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Concise Results
Standard Results
Full Results
phosphoribosylformylglycinamidine synthase [Pseudomonas aeruginosa PAO1]
Protein Classification
phosphoribosylformylglycinamidine synthase ( domain architecture ID 11480567 )
phosphoribosylformylglycinamidine synthase catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1 MLILRG A PALSAFR HG KLL EQ L TQH V PA VT GL YAE FA HFAD VTGA L T A D E EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR F 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP VT SI YAE YV HFAD LSAP L S A E E QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 81 GTISPWSSKA S DIA R NCGLA K I D R L ERGIAYYV QGE LS ESDAQQV AA R LHDRMT QL V LDR L EG A AE LFSH AQ P R PLT A VD 160
Cdd:PRK05297 79 GTISPWSSKA T DIA H NCGLA G I R R I ERGIAYYV EAA LS AEQRAAL AA L LHDRMT ES V FAD L DD A EA LFSH HE P K PLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 161 VLGGGRAALE K ANVELGLALAEDEIDYL LKS F GE LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q D KSLF G MIK 240
Cdd:PRK05297 159 VLGGGRAALE A ANVELGLALAEDEIDYL VEA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 241 NT Y E M N RE GVLSAYKDNAAV IV G HVA GRFFPDP Q T RE Y AASR EP VQ ILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E T N PD GVLSAYKDNAAV ME G SKV GRFFPDP D T GR Y GYHQ EP AH ILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE VP YGKPERI VT ALDIM V EGPLGGAAFNNEFGRP A L T GYFRTFEQK IAT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI AS ALDIM I EGPLGGAAFNNEFGRP N L L GYFRTFEQK VNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 401 EVRGYHKPIMLAGG M GNIR DE HVQKGEI S VGAKLIVLGGPAM L IGLGGGAASSMA T G A SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIR AD HVQKGEI P VGAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 481 EVIDRCWQLG ER NPI SF IHDVGAGGLSNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E T 560
Cdd:PRK05297 478 EVIDRCWQLG DD NPI LS IHDVGAGGLSNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 561 F K AICERERCPFAVVGEA I E Q R Q LT VA DSHFDNKPVD M PL E VLLGK A P R MHR A V TREAEL G DDF D AA G LE L Q E S VERVLR 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA T E E R H LT LE DSHFDNKPVD L PL D VLLGK P P K MHR D V KTVKAK G PAL D YS G ID L A E A VERVLR 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 641 H P A VASKSFLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALLDA P AS G RMA I GE TV TN 720
Cdd:PRK05297 638 L P T VASKSFLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALLDA A AS A RMA V GE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 L AAA RV G K L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCP E LGITIPVGKDS M SMKT R WQ DN GEDK S VTSP V SLI V 800
Cdd:PRK05297 718 I AAA PI G D L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCP A LGITIPVGKDS L SMKT K WQ EG GEDK E VTSP L SLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 801 TG FAPV A DVR QS LTPQLR L DK g E T D L I LIDLGRGKNRLGGS I LAQV HGK LG RAV PDVDDAEDLK A FF AV IQ G L N A D G HI L 880
Cdd:PRK05297 798 SA FAPV E DVR KT LTPQLR T DK - D T A L L LIDLGRGKNRLGGS A LAQV YNQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G LL L 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 881 AYHDRSDGGL I T SVL EMAFAGHCG VELN LDAL ads REELA A V LF S EELGAVIQVR EGATPE V L A QFSAA GL D DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGL L T TLA EMAFAGHCG LDID LDAL --- GDDAL A A LF N EELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 961 P VN G YE I NLNY NG E TV Y S AQ R RI L Q R I WSETSYQ I QRLRDN AD CA E QEFDA L LD EDN PGL SI KL SY D V N D DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DR I VITR NG K TV F S ES R TE L R R W WSETSYQ M QRLRDN PE CA D QEFDA I LD QAD PGL NV KL TF D P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1041 V RPKVAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV D L DA FKGLVACGGFSYGDVLGAGEGWAKSILFN A R A R 1120
Cdd:PRK05297 1034 A RPKVAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T L ED FKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1121 D G F Q AFFAR K D S FALGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFLQGMAGSRLPIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFFAR P D T FALGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFLQGMAGSRLPIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1201 EG H AEF e SEEA L LEADLS G C V S LR F VDNHG K VTE A YPANPNGSP R GITGL SSR DGRVTIMMPHPERVFR A VQNSW R P DD W 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L V A LR Y VDNHG Q VTE T YPANPNGSP N GITGL TTA DGRVTIMMPHPERVFR T VQNSW H P EE W 1272
1290
....*....|....*...
gi 15598958 1281 Q ED GG W L RMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP W M RMFRNAR K WV G 1290
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1 MLILRG A PALSAFR HG KLL EQ L TQH V PA VT GL YAE FA HFAD VTGA L T A D E EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR F 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP VT SI YAE YV HFAD LSAP L S A E E QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 81 GTISPWSSKA S DIA R NCGLA K I D R L ERGIAYYV QGE LS ESDAQQV AA R LHDRMT QL V LDR L EG A AE LFSH AQ P R PLT A VD 160
Cdd:PRK05297 79 GTISPWSSKA T DIA H NCGLA G I R R I ERGIAYYV EAA LS AEQRAAL AA L LHDRMT ES V FAD L DD A EA LFSH HE P K PLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 161 VLGGGRAALE K ANVELGLALAEDEIDYL LKS F GE LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q D KSLF G MIK 240
Cdd:PRK05297 159 VLGGGRAALE A ANVELGLALAEDEIDYL VEA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 241 NT Y E M N RE GVLSAYKDNAAV IV G HVA GRFFPDP Q T RE Y AASR EP VQ ILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E T N PD GVLSAYKDNAAV ME G SKV GRFFPDP D T GR Y GYHQ EP AH ILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE VP YGKPERI VT ALDIM V EGPLGGAAFNNEFGRP A L T GYFRTFEQK IAT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI AS ALDIM I EGPLGGAAFNNEFGRP N L L GYFRTFEQK VNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 401 EVRGYHKPIMLAGG M GNIR DE HVQKGEI S VGAKLIVLGGPAM L IGLGGGAASSMA T G A SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIR AD HVQKGEI P VGAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 481 EVIDRCWQLG ER NPI SF IHDVGAGGLSNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E T 560
Cdd:PRK05297 478 EVIDRCWQLG DD NPI LS IHDVGAGGLSNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 561 F K AICERERCPFAVVGEA I E Q R Q LT VA DSHFDNKPVD M PL E VLLGK A P R MHR A V TREAEL G DDF D AA G LE L Q E S VERVLR 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA T E E R H LT LE DSHFDNKPVD L PL D VLLGK P P K MHR D V KTVKAK G PAL D YS G ID L A E A VERVLR 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 641 H P A VASKSFLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALLDA P AS G RMA I GE TV TN 720
Cdd:PRK05297 638 L P T VASKSFLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALLDA A AS A RMA V GE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 L AAA RV G K L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCP E LGITIPVGKDS M SMKT R WQ DN GEDK S VTSP V SLI V 800
Cdd:PRK05297 718 I AAA PI G D L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCP A LGITIPVGKDS L SMKT K WQ EG GEDK E VTSP L SLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 801 TG FAPV A DVR QS LTPQLR L DK g E T D L I LIDLGRGKNRLGGS I LAQV HGK LG RAV PDVDDAEDLK A FF AV IQ G L N A D G HI L 880
Cdd:PRK05297 798 SA FAPV E DVR KT LTPQLR T DK - D T A L L LIDLGRGKNRLGGS A LAQV YNQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G LL L 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 881 AYHDRSDGGL I T SVL EMAFAGHCG VELN LDAL ads REELA A V LF S EELGAVIQVR EGATPE V L A QFSAA GL D DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGL L T TLA EMAFAGHCG LDID LDAL --- GDDAL A A LF N EELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 961 P VN G YE I NLNY NG E TV Y S AQ R RI L Q R I WSETSYQ I QRLRDN AD CA E QEFDA L LD EDN PGL SI KL SY D V N D DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DR I VITR NG K TV F S ES R TE L R R W WSETSYQ M QRLRDN PE CA D QEFDA I LD QAD PGL NV KL TF D P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1041 V RPKVAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV D L DA FKGLVACGGFSYGDVLGAGEGWAKSILFN A R A R 1120
Cdd:PRK05297 1034 A RPKVAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T L ED FKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1121 D G F Q AFFAR K D S FALGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFLQGMAGSRLPIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFFAR P D T FALGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFLQGMAGSRLPIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1201 EG H AEF e SEEA L LEADLS G C V S LR F VDNHG K VTE A YPANPNGSP R GITGL SSR DGRVTIMMPHPERVFR A VQNSW R P DD W 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L V A LR Y VDNHG Q VTE T YPANPNGSP N GITGL TTA DGRVTIMMPHPERVFR T VQNSW H P EE W 1272
1290
....*....|....*...
