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Conserved domains on  [gi|15599116|ref|NP_252610|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11458467)

helix-turn-helix transcriptional regulator similar to HTH-type transcriptional regulator MalT regulates transcription of the maltose regulon and thus the uptake and catabolism of malto-oligosaccharides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04841 super family cl35271
HTH-type transcriptional regulator MalT;
21-902 5.78e-74

HTH-type transcriptional regulator MalT;


The actual alignment was detected with superfamily member PRK04841:

Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 261.03  E-value: 5.78e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   21 RFFRPPLPSAHVARPRLCRRLRDGLDGRLLLIAAPAGFGKSSLAIEFCESLDprwQSLWLGLSSRESDPGRFLERLLDGL 100
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  101 rqyHPTLGEEALGLLKMRQRHQPFAFETWLDDLLDELAPCldpQRPLLLVLDDYHLAQGAVLDRCLQFLLNHLPEGLVLL 180
Cdd:PRK04841  83 ---QQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADW---HQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  181 VTSRQRPDWHLARLRLSRQLLELSEQDLRLTAEESGALMAAS-GLELDEDALDALLERSEGWVAGLRLWLL-ARgdpeEQ 258
Cdd:PRK04841 157 VLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRlSSPIEAAESSRLCDDVEGWATALQLIALsAR----QN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  259 VSPGVHGADEL-------IRDYLLEEVIERQPPEVQAFLAQTARFERFCAELCDTVREAGDSAAILDHLQQHQVFLVPLD 331
Cdd:PRK04841 233 NSSLHDSARRLaginashLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  332 ENGQWFRYHHLFSDLL-------LARPLPDfgpsagsLHLRACGWFSRHGLLDQAVEQALRAGQPDVAASLVQ------- 397
Cdd:PRK04841 313 DSGEWFRYHPLFASFLrhrcqweLAQELPE-------LHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLqhgwslf 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  398 NLSEEQLLaEQNIATllrwkmdLPDSLLASTPRLILLYGWALALACQLDAAEELAGQLARFLPAPDESAQRDLLAQWQAL 477
Cdd:PRK04841 386 NQGELSLL-EECLNA-------LPWEVLLENPRLVLLQAWLAQSQHRYSEVNTLLARAEQELKDRNIELDGTLQAEFNAL 457

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  478 SGVIARGRGDIDKAEAHCREALQDLAGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYG--NPLFEALVHy 555
Cdd:PRK04841 458 RAQVAINDGDPEEAERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQTEQMARQHDvyHYALWSLLQ- 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  556 dRARVLQARGEVARAEEEVRQGLE-----RLQHLPAQR-RYAVRGRLLLYRGYLrslalqpDEARKWIKQGIEETRSCRD 629
Cdd:PRK04841 537 -QSEILFAQGFLQAAYETQEKAFQlieeqHLEQLPMHEfLLRIRAQLLWEWARL-------DEAEQCARKGLEVLSNYQP 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  630 VSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIpPIYYLAAITLIKCELWLAQGQTELAGVWLqrlggtyggQA 709
Cdd:PRK04841 609 QQQLQCLAMLAKISLARGDLDNARRYLNRLENLLGNGRY-HSDWIANADKVRLIYWQMTGDKEAAANWL---------RQ 678

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  710 ATPPECSpllPLHVELLQAGLERRE----GRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQ 785
Cdd:PRK04841 679 APKPEFA---NNHFLQGQWRNIARAqillGQFDEAEIILEELNENARSLRLMSDLNRNLILLNQLYWQQGRKSEAQRVLL 755

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  786 QAME-----GAVgGALLPLHELLVQQpewLReQLQRFPACPGAQRMRA-------------------------LL--PEP 833
Cdd:PRK04841 756 EALKlanrtGFI-SHFVIEGEAMAQQ---LR-QLIQLNTLPELEQHRAqrilreinqhhrhkfahfdeafvekLLnhPDV 830

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599116  834 PAEPAGSAgevLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHM 902
Cdd:PRK04841 831 PELIRTSP---LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQDL 896
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
21-902 5.78e-74

