MVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEakesASPPSVFNLKEILRLLRLPGVAFLLL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 227 LHAILMASF----VALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFF-LV 301
Cdd:cd17331 215 VKLLSGLPIgmfqSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLaFV 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 302 FGHSLAMLVVGTVVFFTAfnLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVL 381
Cdd:cd17331 295 TTVWQLLVLLLPLVIGGS--VLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAI 372
|
330
....*....|
gi 15599429 382 AALWLAIAVT 391
Cdd:cd17331 373 NGLLTVYLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-207 |
1.61e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIF--A 92
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAalG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 93 AGAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDL-------TREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTH 163
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGlgAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599429 164 LFG---------------LHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRESSVARQA 207
Cdd:COG2211 388 LFGyvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRA 446
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-186 |
3.45e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.33 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 14 TRAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAA 93
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 94 GAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTrEQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLF 171
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGffAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 15599429 172 WFTAGMALVGLLLIL 186
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-189 |
4.64e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 4.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 21 SLVFAFRMLGMFMVLPVLATYGQDLAgatPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAAN 100
Cdd:cd17489 200 ALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 101 ADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMA 178
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGfgLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVV 356
|
170
....*....|.
gi 15599429 179 LVGLLLILFFV 189
Cdd:cd17489 357 LLALVLYIFLL 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-319 |
8.35e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 8.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 9 MSGTETRAAVgLSLVFAFRMLGM-FMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVG 87
Cdd:COG0738 1 MSKKNYRRAL-IAIYLLFFLWGFaTALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 88 LLIFAAGAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREqHRTKAMAMIGMSIGVSFAVAMVLGPVLTHL- 164
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGlgLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 165 --FGLHGLFWFTAGMALVgLLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLAL 242
Cdd:COG0738 159 lsLSWHLPYLILAVLLLL-LALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 243 VHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTA 319
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS 314
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-185 |
8.41e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.18 E-value: 8.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATygqdLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVV-GLLIFAA 93
Cdd:cd17477 191 PLALLGAFVAGFLEGAFYSLLPLYGL----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGcALLGALA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 94 GAALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAMAMIGMsigvSFAVAMVLGPVLTHL----FGL 167
Cdd:cd17477 267 ALLLPLVPGLPLALLVLLFLWGGaaGPLYTLALALAGDRLPGDELVAANAALLL----LYGLGSVIGPLLAGAlmdaFGP 342
|
170
....*....|....*...
gi 15599429 168 HGLFWFTAGMALVGLLLI 185
Cdd:cd17477 343 HGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
26-390 |
1.53e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.50 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 26 FRMLGMFMVLPVLATYGQDLAGATPALI----GLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANA 101
Cdd:cd17391 7 FTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 102 DSIWGVIAGRVLQG--AGAISAAvMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMAL 179
Cdd:cd17391 87 TNVWQLLILRLLQGvfSGYVPNA-TALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 180 VGLLLILFFVPQpDHMTQHRESSVARQALLPTLKHGDLLrldAGILILHAIL-MASFVALPLALVHEGGLPKEQHWWVYL 258
Cdd:cd17391 166 LAFLLTLFFVKE-DFKPVEKKKMVSTKEVWNSVPNPSLL---ISLFVTTFIIqLANQSIEPILTLYIRQLMGDASNLAFI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 259 TALLVGFFGmVPFIIYAEKKRRM------KRVLTGAvatLLACELFFL--VFGHSLAMLVVGTVVFFTAFNLLEASLPSL 330
Cdd:cd17391 242 SGLVFSATG-VSSLLSAPRLGKLgdrighHRILLGA---LLASALLYIpqAFVQTPWQLGILRFLLGLATGGLLPAINSL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599429 331 VSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVL---AALWLAIAV 390
Cdd:cd17391 318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLvllNAIWSFIFL 380
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
67-255 |
2.13e-08 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 55.99 E-value: 2.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 67 LQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGAGA--ISAAVMALLSDLTREQHRTKAMAMIG 144
Cdd:PRK15403 67 LQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSIcfIATVGYVTVQEAFGQTKGIKLMAIIT 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 145 MSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAGI 224
Cdd:PRK15403 147 SIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAAT 226
|
170 180 190
....*....|....*....|....*....|..
gi 15599429 225 LILHAILMASFVAL-PLALVHEGGLPKEQHWW 255
Cdd:PRK15403 227 LSLSYIPMMSWVAVsPVILIDAGGMTTSQFAW 258
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-189 |
2.56e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.73 E-value: 2.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 18 VGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALI---GLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd17391 204 ISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAfisGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQhrtKAMAMIGMSIGVSFaVAMVLGPVL----THLFGLH 168
Cdd:cd17391 284 YIPQAFVQTPWQLGILRFLLGLatGGLLPAINSLLAKITPKE---VAGRIFGYNQSFQY-LGNVAGPLLgsaiAAHFGYR 359
|
170 180
....*....|....*....|.