gi 15598958 1281 Q ED GG W L RMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP W M RMFRNAR K WV G 1290
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
3-1297
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2382.94
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 3 I LRG AP ALS A FR HG KLL EQ L TQH VP AV TG L YAEF AH F ADVTG ALTADEE QV L AR LL KY G PSVPV - Q E P S GR - L FL V V PR F 80
Cdd:TIGR01735 1 F LRG PS ALS G FR LE KLL QK L QTK VP EL TG V YAEF CY F VGWES ALTADEE EK L QL LL LA G SVLEP p Q S P L GR g L LE V G PR L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 81 GTISPWSSKA SD IARNCGLAK I DR L ERG IA YY VQ G E -- LSE SDAQ Q V AA R LHDRMT QL VL DRLEG A A ELFS HAQ P RP LT A 158
Cdd:TIGR01735 81 GTISPWSSKA TS IARNCGLAK V DR I ERG RR YY LS G A hp LSE EQEA Q A AA L LHDRMT ES VL PHEIE A F ELFS VPE P LN LT T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 159 V DVLGGGR A ALEKAN V ELGLAL A EDEIDYL L K S F G EL G RNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA QDKSLF G M 238
Cdd:TIGR01735 161 I DVLGGGR L ALEKAN Q ELGLAL D EDEIDYL T K R F Q EL Q RNP S DVELMMFAQANSEHCRHKIFNA D W I IDG KK QDKSLF Q M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 239 IK N T Y E M N R E GVL SAYKDN AA VI V GH VA GR FF PDP Q TR - EY AASR E - P V Q ILMKVETHNHPTAIAPFPGASTG S GGEIRD 316
Cdd:TIGR01735 241 IK S T H E A N P E NTV SAYKDN SS VI E GH KV GR LR PDP P TR p EY RQHQ E d L V H ILMKVETHNHPTAIAPFPGASTG A GGEIRD 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 317 EGATGRGAKPKAGLTGF T VSNL Q IPG F EQPWE V P YG KPERI VTA LDIM V E G PLG G AAFNNEFGRP A L T GYFRTFE Q K IAT 396
Cdd:TIGR01735 321 EGATGRGAKPKAGLTGF C VSNL N IPG L EQPWE D P FQ KPERI ASP LDIM I E A PLG A AAFNNEFGRP N L L GYFRTFE L K ASL 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 397 P h G EE VRGYHKPIMLAGG M G N I RD EH V QKGEI SV GA K LIVLGGPAMLIGLGGGAASSM AT G ASS ADLDFASVQR D NPEME 476
Cdd:TIGR01735 401 P - G GQ VRGYHKPIMLAGG I G S I DA EH I QKGEI EP GA L LIVLGGPAMLIGLGGGAASSM VS G TNT ADLDFASVQR G NPEME 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 477 RRCQEVIDRCWQLGE R NPI SF IHDVGAGGLSNALPELI N DGGRG GRFE LRAVP N D E PG M SPLEIWCNESQERYVL S V D A A 556
Cdd:TIGR01735 480 RRCQEVIDRCWQLGE K NPI IS IHDVGAGGLSNALPELI H DGGRG AVID LRAVP L D D PG L SPLEIWCNESQERYVL L V R A E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 557 DF E T F K AICERERCPFAVVG E A IEQRQ LT VA D ------------- SHF D N K PVD M PLEVLLGK A P R M H R A V T R E A ELGDD 623
Cdd:TIGR01735 560 NL E I F T AICERERCPFAVVG T A TGDGR LT LV D dtpvrrngqgdap SHF P N N PVD L PLEVLLGK M P K M T R F V Q R K A PMLQP 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 624 F D AA - GL E L Q E SV ERVLR H PAVASK S FLITIGDR TIT GLVARDQMVGPWQ V P V AD C AVTA T SFD V YTGEAMA M GER T P L A 702
Cdd:TIGR01735 640 L D IP p GL D L H E AL ERVLR L PAVASK R FLITIGDR SVG GLVARDQMVGPWQ T P L AD V AVTA A SFD T YTGEAMA I GER P P K A 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 703 LLD AP AS G R M A I GE TV TNLAAA R VG K LSD I KLSANWMAAAGHPGEDA R LYD T VKAV g M ELCP E LGI T IPVGKDS M SMKTR 782
Cdd:TIGR01735 720 LLD PK AS A R L A V GE AI TNLAAA L VG D LSD V KLSANWMAAAGHPGEDA A LYD A VKAV - S ELCP A LGI A IPVGKDS L SMKTR 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 783 WQDNGE D KSVT S P V SL IVTG FAPV A DVR QSL TP Q L RL DKG ETD L I L I DLG R GKNRLGGS I LAQV H G K LG RAV PD V DD A E D 862
Cdd:TIGR01735 799 WQDNGE T KSVT A P G SL VISA FAPV P DVR KTV TP D L KH DKG DSH L L L V DLG P GKNRLGGS A LAQV F G Q LG GDC PD L DD P E R 878
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 863 LKAFFAV I QGL N A D G HI LAYHDRSDGGL I T SV LEMAFAGHCG VELN LDAL A DS ree L A AVLF S EELGAVIQV REGATPE V 942
Cdd:TIGR01735 879 LKAFFAV M QGL V A E G LL LAYHDRSDGGL V T TL LEMAFAGHCG LDVD LDAL G DS --- L F AVLF N EELGAVIQV AKPDLAA V 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 943 L AQFS AAGL DDCVAV IG Q P VNGYE I NLNY NG E T VY S AQ R RI L QR IW S ETS Y Q I QRLRDN AD CAE Q EF DA L L D E D N PGL SI 1022
Cdd:TIGR01735 956 L ELLR AAGL TALILG IG T P TGHPM I RISV NG A T LL S EK R SE L RD IW E ETS F Q L QRLRDN PE CAE E EF EG L R D R D G PGL KL 1035
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1023 K L SY DVN D DIAAP Y I K KGV R PKVAILREQGVNG QV EMAAAFDRAGF A A I DVHMSD I LAGRV D LD A F K GL V ACGGFSYGDV 1102
Cdd:TIGR01735 1036 P L TF DVN E DIAAP F I N KGV K PKVAILREQGVNG DR EMAAAFDRAGF E A W DVHMSD L LAGRV H LD E F R GL A ACGGFSYGDV 1115
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1103 LGAG E GWAKSILFN A R A RD G FQAFF A R K D S F A LGVCNGCQM M SNL H E L IPGTE F WPHFVRN R SE Q FEARVA M V Q V Q ES S S 1182
Cdd:TIGR01735 1116 LGAG K GWAKSILFN P R L RD Q FQAFF K R P D T F S LGVCNGCQM L SNL L E W IPGTE N WPHFVRN N SE R FEARVA S V R V G ES P S 1195
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1183 I F L Q GMAGSRLP I A I AHGEG H A E F E S E E ALLE AD L SG CVS LR FV D NH G KV TEAYP A NPNGSP R GI T G LS S R DGRVTIMMP 1262