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 261.03  E-value: 5.78e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   21 RFFRPPLPSAHVARPRLCRRLRDGLDGRLLLIAAPAGFGKSSLAIEFCESLDprwQSLWLGLSSRESDPGRFLERLLDGL 100
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  101 rqyHPTLGEEALGLLKMRQRHQPFAFETWLDDLLDELAPCldpQRPLLLVLDDYHLAQGAVLDRCLQFLLNHLPEGLVLL 180
Cdd:PRK04841  83 ---QQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADW---HQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  181 VTSRQRPDWHLARLRLSRQLLELSEQDLRLTAEESGALMAAS-GLELDEDALDALLERSEGWVAGLRLWLL-ARgdpeEQ 258
Cdd:PRK04841 157 VLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRlSSPIEAAESSRLCDDVEGWATALQLIALsAR----QN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  259 VSPGVHGADEL-------IRDYLLEEVIERQPPEVQAFLAQTARFERFCAELCDTVREAGDSAAILDHLQQHQVFLVPLD 331
Cdd:PRK04841 233 NSSLHDSARRLaginashLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  332 ENGQWFRYHHLFSDLL-------LARPLPDfgpsagsLHLRACGWFSRHGLLDQAVEQALRAGQPDVAASLVQ------- 397
Cdd:PRK04841 313 DSGEWFRYHPLFASFLrhrcqweLAQELPE-------LHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLqhgwslf 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  398 NLSEEQLLaEQNIATllrwkmdLPDSLLASTPRLILLYGWALALACQLDAAEELAGQLARFLPAPDESAQRDLLAQWQAL 477
Cdd:PRK04841 386 NQGELSLL-EECLNA-------LPWEVLLENPRLVLLQAWLAQSQHRYSEVNTLLARAEQELKDRNIELDGTLQAEFNAL 457

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  478 SGVIARGRGDIDKAEAHCREALQDLAGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYG--NPLFEALVHy 555
Cdd:PRK04841 458 RAQVAINDGDPEEAERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQTEQMARQHDvyHYALWSLLQ- 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  556 dRARVLQARGEVARAEEEVRQGLE-----RLQHLPAQR-RYAVRGRLLLYRGYLrslalqpDEARKWIKQGIEETRSCRD 629
Cdd:PRK04841 537 -QSEILFAQGFLQAAYETQEKAFQlieeqHLEQLPMHEfLLRIRAQLLWEWARL-------DEAEQCARKGLEVLSNYQP 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  630 VSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIpPIYYLAAITLIKCELWLAQGQTELAGVWLqrlggtyggQA 709
Cdd:PRK04841 609 QQQLQCLAMLAKISLARGDLDNARRYLNRLENLLGNGRY-HSDWIANADKVRLIYWQMTGDKEAAANWL---------RQ 678

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  710 ATPPECSpllPLHVELLQAGLERRE----GRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQ 785
Cdd:PRK04841 679 APKPEFA---NNHFLQGQWRNIARAqillGQFDEAEIILEELNENARSLRLMSDLNRNLILLNQLYWQQGRKSEAQRVLL 755

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  786 QAME-----GAVgGALLPLHELLVQQpewLReQLQRFPACPGAQRMRA-------------------------LL--PEP 833
Cdd:PRK04841 756 EALKlanrtGFI-SHFVIEGEAMAQQ---LR-QLIQLNTLPELEQHRAqrilreinqhhrhkfahfdeafvekLLnhPDV 830

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599116  834 PAEPAGSAgevLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHM 902
Cdd:PRK04841 831 PELIRTSP---LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 843-906 2.69e-21

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 90.34  E-value: 2.69e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599116 843 EVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLLR 906
Cdd:COG2197  68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 845-899 3.33e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 81.80  E-value: 3.33e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15599116    845 LSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARA 899
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 475-791 1.02e-18

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 88.52  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   475 QALSGVIARGRGDIDKAEAHCREALQDLAGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYGNPLFEALVH 554
Cdd:pfam17874   4 AALRAQLAISKGDAERALELAEQALALLPEDDLLARGLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   555 YDRARVLQARGEVARAEEEVRQGLE-----RLQHLPAQRR-YAVRGRLLLYRGYLrslalqpDEARKWIKQGIEETRSCR 628
Cdd:pfam17874  84 LQQGEILRAQGRLHQALETYQQALQlardhGLQHLPLHGFlLVGLADLLYEWNDL-------EEAEQHAQQGIQLGRQWE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   629 DVSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIPPiYYLAAITLIKCELWLAQGQTELAGVWLqrlggtyggQ 708
Cdd:pfam17874 157 PDAAVDAYVLLARIALAQGELEEALTLLRRAELLARQSFFHV-DWLANAERVRVRLWLARGDLRAAVRWL---------R 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   709 AATPPEC--SPLLPLHVELLqAGLERREGRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQQ 786
Cdd:pfam17874 227 AAEPPSDadNHFLERELRNL-ARVLLALGRFDDALSLLERLQNLAEQLGRVRSLIENLILQALALLALGRPDEALQALLD 305


