|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
12-404 |
9.77e-101 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 305.33 E-value: 9.77e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYG 91
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 92 LAFASQ-YWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTA-MGIFGAGNAGAAITNLVAPMIVVA-------FGWR 162
Cdd:cd17341 81 LALAVSsYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAaGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 163 MVPQVYSVAMLVTAVLFWLFTWTDPAHLkgaaeASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAE 242
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGK-----ASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 243 YGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYPQTTMtihgiqgdlslgiGLNVWLF 322
Cdd:cd17341 236 FGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTS-------------GTNLVLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 323 TFLVFVVGIAQGFGKASVYRIIHDYYPSNMGTVGGMVGVIGGLGGFCLPILFGYAADHIGVRSSCFMLLFGLTVVCMVWM 402
Cdd:cd17341 303 LALFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
..
gi 15599072 403 HY 404
Cdd:cd17341 383 WL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-411 |
3.81e-90 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 278.30 E-value: 3.81e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 7 KQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVA 86
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 87 IPIYGLAFASQYWHYLVLGLFVGL-AGGSFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAITNLVAPMIVVAFGWRMV 164
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 165 PQVYSVAMLVTAVLFWLFTWTDPAHLKGAAEASqrpnLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYG 244
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS----LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 245 LDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYPQTtmtihgiqgdlslgiglNVWLFTF 324
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-----------------SLWLFLV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 325 LVFVVGIAQGFGKASVYRIIHDYYPS-NMGTVGGMVGVIGGLGGFCLPILFGYAADHIGVRSSCFMLLFGLTVVCMVWMH 403
Cdd:COG2223 301 LFLLLGLALGGGNGAVFALVPDIFPTkNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
....*...
gi 15599072 404 YAIKQQRR 411
Cdd:COG2223 381 LLYRRPRR 388
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
11-344 |
2.32e-46 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 163.24 E-value: 2.32e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIR-IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPI 89
Cdd:TIGR00886 2 NLFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 90 YGLAFASQ-YWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAITNLVAPMIV----------- 156
Cdd:TIGR00886 82 LWAGLAVQsYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIgslifgggqpa 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 157 -VAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAHLKGAAeASQRPnlakQLAPLAELRVWRFGLYYFFVFGGFVALALWL 235
Cdd:TIGR00886 162 hLAWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGK-LSFKE----ALKVFGNRHTWILALLYSVTFGSFLGVSSIF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 236 PKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWgvFWVCLVCLFFLSYPQTTMTihgiQGDLSLGI 315
Cdd:TIGR00886 237 AMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLL--MNFLGVAMGAFLVVLGLVS----DGSLAAFI 310
|
330 340
....*....|....*....|....*....
gi 15599072 316 GLNVWLFTFLvfvvgiaqGFGKASVYRII 344
Cdd:TIGR00886 311 VLFVALFFFA--------GAGNGSTFALV 331
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-411 |
6.29e-34 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.99 E-value: 6.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 1 MASLRQKQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFI 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 81 HMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVA 158
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 159 FGWRMVPQVYSVAMLVTAVLfwlftwtdpahlkgaaeasqrpnlakqlaplaelRVWRFGLYYFFVFGGFVALALWLPKY 238
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 239 YIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYPQTTmtihgiqgdlslgiglN 318
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP----------------S 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 319 VWLFTFLVFVVGIAQGFGKASVYRIIHDYYPSNMGTVGG-MVGVIGGLGGFCLPILFGYAADHIGVRSScFMLLFGLTVV 397
Cdd:COG2271 271 PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASgLVNTFGFLGGALGPLLVGYLLDATGYQAA-FLLLAALALL 349
|
410
....*....|....
gi 15599072 398 CMVWMHYAIKQQRR 411
Cdd:COG2271 350 AALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-352 |
8.72e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 8.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 1 MASLRQKQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFI 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 81 HMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF-AVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVA 158
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 159 FGWRMVPQVYSVAMLVTAVLFWLFtwtdpahLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKY 238
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL-------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 239 YIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYPQttmtihgiqgdlslgiglN 318
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG------------------S 295
|
330 340 350
....*....|....*....|....*....|....
gi 15599072 319 VWLFTFLVFVVGIAQGFGKASVYRIIHDYYPSNM 352
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-352 |
1.32e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.73 E-value: 1.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 14 MSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 94 FASQYWHYLVLGLFVGLAGGS-FAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVA 171
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGAlFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 172 MLVTAVLFWLFTwTDPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIaEYGLDLKTAS 251
Cdd:pfam07690 161 SLLAAVLLLLPR-PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 252 FITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdlsLGIGLNVWLFTFLVFVVGI 331
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL---------------LSLTLSSLWLLLALLLLGF 303
|
330 340
....*....|....*....|.
gi 15599072 332 AQGFGKASVYRIIHDYYPSNM 352
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEE 324
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
24-400 |
2.63e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 100.72 E-value: 2.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 24 AVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLV 103
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 104 LGLFVGLAGG-SFAVGIAYTSAWFEKeRQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWL 181
Cdd:COG2807 112 GTALIGAGIAvGNVLLPGLIKRWFPD-RVGLMTGLYTAAmGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 182 FTWTDPAHLKGAAEASQRPNLAKQlaPLAelrvWRFGLYYFFVFGGFVALALWLPKYYIaEYGLDLKTASFITMLFTLPS 261
Cdd:COG2807 191 LLRRRPAAAAAAPAAASLRSLWRS--PLA----WLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 262 GLIRALGGWFSDHYGARsvnWGVFWVCLVCLFFlsypqttmtihGIQGdLSLGIGLNVWLFtflVFVVGIAQGFGKASVY 341
Cdd:COG2807 264 IPGSLLVPLLADRLGDR---RPLLLLLGLLGLA-----------GLLG-LLLAPGSLPWLW---AVLLGLGQGGLFPLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599072 342 RIIHDYYPSNMGTVGG--MVGVIGGLGGFCLPILFGYAADHIGVRSSCFMLLFGLTVVCMV 400
Cdd:COG2807 326 TLIGLRARTPAEAAALsgMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
15-274 |
2.66e-23 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 100.78 E-value: 2.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 15 STLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAF 94
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 95 ASQYWHYLVLGLFVGLAGGSF-AVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAM 172
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVqPGGGRAIMRWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 173 LVTAVLFWLFTWTDPAhlKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASF 252
Cdd:cd17475 161 ILAAVLFWLFYREPPA--ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGA 238
|
250 260
....*....|....*....|..