Cdd:TIGR01735 1196 I M L R GMAGSRLP V A V AHGEG Y A A F S S P E LQAQ AD A SG LAA LR YI D DD G NP TEAYP L NPNGSP G GI A G IT S C DGRVTIMMP 1275
1290 1300 1310
....*....|....*....|....*....|....*
gi 15598958 1263 HPERVFRA V QNSWRP D DW Q ED GG WLR M FRNAR V W V 1297
Cdd:TIGR01735 1276 HPERVFRA W QNSWRP E DW D ED TP WLR L FRNAR N W L 1310
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
162-1001
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 1024.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 162 L G GGR A ALE K AN V ELGLAL AE DE I DY LLK sfg E LGRNP H DVEL M MF A Q AN SEHC RH K IF NA SW didgqaqdkslfgmik N 241
Cdd:COG0046 6 L E GGR E ALE E AN R ELGLAL SD DE Y DY IVE --- I LGRNP T DVEL G MF S Q MW SEHC SY K SS NA LL ---------------- K 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 242 TYEMNREG VLS AYK DNA A V IVGH vagrffpdpqtreyaasr EPVQILM KVE T HNHP T AI A P FP GA S TG S GG E IRD EG at G 321
Cdd:COG0046 67 SLPTEGPR VLS GPG DNA G V VDIG ------------------ DGLAVVF KVE S HNHP S AI E P YQ GA A TG V GG I IRD IF -- G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 322 R GA K P K AGL TGFTVS NL qipgf E QP W evpygkperi VTALD I MVEGPL G G A AFN N E FG R P ALT G YF R TF E QKI atphgee 401
Cdd:COG0046 127 M GA R P I AGL DSLRFG NL ----- D QP P ---------- ASPRY I LIGVVA G I A DYG N C FG V P TVG G EV R FD E SYE ------- 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 402 vrgy HK P IML AGG M G N IR DE H VQ K G - EIS VG A K LIVL GGP AMLI G L GG GAAS S MAT G AS S A d LD FAS VQ RDN P E ME R R CQ 480
Cdd:COG0046 185 ---- GN P LVN AGG V G I IR AD H IF K A k APG VG N K VVYV GGP TGRD G I GG ATFA S EEL G ED S E - LD RPA VQ VGD P F ME K R LI 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 481 E V I DRC wql G ERNP I SF I H D V GAGGLS N A LP E LIND GG R G GRFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAADF E T 560
Cdd:COG0046 260 E A I LEL --- G DTGL I VG I Q D M GAGGLS S A SS E MAAK GG L G AEID L DK VP LR EPGMSP Y EIW LS ESQER ML L V V KPEKL E E 336
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 561 F K AI C ER E R C P F AV V GE AIEQRQ L T V ad SHFDNKPV D M PL EV L L G K AP RM HR AVT R E A E L GDDFDAAGLE L Q E SVE R V L R 640
Cdd:COG0046 337 F E AI F ER W R L P A AV I GE VTDDGR L V V -- TDHGETVA D L PL DF L A G G AP KY HR PAK R P A Y L EPLDLPEPID L E E ALL R L L S 414
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 641 H P A VASK SF L ITIG DR TIT G LVA RD Q mvgpwqv P VAD C AV TATS f DV Y T G E AM AM GE RTPL ALLD AP A SG RMA IG E TVT N 720
Cdd:COG0046 415 S P N VASK EW L YRQY DR EVG G NTV RD P ------- G VAD A AV VRVD - GT Y K G L AM ST GE NPRY ALLD PY A GA RMA VA E AAR N 486
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 LAA ARVGK L s D I KLSA NW MAAA g H P G E D A R L YDT VK AVG m EL C PE LGI TI P V G KD S MSMK T R wqdnge D KS V TS P VSLIV 800
Cdd:COG0046 487 LAA VGAEP L - A I TDCL NW GNPE - K P E E M A Q L VEA VK GLA - DA C RA LGI PV P S G NV S LYNE T K ------ D GK V AI P PTPVI 557
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 801 TGFAP V A DVR QSL TP Q L RLD kg ETD L I LI dl G RG KN R LGGS IL AQV H G K LG RAV PDV d D A E DL KA F F AVI Q G L NAD G H IL 880
Cdd:COG0046 558 GAVGL V D DVR KTV TP D L KKE -- GDL L Y LI -- G ET KN E LGGS EY AQV L G Q LG GEP PDV - D L E AE KA L F EAV Q E L IRE G L IL 632
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 881 A Y HD R SDGGL ITSVL EMAFAG HC G VELN LDAL A D S R ee LA A V LFSE EL G - AV I QV REGATPE V L A QFSA AGL dd CVA VIG 959
Cdd:COG0046 633 A A HD V SDGGL AVALA EMAFAG GL G ADID LDAL G D L R -- PD A A LFSE SQ G r AV V QV APEDAEA V E A LLAE AGL -- PAH VIG 708
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 15598958 960 QPVNGYEINLNYN GET VY S AQRRI L QRI W S ET syq IQ RLRDN 1001
Cdd:COG0046 709 TVTGDDRLVIRRG GET LL S LSLAE L RDA W E ET --- LP RLRDN 747
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1042-1297
2.80e-148
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 448.10
E-value: 2.80e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1042 R P K VAILRE Q G V NG QV EMAAAF D RAGF A A I DVHMSD I L A GRV D LD A F K GL V A C GGFSYGDVLG A G E GWA K SILFN ARA RD 1121
Cdd:pfam13507 1 K P R VAILRE P G T NG EY EMAAAF E RAGF D A V DVHMSD L L S GRV S LD D F Q GL A A P GGFSYGDVLG S G K GWA A SILFN PKL RD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1122 G F Q AFF A R K D S F A LG V CNGCQ MM S N L H e LIPG T E F ----- WP HFV RN R S EQ FE A R VAM V QV - QE S S S I FL Q GM A GS R LP i 1195
Cdd:pfam13507 81 A F E AFF N R P D T F S LG I CNGCQ LL S K L G - LIPG G E G dlaer WP TLT RN D S GR FE S R WVN V KI s EK S P S V FL R GM D GS G LP - 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1196 a I AHGEG HAE F E SEE A L LEADLS G C V S LR F VDN H G KV TE A YP A NPNGSP R GI T G LS S R DGRV TIM MPHPERVFR AV Q NS - 1274
Cdd:pfam13507 159 - V AHGEG RFV F R SEE V L ARLEAN G Q V A LR Y VDN A G NP TE E YP F NPNGSP L GI A G IC S P DGRV LGL MPHPERVFR PW Q WP h 237
250 260
....*....|....*....|...