                  ....*
gi 15599116   787 AMEGA 791
Cdd:pfam17874 306 ALSLA 310
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 845-899 3.79e-17

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 76.03  E-value: 3.79e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599116 845 LSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARA 899
Cdd:cd06170   1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 464-789 2.12e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   464 ESAQRDLLAQWQALSGVIARGRGDIDKAEAHCREALQDLAgerygTRLQCLSTLSNLAVTRGDFWQARNYNRDALEfaqr 543
Cdd:TIGR02917 117 TLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDP-----RSLYAKLGLAQLALAENRFDEARALIDEVLT---- 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   544 yGNPLFeALVHYDRARVLQARGEVARAEEEVRQGLErLQHLPAQRRYAvRGRLLLYRGYLRSLALQPDEARKWI------ 617
Cdd:TIGR02917 188 -ADPGN-VDALLLKGDLLLSLGNIELALAAYRKAIA-LRPNNIAVLLA-LATILIEAGEFEEAEKHADALLKKApnspla 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   618 ----------KQGIEETRSCRDVSLVIGYCVLASL------EGRLGNYAAAFARLGDVerLMHAWDIPPIYYLAAITLik 681
Cdd:TIGR02917 264 hylkalvdfqKKNYEDARETLQDALKSAPEYLPALllagasEYQLGNLEQAYQYLNQI--LKYAPNSHQARRLLASIQ-- 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   682 celwLAQGQTELAGVWLQRLGGTYGGQAATppecspLLPLHVELLQAglerreGRPEEAARRLDRLARSTRENGAllpAR 761
Cdd:TIGR02917 340 ----LRLGRVDEAIATLSPALGLDPDDPAA------LSLLGEAYLAL------GDFEKAAEYLAKATELDPENAA---AR 400

                         330       340
                  ....*....|....*....|....*...
gi 15599116   762 LALGQlaaLHLEQGREREALATLQQAME 789
Cdd:TIGR02917 401 TQLGI---SKLSQGDPSEAIADLETAAQ 425
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
21-902 5.78e-74

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 261.03  E-value: 5.78e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   21 RFFRPPLPSAHVARPRLCRRLRDGLDGRLLLIAAPAGFGKSSLAIEFCESLDprwQSLWLGLSSRESDPGRFLERLLDGL 100
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  101 rqyHPTLGEEALGLLKMRQRHQPFAFETWLDDLLDELAPCldpQRPLLLVLDDYHLAQGAVLDRCLQFLLNHLPEGLVLL 180
Cdd:PRK04841  83 ---QQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADW---HQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  181 VTSRQRPDWHLARLRLSRQLLELSEQDLRLTAEESGALMAAS-GLELDEDALDALLERSEGWVAGLRLWLL-ARgdpeEQ 258
Cdd:PRK04841 157 VLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRlSSPIEAAESSRLCDDVEGWATALQLIALsAR----QN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  259 VSPGVHGADEL-------IRDYLLEEVIERQPPEVQAFLAQTARFERFCAELCDTVREAGDSAAILDHLQQHQVFLVPLD 331
Cdd:PRK04841 233 NSSLHDSARRLaginashLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  332 ENGQWFRYHHLFSDLL-------LARPLPDfgpsagsLHLRACGWFSRHGLLDQAVEQALRAGQPDVAASLVQ------- 397
Cdd:PRK04841 313 DSGEWFRYHPLFASFLrhrcqweLAQELPE-------LHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLqhgwslf 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  398 NLSEEQLLaEQNIATllrwkmdLPDSLLASTPRLILLYGWALALACQLDAAEELAGQLARFLPAPDESAQRDLLAQWQAL 477
Cdd:PRK04841 386 NQGELSLL-EECLNA-------LPWEVLLENPRLVLLQAWLAQSQHRYSEVNTLLARAEQELKDRNIELDGTLQAEFNAL 457