gi 15599072 253 ITMLFTLPSGLIRALGGWFSDH 274
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDR 260
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
12-300 |
1.11e-21 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 96.88 E-value: 1.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRI-KDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIY 90
Cdd:PRK15034 36 LWISVSCLLLAFCVWMLFSAVTVNLnKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFASQ-----YWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIFGA-GNAGAAITNLVAPMIVVA-----F 159
Cdd:PRK15034 116 WLGIAVQnpntpFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINGGlGNLGVSVMQLVAPLVIFVpvfafL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 160 GWRMVPQV-YSVAMLVTAVLFW---LFTWTDPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALAlwl 235
Cdd:PRK15034 196 GVNGVPQAdGSVMSLANAAWIWvplLAIATIAAWSGMNDIASSRASIADQLPVLQRLHLWLLSLLYLATFGSFIGFS--- 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599072 236 pkyyiAEYGLDLKT----ASFITMLFTLP--SGLIRALGGWFSDHYGARSVNW--GVFWVCLVCLFFLSYPQT 300
Cdd:PRK15034 273 -----AGFAMLAKTqfpdVNILRLAFFGPfiGAIARSVGGAISDKFGGVRVTLinFIFMAIFSALLFLTLPGT 340
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-295 |
1.43e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 95.33 E-value: 1.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIY 90
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFASQYWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWRMVPQVY 168
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGWLLLLFGWRWAFIIE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 169 SVAMLVTAVLFWLFTWtdpahlkgaaeasqrpnlakqlaplaelRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLK 248
Cdd:cd17319 164 GLLGLLLAVLWWFYLR----------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLK 215
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15599072 249 TASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFL 295
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGL 262
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-403 |
1.21e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.02 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 39 ELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF-AV 117
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVwPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 118 GIAYTSAWFEKERQGTAMGIFGAGN-AGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWtDPAHLKGAAEA 196
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP-EPRPPPNKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 197 SQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYG 276
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 277 ARSVNWGVFWVCLVCLFFLSYPQttmtihgiqgdlslgiglNVWLFTFLVFVVGIAQGFGKASVYRIIHDYYPSNMGTVG 356
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLAT------------------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15599072 357 GMVGVIGGLGGFCL-PILFGYAADHIGVRSScFMLLFGLTVVCMVWMH 403
Cdd:cd17325 326 MGLFNTAFSLGMVLgPLLGGFLYDAFGFATP-FLAAAALLLLAAVLFL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
17-304 |
2.16e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.84 E-value: 2.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 17 LSFAVNFAVWTMFSIIGI--RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAF 94
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLlpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 95 ASQYWHYLVLGLFVGLAGGSF-AVGIAYTSAWFEKERQGTAMGIFGAGNAGAAITNLVAP-MIVVAFGWRMVPQVYSVAM 172
Cdd:cd17324 84 APSFALLLLARALAGLAHGGFwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGgLLGQLLGWRAAFLAIAVLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 173 LVTAVLFWLFTWTDPAHlkgaaEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASF 252
Cdd:cd17324 164 LLAALLLWRLLPSLPPK-----KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15599072 253 ITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYPQTTMTI 304
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLL 290
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-411 |
4.43e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 88.37 E-value: 4.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 14 MSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLA 93
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 94 FASQYWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAAItnlVAPMIVVAF-------GWRMVPQ 166
Cdd:COG0738 92 LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGAL---LGPLLGGLLillglslSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 167 VYSVAMLVTAVLFWLFTWTDPAhlkgAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLD 246
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIE----EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 247 LKTASFITMLFTLPSGLIRALGGWFSDHYGARSVnwgVFWVCLVCLFFLsypqttmtihgiqgdLSLGIGLNVWLFTFLV 326
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL---LRLSALLAAVGL---------------LLALLAPGPWLALIGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 327 FVVGIAQGFGKASVYRIIHDYYPSNMGTVGGMVGVIGGLGGFCLPILFGYAADHIGVRSScfMLLFGLTVVCMVWMHYAI 406
Cdd:COG0738 307 ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAA--FLVPLVCYLLILLLALAL 384
|
....*
gi 15599072 407 KQQRR 411
Cdd:COG0738 385 KRKRR 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-400 |
1.90e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.63 E-value: 1.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 16 TLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFA 95
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 96 SQYWHYLVLGLFVGLAGGSFAV-GIAYTSAWFEKERQGTAMGIFGAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLV 174
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPaVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 175 TAVLFWLFTWTDPAHLKGAAEASQRPNLAKQLAPLAEL----RVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTA 250
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVlknpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 251 SFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLsypqttmtihgiqgdlsLGIGLNVWLFTFLVFVVG 330
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL-----------------LLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599072 331 IAQGFGKASVYRIIHDYYPSNMGTVGG-MVGVIGGLGGFCLPILFGYAADHIGVRSSCFMLLFGLTVVCMV 400
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFgLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-182 |
1.28e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 7 KQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVA 86
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 87 IPIYGLAFASQYWHYLVLGLFVGLAGG-SFAVGIAYTSAWFEKERQGTAMGIFG-AGNAGAAITNLVAPMIVVAFGWRMV 164
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNtAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*...
gi 15599072 165 PQVYSVAMLVTAVLFWLF 182
Cdd:cd17325 357 FLAAAALLLLAAVLFLLL 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-273 |
1.30e-15 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 77.70 E-value: 1.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 8 QYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAI 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 88 PIYGLAFASQYWHYLVLGLFVGLAGGS-FAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVP 165
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTShNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 166 QVYSVAMLVTAVLFWLFTWTDPAHlkgaaeasqrpnlakqlaplaelrVWRFGLYYFFVFGGFVALALWLPKYYIAEYGL 245
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPY------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGY 216
|
250 260
....*....|....*....|....*....
gi 15599072 246 DLKTASFITMLFTLpSGLIRALG-GWFSD 273
Cdd:cd17312 217 SLIDAGWFSSLYEV-GGIAGTILaGLLSD 244
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-304 |
6.51e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 75.67 E-value: 6.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF 115
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 116 ---AVGIAYTSAwfeKERQGTAMGIFGA-GNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAHLK 191
Cdd:cd17478 102 hpeGARLASQAA---GGRRGLAMSIFSVgGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 192 GAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALwlpkyYIAEYGLDLKTASFITMLFTLPSGLIRALGGWF 271
Cdd:cd17478 179 KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPF-----YLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPL 253
|
250 260 270
....*....|....*....|....*....|...
gi 15599072 272 SDHYGARSVNWGVFWVCLVCLFFLSYPQTTMTI 304
Cdd:cd17478 254 SDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSY 286
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
14-290 |
1.11e-14 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 75.73 E-value: 1.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 14 MSTLSFAVNFAVWtmFSI---IGIrIKDELGLSESQFGLmVALPILTGSLV-RLPLGLITDRFGGRIVFFIHMLLVAIPI 89
Cdd:PLN00028 40 LSWISFFTCFVST--FAAaplLPI-IRDNLNLTKSDIGN-AGIASVSGSIFsRLAMGPVCDLYGPRYGSAFLLMLTAPAV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 90 YGLAFASQYWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAITNLVAPMIVVAF--------- 159
Cdd:PLN00028 116 FCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGGGVTQLLMPLVFPLIkdagapsft 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 160 GWRMVPQVYSVAMLVTAVLFWLFTWTDP----AHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGgfVAL---- 231
Cdd:PLN00028 196 AWRIAFFVPGLLHIIMGILVLTLGQDLPdgnyRELKKSGTMPKDSFSKVLRYGVTNYRTWILALTYGYSFG--VELtmdn 273
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599072 232 --ALwlpkYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSD----HYGARSVNWGVfWVCLV 290
Cdd:PLN00028 274 iiAE----YFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDvaarRFGMRGRLWAL-WIVQT 333
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-335 |
1.16e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.86 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTMFSIIGIRIKDeLGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQ 97
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 98 YWHYLVLGLFVGLAGGSFAVGIAYTSAWF-EKERQGTAMGIFGAGNAGAaitNLVAPMIVVA----FGWRMVPQVYSVAM 172
Cdd:cd17489 84 VALLLVLRLIHGIGWGAFTTAAATLVADIiPPSRRGEGIGYYGLATTLA---MALGPALGLFlyqhLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 173 LVTAVLFWLFTWTDPAHlkgaaeASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAeygLDLKTASF 252
Cdd:cd17489 161 LLALLLVFLVKDPPPVA------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 253 ITMLFTLPSGLIRALGGWFSDHygarsvnWGVFWVCLVCLFFLSYpqttmtihgiqGDLSLGIGLNVWLFTFLVFVVGIA 332
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDR-------KGPKTVIIPGLLLLAL-----------GLLLLSFAGSPWMLLLAAVLYGLG 293
|
...