gi 15599429 169 GLFWFTAGMALVGLLLILFFV 189
Cdd:cd17391 360 AVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-353 |
3.51e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 3.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFMVL-------PVLATYGQDLaGATPALIGLAIGAYGLTQAILqIPF-GTISDRIGRRPVIVVGLLIFAAGAALAA 99
Cdd:cd17503 2 LLGAFMAIldttivnVALPTIMGDL-GASLDTVQWVITSYLLALAIM-IPLsGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 100 NADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGM 177
Cdd:cd17503 80 LAPNLASLIIFRILQGFggGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 178 ALVGLLLIlffvpqpdhmtqhressvarqALLP--TLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGLPKEQHWW 255
Cdd:cd17503 160 GILALLLA---------------------PLLDlrLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 256 VYLTALLVGFFGMvPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGH--SLAMLVVGTVVFFTAFNLLEASLPSLVSK 333
Cdd:cd17503 219 VLAPGGLASAILS-PLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPdtSLWLIILPLFIRGLGMGLVFMPLNTLALN 297
|
330 340
....*....|....*....|
gi 15599429 334 VSPAGGKGTAMGVYSTSQFL 353
Cdd:cd17503 298 SLPPEQIGDATALFNTIRQL 317
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-314 |
5.61e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 5.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 25 AFRMLGMFMVLPVLATYGqDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSI 104
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 105 WGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAvamvLGPVLTHLFGLHGLFWFTAGMALVGL 182
Cdd:cd17477 85 WVWFLLRFVMGIGlaGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFA----LGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 183 LLILFFVPQPDHMTQHRESSVARQALLPTLKHGDLlrldaGILILHAILMASFVALPLALVHEGGLPKEQHWWVyLTALL 262
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALL-----GAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLL-AAFVL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15599429 263 VGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTV 314
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL 286
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-184 |
1.01e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.74 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 51 ALIGLAIGAygltqailqIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGA--GAISAAVMALLS 128
Cdd:cd17365 43 ALFGMAIGA---------LLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLglGAAMPNAITLVS 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 15599429 129 DLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLL 184
Cdd:cd17365 114 EYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
22-188 |
1.07e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.77 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 22 LVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGR-RPVIVVGLLIFAAGAALAAN 100
Cdd:cd17353 220 LMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRkNTLSIAFLIQGVAMFLLPFI 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 101 ADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMA 178
Cdd:cd17353 300 GSVAVLFVLGVALIGFcyGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALS 379
|
170
....*....|
gi 15599429 179 LVGLLLILFF 188
Cdd:cd17353 380 LVALALALLL 389
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
52-191 |
1.41e-07 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 53.43 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 52 LIGLAIGA-YGLTQAILQIPFGTISDRIGRRPVI---VVGLLIFAAgaalaanadsIWGV-------IAGRVLQG--AGA 118
Cdd:cd17389 64 LFGGLIGSlFSLLQFLSSPITGAASDVYGRKPVLlltMIGLAISYA----------LWAVsrsftifLLSRIVGGisKGN 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 119 ISAAvMALLSDLTREQHRTKAMAMigmsIGVSFAVAMVLGPVLTHLFGLHGLF----------WFTAGMALVGLLLILFF 188
Cdd:cd17389 134 VSLS-TAIVADVTSPKKRSKGMAL----IGVAFSLGFIIGPMIGAYFASFTRSlgevffsmpaLFALVLALADLLFIFFF 208
|
...
gi 15599429 189 VPQ 191
Cdd:cd17389 209 LPE 211
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-186 |
3.73e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 18 VGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAA- 96
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALp 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 97 -LAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMI-GMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:cd17316 260 lFYLLSGSPTLLLLLLFILSffVGGVWGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
170
....*....|....
gi 15599429 173 FTAGMALVGLLLIL 186
Cdd:cd17316 340 ILALLAIVALIVAL 353
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
46-188 |
6.35e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.43 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 46 AGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGA--GAISAAV 123
Cdd:cd17335 228 LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLtfALVWAAA 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599429 124 MALLSDLTREQHRTKAMAMI-GMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFF 188
Cdd:cd17335 308 VSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
28-190 |
7.96e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 51.23 E-value: 7.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFM----------VLPVLATygqDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAAL 97
Cdd:TIGR00711 8 MLGTFMavldstivnvAIPTIAG---DL-GSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 98 AANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTA 175
Cdd:TIGR00711 84 CGVAPNLELMIIFRVIQGfgGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163
|
170
....*....|....*
gi 15599429 176 GMALVGLLLILFFVP 190
Cdd:TIGR00711 164 PIGIIVVVVAFFILP 178
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
16-186 |
9.09e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 9.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAFRMLGMfMVLPVLATygQDLaGATPALIGLAIGayglTQAILQIPF----GTISDRIGRRPVIVVGLLIF 91
Cdd:cd17471 204 LFAAFTLLFAANSMYI-IAMPLYVT--NEL-GGSESWVGLLFG----LAAALEIPImllaGLLAKRFGKRRLLLAGFLAG 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 92 AAGAALAANADSIWGVIAGRVLQGAG-AISAAV-MALLSDLTREQhRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHG 169
Cdd:cd17471 276 VLFYLGLALATSLWQLIALQLLNAIFiGITAGLgISYFQDLMPGQ-PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRA 354
|
170
....*....|....*..