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  478 SGVIARGRGDIDKAEAHCREALQDLAGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYG--NPLFEALVHy 555
Cdd:PRK04841 458 RAQVAINDGDPEEAERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQTEQMARQHDvyHYALWSLLQ- 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  556 dRARVLQARGEVARAEEEVRQGLE-----RLQHLPAQR-RYAVRGRLLLYRGYLrslalqpDEARKWIKQGIEETRSCRD 629
Cdd:PRK04841 537 -QSEILFAQGFLQAAYETQEKAFQlieeqHLEQLPMHEfLLRIRAQLLWEWARL-------DEAEQCARKGLEVLSNYQP 608

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  630 VSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIpPIYYLAAITLIKCELWLAQGQTELAGVWLqrlggtyggQA 709
Cdd:PRK04841 609 QQQLQCLAMLAKISLARGDLDNARRYLNRLENLLGNGRY-HSDWIANADKVRLIYWQMTGDKEAAANWL---------RQ 678

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  710 ATPPECSpllPLHVELLQAGLERRE----GRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQ 785
Cdd:PRK04841 679 APKPEFA---NNHFLQGQWRNIARAqillGQFDEAEIILEELNENARSLRLMSDLNRNLILLNQLYWQQGRKSEAQRVLL 755

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  786 QAME-----GAVgGALLPLHELLVQQpewLReQLQRFPACPGAQRMRA-------------------------LL--PEP 833
Cdd:PRK04841 756 EALKlanrtGFI-SHFVIEGEAMAQQ---LR-QLIQLNTLPELEQHRAqrilreinqhhrhkfahfdeafvekLLnhPDV 830

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599116  834 PAEPAGSAgevLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHM 902
Cdd:PRK04841 831 PELIRTSP---LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 843-906 2.69e-21

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 90.34  E-value: 2.69e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15599116 843 EVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLLR 906
Cdd:COG2197  68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 834-905 1.06e-19

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 83.86  E-value: 1.06e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599116 834 PAEPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLL 905
Cdd:COG5905   2 MPSSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 845-899 3.33e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 81.80  E-value: 3.33e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 15599116    845 LSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARA 899
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 475-791 1.02e-18

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 88.52  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   475 QALSGVIARGRGDIDKAEAHCREALQDLAGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYGNPLFEALVH 554
Cdd:pfam17874   4 AALRAQLAISKGDAERALELAEQALALLPEDDLLARGLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   555 YDRARVLQARGEVARAEEEVRQGLE-----RLQHLPAQRR-YAVRGRLLLYRGYLrslalqpDEARKWIKQGIEETRSCR 628
Cdd:pfam17874  84 LQQGEILRAQGRLHQALETYQQALQlardhGLQHLPLHGFlLVGLADLLYEWNDL-------EEAEQHAQQGIQLGRQWE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   629 DVSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIPPiYYLAAITLIKCELWLAQGQTELAGVWLqrlggtyggQ 708
Cdd:pfam17874 157 PDAAVDAYVLLARIALAQGELEEALTLLRRAELLARQSFFHV-DWLANAERVRVRLWLARGDLRAAVRWL---------R 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   709 AATPPEC--SPLLPLHVELLqAGLERREGRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQQ 786
Cdd:pfam17874 227 AAEPPSDadNHFLERELRNL-ARVLLALGRFDDALSLLERLQNLAEQLGRVRSLIENLILQALALLALGRPDEALQALLD 305


                  ....*
gi 15599116   787 AMEGA 791
Cdd:pfam17874 306 ALSLA 310
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 845-899 3.79e-17

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 76.03  E-value: 3.79e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15599116 845 LSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARA 899
Cdd:cd06170   1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
GerE pfam00196
Bacterial regulatory proteins, luxR family;
843-899 9.97e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 71.85  E-value: 9.97e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15599116   843 EVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARA 899
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
770-906 2.83e-15

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 74.74  E-value: 2.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 770 LHLEQGREREALATLQQAMEGAVGGALLPLHEL------LVQQPEWLREQLQRFPACPGAQRMRALLpeppAEPAGSAGE 843
Cdd:COG2909  46 LRADDLRREEAAALLRRRLLPLSEEDAARLAERtegwarLALDPEEALALLERLLALAEAAGRLLLR----ALALRALGD 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599116 844 VLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLLR 906
Cdd:COG2909 122 REEALAALRRRLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
148-252 2.65e-13

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 69.35  E-value: 2.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 148 LLVLDDYHLAQgavlDRCLQFLLNHLPEGLVLLVTSRQRPdwhLARLRLSrqlLELSEQDLRltAEESGALMAASGLELD 227
Cdd:COG2909   1 ALVLDDYHLID----DIHLAFLLRHLPPNLHLVLASRTDP---LARLRAR---LELRADDLR--REEAAALLRRRLLPLS 68