gi 15599072 333 QGF 335
Cdd:cd17489 294 FGL 296
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
12-293 |
2.56e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.11 E-value: 2.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYG 91
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 92 LAFASQYWHYLVLGLFVGLAGGSFAVgIAYT--SAWFEKERQGTAMGIFG-AGNAGAAITNLVAPMIV-VAFGWRMVPQV 167
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSP-IAPTiiADLFPKEKRTRALGVFYfAIPLGSGLGYVVGGLVAqATGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 168 YSVAMLVTAVLFWLFtwTDPAHLKGAAEASQRPNLAKQLAPLAE--LRVWRFGLYYF-FVFGGFV--ALALWLPKYYIAE 242
Cdd:cd17328 160 TGVLGVLLAILLLLF--VREPPRGAAEGGVMAKSTATSFLADLKalAKNPSFILSTLgFTAVSFVtgALAFWAPTFFLRA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 15599072 243 YGLDLKTASFITMLFTLPSGLIRALGGWF----SDHYGARSVNWGVfWVCLVCLF 293
Cdd:cd17328 238 FGVGDLSSADVGLIFGAITCIAGVLGVLLggilADRLRRKTPRADP-LVCAVGLL 291
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
17-302 |
3.43e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 70.76 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 17 LSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFAS 96
Cdd:cd17355 10 LILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 97 QYWH-YLVLGLFVGL-AGGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAAITNL-VAPMIVVAFGWRMVPQVYSVAML 173
Cdd:cd17355 90 SLWQlYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLpLGAALIEAFGWRTALLVLALLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 174 VTAVLFWLFTWTDPAHLKGAAEASQRPnlakQLAPLAELRVWRFGLYYFFVFGGFVALALW------LPKyYIAEYGLDL 247
Cdd:cd17355 170 LVLVPVLLLLRRRPADLALRAYDDASP----ASPGSTLKEALRSASFWLLALAFFLCGFAVvglivhLVP-YLADRGISP 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599072 248 KTASFITMLFTLPSGLIRALGGWFSDHYGAR---SVNWGVFWVCLVCLFFLSYPQTTM 302
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDRYSPRrllAASYALRALGLALLLLLPFPPLAL 302
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-335 |
3.70e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.70 E-value: 3.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIY 90
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFASQYW--HYLVLGLFVGLAGGSFAVGIAYT------SAWF------EKERQGTAMGIFGAGNAGAAITNLVAPMIV 156
Cdd:COG2211 92 ALSFVLLFTapDLSPTGKLIYALVTYLLLGLAYTlvnipySALGaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 157 VAF------GWRMVPQVYSVAMLVTAVLFWLFTWTDPahlkgaAEASQRPNLAKQLAPLAELRVWR-FGLYYFFVFGGFV 229
Cdd:COG2211 172 AAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERP------VPEEEKVSLKESLKALLKNRPFLlLLLAYLLFFLALA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 230 ALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVN-WGVFWVCLVCLFFLSYPQTtmtihgiq 308
Cdd:COG2211 246 LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFiIGLLLAALGLLLLFFLGPG-------- 317
|
330 340
....*....|....*....|....*..
gi 15599072 309 gdlslgiglNVWLFTFLVFVVGIAQGF 335
Cdd:COG2211 318 ---------NLWLLLVLAALAGIGLGA 335
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-297 |
4.09e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 67.40 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGG-S 114
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGmG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 115 FAVGIAYTSAWFEKERQGTAMGIFGAGN--AGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAvLFWLFTWTDPAHLKG 192
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWNCSHnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVS-LICFLLLRDSPQSCG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 193 AAEASQRPN----LAKQLAPLAELR-------------VWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITM 255
Cdd:TIGR00881 180 LPPAEEMPNeepdGDAEKKEEELTKkqiflqyvllnkvLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFT 259
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15599072 256 LFTLPSGLIRALGGWFSDH-YGARSVNWGVFWVCLVCLFFLSY 297
Cdd:TIGR00881 260 LYELGGLVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLLVY 302
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-336 |
4.97e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 66.94 E-value: 4.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 28 MFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLF 107
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 108 VGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAGNA-----GAAITNLVAPMIVVAFGWRmvpqvysvAMLVTAVLFWL 181
Cdd:cd17371 97 AGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwllATLLAALLFPLLPPEIAWR--------VLFLLGALPAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 182 FTWTDPAHLK---GAAEASQRPNLAKQLAPLAELRVWRF-------GLYYFFVFGGFVALALWLPKYYIAEYGLDLKTAS 251
Cdd:cd17371 169 LVLFIRRFVKeppQWQAARAARRHFADRPSLRELFSPPLlrttllaSLLATGALGGYYGITTWLPSYLTGERGLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 252 FITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdLSLGIGLNVWL-FTFLVFVVG 330
Cdd:cd17371 249 GYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF-------------LPLSPTLILILgFPLGFFASG 315
|
....*.