gi 15599429 170 LFWFTAGMALVGLLLIL 186
Cdd:cd17471 355 VFLVCAVLALLALVLLL 371
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
33-396 |
1.50e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 50.32 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRV 112
Cdd:PRK15402 31 MIQPGMLAVVEDF-NAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 113 LQGAGA--ISAAVMALLSDLTREQHRTKAMA-MIGMSIgvsfaVAMVLGPV----LTHLFGLHGLFWFTAGMALVGLLLI 185
Cdd:PRK15402 110 LQGIGLcfIGAVGYAAIQESFEEADAIKITAlMANVAL-----LAPLLGPLvgaaLIHVLPWRGMFVLFAALAALSFFGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 186 LFFVPQPDHMTQHRES--SVARQALLpTLKHGDLLRLDAGILILHAILMAsFVAL-PLALVHEGGLPKEQHwwvyltALL 262
Cdd:PRK15402 185 WRAMPETAGRVGEKLSlkELGRDYKL-VLKNRRFVAGALALGLVSLPLLA-WIALsPVILISGEQLSSYEY------GLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 263 -VGFFGMVP----FIIYAEKKRRMKRVLTGA----VATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSK 333
Cdd:PRK15402 257 qVPVFGALIagnlTLARLTSRRPLRSLIRMGlwpmVAGLLLAALATVISSHAYLWLTAGLSLYAFGIGLANAGLYRLTLF 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599429 334 VSPAgGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLA-IAVTMREPP 396
Cdd:PRK15402 337 SSDV-SKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLlVRIFLKDKP 399
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-187 |
1.64e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVlatYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd17503 181 TLGLLLSFLLGLGLFGAMFLLPL---YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANAD---SIWGVIAGRVLQGAG---AISAAVMALLSDLTREQ--HRTKAMAMI---GMSIGVSFAVAMV------- 156
Cdd:cd17503 258 TLLLAFLTpdtSLWLIILPLFIRGLGmglVFMPLNTLALNSLPPEQigDATALFNTIrqlGGSIGTALLATLLtnrtqfh 337
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15599429 157 --------LGPVLTH--LFGLHGLFWFTAGMALVGLLLILF 187
Cdd:cd17503 338 hsrlsellAQQVQKQalIIAFNDAFLVSAILLLVGLLLALF 378
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-391 |
1.76e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAFRMLGMFMVLPVLATYGqdlagATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGA 95
Cdd:cd17355 8 TFLILILSWGIRYYFGVFIIPIIAEFG-----WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 96 ALAANADSIWGVIAGR---VLQGAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGV-SFAVAMVLGPVLTHLFGLHGLF 171
Cdd:cd17355 83 VLLALATSLWQLYLLWgllGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLgSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 172 WFTAGMALVGLLLILFFVPQPDHMTQHRESSVARQALLPTLK----HGDLLRLDAGILILHAILMASFVALPLALVHEGG 247
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKealrSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 248 LPKEQHWwvylTALLVGFFGMVPFIIYAEKKRRM-KRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLLEAS 326
Cdd:cd17355 243 SPAAAAV----ALALIGLFNIVGRLLSGWLGDRYsPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 327 LPS-LVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQH-GGLSMVFIGCAVLAALWLAIAVT 391
Cdd:cd17355 319 LTAaLAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-187 |
3.19e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.09 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 14 TRAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIF-- 91
Cdd:cd17321 167 ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTav 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 92 -AAGAALAANADSIWGVIAGRVLQGAG---AISAAVMALLSDLTREQHRT-----KAMAMIGMSIGVSFAVAMVLGPVLT 162
Cdd:cd17321 247 gLLLLALLGADSSVWLLLPGLVLLGLGlglFATPLTNAALSSVPKEKAGAasgilNTARQLGGALGVALLGALLTAGLSA 326
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15599429 163 HLF-----------------GLHGLFWFTAGMALVGLLLILF 187
Cdd:cd17321 327 NLGdsgvaallsaaaaafaaGFHLAFLVAAALALLAALLALL 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-189 |
4.44e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGAGAI--SAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMlvFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....*..