                        90       100
                ....*....|....*....|....*
gi 15599116 228 EDALDALLERSEGWVAGLRLWLLAR 252
Cdd:COG2909  69 EEDAARLAERTEGWARLALDPEEAL 93
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
718-905 1.24e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 67.47  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 718 LLPLHVELLQAGLERREGRPEEAARRLDRLARSTRENGALLPARLALGQLAALHLEQGREREALATLQQAMEGAVGGALL 797
Cdd:COG2771   1 LLLLALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 798 PLHELLVQQPEWLREQLQRFPACPGAQRMRALLPEPPAEPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVK 877
Cdd:COG2771  81 LLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVR 160

                       170       180
                ....*....|....*....|....*...
gi 15599116 878 SHARHINDKLGVERRTQAVARAKHMGLL 905
Cdd:COG2771 161 THLKRIYRKLGVSSRAELVALALRLGLI 188
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 806-895 2.40e-08

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 55.42  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  806 QPEWLREQLQRfpACPG--------AQRMRALLPEPPaEPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVK 877
Cdd:PRK10651 112 EPEDLLKALQQ--AAAGemvlsealTPVLAASLRANR-ATTERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVK 188

                         90
                 ....*....|....*...
gi 15599116  878 SHARHINDKLGVERRTQA 895
Cdd:PRK10651 189 VHVKHMLKKMKLKSRVEA 206
COG3899 COG3899
Predicted ATPase [General function prediction only];
442-906 4.38e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 57.18  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  442 ACQLDAAEELAGQLARFLPAPDESAQRDLLAQWQALSGVIARGRGDIDKAEAHCREALQ-----DLAGERYGTRLQCLST 516
Cdd:COG3899  715 ALARGAYAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAaralaALAALRHGNPPASARA 794

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  517 LSNLAVT-RGDFWQARNYNRDALEFAQRYGNPLFEALVHYDRARVLQARGEVARAEEEVRQGLERLQHLPAQRRYAVRGR 595
Cdd:COG3899  795 YANLGLLlLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALA 874

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  596 LLLYRGYLRSLALQPDEARKWIKQGIEEtrsCRDVSLVIGYCVLASLEGRLGNYAAAFARLGDVERLMHAWDIPPIYYLA 675
Cdd:COG3899  875 AAAAAAAAAAALAAAAAAAARLLAAAAA---ALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAA 951

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  676 AITLIKCELWLAQGQTELAGVWLQRLGGTYGGQAATPPECSPLLPLHVELLQAGLERREGRPEEAARRLDRLARSTRENG 755
Cdd:COG3899  952 AALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAA 1031

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  756 ALLPARLALGQLAALHLEQGREREALATLQQAMEGAVGGALLPLHELLVQQPEWLREQLQRFPACPGAQRMRALLPEPPA 835
Cdd:COG3899 1032 AAAALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAAL 1111

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599116  836 EPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLLR 906
Cdd:COG3899 1112 AALALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAAL 1182
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 403-614 5.99e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 5.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 403 QLLAEQNIATLLRWKMDLPDSLLASTPRLILLYGWALALACQLDAAEELAGQLARFLPA----PDESAQRDLLAQWQALS 478
Cdd:COG3914   5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAageaAAAAAALLLLAALLELA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 479 GVIARGRGDIDKAEAHCREALqdlagERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRYgnplfeALVHYDRA 558
Cdd:COG3914  85 ALLLQALGRYEEALALYRRAL-----ALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLG 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599116 559 RVLQARGEVARAEEEVRQGLERL-QHLPAQRRyavRGRLLLYRG--------YLRSLALQPDEAR 614
Cdd:COG3914 154 EALRRLGRLEEAIAALRRALELDpDNAEALNN---LGNALQDLGrleeaiaaYRRALELDPDNAD 215
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 845-889 9.96e-08

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 53.18  E-value: 9.96e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15599116 845 LSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGV 889
Cdd:COG4566 138 LTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGA 182
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
844-905 1.16e-07

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 53.34  E-value: 1.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599116  844 VLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLL 905
Cdd:PRK09935 149 VLSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
806-895 1.92e-07