gi 15599072 331 IAQGFG 336
Cdd:cd17371 316 PFSGMG 321
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-146 |
2.67e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.53 E-value: 2.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 10 SVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPI 89
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15599072 90 YGLAFASQYWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAA 146
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
43-402 |
2.75e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.44 E-value: 2.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 43 SESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGSFAVGIAY 121
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGvAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 122 TSAWFEKERQGTAMGIFGAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVtAVLFWLFTWtDPAHLKGAAEASQrpn 201
Cdd:cd17473 113 IGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPV-LILVLLFLP-EPARKSKSAASPG--- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 202 lAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSvn 281
Cdd:cd17473 188 -AATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR-- 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 282 wgvfwvcLVCLFFLSYpqttmtihgIQGDLSLGIGLNVWLFTFLVFVVGIAQGFGKASVY-RIIHDYYPSNMGTVGGMVG 360
Cdd:cd17473 265 -------LLAIGFALM---------ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNsWAMSLVPPELRGRAMGIVT 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 15599072 361 VIGGLGGFCLPILFGYAADHIGVRSSCFMLLFGLTVVCMVWM 402
Cdd:cd17473 329 SAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
35-352 |
3.14e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.45 E-value: 3.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 35 RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GG 113
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGlGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 114 SFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWlftwtdpahlkg 192
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 193 aaeasqrpnlakqlaplAELRVWrfgLYYFFVFGGFVALALWLPKyYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFS 272
Cdd:cd17365 172 -----------------GTLLLW---VTFFMGLLLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 273 DHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdlslgIGLNVWLFTFLVFVVGIAQGFGKASVYRIIHDYYPSNM 352
Cdd:cd17365 231 DRFGPKRVLALFFALGAVSLALLGV-----------------SPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV 293
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-351 |
3.75e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.22 E-value: 3.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 2 ASLRQKQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIH 81
Cdd:TIGR00895 9 QPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 82 MLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAF 159
Cdd:TIGR00895 89 ILLFSVFTLLCALATNVTQLLILRFLAGLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 160 GWRMVPQVYSVAMLVTAVLFWLF-----TWTDPAHLKGAAEASQRPNLAKQLAPLAEL-------RVWR----------- 216
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFlpesiDFLVSKRPETVRRIVNAIAPQMQAEAQSALpeqkstqGTKRsvfkalfqgkt 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 217 ------FGLYYFFVFGGFVALALWLPKyYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARsVNWGVFWVCLV 290
Cdd:TIGR00895 249 aritvlLWLLYFMLLVGVYFLTNWLPK-LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAV 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599072 291 CLFFLSYPQTTMTIhgiqgdlslgiglnvwlFTFLVFVVGIAQGFGKASVYRIIHDYYPSN 351
Cdd:TIGR00895 327 FAVLVGSTLFSPTL-----------------LLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-335 |
1.22e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 23 FAVWTMFSIIGI---RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYW 99
Cdd:cd17321 6 FLAALDVTIVNValpTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 100 HYLVLGLFVGLAGGS-FAVGIAYTSAWFEKERQGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAV 177
Cdd:cd17321 86 FLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAVVGiGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 178 LFWLFTWTdpahlkgaaeasqrpNLAkqlaplaelrvwrfglyYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLF 257
Cdd:cd17321 166 LARTFSGA---------------VLA-----------------AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599072 258 TLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdlsLGIGLNVWLFTFLVFVVGIAQGF 335
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL---------------LGADSSVWLLLPGLVLLGLGLGL 276
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-352 |
1.52e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.15 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRIKDE--LGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPI 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 90 YGLAFASQYWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGI-FGAGNAGAAITNLVA----PMIVVAFGWRm 163
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLlQSGWALGALLAALVAslliPLLSGDWGWR- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 164 vpqvysvAMLVTAVLFWLFTWtdpahlkgaaeasqrpnlakqlapLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEY 243
Cdd:cd17316 160 -------ILFLIGALPALLAL------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 244 GLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdlslGIGLNVWLFT 323
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY----------------LLSGSPTLLL 272
|
330 340
....*....|....*....|....*....
gi 15599072 324 FLVFVVGIAQGFGKASVYRIIHDYYPSNM 352
Cdd:cd17316 273 LLLFILSFFVGGVWGALYAYLAELFPTEV 301
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
29-348 |
7.84e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 57.23 E-value: 7.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 29 FSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWH-YLVLGLF 107
Cdd:cd17353 22 WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLlFLGYGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 108 VGLaggsfAVGIAYTSA------WFeKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFW 180
Cdd:cd17353 102 GGI-----GAGIGYITPvstavkWF-PDKRGLATGIVIAGfGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 181 LFTWTDPAHLKGAAEASQRPNLAK---QLAPLAELRVWRFGL----YYFFVFGGFVALALWLPkYYIAEYGLDLKTASFI 253
Cdd:cd17353 176 FLIRDPPKGWVPPGVDPLANNAENsprDYTPREMLRTPTFWLlwlmFFLNATAGLMLIGQAKP-IGQEFAGLDAGIAALA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 254 TMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdlslgIGLNVWLFTFLVFVVGIAQ 333
Cdd:cd17353 255 VSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPF-----------------IGSVAVLFVLGVALIGFCY 317
|
330
....*....|....*
gi 15599072 334 GFGKASVYRIIHDYY 348
Cdd:cd17353 318 GGGFALFPALTADFF 332
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
35-285 |
8.19e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.28 E-value: 8.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 35 RIKDELGLSESQFGLMV---ALPILTGSLVRlplGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA 111
Cdd:PRK11551 40 RMAQEFGLDVAQMGWAFsagILGLLPGALLG---GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 112 -GGSFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAH 189
Cdd:PRK11551 117 lGGALPNLIALTSEAVGPRLRGTAVSLMYCGvPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 190 LKGAAEASQRPNLAKQL----APLAELRVWrfgLYYFFVFGGFVALALWLPKYYIAEyGLDLKTASFITMLFTLPSGLIR 265
Cdd:PRK11551 197 AQAAGAGKQRAPVLRALfgegRATATLLLW---ISYFFTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGS 272
|
250 260
....*....|....*....|
gi 15599072 266 ALGGWFSDHYGARSVNWGVF 285
Cdd:PRK11551 273 LLIGALMDRLRPRRVVLLIY 292
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
36-280 |
9.09e-09 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 56.88 E-value: 9.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMV-ALPIltGSLVRLPL-GLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGG 113
Cdd:cd17393 25 IKDRLGLSDAALGLLLlALGV--GALVAMPLaGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 114 SFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAITNLVApmiVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAHLKG 192
Cdd:cd17393 103 ALDVAMNAQGVAVERAYGRPIMSSLhAMWSLGGLAGALLG---AAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 193 AAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFS 272
Cdd:cd17393 180 EAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLV 259
|
....*...
gi 15599072 273 DHYGARSV 280
Cdd:cd17393 260 DRFGDVAV 267
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-181 |
1.08e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.46 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 9 YSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIP 88
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 89 IYGLAFASQYWHYLVLGLFV---GLAGGSFAVGIAYTSAWFEKERQGTAMGI-FGAGNAGAAITNLVAPMIVVAFGWRMV 164
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFilsFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
170
....*....|....*..
gi 15599072 165 PQVYSVAMLVTAVLFWL 181
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-272 |
1.63e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.59 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 7 KQYSVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVA 86
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 87 IPIYGLAFASQYWHYLVLGLFVGL-AGGSFAVGIAYTSAWFEKERQGTAMGIFGAGN-AGAAITNLVAPMIVVAFGWRMV 164
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIgLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 165 PQVYSVAMLVTAVLFWLFTWTDPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYG 244
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260
....*....|....*....|....*...
gi 15599072 245 LDLKTASFITMLFTLPSGLIRALGGWFS 272
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLAL 278
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
20-183 |
4.09e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.87 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 20 AVNFAVWTMFSIIGIRikdeLGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYW 99
Cdd:cd17477 202 FLEGAFYSLLPLYGLR----LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 100 HYLVLGLFV--GLAGGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAAItnlVAPMIVVAFGWRMVPQVYSVAMLVTAV 177
Cdd:cd17477 278 LALLVLLFLwgGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSV---IGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
....*.