gi 15598958 1275 W R P DD W Q E DGG WLR M FRNAR V WV 1297
Cdd:pfam13507 238 W P P GE W E E VSP WLR L FRNAR K WV 260
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
203-598
1.34e-126
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 392.99
E-value: 1.34e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 203 EL M MFAQ AN SEHCRHK I F naswdidgqaqd KSL FG MI KN tyemnregvlsaykdnaavivghvagrffpdpqtreyaasr 282
Cdd:cd02203 1 EL G MFAQ MW SEHCRHK S F ------------ KSL LK MI WA ----------------------------------------- 27
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 283 epvq ILM KVETHNHP T AI A PF P GA S TG S GG E IRD EGAT G rg A K P K A G L T G FTVSN L Q IPG F E qpwevpygk P ERIVTALD 362
Cdd:cd02203 28 ---- VVF KVETHNHP S AI E PF G GA A TG V GG I IRD ILSM G -- A R P I A L L D G LRFGD L D IPG Y E --------- P KGKLSPRR 92
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 363 I MVEGPL G GAAFN N EF G R P ALT G YF R TFEQK iatphgeevrg Y HK P IMLA G GM G NIRDE H VQ K G - EISV G AKLIVL GG PA 441
Cdd:cd02203 93 I LDGVVA G ISDYG N CI G I P TVG G EV R FDPSY ----------- Y GN P LVNV G CV G IVPKD H IV K S k APGP G DLVVLV GG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 442 MLI G L GG GAA SS MATGAS S AD LD FAS VQ RDN P E ME RRC QE V I DRCW qlg E RNP I SF I H D V GAGGLS N A LP E LIND GG R G G 521
Cdd:cd02203 162 GRD G I GG ATF SS KELSEN S SE LD RPA VQ VGD P F ME KKL QE A I LEAR --- E TGL I VG I Q D L GAGGLS S A VS E MAAK GG L G A 238
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598958 522 RFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAA D F E T F K AIC ER E RCPF AV V GE AIEQRQ L TVADS hf DNKPV D M 598
Cdd:cd02203 239 EID L DK VP LR EPGMSP W EIW IS ESQER ML L V V PPE D L E E F L AIC KK E DLEA AV I GE VTDDGR L RLYYK -- GEVVA D L 313
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1 MLILRG A PALSAFR HG KLL EQ L TQH V PA VT GL YAE FA HFAD VTGA L T A D E EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR F 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP VT SI YAE YV HFAD LSAP L S A E E QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 81 GTISPWSSKA S DIA R NCGLA K I D R L ERGIAYYV QGE LS ESDAQQV AA R LHDRMT QL V LDR L EG A AE LFSH AQ P R PLT A VD 160
Cdd:PRK05297 79 GTISPWSSKA T DIA H NCGLA G I R R I ERGIAYYV EAA LS AEQRAAL AA L LHDRMT ES V FAD L DD A EA LFSH HE P K PLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 161 VLGGGRAALE K ANVELGLALAEDEIDYL LKS F GE LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q D KSLF G MIK 240
Cdd:PRK05297 159 VLGGGRAALE A ANVELGLALAEDEIDYL VEA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 241 NT Y E M N RE GVLSAYKDNAAV IV G HVA GRFFPDP Q T RE Y AASR EP VQ ILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E T N PD GVLSAYKDNAAV ME G SKV GRFFPDP D T GR Y GYHQ EP AH ILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE VP YGKPERI VT ALDIM V EGPLGGAAFNNEFGRP A L T GYFRTFEQK IAT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI AS ALDIM I EGPLGGAAFNNEFGRP N L L GYFRTFEQK VNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 401 EVRGYHKPIMLAGG M GNIR DE HVQKGEI S VGAKLIVLGGPAM L IGLGGGAASSMA T G A SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIR AD HVQKGEI P VGAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 481 EVIDRCWQLG ER NPI SF IHDVGAGGLSNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E T 560
Cdd:PRK05297 478 EVIDRCWQLG DD NPI LS IHDVGAGGLSNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 561 F K AICERERCPFAVVGEA I E Q R Q LT VA DSHFDNKPVD M PL E VLLGK A P R MHR A V TREAEL G DDF D AA G LE L Q E S VERVLR 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA T E E R H LT LE DSHFDNKPVD L PL D VLLGK P P K MHR D V KTVKAK G PAL D YS G ID L A E A VERVLR 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 641 H P A VASKSFLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALLDA P AS G RMA I GE TV TN 720
Cdd:PRK05297 638 L P T VASKSFLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALLDA A AS A RMA V GE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 L AAA RV G K L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCP E LGITIPVGKDS M SMKT R WQ DN GEDK S VTSP V SLI V 800
Cdd:PRK05297 718 I AAA PI G D L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCP A LGITIPVGKDS L SMKT K WQ EG GEDK E VTSP L SLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 801 TG FAPV A DVR QS LTPQLR L DK g E T D L I LIDLGRGKNRLGGS I LAQV HGK LG RAV PDVDDAEDLK A FF AV IQ G L N A D G HI L 880
Cdd:PRK05297 798 SA FAPV E DVR KT LTPQLR T DK - D T A L L LIDLGRGKNRLGGS A LAQV YNQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G LL L 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 881 AYHDRSDGGL I T SVL EMAFAGHCG VELN LDAL ads REELA A V LF S EELGAVIQVR EGATPE V L A QFSAA GL D DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGL L T TLA EMAFAGHCG LDID LDAL --- GDDAL A A LF N EELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 961 P VN G YE I NLNY NG E TV Y S AQ R RI L Q R I WSETSYQ I QRLRDN AD CA E QEFDA L LD EDN PGL SI KL SY D V N D DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DR I VITR NG K TV F S ES R TE L R R W WSETSYQ M QRLRDN PE CA D QEFDA I LD QAD PGL NV KL TF D P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1041 V RPKVAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV D L DA FKGLVACGGFSYGDVLGAGEGWAKSILFN A R A R 1120
Cdd:PRK05297 1034 A RPKVAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T L ED FKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1121 D G F Q AFFAR K D S FALGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFLQGMAGSRLPIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFFAR P D T FALGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFLQGMAGSRLPIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1201 EG H AEF e SEEA L LEADLS G C V S LR F VDNHG K VTE A YPANPNGSP R GITGL SSR DGRVTIMMPHPERVFR A VQNSW R P DD W 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L V A LR Y VDNHG Q VTE T YPANPNGSP N GITGL TTA DGRVTIMMPHPERVFR T VQNSW H P EE W 1272
1290
....*....|....*...