gi 15599429 173 FTAGMALVGLLLILFFV 189
Cdd:cd17329 360 ILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
65-190 |
6.98e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 65 AILQIPFGTISDRIGRRPVIVVGLLI--FAAGAALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAM 140
Cdd:cd17380 48 ALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSSLPLLILSRILLGLgeGVHFPSMTSLFSRWVPVSERSRAV 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15599429 141 AMI--GMSIGVsfAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:cd17380 128 SIVtaGSYLGT--LLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-188 |
7.98e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 7.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLAtygQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAG 94
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLA---KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFW 172
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLagGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 15599429 173 FTAGMALVGLLLILFF 188
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
72-189 |
9.44e-06 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 47.66 E-value: 9.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 72 GTISDRIGRRPVIVVGLL------IFAAGAALAANADSIWGVIAGRVLQ----GAGAISAAVMALLSDLTREQHRTKAMA 141
Cdd:cd17386 51 GSWSDRYGRKPPLLMSLVglllssLILVLIVYFTTVPSVWWFYLSAIPLalfgGFTAFLSASFAYISDISSEKKRTYRMA 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15599429 142 MIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFV 189
Cdd:cd17386 131 ILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL 178
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-187 |
1.19e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.19 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 22 LVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPF-GTISDRIGRRPVIVVGLLIFAAGAALAAN 100
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPF 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 101 ADSIWGVIAGRVLQGAGAISA--AVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMA 178
Cdd:cd17330 261 ASSVPLLVLAAAILAFGTGIVfpALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLL 340
|
....*....
gi 15599429 179 LVGLLLILF 187
Cdd:cd17330 341 LIALFLLSL 349
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
71-190 |
1.71e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.80 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 71 FGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTkamaMIGMSIG 148
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTsaGIFTVGFVLGMEIVGPKYRS----FVGILFG 120
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15599429 149 VSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:cd17317 121 LFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP 162
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
29-148 |
1.96e-05 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 46.59 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 29 LGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVI 108
Cdd:PRK11646 24 LGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLW 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15599429 109 AGRVLQGAGA--ISAAVMALLSDLTREQHRTK----------AMAMIGMSIG 148
Cdd:PRK11646 104 LSCILSGLGGtlFDPPRTALVIKLIRPHQRGRffsllmmqdsAGAVIGALLG 155
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
28-190 |
8.86e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.56 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 28 MLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAagaalaanadsIWGV 107
Cdd:cd17476 11 QAGLGSVIVILPIIGDSF-GTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFA-----------IWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 108 IAG-----------RVLQGAGA--ISAAVMALLSDLTRE-QHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWF 173
Cdd:cd17476 79 IAGfspnfiffiicRALQGLGPafLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
|
170
....*....|....*...
gi 15599429 174 TAGM-ALVGLLLILFFVP 190
Cdd:cd17476 159 LAILaAIVAVAAIFWTSP 176
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
38-348 |
1.40e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.03 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 38 LATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAalaanadsiwgviAGRVLQGAG 117
Cdd:cd17337 20 LSPYLVDL-GFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFE-------------VLFLAFGLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 118 AISAAVMALL-------------SDLTREQHRTKAmAMIGMSIG---VSFAVAM-VLGPVLTHL----FGLHGLFWFTAG 176
Cdd:cd17337 86 SHNYPLMLLTyglrgfgyplfaySFLVWITYRTPA-ERLGSAVGwfwFAFTGGLpVLGSYLASFtipvIGEIGTLWLSLV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 177 MALVGLLLILFFVpqPDHMTQHRESSVARQALLPTLKHGDLLRLDAGIL---ILHAI----LMASFVALPLALVHEGGLP 249
Cdd:cd17337 165 FVALGGLIALFLV--RDRTGEQPLANPSEEPLKELLSGITILFRNPKIAiggIVRIIntlsQFGFPVFMPLYFTDTGGFS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 250 KEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRV-LTGAVATLLACELFFLV---FGHSLAMLVVGTVVF---FTAFNL 322
Cdd:cd17337 243 TSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVrWFGGVGCAISTLLFYYVpqlFGHNYWAALIAAILFgigLAGFVP 322
|
330 340
....*....|....*....|....*.
gi 15599429 323 LEASLPSLVSKvspagGKGTAMGVYS 348
Cdd:cd17337 323 LSALMPSLAPE-----HKGAAMSILN 343
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
33-218 |
1.69e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 43.72 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDlagatPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRV 112
Cdd:cd17384 18 VVVPIIPDYLNE-----NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 113 LQGAG--AISAAVMALLSDL-TREQHRTKAM--AMIGMSIGVSfaVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILF 187
Cdd:cd17384 93 LQGVGsaCSSVAGMGMLASLyPDDKERGKAMgiALGGLALGVL--VGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLF 170
|
170 180 190
....*....|....*....|....*....|.