gi 15599072 178 LFWLFT 183
Cdd:cd17477 355 LFLLFL 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-335 |
1.29e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.35 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF 115
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 116 AVgIAYTSAwFEKERQGTAMGIFGAGNAGAAITNLVAPM----IVVAFGWRMVPQVYSVAMLVTAVLFWLFTwtdPAHLK 191
Cdd:cd17320 105 SV-VARAIV-RDLYSGAELAKIFSLLMMILAIAPALAPLlgglLLLFFGWRAIFVFLALLGLLLLLLVLLFL---PETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 192 GAAEASQRPNLAKQLAP-LAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGW 270
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRvLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGR 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599072 271 FSDHYGARSVNWGVFWVCLVCLFFLSYpqttmtihgiqgdLSLGIGLNVWLFTFLVFVVGIAQGF 335
Cdd:cd17320 260 LVRRFGPRRLLRLGLLLLLAAALVLLL-------------AALLGGLSLWPLVAPLFLIFFGFGL 311
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
35-333 |
2.33e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.58 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 35 RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGS 114
Cdd:cd17504 21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 115 FAVGIAYTSAWFEKERQGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWRMvpqVYSVAMLVTAVLFWLFTWTDPAHLKga 193
Cdd:cd17504 101 FPLAFALVREEFPPERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRW---IFWTAAPVAVLLAALVPLIDLRLLR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 194 aeasqRPNLAKQLAPLAelrvwRFGLYYFFVFGGFVALaLWLPKyyIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSD 273
Cdd:cd17504 176 -----RRNVLLANITAL-----LAGFGMFMVFQLLPQL-LQLPT--PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIA 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15599072 274 HYGAR-SVNWGVFWVCLVCLFFLSYPQTTMTIHGIQGDLSLGIGL-NVWLFTFLVFVVGIAQ 333
Cdd:cd17504 243 RVGPRrVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLaFASLPNIVVESVPPDR 304
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
21-275 |
2.66e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 52.41 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 21 VNFAVWTMFSiigirikdELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWH 100
Cdd:cd17488 22 FNAAMPAMLA--------DLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 101 YLVL-GLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRM---VPQVYSVAMlvt 175
Cdd:cd17488 94 FAVLwTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTShNIGGALIPILTGFAALTYGWRAgmyVPGIIAILM--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 176 aVLFWLFTWTDpahlkgaaeasqRPNLakqlaplaelrVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITM 255
Cdd:cd17488 171 -GIVLCWRLRD------------RPPY-----------IWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVS 226
|
250 260
....*....|....*....|.
gi 15599072 256 LFTLpSGLIRAL-GGWFSDHY 275
Cdd:cd17488 227 LFEV-GGLIGALvAGWGSDKL 246
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-182 |
3.36e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.19 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 10 SVLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPI 89
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 90 YGLAFASQYWHYLVLGLFVGLAGG-SFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAIT-NLVAPMIVVAFGWRMVPQ 166
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVtSAFFLGQFLSpLVLGPLVNLTGGLSGAFL 357
|
170
....*....|....*.
gi 15599072 167 VYSVAMLVTAVLFWLF 182
Cdd:cd17473 358 ILGVLALVLAIVLLLL 373
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-334 |
3.40e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.80 E-value: 3.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 16 TLSFAVNFAVWTMFSIIGI--RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLA 93
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPIlpAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 94 FASQYWHYLVLGLFVGLAGGSF-AVGIAYTSAWFEKERQGTAMGIFGAGNaGAAITnlVAPMI---VVAFGWRMVPQVYS 169
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLgPLALTLIGDLFEGGERAKAMGLYEAAL-GLGIA--VGPLLgglLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 170 VAMLVtAVLFWLFTWTDPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVAlalWLPKYYIAEYGLdlkT 249
Cdd:cd17474 160 ALIPV-AFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLT---YLPFLLELLYGI---S 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 250 ASFITMLFTLPSGLIRA----LGGWFSDHYGARSVNWGVFWVCLVCLfflsypqttmtihgiqgdLSLGIGLNVWLFTFL 325
Cdd:cd17474 233 PIIIGLLFAGWSVLLALgslfVGRLLKKRFGARRILVIGLLLYALSL------------------LLLGFVPSLALLLIA 294
|
....*....
gi 15599072 326 VFVVGIAQG 334
Cdd:cd17474 295 IVLFGLGLG 303
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
35-259 |
3.41e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 3.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 35 RIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWhylvlgLFVG--LAG 112
Cdd:cd17339 24 EIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIAL------LFLGtaLAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 113 GSFAVGIAYTSAWFEK---ERQGTAMGIFGAG-NAGAAITNLVAPMI--VVAFGWRMVPQVYSVAMLVTAVLFWLFTWTD 186
Cdd:cd17339 98 AGIAVGNVLLPSLIKRdfpRRVGLMTGLYTTSmNLGAALASGLSVPLaqALGGGWRGALAIWALPALLALLIWLPQLRRR 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15599072 187 PAHLKGAAEASQRPNLAKQLAplaelrvWRFGLYYFFVFGGFVALALWLPKYYIaEYGLDLKTASFITMLFTL 259
Cdd:cd17339 178 KRAAAAAAPLTKISVWRSPLA-------WQVTLFMGLQSLLFYTLMAWLPTILI-DAGLSAATAGWLLSLFQL 242
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
17-278 |
5.88e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.17 E-value: 5.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 17 LSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFAS 96
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 97 QYWHYLVLGLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIF-GAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVT 175
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLhGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 176 AVLFWLFTWTDPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITM 255
Cdd:cd17333 163 LAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS 242
|
250 260
....*....|....*....|...
gi 15599072 256 LFTLPSGLIRALGGWFSDHYGAR 278
Cdd:cd17333 243 GFWVGITIGRLLGGPISRRIKPH 265
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-295 |
6.46e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 6.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTMFSIIGIRIKDElGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQ 97
Cdd:cd17477 5 VALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 98 YWHYLVLGLFVGLAGGSFAVGI-AYTSAWFEKERQGTAMGIFGAGNAGAAItnlVAPMIVVAFGWR-MVPQVYSVAMLVT 175
Cdd:cd17477 84 PWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFA---LGPLLLALVGTAgALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 176 AVLFWLFTWTDPAHLKGAAEASQRpnLAKQLAPLAELRVwrfglyyfFVFGGFVALALWLPKYYIAEYGLDLKTASFITM 255
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLR--RLLRIAPLALLGA--------FVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLA 230
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 15599072 256 LFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFL 295
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLL 270
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-180 |
1.48e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGG---RIVFFIHMLLVAIPIYGLAF 94
Cdd:cd17475 207 GALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 95 ASQYWHYLVLGLFVGLAG----GSFAVGIAYTSAWFEKERQGTAMGIFGAGN-AGAAITNLVAPMIV-VAFGWRMVPQVY 168
Cdd:cd17475 287 LSPGTPLWLLVLLLILLGlfaiGWNGLYLTLVAESAGPEQAGTALGLANTINfIGIAIGPPLFGLLVdATHSYAPAWLAL 366
|
170
....*....|..