gi 15598958 1281 Q ED GG W L RMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP W M RMFRNAR K WV G 1290
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
3-1297
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2382.94
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 3 I LRG AP ALS A FR HG KLL EQ L TQH VP AV TG L YAEF AH F ADVTG ALTADEE QV L AR LL KY G PSVPV - Q E P S GR - L FL V V PR F 80
Cdd:TIGR01735 1 F LRG PS ALS G FR LE KLL QK L QTK VP EL TG V YAEF CY F VGWES ALTADEE EK L QL LL LA G SVLEP p Q S P L GR g L LE V G PR L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 81 GTISPWSSKA SD IARNCGLAK I DR L ERG IA YY VQ G E -- LSE SDAQ Q V AA R LHDRMT QL VL DRLEG A A ELFS HAQ P RP LT A 158
Cdd:TIGR01735 81 GTISPWSSKA TS IARNCGLAK V DR I ERG RR YY LS G A hp LSE EQEA Q A AA L LHDRMT ES VL PHEIE A F ELFS VPE P LN LT T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 159 V DVLGGGR A ALEKAN V ELGLAL A EDEIDYL L K S F G EL G RNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA QDKSLF G M 238
Cdd:TIGR01735 161 I DVLGGGR L ALEKAN Q ELGLAL D EDEIDYL T K R F Q EL Q RNP S DVELMMFAQANSEHCRHKIFNA D W I IDG KK QDKSLF Q M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 239 IK N T Y E M N R E GVL SAYKDN AA VI V GH VA GR FF PDP Q TR - EY AASR E - P V Q ILMKVETHNHPTAIAPFPGASTG S GGEIRD 316
Cdd:TIGR01735 241 IK S T H E A N P E NTV SAYKDN SS VI E GH KV GR LR PDP P TR p EY RQHQ E d L V H ILMKVETHNHPTAIAPFPGASTG A GGEIRD 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 317 EGATGRGAKPKAGLTGF T VSNL Q IPG F EQPWE V P YG KPERI VTA LDIM V E G PLG G AAFNNEFGRP A L T GYFRTFE Q K IAT 396
Cdd:TIGR01735 321 EGATGRGAKPKAGLTGF C VSNL N IPG L EQPWE D P FQ KPERI ASP LDIM I E A PLG A AAFNNEFGRP N L L GYFRTFE L K ASL 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 397 P h G EE VRGYHKPIMLAGG M G N I RD EH V QKGEI SV GA K LIVLGGPAMLIGLGGGAASSM AT G ASS ADLDFASVQR D NPEME 476
Cdd:TIGR01735 401 P - G GQ VRGYHKPIMLAGG I G S I DA EH I QKGEI EP GA L LIVLGGPAMLIGLGGGAASSM VS G TNT ADLDFASVQR G NPEME 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 477 RRCQEVIDRCWQLGE R NPI SF IHDVGAGGLSNALPELI N DGGRG GRFE LRAVP N D E PG M SPLEIWCNESQERYVL S V D A A 556
Cdd:TIGR01735 480 RRCQEVIDRCWQLGE K NPI IS IHDVGAGGLSNALPELI H DGGRG AVID LRAVP L D D PG L SPLEIWCNESQERYVL L V R A E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 557 DF E T F K AICERERCPFAVVG E A IEQRQ LT VA D ------------- SHF D N K PVD M PLEVLLGK A P R M H R A V T R E A ELGDD 623
Cdd:TIGR01735 560 NL E I F T AICERERCPFAVVG T A TGDGR LT LV D dtpvrrngqgdap SHF P N N PVD L PLEVLLGK M P K M T R F V Q R K A PMLQP 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 624 F D AA - GL E L Q E SV ERVLR H PAVASK S FLITIGDR TIT GLVARDQMVGPWQ V P V AD C AVTA T SFD V YTGEAMA M GER T P L A 702
Cdd:TIGR01735 640 L D IP p GL D L H E AL ERVLR L PAVASK R FLITIGDR SVG GLVARDQMVGPWQ T P L AD V AVTA A SFD T YTGEAMA I GER P P K A 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 703 LLD AP AS G R M A I GE TV TNLAAA R VG K LSD I KLSANWMAAAGHPGEDA R LYD T VKAV g M ELCP E LGI T IPVGKDS M SMKTR 782
Cdd:TIGR01735 720 LLD PK AS A R L A V GE AI TNLAAA L VG D LSD V KLSANWMAAAGHPGEDA A LYD A VKAV - S ELCP A LGI A IPVGKDS L SMKTR 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 783 WQDNGE D KSVT S P V SL IVTG FAPV A DVR QSL TP Q L RL DKG ETD L I L I DLG R GKNRLGGS I LAQV H G K LG RAV PD V DD A E D 862
Cdd:TIGR01735 799 WQDNGE T KSVT A P G SL VISA FAPV P DVR KTV TP D L KH DKG DSH L L L V DLG P GKNRLGGS A LAQV F G Q LG GDC PD L DD P E R 878
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 863 LKAFFAV I QGL N A D G HI LAYHDRSDGGL I T SV LEMAFAGHCG VELN LDAL A DS ree L A AVLF S EELGAVIQV REGATPE V 942
Cdd:TIGR01735 879 LKAFFAV M QGL V A E G LL LAYHDRSDGGL V T TL LEMAFAGHCG LDVD LDAL G DS --- L F AVLF N EELGAVIQV AKPDLAA V 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 943 L AQFS AAGL DDCVAV IG Q P VNGYE I NLNY NG E T VY S AQ R RI L QR IW S ETS Y Q I QRLRDN AD CAE Q EF DA L L D E D N PGL SI 1022
Cdd:TIGR01735 956 L ELLR AAGL TALILG IG T P TGHPM I RISV NG A T LL S EK R SE L RD IW E ETS F Q L QRLRDN PE CAE E EF EG L R D R D G PGL KL 1035
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1023 K L SY DVN D DIAAP Y I K KGV R PKVAILREQGVNG QV EMAAAFDRAGF A A I DVHMSD I LAGRV D LD A F K GL V ACGGFSYGDV 1102
Cdd:TIGR01735 1036 P L TF DVN E DIAAP F I N KGV K PKVAILREQGVNG DR EMAAAFDRAGF E A W DVHMSD L LAGRV H LD E F R GL A ACGGFSYGDV 1115
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1103 LGAG E GWAKSILFN A R A RD G FQAFF A R K D S F A LGVCNGCQM M SNL H E L IPGTE F WPHFVRN R SE Q FEARVA M V Q V Q ES S S 1182
Cdd:TIGR01735 1116 LGAG K GWAKSILFN P R L RD Q FQAFF K R P D T F S LGVCNGCQM L SNL L E W IPGTE N WPHFVRN N SE R FEARVA S V R V G ES P S 1195
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1183 I F L Q GMAGSRLP I A I AHGEG H A E F E S E E ALLE AD L SG CVS LR FV D NH G KV TEAYP A NPNGSP R GI T G LS S R DGRVTIMMP 1262
Cdd:TIGR01735 1196 I M L R GMAGSRLP V A V AHGEG Y A A F S S P E LQAQ AD A SG LAA LR YI D DD G NP TEAYP L NPNGSP G GI A G IT S C DGRVTIMMP 1275
1290 1300 1310
....*....|....*....|....*....|....*
gi 15598958 1263 HPERVFRA V QNSWRP D DW Q ED GG WLR M FRNAR V W V 1297