gi 15599429 188 FVPqpdhMTQHRESSVARQALLPTLKHGDLL 218
Cdd:cd17384 171 ILQ----PSVKSEESEEGTPWKTLLKDPYIL 197
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
262-402 |
1.88e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.72 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 262 LVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLAceLFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKG 341
Cdd:cd17325 42 LAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS--TLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERG 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599429 342 TAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMREPPYVTSIR 402
Cdd:cd17325 120 RAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
52-190 |
2.20e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 52 LIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGV---IAGRVLQG--AGAISAAVMAL 126
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGigVGGASVLAPMY 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 127 LSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLF---GLHGLFWFTAGMALVgLLLILFFVP 190
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsdGWRIPLGLQLVPALL-LIIGLLFLP 192
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
10-392 |
2.25e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 43.51 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 10 SGTETRAAVGLSLV-FAFRMLGMFMV----LPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVI 84
Cdd:PRK12382 5 SQTETRSSANFSLFrIAFAVFLTYMTvglpLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 85 VVG--------LLIFAAGAALAANADSIWGVIAGRVLQGAGA---ISAAVMALLSdLTREQHRTKAMAMIGMSIGVSFAV 153
Cdd:PRK12382 85 LQGmlacglagLAYLLAAILPVSAPFKFALLVVGRLILGFGEsqlLTGALTWGLG-LVGPKHSGKVMSWNGMAMYGALAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 154 AMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPDHMTQHRE-SSVARQALLPTLkhgdllrldagILILHAILM 232
Cdd:PRK12382 164 GAPLGLLLHSHFGFAALALTTMVLPLLAWAFNGTVRKVPAHAGERPSlWSVVGLIWKPGL-----------GLALQGVGF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 233 AS---FVALPLAlvhegglpkEQHW---WVYLTALLVGFFGMVpfIIYAEKKRRMKRVLTGAVATLL-ACELFFLVFGHS 305
Cdd:PRK12382 233 AVigtFVSLYFA---------SKGWamaGFTLTAFGGAFVLMR--VLFGWMPDRFGGVKVAIVSLLVeTVGLLLLWLAPT 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 306 LAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALW 385
Cdd:PRK12382 302 AWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLG 381
|
....*..
gi 15599429 386 LAIAVTM 392
Cdd:PRK12382 382 IIVTILS 388
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-190 |
3.38e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.61 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 66 ILQIPFGTISDRIGRRPVIVVGLLI--FAAGAALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLTREQHRTK--A 139
Cdd:cd17318 71 LTQIPGGYLAEKYGAKRVLGYSILItaLLTLLTPLAARGGYGALIVLRILQGLaqGVTFPAMHALWAKWAPPLERSRltS 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15599429 140 MAMIGMSIGVsfAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVP 190
Cdd:cd17318 151 IAYSGSQFGT--VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
43-190 |
4.50e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.17 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 43 QDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQG--AGAIS 120
Cdd:cd17359 28 QTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGlaVGGAS 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 121 AAVMALLSDLTREQHRTKAMA----MIGMSIGVSFAVAMVLGPVLTH-LFGLHGLFWFTAGMAL--VGLLLILFFVP 190
Cdd:cd17359 108 ALVPMYIAEVAPAEIRGRLVSlnqlMIVFGQLLAYIVNYLIANAGGAdWLGAEGWRWMLGLEAIpaILFLLGMLFIP 184
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-155 |
4.77e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 14 TRAAVGLSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAA 93
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 94 GAALAANADSIWGVIAGRVLQ-----GAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAM 155
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALlllgfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
53-214 |
5.41e-04 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 42.10 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 53 IGLAIGAYGLTQAILqipFGTISDRIGRRPVIVV---GLLIFAAGAALAANAD-SIWGVIAGRVLQGA----GAISAAVM 124
Cdd:cd17449 70 INLGGFLVGLFSVTL---LGPWSDSVGRRPVLILpslGLALQAAVYLLVMYLQlHVAYFLIGRILSGLlgdfNGILAGCF 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 125 ALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQpdhmtqhrESSVA 204
Cdd:cd17449 147 AYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGE--------SVKEP 218
|
170
....*....|
gi 15599429 205 RQALLPTLKH 214
Cdd:cd17449 219 KSARLFTTRH 228
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
15-187 |
6.65e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 15 RAAVGLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIG---RRPVIVVGLLIF 91
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgaRRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 92 AAGAALAANADSIWGVIAGRVLQGAG--AISAAVMALLSDLTREQHRTKAMAMIGMSIGV-SFAVAMVLGPVLTHLFGLH 168
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGigAASPVFWSLPADLLPGEAAATAGGLINSGGNLgGFVAPLLIGYLVDATGSYT 338
|
170
....*....|....*....
gi 15599429 169 GLFWFTAGMALVGLLLILF 187
Cdd:cd17319 339 AAFLFLAAVALLAALLVLL 357
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
16-233 |
7.94e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 16 AAVGLSLVFAfrmLGMFMVLPVLATYGqdlagATPALIGLAIGAYGLTQAILQIPFGTISDR----IGRR-PVIVVGLLI 90
Cdd:cd17313 7 GFFGIEFGWA---LENSYVPPILQTLG-----LSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGAPL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 91 FAAGAALAANADSIWGVIAGRVLQGA---GAISAAVM------------ALLSDLTREQHRTKAMAMIGMSIGVSFAVAM 155
Cdd:cd17313 79 AALGLILIPNAADIGLALGDGPRTWAlvlFVLGIVLLdfamnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 156 VLGPVL---THLFGLHG-----LFWFTAGMALVGLLLILFFVPQPDHMTQHRESSV--ARQALLPTLKHGDLLRLDAGIL 225
Cdd:cd17313 159 LLGAILwdhNWFGFALGgnlkvPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSEnpSLGEVLKSLLKLLKIMPRSLLR 238
|
....*...