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 52.55  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  806 QPEWLREQLQRFPACPGA---QRMRALLPEPPAEPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARH 882
Cdd:PRK10403 112 DPEVLLEAIRAGAKGSKVfseRVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRN 191

                         90
                 ....*....|...
gi 15599116  883 INDKLGVERRTQA 895
Cdd:PRK10403 192 LLRKLNVRSRVAA 204
PRK10100 PRK10100
transcriptional regulator CsgD;
820-901 5.56e-07

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 51.41  E-value: 5.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  820 CPGAQRMRALLPEPPAEPAGSAGE--VLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVA 897
Cdd:PRK10100 129 CYFTQKLASYLITHSGNYRYNSTEsaLLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVS 208


                 ....
gi 15599116  898 RAKH 901
Cdd:PRK10100 209 WAND 212
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 479-789 1.73e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 479 GVIARGRGDIDKAEAHCREALQDlagerYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALEFAQRygnplfEALVHYDRA 558
Cdd:COG2956  15 GLNYLLNGQPDKAIDLLEEALEL-----DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD------RAEALLELA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 559 RVLQARGEVARAEEEvrqgLERLQHLPAQRRYAVRGRLLLYRgylrsLALQPDEARKWIKQGIEETRSCRDVslvigYCV 638
Cdd:COG2956  84 QDYLKAGLLDRAEEL----LEKLLELDPDDAEALRLLAEIYE-----QEGDWEKAIEVLERLLKLGPENAHA-----YCE 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 639 LASLEGRLGNYAAAFARLGDVerLMHAWDIPPIYYLAAitlikcELWLAQGQTELAGVWLQRLggtyggqAATPPECSPL 718
Cdd:COG2956 150 LAELYLEQGDYDEAIEALEKA--LKLDPDCARALLLLA------ELYLEQGDYEEAIAALERA-------LEQDPDYLPA 214

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599116 719 LPLHVELLQaglerREGRPEEAARRLDRLARSTRENGALLparlalgQLAALHLEQGREREALATLQQAME 789
Cdd:COG2956 215 LPRLAELYE-----KLGDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQLR 273
PRK15369 PRK15369
two component system response regulator;
843-905 2.95e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 48.92  E-value: 2.95e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599116  843 EVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVARAKHMGLL 905
Cdd:PRK15369 148 PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
Cohesin_load pfam10345
Cohesin loading factor; Cohesin_load is a common cohesin loading factor protein that is ...
 431-584 4.38e-05

Cohesin loading factor; Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.


Pssm-ID: 463053 [Multi-domain]  Cd Length: 585  Bit Score: 47.31  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   431 LILLY-GWALALACQLDAAEELAGQLARFLPAPDESAQRDLLAQWQALSGVIARGRGDIDKAEAHCREALQDL------- 502
Cdd:pfam10345 356 YLLIYqAFAACVRSDWTKANEFLNALHKLLKKSELQLPGSLTPLLHYLLGLYAQGTGDLEAALAIYVSPLLSLlpspskt 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   503 AGERYGTRLQCLSTLSNLAVTRGDFWQARNYNRDALE----FAQRYGNPLFEALVHYDRARVLQARGEVARAEEEVRQGL 578
Cdd:pfam10345 436 TALDIPRELAILAALNLILILRDPRHPDHIELNWLLEqlepFCLNHPNKSLRAAYYLVKALQAFPQNSLLDAKKHLQEAL 515


                  ....*.
gi 15599116   579 ERLQHL 584
Cdd:pfam10345 516 QAAKKI 521
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 725-838 9.78e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 45.57  E-value: 9.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  725 LLQAGLERREGRPEEAARRLDRLARstrENGALLParLALGQLAALHLEQGREREALATLQQAMEGAVGG-ALLPLHELL 803
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEE---QDPEYLS--EVLPKLMECYQALGDEAEGLEFLRRALEEYPGAdLLLALAQLL 292

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15599116  804 VQQP------EWLREQLQRFPACPGAQR-MRALLPEPPAEPA 838
Cdd:PRK11788 293 EEQEgpeaaqALLREQLRRHPSLRGFHRlLDYHLAEAEEGRA 334
PRK10360 PRK10360
transcriptional regulator UhpA;
829-898 1.93e-03