Cdd:TIGR01735 1276 HPERVFRA W QNSWRP E DW D ED TP WLR L FRNAR N W L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
18-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1122.16
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 18 LL EQLTQH V P - AVTGLYA E FAHFADVTGA L T A DEEQV L AR LL K -- YG P ------ S VPVQEP S GR L FL VV ---- PR FGTIS 84
Cdd:PLN03206 3 LL RKVQTK V S n DIVSIET E QCFNVGLESP L S A EKLET L KW LL R et FE P enlgte S FLEAKK S EG L NA VV vevg PR LSFTT 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 85 P WS SK A SD I ARN CGL AKID RLER GIA Y -- YVQGE L S ES DAQQV AA RL HDRMT QL V LD rl EGAAELF S HAQ P R P LTA V D V L 162
Cdd:PLN03206 83 A WS TN A VS I CSA CGL TEVT RLER SRR Y ll FSSSP L D ES QINAF AA MV HDRMT EC V YP -- QPLTSFE S GVV P E P VYT V P V M 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 163 GG GRAALE KA N V E L GLA LA E DEI DY LLKS F GE - LG R N P HD VEL MMF AQ A NSEH C RH KI F NASWD IDGQ AQD K S LF G M I K N 241
Cdd:PLN03206 161 EE GRAALE EI N K E M GLA FD E QDL DY YTRL F RD d IK R D P TN VEL FDI AQ S NSEH S RH WF F SGKLV IDGQ PMP K T LF Q M V K D 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 242 T YEM N REGVLSAY KDN AAV I V G H V AGRFF P --------- D P QT R EY aasrepv Q IL MKV ETHN H P T A I AP F PGA S TG S GG 312
Cdd:PLN03206 241 T LKA N PNNSVIGF KDN SSA I R G F V VQPLR P vspgspspl A P VD R DL ------- D IL LTA ETHN F P C A V AP Y PGA E TG A GG 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 313 E IRD EG ATGRG AKPK AG LT G FT V S NL Q I P G FEQ PWE VP - YGK P ERIVTA L D I MVEGPL G GAAFN N E FG R P ALT GY F RTF E 391
Cdd:PLN03206 314 R IRD TH ATGRG SFVV AG TA G YC V G NL R I E G SYA PWE DS s FVY P SNLASP L Q I LIDASN G ASDYG N K FG E P LIQ GY T RTF G 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 392 QKI at P H GE E v R GYH KPIM LA GG M G N I RDE H VQ KGE ISV G AKLIVL GGPA ML IG L GGGAASSM AT G ASS A D LDF AS VQR D 471
Cdd:PLN03206 394 MRL -- P N GE R - R EWL KPIM FS GG I G Q I DHT H LT KGE PDI G MLVVKI GGPA YR IG M GGGAASSM VS G QND A E LDF NA VQR G 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 472 NP EM ERRCQE V IDR C WQL GE R NPI SF IHD V GAGG LS N ALP E L I ND gg R G GRFEL RAV PNDEPGM S P LEIW CN E S QE RYV L 551
Cdd:PLN03206 471 DA EM SQKLYR V VRA C VEM GE D NPI VS IHD Q GAGG NC N VVK E I I YP -- K G AEIDI RAV VVGDHTL S V LEIW GA E Y QE QDA L 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 552 SVDAADFETFKA IC E RERC PF AV V G EAIEQRQLTVA DS HFDN K ----------- P VD MP LE VL LG KA P RMHRAVT R E A EL 620
Cdd:PLN03206 549 LIKPESRDLLQS IC D RERC SM AV I G TIDGSGRVVLV DS AAPE K ceanglppppp A VD LD LE KV LG DM P QKTFEFK R V A NK 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 621 GDDF D - AA G LELQESVE RVLR H P A V A SK S FL I T IG DR TI TGLVA RD Q M VGP W Q V P V AD C AV T A TSFDVY TG E A M A M GE RT 699
Cdd:PLN03206 629 LEPL D i PP G ITVMDALK RVLR L P S V C SK R FL T T KV DR CV TGLVA QQ Q T VGP L Q I P L AD V AV I A QTHTGL TG G A C A I GE QP 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 700 PLA L L D AP A SG R M A I GE TV TNL AA A R V GK LSD I K L S A NWM A AA GHP GE D A RL YD TVK A VG m ELCP ELG IT I PV GKDS M SM 779
Cdd:PLN03206 709 IKG L V D PK A MA R L A V GE AL TNL VW A K V TA LSD V K A S G NWM Y AA KLD GE G A DM YD AAV A LR - DAMI ELG VA I DG GKDS L SM 787
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 780 KT rw Q DN GE dk S V TS P VS L IVTGFAPVA D VRQSL TP Q L R L D k GETD L ILI DLG R GK N RLGGS I LAQ VHGKL G RAV PD V DD 859
Cdd:PLN03206 788 AA -- Q AG GE -- V V KA P GN L VISAYVTCP D ITKTV TP D L K L G - DDGV L LHV DLG K GK R RLGGS A LAQ AYDQI G DDC PD L DD 862
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 860 AED LK AF F AVI Q G L N A DGH I L A Y HD R SDGGL ITSV LEMAFAG H CG VELN L DALAD S ree LAAV LF S EELG A V IQ V REGAT 939
Cdd:PLN03206 863 VAY LK KA F EAT Q D L I A KRL I S A G HD I SDGGL VVTL LEMAFAG N CG INVD L PSSGH S --- AFET LF A EELG L V LE V SRKNL 939
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 940 PE V LAQFS AAG LD dc VA VIGQ PVNGYE I NLNYN G E T VY S AQRRI L QRI W S ETS Y Q IQR L RDNAD C AE QE FDA L LDEDN P g 1019
Cdd:PLN03206 940 DA V MEKLA AAG VT -- AE VIGQ VTASPL I EVKVD G A T CL S EKTAS L RDM W E ETS F Q LEK L QRLES C VA QE KEG L KSRKA P - 1016
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1020 l SI KLS Y d VNDDIAAPYIKKGVR PKVAI L RE Q G V NG QV EMAAAF DR AGF AAI DV H MSD I L A GR VD LD A F K G L V AC GGFSY 1099
Cdd:PLN03206 1017 - TW KLS F - TPAFTDKKIMNATSK PKVAI I RE E G S NG DR EMAAAF YA AGF EPW DV T MSD L L N GR IS LD D F R G I V FV GGFSY 1094
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1100 G DVL GAGE GWA K SI L FN ARARDG FQ A F FA R K D S F A LGVCNGCQ M M S n L HELI PG TEFW ----------- P H FV R N R S EQ F 1168
Cdd:PLN03206 1095 A DVL DSAK GWA G SI R FN EPLLQQ FQ E F YN R P D T F S LGVCNGCQ L M A - L LGWV PG PQVG gglgaggdpsq P R FV H N E S GR F 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1169 E A R VAM V QVQE S SS I F L Q GM A GS R L PIAI AHGEG H A E F ES E EA L L E ADL S GCVSL R FV D NH G KV TE A YP A NPNGSP R GI T 1248
Cdd:PLN03206 1174 E C R FTS V TIED S PA I M L K GM E GS T L GVWA AHGEG R A Y F PD E SV L D E VLK S NLAPV R YC D DD G EP TE Q YP F NPNGSP L GI A 1253
1290 1300 1310 1320 1330
....*....|....*....|....*....|....*....|....*....|....