gi 15599429 226 ILHAILMA 233
Cdd:cd17313 239 LLLVIFFW 246
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
33-337 |
8.75e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.47 E-value: 8.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIG-RRPVIVVGLLIFAAGAALAANADSIWGVIAGR 111
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 112 VLQG-AGAISAAVMALLSDL-TREQHRTKAMAMIGM-SIGVSFA-----VAMVLGPVLTHLFGLHGLFWFTAGMALVGLL 183
Cdd:cd17341 96 FLLGfAGANFASGQPWASFWfPKEKIGGAAGGIAGAgNMGVAVSqllapLIAGAIVFDGGFVGWRNAFFVPGILLAIAAV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 184 LILFFvpqPDHMTQHRESSVARQA-LLPTLKHGDLLRLdagiLILHAILMASFVA----LPLALVHEGGLPKEQhwwvyl 258
Cdd:cd17341 176 LVLLF---GDDLPTGKASALEFLKvQLAVLKNYRTWIL----SLLYGVTFGSFVGfsnvLPTYFKTRFGLPLVT------ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 259 TALLVGFFGMVPFII-----YAEKKRRMKRVLTGAVATLLACELFFLVFGHSLAMLVVGTVVFFTAFNLL----EASLPS 329
Cdd:cd17341 243 AGILAALFPLAGALArpaggWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGagagNGSVFR 322
|
....*...
gi 15599429 330 LVSKVSPA 337
Cdd:cd17341 323 MVPFIFRR 330
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
72-390 |
9.82e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 9.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 72 GTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQG--AGAISAAVMALLSDLTREQHRTkAMAMigmsIGV 149
Cdd:cd17333 52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGlgAGILDTGANTFVGALFEESSAT-RLNV----LHG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 150 SFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILF------FVPQPDHMTQHRESSVARQALLPTLKHGDLLRLDAG 223
Cdd:cd17333 127 FFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAililltLFPELPSARNPQQSVGAFSASASRLLRNPSIILGAL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 224 ILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVGFF-GMVPFIIYAEKKRRMKRVLTGAVATLLACelFFLVF 302
Cdd:cd17333 207 ALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITiGRLLGGPISRRIKPHTLLVLSGSGALLGL--LILLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 303 GHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPaGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLA 382
Cdd:cd17333 285 APTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILY 363
|
....*...
gi 15599429 383 ALWLAIAV 390
Cdd:cd17333 364 AIIFVLAL 371
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
24-334 |
1.23e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.14 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 24 FAFRMLGMFMVLPVLATYGQ----DLAGATPALIGLAIGAYGLTQAILQIPFGTISD----RIGRR--------PVIVVG 87
Cdd:pfam13347 2 YGSGALAAGIKYAGLATYLLyfytDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRRrpwlllsaIILAVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 88 LLIFAAGAALAANADSIWGV---IAGRVLQGAGAISAAvmALLSDLTREQH-RTKA-----MAMIGMSIGVSFAVAMVLG 158
Cdd:pfam13347 82 FILLFTPPELGRAPLFIWLLatyILLRIAYTFFEIPYW--SLGPELTRDYDeRTSLtsyrsFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 159 PVLTHLFGLHGLFWFTAGMALVGLLLILF---FVPQPDHM-----TQHRESSVARQALLPTLKHGDLLRLDAGILILHAI 230
Cdd:pfam13347 160 ILGGTGLERKGYRIFALIGAVLMLLGVIItaaGTKERVSMrskedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 231 LMASFVALPLALVHEGGLPKEQHWWvyLTALLVGFFGMVPFIIYAEKKRRMKR-VLTGAVATLLACELFFLVFGHSLAML 309
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAF--PLVFTIGALLGIPLWPPLAKRIGKKNtYILGALITIAGFALALLLGPNNTLLF 317
|
330 340
....*....|....*....|....*
gi 15599429 310 VVGTVVFFTAFNLLEASLPSLVSKV 334
Cdd:pfam13347 318 LVLYIIIGFGYGSSFFLPWSMLADV 342
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
55-203 |
1.24e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 41.14 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 55 LAIGAYGLTQAILQI---PF-GTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGAGAISA--AVMALLS 128
Cdd:cd17383 30 IAIGVLFASKAIVQLlvnPFsGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFAdtAGLAMIA 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599429 129 D-LTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALV-GLLLILFFVPQPDHMTQHRESSV 203
Cdd:cd17383 110 DrFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLdGLLLLLVMKPVRRETRANMPEPV 186
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
47-190 |