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 40.35  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116  829 LLPEPPAEPAGSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGVERRTQAVAR 898
Cdd:PRK10360 122 LTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELARR 191
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 464-789 2.12e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   464 ESAQRDLLAQWQALSGVIARGRGDIDKAEAHCREALQDLAgerygTRLQCLSTLSNLAVTRGDFWQARNYNRDALEfaqr 543
Cdd:TIGR02917 117 TLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDP-----RSLYAKLGLAQLALAENRFDEARALIDEVLT---- 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   544 yGNPLFeALVHYDRARVLQARGEVARAEEEVRQGLErLQHLPAQRRYAvRGRLLLYRGYLRSLALQPDEARKWI------ 617
Cdd:TIGR02917 188 -ADPGN-VDALLLKGDLLLSLGNIELALAAYRKAIA-LRPNNIAVLLA-LATILIEAGEFEEAEKHADALLKKApnspla 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   618 ----------KQGIEETRSCRDVSLVIGYCVLASL------EGRLGNYAAAFARLGDVerLMHAWDIPPIYYLAAITLik 681
Cdd:TIGR02917 264 hylkalvdfqKKNYEDARETLQDALKSAPEYLPALllagasEYQLGNLEQAYQYLNQI--LKYAPNSHQARRLLASIQ-- 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116   682 celwLAQGQTELAGVWLQRLGGTYGGQAATppecspLLPLHVELLQAglerreGRPEEAARRLDRLARSTRENGAllpAR 761
Cdd:TIGR02917 340 ----LRLGRVDEAIATLSPALGLDPDDPAA------LSLLGEAYLAL------GDFEKAAEYLAKATELDPENAA---AR 400

                         330       340
                  ....*....|....*....|....*...
gi 15599116   762 LALGQlaaLHLEQGREREALATLQQAME 789
Cdd:TIGR02917 401 TQLGI---SKLSQGDPSEAIADLETAAQ 425
PRK09483 PRK09483
response regulator; Provisional
 815-889 2.81e-03

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 40.09  E-value: 2.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599116  815 QRFPACPGAQRMRALLPEPPAEpagSAGEVLSGRELAVLELIAQGLSNQEISERLFISLHTVKSHARHINDKLGV 889
Cdd:PRK09483 122 QRYIASDIAQQMALSQIEPATE---NPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNI 193
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 39-181 4.16e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.02  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116    39 RRLRDGlDGRLLLIAAPAGFGKSSLAIEFCESLDPRWQ-------------SLWLGLSSRESDPGRFLERLLDGLRQYHP 105
Cdd:pfam13191  17 DRVRSG-RPPSVLLTGEAGTGKTTLLRELLRALERDGGyflrgkcdenlpySPLLEALTREGLLRQLLDELESSLLEAWR 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599116   106 TLGEEALGLLKMRQRHQPFAFetwLDDLLDELAPCLDPQRPLLLVLDDYHLAQGAVLDRcLQFLLNHLPEGLVLLV 181
Cdd:pfam13191  96 AALLEALAPVPELPGDLAERL---LDLLLRLLDLLARGERPLVLVLDDLQWADEASLQL-LAALLRLLESLPLLVV 167
TPR_12 pfam13424
Tetratricopeptide repeat;
728-791 7.79e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15599116   728 AGLERREGRPEEAARRLDR-LARSTRENGALLPARL-ALGQLAALHLEQGREREALATLQQAMEGA 791
Cdd:pfam13424  10 AAVLRRLGRYDEALELLEKaLEIARRLLGPDHPLTAtTLLNLGRLYLELGRYEEALELLERALALA 75
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 542-789 7.82e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 7.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 542 QRYGNPLFEALVHYDRARVLQARGEVARAEEEVRQGLERLQHLPAQRRYAVRGRLLLYRGYLRSLALQPDEARKWIKQGI 621
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 622 EETrscrdvslvigycvLASLEGRLGNYAAAFARLGdverlmHAWDIPPIYYLAAITLIkcELWLAQGQTELAGVWLQRL 701
Cdd:COG3914  81 LEL--------------AALLLQALGRYEEALALYR------RALALNPDNAEALFNLG--NLLLALGRLEEALAALRRA 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599116 702 ggtyggqAATPPECSPLLplhveLLQAGLERREGRPEEAARRLDRLARstrengaLLPARL-ALGQLAALHLEQGREREA 780
Cdd:COG3914 139 -------LALNPDFAEAY-----LNLGEALRRLGRLEEAIAALRRALE-------LDPDNAeALNNLGNALQDLGRLEEA 199


                ....*....
gi 15599116 781 LATLQQAME 789
Cdd:COG3914 200 IAAYRRALE 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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