gi 15598958 1249 G L S S R DGR VTI MMPHPER V F RAV Q NS W R P DD W QE D ---- GG WL R MF R NAR V W VD 1298
Cdd:PLN03206 1254 A L C S P DGR HLA MMPHPER C F LMW Q FP W Y P KE W GV D pagp SP WL K MF Q NAR E W CE 1307
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
162-1001
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 1024.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 162 L G GGR A ALE K AN V ELGLAL AE DE I DY LLK sfg E LGRNP H DVEL M MF A Q AN SEHC RH K IF NA SW didgqaqdkslfgmik N 241
Cdd:COG0046 6 L E GGR E ALE E AN R ELGLAL SD DE Y DY IVE --- I LGRNP T DVEL G MF S Q MW SEHC SY K SS NA LL ---------------- K 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 242 TYEMNREG VLS AYK DNA A V IVGH vagrffpdpqtreyaasr EPVQILM KVE T HNHP T AI A P FP GA S TG S GG E IRD EG at G 321
Cdd:COG0046 67 SLPTEGPR VLS GPG DNA G V VDIG ------------------ DGLAVVF KVE S HNHP S AI E P YQ GA A TG V GG I IRD IF -- G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 322 R GA K P K AGL TGFTVS NL qipgf E QP W evpygkperi VTALD I MVEGPL G G A AFN N E FG R P ALT G YF R TF E QKI atphgee 401
Cdd:COG0046 127 M GA R P I AGL DSLRFG NL ----- D QP P ---------- ASPRY I LIGVVA G I A DYG N C FG V P TVG G EV R FD E SYE ------- 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 402 vrgy HK P IML AGG M G N IR DE H VQ K G - EIS VG A K LIVL GGP AMLI G L GG GAAS S MAT G AS S A d LD FAS VQ RDN P E ME R R CQ 480
Cdd:COG0046 185 ---- GN P LVN AGG V G I IR AD H IF K A k APG VG N K VVYV GGP TGRD G I GG ATFA S EEL G ED S E - LD RPA VQ VGD P F ME K R LI 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 481 E V I DRC wql G ERNP I SF I H D V GAGGLS N A LP E LIND GG R G GRFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAADF E T 560
Cdd:COG0046 260 E A I LEL --- G DTGL I VG I Q D M GAGGLS S A SS E MAAK GG L G AEID L DK VP LR EPGMSP Y EIW LS ESQER ML L V V KPEKL E E 336
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 561 F K AI C ER E R C P F AV V GE AIEQRQ L T V ad SHFDNKPV D M PL EV L L G K AP RM HR AVT R E A E L GDDFDAAGLE L Q E SVE R V L R 640
Cdd:COG0046 337 F E AI F ER W R L P A AV I GE VTDDGR L V V -- TDHGETVA D L PL DF L A G G AP KY HR PAK R P A Y L EPLDLPEPID L E E ALL R L L S 414
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 641 H P A VASK SF L ITIG DR TIT G LVA RD Q mvgpwqv P VAD C AV TATS f DV Y T G E AM AM GE RTPL ALLD AP A SG RMA IG E TVT N 720
Cdd:COG0046 415 S P N VASK EW L YRQY DR EVG G NTV RD P ------- G VAD A AV VRVD - GT Y K G L AM ST GE NPRY ALLD PY A GA RMA VA E AAR N 486
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 LAA ARVGK L s D I KLSA NW MAAA g H P G E D A R L YDT VK AVG m EL C PE LGI TI P V G KD S MSMK T R wqdnge D KS V TS P VSLIV 800
Cdd:COG0046 487 LAA VGAEP L - A I TDCL NW GNPE - K P E E M A Q L VEA VK GLA - DA C RA LGI PV P S G NV S LYNE T K ------ D GK V AI P PTPVI 557
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 801 TGFAP V A DVR QSL TP Q L RLD kg ETD L I LI dl G RG KN R LGGS IL AQV H G K LG RAV PDV d D A E DL KA F F AVI Q G L NAD G H IL 880
Cdd:COG0046 558 GAVGL V D DVR KTV TP D L KKE -- GDL L Y LI -- G ET KN E LGGS EY AQV L G Q LG GEP PDV - D L E AE KA L F EAV Q E L IRE G L IL 632
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 881 A Y HD R SDGGL ITSVL EMAFAG HC G VELN LDAL A D S R ee LA A V LFSE EL G - AV I QV REGATPE V L A QFSA AGL dd CVA VIG 959
Cdd:COG0046 633 A A HD V SDGGL AVALA EMAFAG GL G ADID LDAL G D L R -- PD A A LFSE SQ G r AV V QV APEDAEA V E A LLAE AGL -- PAH VIG 708
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 15598958 960 QPVNGYEINLNYN GET VY S AQRRI L QRI W S ET syq IQ RLRDN 1001
Cdd:COG0046 709 TVTGDDRLVIRRG GET LL S LSLAE L RDA W E ET --- LP RLRDN 747
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1042-1297
2.80e-148
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 448.10
E-value: 2.80e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1042 R P K VAILRE Q G V NG QV EMAAAF D RAGF A A I DVHMSD I L A GRV D LD A F K GL V A C GGFSYGDVLG A G E GWA K SILFN ARA RD 1121
Cdd:pfam13507 1 K P R VAILRE P G T NG EY EMAAAF E RAGF D A V DVHMSD L L S GRV S LD D F Q GL A A P GGFSYGDVLG S G K GWA A SILFN PKL RD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1122 G F Q AFF A R K D S F A LG V CNGCQ MM S N L H e LIPG T E F ----- WP HFV RN R S EQ FE A R VAM V QV - QE S S S I FL Q GM A GS R LP i 1195
Cdd:pfam13507 81 A F E AFF N R P D T F S LG I CNGCQ LL S K L G - LIPG G E G dlaer WP TLT RN D S GR FE S R WVN V KI s EK S P S V FL R GM D GS G LP - 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1196 a I AHGEG HAE F E SEE A L LEADLS G C V S LR F VDN H G KV TE A YP A NPNGSP R GI T G LS S R DGRV TIM MPHPERVFR AV Q NS - 1274
Cdd:pfam13507 159 - V AHGEG RFV F R SEE V L ARLEAN G Q V A LR Y VDN A G NP TE E YP F NPNGSP L GI A G IC S P DGRV LGL MPHPERVFR PW Q WP h 237
250 260
....*....|....*....|...