1.61e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.70 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 47 GATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFAA-GAALAANADSIWGVIAGRVLQG--AGAISAAV 123
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGlgVGFASVLV 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599429 124 MALLSDLTREQHRTKAMAMIG--MSIGVSFAVAMVLGpvlTHLFGLHGLFWFTAGMALVGLLLIL---FFVP 190
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQlaITIGILVAYCINYG---THKLDGSAQWRIPLGLQIVWGLLLLigmFFLP 189
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-390 |
1.61e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 20 LSLVFAFRMLGMFMVLPVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLLIFA--AGAAL 97
Cdd:cd17335 2 LKLFYFFFFAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAvlFFLSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 98 AANADSIWGVIAGRVLqgAGAISAAVMAL-----LSDLTREQHRTKAMAMIGmSIGvsFAVAMVL-GPVLTHL---FGLH 168
Cdd:cd17335 81 FFVAQIFWLLLLLVIL--GAFFSAPVVPLvdsitLQYLGEERERYGKQRLWG-SIG--FGIAALLvGILIDRSstyKNYT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 169 GLFWFTAGMALVGLLLILFFVPQPDHmtqhRESSVARQALLPTLKHGDLLRLDAGILILHAILMASFVALPLALVHEGGL 248
Cdd:cd17335 156 IAFYVFAVLMLLALLLALKFPFRPKH----PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 249 PkeqhwwvYLTALLVGFFGMVPFIIYAEKKRRMKRVltGAVATLLACELFFLV------FGHSLAMLVVGTVVFFTAFNL 322
Cdd:cd17335 232 K-------TLIGLLWTVGVVSEIPFFFFSSRLIQRF--GHVGLLYLGLLAYVVrwllysFLENPWLVLPIELLHGLTFAL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599429 323 LEASLPSLVSKVSPAGGKGTAMGVYSTSQF-LGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAV 390
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
33-390 |
1.93e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 33 MVLPVLATYGQDLAGATPALIGLAIGAYGLTqAILQIPF-GTISDRIGRRPVIVVGL--------LIFAAGAALAANADS 103
Cdd:PRK05122 33 LPLAVLPGYVHDQLGFSAFLAGLVISLQYLA-TLLSRPHaGRYADTLGPKKAVVFGLcgcalsglLYLLAGLLAAWPVLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 104 IWGVIAGRVLQGAGAISAAVMALLSDLTR--EQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVG 181
Cdd:PRK05122 112 LLLLLLGRLLLGIGESLAGTGSILWGIGRvgALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIMLLALLG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 182 LLLILFFVPQPDHmtqHRESSVARQALLPTLKHGDLLRL-DAGILILhailmASFVALPLAlvhegglpkEQHW---WVY 257
Cdd:PRK05122 192 LLLARPRPAVPPV---KGERLPFRRVLGRVWPYGMGLALaSIGFGTI-----ATFITLYYA---------ARGWdgaALA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 258 LTALLVGFFGMVPFIIYAEKKRRMKRVltgAVATLL--ACELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVS 335
Cdd:PRK05122 255 LTLFGVAFVGARLLFGNLINRLGGLRV---AIVSLLveILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRV 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15599429 336 PAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAV 390
Cdd:PRK05122 332 PPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTW 386
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
38-188 |
2.05e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.36 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 38 LATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVV----GLLIFAAGAALAANADSIWG----VIA 109
Cdd:cd17367 246 LQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFfgigGTLATVPLLSALDHTDSPYTafalVLV 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 110 GRVLQGAG-AISAAVMALLSdltreqhrTKAMAMIGMSIGVSFAVAMVLG--PVLTHLFGLHGL----FWFTAGMALVGL 182
Cdd:cd17367 326 GLVFLSGYtSINAVVKAELF--------PTHVRALGVGLPYALAVAIFGGtaPYVALWLKSIGHewvfFWYVAGLIAISL 397
|
....*.
gi 15599429 183 LLILFF 188
Cdd:cd17367 398 VVYLRM 403
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
8-186 |
3.34e-03 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 39.60 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 8 RMSGTETRAAVGLSLVFAFRMLGMFMVLpVLATYGQDLaGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVG 87
Cdd:cd17479 197 RLLGGDGRAILYALTVFLVGFVGSTVQN-FLFWLMQDK-GGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 88 LLIFAAGAALAANADSIWGVIAGRVLQ--GAGAISAAVMALLSDLTREQ-HRTKAMAMIGMSIGVSFAVAMVLGPVLTHL 164
Cdd:cd17479 275 LLGLGAQLLYYSFLWTPWAVLPIELLHafSNGALWWAVNSQVEFLASPGmERSLQLVLRALYYGIGFALGSFVSGFIYDR 354
|
170 180
....*....|....*....|..