gi 15599072 169 SVAMLVTAVLFW 180
Cdd:cd17475 367 ALLLVLAALLLL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-199 |
1.49e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIgirIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIY 90
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYY---FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFA--SQYWHYLVLGLFVGLAGGSFAVG--------IAYTSAWFEKERQGTAMGIFGAGN-AGAAITNLVAPMIVVAF 159
Cdd:COG2211 310 LLFFLgpGNLWLLLVLAALAGIGLGAILVLpwamladvVDYDEWKTGRRREGLYFGIFTFAIkLGQALAGALAGLLLALF 389
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15599072 160 GWRM-VPQ--------------VYSVAMLVTAVLFWLFTWTDPAHLKGAAEASQR 199
Cdd:COG2211 390 GYVAgAAQspsaltgirllfflLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
39-256 |
1.91e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 49.64 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 39 ELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGSFAV 117
Cdd:cd17343 32 ELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAqGLGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 118 GIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDP--AHLKGAA 194
Cdd:cd17343 112 CAKILRKWFSPSQFGTWWSVLSTSmNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPsdVGLNNIE 191
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 195 EASQRPNLAKQLAPLAELR-------VWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTAS-FITML 256
Cdd:cd17343 192 EEESKGKKKKSPRGESTLKelllspfLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSsFMSSL 261
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-182 |
1.93e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITD-RFGGRIVFFIHMLLVAIPIY 90
Cdd:cd17474 201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFASQYWHYLVLGLFVGLAGG-SFAVGIAYTSAWFEKERQGTAMGIFG-AGNAGAAITNLVAPMIVVAFGWRMVPQVY 168
Cdd:cd17474 281 LLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNfVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
170
....*....|....
gi 15599072 169 SVAMLVTAVLFWLF 182
Cdd:cd17474 361 AAIALAAAVLLALL 374
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
66-331 |
2.62e-06 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 49.24 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 66 GLITDRFGGRIVFFIHMLLVAI--PIYGLAFAS---QYWHYLVLGLFVGLA--GGSFAVgIAYTSAWFEKERQGTAMGIF 138
Cdd:cd17344 83 GHIGERLPLRYFLSFGMLLSGLftALFGLGYYWnihSLWYFVVVQILAGLFqsTGWPSV-VACVGNWFGKGKRGLIMGIW 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 139 GAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAhlkGAAEASQRPNLAKQLAplaelrvwrfg 218
Cdd:cd17344 162 NSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHPP---GVIEFSLCLFFAKLVS----------- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 219 lyYFFVFggfvalalWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFwvclvclFFLSYP 298
Cdd:cd17344 228 --YTFLY--------WLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAM-------LILAAP 290
|
250 260 270
....*....|....*....|....*....|...
gi 15599072 299 qtTMTIHGIQGDLSLGIGLnvwlftFLVFVVGI 331
Cdd:cd17344 291 --MLFIYNYFGQVSMTTNI------VLLIVCGL 315
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
39-326 |
3.04e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 39 ELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVF-FIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFAV 117
Cdd:cd17490 25 SLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 118 GIAYTSAWFEKERQGTAMGIFGA-GNAGAAITNLVAPMIVVAFGWRmVPQVYSVAMLVTAVLFWLFTWTDPAHLKGAAea 196
Cdd:cd17490 105 FTVLYASYFPPDEAAKAMGLINLvNNLGQLIAFLIGGLIAEHFGMR-APFLLAALAGVLGFILSLFIKEERREKKPVL-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 197 sqrPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGW-FSDHY 275
Cdd:cd17490 182 ---TELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTlFYKKL 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15599072 276 GARSVNWGVFWVCLVCLFFLSYPQTTMTIHGIQGDLSLGIGLNVWLFTFLV 326
Cdd:cd17490 259 GERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLS 309
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
18-264 |
4.57e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 4.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQ 97
Cdd:cd17329 8 SFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 98 YWHYLVLGLFVGLAGGSF--AVGIAYTSAWFEKERQGTAMGIFGAGNAGAAITNLVApMIVVAFGWRMVPQVYSVAMLVT 175
Cdd:cd17329 88 PWLFAIALVLTGFGGGLFepASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 176 AVLFWLFTwtdPAHLKGAAEASQRPNLAKQLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLdlkTASFITM 255
Cdd:cd17329 167 ALVLLFLL---PETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL---GESLLGL 240
|
....*....
gi 15599072 256 LFTLPSGLI 264
Cdd:cd17329 241 LLALNALLI 249
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
39-181 |
5.65e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 39 ELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF-AV 117
Cdd:cd17370 228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSI 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15599072 118 GIAYTSAWFEKERQGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWrMVPQVYSVAMLVTAVLFWL 181
Cdd:cd17370 308 ERAAVADLVPAELRGTAYGLFNTVVGiGWLLASLIAGYLWDLISP-SAAFLFSAVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-182 |
6.48e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 6.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALP---ILTGSLVrlpLGLITDRFGGRIVFFIHMLLVAI 87
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFgvgALLGALL---LGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 88 PIYGLAFASQYWHYLVLGLFVGLAGGSFAVGI-AYTSAWFEKERQGTAMGIFGAGNAGA-AITNLVAPMIVVAFGWRMVP 165
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAmPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 15599072 166 QVYSVAMLVTAVLFWLF 182
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
38-305 |
1.11e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.16 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 38 DELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGR-IVFFIHMLLVAIPIYGLAFASQYWHYLVLG-LFVGLAGGSF 115
Cdd:cd17471 25 EELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLFAFLRNYWVLLLVGvVLLSLGAAAF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 116 AVGIAYTSAWFEK---ERQGTAMGIFGAGNAGA-AITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAHLK 191
Cdd:cd17471 105 PQLFALAREYADRssgRDATLFNSVLRAAFSLAwVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 192 GAAEASQRPNlakqlaPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLdlkTASFITMLFTLPSGL---IRALG 268
Cdd:cd17471 185 KATPASSLVK------APVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG---SESWVGLLFGLAAALeipIMLLA 255
|
250 260 270
....*....|....*....|....*....|....*..
gi 15599072 269 GWFSDHYGARSVNWGVFWVClvCLFFLSYPQTTMTIH 305
Cdd:cd17471 256 GLLAKRFGKRRLLLAGFLAG--VLFYLGLALATSLWQ 290
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-147 |
1.51e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.78 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 12 LGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYG 91
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599072 92 LAFASQ---YWHYLVLGLFVGLAGGSFAVGIAYTS-AWFEKERQGTAMGIFG-AGNAGAAI 147
Cdd:cd17321 251 LALLGAdssVWLLLPGLVLLGLGLGLFATPLTNAAlSSVPKEKAGAASGILNtARQLGGAL 311
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
36-147 |
2.81e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.09 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSF 115
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGV 111
|
90 100 110
....*....|....*....|....*....|...
gi 15599072 116 AVG-IAYTSAWFEKERQGTAMGIFGAGNAGAAI 147
Cdd:cd17327 112 FPGfILYLGMWYKREEQAKRIAFFYAAAGLGSI 144
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
18-195 |
2.91e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.91 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQ 97
Cdd:COG2270 247 YFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTT 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 98 YWHYLVLGLFVGLA-GGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAAItnlVAPMIVVAFGWrmVPQVYSVAMLVTA 176
Cdd:COG2270 327 ALAFWILGLLIGLVmGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASF---LGPLLFGLVTQ--LTGSQRLGILSLI 401
|
170 180
....*....|....*....|...
gi 15599072 177 VLF----WLFTWTDPAHLKGAAE 195
Cdd:COG2270 402 VFFviglVLLLRVKVPRGRAAAG 424
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-295 |
3.48e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.62 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 18 SFAVNFAVWTM---FSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAF 94
Cdd:cd17352 8 SFLVNFFTDGIlnsFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 95 ASQYWH-YLVLGLFVGLAGG-SFAVGIAYTSAWFEKERqGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWRMVPQVYSVA 171
Cdd:cd17352 88 ATSLWQlYLTYGVLGGLGLGlIYSPAIVIVGQYFEKKR-GLATGIAVAGSGvGTFVFPPLLRYLLDNYGWRGALLILGGL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 172 MLVTAVLfwlftwtdpahlkGAAeasqrpnlakqlaplaeLRVWRFGLYYFFVFGGFVA-LALWLPKYYIAEY----GLD 246
Cdd:cd17352 167 CLNLCVC-------------GLL-----------------LRLLKDPTFVLLALGVSFAmLGFFVPFVYLPSYakslGID 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 15599072 247 LKTASFITMLFTLPSGLIRALGGWFSDHYGARSVNWGVFWVCLVCLFFL 295
Cdd:cd17352 217 ESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLL 265
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
38-184 |
3.90e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.65 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 38 DELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGSFA 116
Cdd:cd17335 226 QDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWA 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 117 VGIAYTSAWFEKERQGTAMGIFGAGNAGA--AITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTW 184
Cdd:cd17335 306 AAVSYASAAAPPGLRATAQGLLQGLYFGLggGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
41-259 |
4.15e-05 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 45.57 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 41 GLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFAVGIA 120
Cdd:PRK09705 40 GMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVGIGIIQAVMP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 121 YTSAWFEKERQGTAMGIF-----GAGNAGAAITNLVAPMIVV---AFGWRMVPqvysvAMLVTAVLFWLFTWTDPAHLKG 192
Cdd:PRK09705 120 SVIKRRFQQRTPLVMGLWsaalmGGGGLGAAITPWLVQHSETwyqTLAWWALP-----AVVALFAWWWQSAREVASSHKT 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15599072 193 AAEAsqrpnlakqLAPLAELRVWRFGLYYFFVFGGFVALALWLPKYYIaEYGLDLKTASFITMLFTL 259
Cdd:PRK09705 195 TTTP---------VRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFYI-EIGASAQYSGSLLALMTL 251
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
28-179 |
4.65e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 45.29 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 28 MFSIIgirIKDELGLSESQFGLMVALPILTGSLVR-LPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGL 106
Cdd:cd17331 229 MFSLV---AMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599072 107 FVGLAGGSFAVGI-AYTSAWFEKERQGTAMGIFGAGNAGAAItnlVAPMIVVA----FGWRMVPQV-YSVAMLVTAVLF 179
Cdd:cd17331 306 PLVIGGSVLYTVItSLLTKAVPPEDTGTALGLSHALFSLVRT---VSPTIGGAllqaYGFPSFGLLgAAINGLLTVYLL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-180 |
4.93e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIhMLLVAIPIY 90
Cdd:cd17324 200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA-LLLLAAALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 91 GLAFASQYWHYLVLGLFVgLAGGSFAVGIAYTSAWFE--KERQGTAMGIF-GAGNAGAAITNLVAPMIVVAFGWRMVPQV 167
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVL-WGLGFFAAHSALQTRVLRlaPEARGLASSLYlAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
170
....*....|...
gi 15599072 168 YSVAMLVTAVLFW 180
Cdd:cd17324 358 GAALLLLALLLAL 370
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
36-240 |
6.10e-05 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 45.09 E-value: 6.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAipiyGLAFASQYWHYLVLGLFVGLAGGsf 115
Cdd:cd17410 25 IRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIA----AACLWRLWSGTGPTLIASALLGG-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 116 aVGIAYTSAWFE-------KERQGTAMGIFGAG-NAGAAITNLVAPMIVVAF-GWRMVPQVYSVAMLVTAVLFWlftWTD 186
Cdd:cd17410 99 -LGIAIIQALVPglikrrfPARVPLAMGLYSASlMAGGGLAASLSPRLAQHSaGWQLGLGIWAVPALVALVLWW---RQP 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15599072 187 PAHLKGAAEASQRPNlakqlaPLAELRVWRFGLYYFFVFGGFVALALWLPKYYI 240
Cdd:cd17410 175 PREVAPSDTAGPGVR------FFRNRRAWLLALYFGLINAGYTSMIAWLPAYYL 222
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
66-335 |
7.03e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.87 E-value: 7.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 66 GLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFA-VGIAYTSAWFEKERQGTAMGIFGagnag 144
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVG----- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 145 aaITNLVAPMI--------VVAFGWRMVpqvYSVAMLVTAVLFWLftwtdpahlkgaaeasqrpnlakqlAPLAELRVWR 216
Cdd:cd17503 127 --LVILLAPAIgptlggwlTDNLSWRWI---FYINLPIGILALLL-------------------------APLLDLRLFK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 217 FG------LYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDHYGARSvnwgVFWVCLV 290
Cdd:cd17503 177 DRnftlglLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL----LLLAGLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 15599072 291 CLFFLSYPQTTMTIHgiqgdlslgigLNVWLFTFLVFVVGIAQGF 335
Cdd:cd17503 253 LLALGTLLLAFLTPD-----------TSLWLIILPLFIRGLGMGL 286
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
48-182 |
1.37e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 48 GLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFAVGIAYTSAWFE 127
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 15599072 128 KERQGTAMG-IFGAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLF 182
Cdd:cd17391 119 KEKSGWALGtLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFF 174
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-180 |
1.71e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.57 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 11 VLGMSTLSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGR-IVFFIHMLLVAIPI 89
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 90 YGLAFASQYWHYLVLGLFVGL-AGGSFAVGIAYTSAWFEKERQGTAMGIFGAGNAGAAITN--LVAPMIVVAFGWRMVPQ 166
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFgLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGplLAGFLLAATFGLTGAFL 364
|
170
....*....|....
gi 15599072 167 VYSVAMLVTAVLFW 180
Cdd:cd06174 365 VLAVLLLLAAILLL 378
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
36-181 |
2.77e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.15 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 36 IKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLA-GGS 114
Cdd:PRK03893 46 VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGmAGE 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15599072 115 FAVGIAYTSAWFEKERQGTAMGIFGAGNA-GAAITNLVAPMIVVAFGWRMvpqVYSVAMLVTAVLFWL 181
Cdd:PRK03893 126 YGSSATYVIESWPKHLRNKASGFLISGFSiGAVVAAQVYSLVVPVWGWRA---LFFIGILPIIFALWL 190
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
14-162 |
3.23e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 14 MSTLSFAVNFAVWTMFSIIGIrIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLA 93
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQ-IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15599072 94 FASQYWHYLVLGLFVGLAGGSF-AVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWR 162
Cdd:cd17323 83 LAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSLGpLLGPALGPIIGGFITQSLGWR 153
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-281 |
4.22e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.16 E-value: 4.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 17 LSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVffihmLLVAIPIYGLA--- 93
Cdd:cd17380 6 LATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKV-----LLLAVALWSLAtll 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 94 ---FASQYWHYLVLG-LFVGLAGG-SFAVGIAYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQV 167
Cdd:cd17380 81 tplLAYSSLPLLILSrILLGLGEGvHFPSMTSLFSRWVPVSERSRAVSIVTAGsYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 168 YSVAMLVTAVLFWLFTWTdpahlkgaaeasqrpnlakqlaplaelrVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDL 247
Cdd:cd17380 161 FGLLGLLWALVWLIYLPP----------------------------VWAIIVAHFCMNWGFYILLSWLPTYFHEVLVPLA 212
|
250 260 270
....*....|....*....|....*....|....