gi 15599429 165 FGLHGLFWFTAGMALVGLLLIL 186
Cdd:cd17479 355 FGLAILYQACCVVLGLWLIIFA 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
275-396 |
3.35e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 275 AEKKRRMKRVLTGAVATLLACelFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLG 354
Cdd:cd17489 55 LDRFGRKRLLLIGLLIFALAT--LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLA 132
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15599429 355 AALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMREPP 396
Cdd:cd17489 133 MALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPP 174
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
19-186 |
4.02e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.54 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 19 GLSLVFAFRMLGMFMVLPVLATYGQDLAGATPALIGLAIGAYGLTQAILQ-IPFGTISDRIGRRPVIVVGLLIFAAGAAL 97
Cdd:cd17388 210 GLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 98 AANADSIWGVIAGRVLQGAGAISA-AVMALLSDLTREQHRTKAMAMIG--MSIgvsfavAMVLGPVL-THLFGLHGLFW- 172
Cdd:cd17388 290 LAFATQGWMVFPILILLALGGIAGpALQGLLSRQVPENEQGELQGVLTslTSL------TSIIGPLLfTGIFAASPATWp 363
|
170
....*....|....*..
gi 15599429 173 ---FTAGMALVGLLLIL 186
Cdd:cd17388 364 glaWIIGAALYLICLVL 380
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-208 |
5.22e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.17 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 52 LIGLAIGAYGLtqailqipfGTISDRIGRRPVIVVGLLIFAAGAALAANADSIWGV---IAGRVLQG--AGAISAAVMAL 126
Cdd:cd17357 59 FIGGAIGSFIS---------AFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPellIFGRFLVGiaCGLSTGFVPMY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 127 LSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGpvLTHLFG----LHGLFWFTAGMALVGLLLILFFVPQPDH-MTQHRES 201
Cdd:cd17357 130 LQEISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLGtetlWPYLLFFPGIPALLQLAALPFFPESPKFlLISKGDE 207
|
....*..
gi 15599429 202 SVARQAL 208
Cdd:cd17357 208 EEAEKSL 214
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
22-187 |
5.43e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.05 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 22 LVFAFRMLGMFMVLPVLAT----YGQDLAGATPALIGLAIGAYGLTQAILQIPFGTISDRIGRRPVIVVGLL---IFAAG 94
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTfalsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALlaaLFAFP 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 95 AALAANADSIWGVIAGRVLQGA---GAISAAVMALLSDLTREQHRTKAMAmIGMSIG---VSFAVAMVLGPVLTHLFGLH 168
Cdd:cd17369 311 FFWLLDTGSTWLIVLAAVVVLGvlhGMMYGPQAAFLAELFPTRVRYTGAS-LGYQLGailGGGFAPLIATALVAATGSWW 389
|
170
....*....|....*....
gi 15599429 169 GLFWFTAGMALVGLLLILF 187
Cdd:cd17369 390 PVALYLAALAVISLVAALF 408
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
223-396 |
5.46e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 223 GILILHAILMASFVALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACelFFLVF 302
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL--LLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 303 GHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCAVLA 382
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|....
gi 15599429 383 ALWLAIAVTMREPP 396
Cdd:pfam07690 162 LLAAVLLLLPRPPP 175
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
115-351 |
8.68e-03 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 38.49 E-value: 8.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 115 GAGAISAAVMALLSDLTREQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQPDH 194
Cdd:pfam03209 101 GVHMSQTPGLALAADLADEERRPKVVGIMWVMLLIGIIVSAITVGWLLDDYTPARLIRVIQGVALITFVLNIIALWKIEV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 195 MTQHRESSVARQALlPTLKHGDLLRLDAGILILHAILMASFVALPLA-LVHEG------GLPKEQHWWvyLTAL-----L 262
Cdd:pfam03209 181 GRPSRPAERPEQDP-SFLEAWLLLVAEPQALIFLFFLFLGTLAFFMQdVILEPyggevfGLTVGETTK--LTAFfaggtL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 263 VGFFGMVPFIIYAEKKRRM-KRVLTGAVATLLAceLFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKG 341
Cdd:pfam03209 258 VGFGLAGRVLSPGLGPGRLaGLGCLLGLPSFLA--LILAGLLGNVALFFAGVLLFGLGGGLFTVAALTAMMDLAPEGRAG 335
|
250
....*....|
gi 15599429 342 TAMGVYSTSQ 351
Cdd:pfam03209 336 TALGAWGAAQ 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
222-397 |
8.84e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 222 AGILILHAILMASFV--ALPLALVHEGGLPKEQHWWVYLTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLACelFF 299
Cdd:COG2223 9 LATLAFFLAFGVWYLwsVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL--LL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599429 300 LVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLGAALGGILGGWMFQHGGLSMVFIGCA 379
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170
....*....|....*....
gi 15599429 380 VLAALW-LAIAVTMREPPY 397
Cdd:COG2223 167 ILLLVVaVLAWLFLRDPPA 185
|
|
| |