gi 15599072 248 KTASFiTMLFTLPSGLIRALGGWFSDHYGARSVN 281
Cdd:cd17380 213 KGWVF-NVVPWLVMFPSSNVAGWLADHLISRGWT 245
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
63-274 |
5.33e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.84 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 63 LPLGLITDRFGGRIVFFIHMLLVA-----IPiygLAFASQYWHYLVLGLFVGLAGGSFAVGI-AYTSAWF-EKERQGTAM 135
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITAlltllTP---LAARGGYGALIVLRILQGLAQGVTFPAMhALWAKWApPLERSRLTS 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 136 GIFGAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTwtdpahlkgaaeasqrpnlakqlaplaeLRVW 215
Cdd:cd17318 151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------LPVW 202
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 15599072 216 RFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIRALGGWFSDH 274
Cdd:cd17318 203 AIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADW 261
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
55-182 |
7.12e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 7.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 55 ILTGSLVrlpLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFAVgIAYT--SAWFEKE--- 129
Cdd:TIGR00898 140 VLLGSFV---FGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWV-QAVVlnTEFLPKKqra 215
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 15599072 130 RQGTAMGIFGAGnaGAAITNLVAPMIVvafGWRMVPQVYSVAMLVTAVLFWLF 182
Cdd:TIGR00898 216 IVGTLIQVFFSL--GLVLLPLVAYFIP---DWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
16-180 |
8.74e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 8.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 16 TLSFAVNFAVWTMFSIIgirIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFA 95
Cdd:cd17471 209 TLLFAANSMYIIAMPLY---VTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 96 SQYWHYLVLGLFVGLAGGSFA-VGIAYTSaWFEKERQGTAMGIFG-AGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAML 173
Cdd:cd17471 286 TSLWQLIALQLLNAIFIGITAgLGISYFQ-DLMPGQPGLATTLYSnASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLAL 364
|
....*..
gi 15599072 174 VTAVLFW 180
Cdd:cd17471 365 LALVLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-402 |
9.44e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 40 LGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLFVGLAGGSFAVGI 119
Cdd:cd17330 29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 120 AYTSAWFEKERQGTAMGIFGAG-NAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTdpahlkgaaeasq 198
Cdd:cd17330 109 AYIADITDEEERAKAFGIISAAfGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 199 rpnlakqlaplaelrVWRFGLYYFFVFGGFVALALWLPKYYIAEYGLDLKTASFITMLFTLPSGLIR-ALGGWFSDHYG- 276
Cdd:cd17330 176 ---------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 277 ARSVNWGVFwvcLVCLFFLSYPqttmtihgiqgdlslgIGLNVWLFTFLVFVVGIAQGFGKASVYRIIHDY-YPSNMGTV 355
Cdd:cd17330 241 RKLLRLGLL---LAIIGLLLLP----------------FASSVPLLVLAAAILAFGTGIVFPALSALLSKSvPSKEQGKA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 15599072 356 GGMVGVIGGLGGFCLPILFGYAADHIGVRSScFMLLFGLTVVCMVWM 402
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVP-FLLAAGLLLIALFLL 347
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-181 |
1.20e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 17 LSFAVNFAVWTMFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPL-GLITDRFGGRIVFFIHMLLVAIPIYGLAFA 95
Cdd:cd17330 182 VYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 96 SQYWHYLVLGLFVGLAGGSFAVGI-AYTSAWFEKERQGTAMGIFGAGNAGAAITN-LVAPMIVVAFGWRMVPQVYSVAML 173
Cdd:cd17330 262 SSVPLLVLAAAILAFGTGIVFPALsALLSKSVPSKEQGKAQGIIQSLQSLARIIGpLLAGPLYSFLGPGVPFLLAAGLLL 341
|
....*...
gi 15599072 174 VTAVLFWL 181
Cdd:cd17330 342 IALFLLSL 349
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
28-185 |
1.41e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.60 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 28 MFSIIGIRIKDELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRIVFFIHMLLVAIPIYGLAFASQYWHYLVLGLF 107
Cdd:cd17372 17 LLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15599072 108 VGLAGGSFAVGIAYTSAWFEKERQGTAMGIFGA-GNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWT 185
Cdd:cd17372 97 VGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVfWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKT 175
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
22-275 |
2.87e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 39.69 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 22 NFAVWTMFSiigirikdELGLSESQFGLMVALPILTGSLVRLPLGLITDRFGGRivFFIHMLLVAIPIYGLAF--ASQYW 99
Cdd:PRK11663 43 NAAMPEMLA--------DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNAR--YFMGIGLIATGIINILFgfSSSLW 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 100 HYLVL-GLFVGLAGGSFAVGIAYTSAWFEKERQGTAMGIFG-AGNAGAAITNLVAPMIVVAFGWR---MVPQVysVAMLV 174
Cdd:PRK11663 113 AFALLwVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNtAHNVGGALIPLVVGAIALHYGWRygmMIAGI--IAIVV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 175 TAVLFWLF-------------TW-TDP---AHLKGAAEASQRPNLAKQLapLAELRVWRFGLYYFFVFGGFVALALWLPK 237
Cdd:PRK11663 191 GLFLCWRLrdkpqamglpsvgEWrHDAlelAQQQEGAGLSRKEILTKYV--LLNPYIWLLSFSYVLVYVVRAAINDWGNL 268
|
250 260 270
....*....|....*....|....*....|....*....
gi 15599072 238 YYIAEYGLDLKTASFITMLFTLpSGLIRAL-GGWFSDHY 275
Cdd:PRK11663 269 YMSETLGVDLVTANSAVSMFEL-GGFIGALvAGWGSDKL 306
|
|
| mfs |
NF037955 |
MFS transporter; |
40-206 |
8.25e-03 |
|
MFS transporter;
Pssm-ID: 411561 [Multi-domain] Cd Length: 366 Bit Score: 38.09 E-value: 8.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 40 LGLSESQFGLMVALPILTGSLVRLPL-GLITDRFGGRIVFFIHMLLVAIpIYGLAFASQYWHYLVLGLFVGL---AGGSF 115
Cdd:NF037955 27 LGLDAGVIGLLLALPIAVRIVATAPLmSLIDRGVGARRLLLAGSLGLAL-TYALMPAAAALGWPLLALLVALnavAQAPL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599072 116 AVGIAY-TSAWFEKERQGTAMGIFGAGNAGAAITNLVAPMIVVAFGWRMVPQVYSVAMLVTAVLFWLFTWTDPAHLKGAA 194
Cdd:NF037955 106 VPSIDYlTLAAVRRDPRLDYARIRMSGSVAFLAANLAGGALLGALGERVAVPLLLTGLALVAALVALASRVRAAAAPPRP 185
|
170
....*....|..
gi 15599072 195 EASQRPNLAKQL 206
Cdd:NF037955 186 REAGRPRLPRVL 197
|
|
| |