gi 15598958 1275 W R P DD W Q E DGG WLR M FRNAR V WV 1297
Cdd:pfam13507 238 W P P GE W E E VSP WLR L FRNAR K WV 260
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
203-598
1.34e-126
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 392.99
E-value: 1.34e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 203 EL M MFAQ AN SEHCRHK I F naswdidgqaqd KSL FG MI KN tyemnregvlsaykdnaavivghvagrffpdpqtreyaasr 282
Cdd:cd02203 1 EL G MFAQ MW SEHCRHK S F ------------ KSL LK MI WA ----------------------------------------- 27
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 283 epvq ILM KVETHNHP T AI A PF P GA S TG S GG E IRD EGAT G rg A K P K A G L T G FTVSN L Q IPG F E qpwevpygk P ERIVTALD 362
Cdd:cd02203 28 ---- VVF KVETHNHP S AI E PF G GA A TG V GG I IRD ILSM G -- A R P I A L L D G LRFGD L D IPG Y E --------- P KGKLSPRR 92
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 363 I MVEGPL G GAAFN N EF G R P ALT G YF R TFEQK iatphgeevrg Y HK P IMLA G GM G NIRDE H VQ K G - EISV G AKLIVL GG PA 441
Cdd:cd02203 93 I LDGVVA G ISDYG N CI G I P TVG G EV R FDPSY ----------- Y GN P LVNV G CV G IVPKD H IV K S k APGP G DLVVLV GG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 442 MLI G L GG GAA SS MATGAS S AD LD FAS VQ RDN P E ME RRC QE V I DRCW qlg E RNP I SF I H D V GAGGLS N A LP E LIND GG R G G 521
Cdd:cd02203 162 GRD G I GG ATF SS KELSEN S SE LD RPA VQ VGD P F ME KKL QE A I LEAR --- E TGL I VG I Q D L GAGGLS S A VS E MAAK GG L G A 238
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598958 522 RFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAA D F E T F K AIC ER E RCPF AV V GE AIEQRQ L TVADS hf DNKPV D M 598
Cdd:cd02203 239 EID L DK VP LR EPGMSP W EIW IS ESQER ML L V V PPE D L E E F L AIC KK E DLEA AV I GE VTDDGR L RLYYK -- GEVVA D L 313
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
1043-1297
2.21e-111
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 348.97
E-value: 2.21e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1043 PKVAIL REQ G V N GQVE MAAAF D RAG FA A I DV HM SD I lag R V DLD A F K GLV AC GGFSYGD V L G AG EGW A K S ilfna RAR D G 1122
Cdd:COG0047 1 PKVAIL VFP G S N CDRD MAAAF E RAG AE A E DV WH SD L --- R T DLD D F D GLV LP GGFSYGD Y L R AG AIA A F S ----- PIM D A 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1123 FQA F f AR KDSFA LG V CNG C Q MMSN L H e L I PG te F WP HFV RNRS EQ F EA R VAMVQ V QESS S I F LQ GM - AG SRL PI A IAHGE 1201
Cdd:COG0047 73 VRE F - AR RGGLV LG I CNG F Q ILTE L G - L L PG -- I WP ALT RNRS LR F IC R WVYLR V ENND S P F TS GM e AG EVI PI P IAHGE 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1202 G HAEF e S EE A L L E ADLS G C V SL R F VD NH G K VT ea YPANPNGS PRG I T G LSSR DG R V TI MMPHPER VFRAVQNS wrpddw Q 1281
Cdd:COG0047 149 G RYVA - D EE T L A E LEAN G Q V AF R Y VD AD G N VT -- YPANPNGS LNN I A G ITNE DG N V LG MMPHPER AVEPLLGP ------ G 219
250
....*....|....*.
gi 15598958 1282 E DGGW LR M FR N A RVWV 1297
Cdd:COG0047 220 E STDG LR I FR S A VKYF 235
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
287-578
1.73e-104
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 331.95
E-value: 1.73e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 287 IL MK V E T HNHP T AI A P FP GA S TG S GG E IRD EG ATG RG AKP K A GLTGFTV S NLQI pgfeqpwevpygkperiv TALD I MVE 366
Cdd:cd02193 3 EA MK I E E HNHP A AI D P AA GA A TG V GG A IRD IA ATG ID AKP I A LSANWMA S AGHP ------------------ GEDA I LYD 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 367 GPL G G A AFN N EF G R P ALT G YF R TFEQKIATPHG E EVRGY H K P IMLAGGM G NI RD EHVQK - GEISV G AK L IVL GG PAMLI G 445
Cdd:cd02193 65 AVK G V A ELC N QL G L P IPV G KD R MSMKTRWQEGN E QREMT H P P SLVISAF G RV RD DRHTL p QLSTE G NA L LLI GG GKGHN G 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 446 LGG G A AS S M A T ga S SAD L DFA S V Q RDN P EM E RRCQ E VIDRCWQL G ern PISFI HD V GAGGL SN AL P EL IND G GR G GRFE L 525
Cdd:cd02193 145 LGG T A LA S V A L -- S YRQ L GDK S A Q VRD P AQ E KGFY E AMQALVAA G --- KLLAW HD R GAGGL LV AL A EL VFA G HC G VQVD L 219
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15598958 526 R A VPN DEP G M S PLEI WCN ESQER Y V LS V D A A D FETFKAICERERCPFA V V G E A 578
Cdd:cd02193 220 A A LGD DEP D M E PLEI ALF ESQER G V IQ V R A E D RDAVEEAQYGLADCVH V L G Q A 272
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
1045-1294
1.07e-90
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 292.60
E-value: 1.07e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1045 VA I LR EQ G V N GQVE MA A AF DR AGF A A I DV HMS D I LAGR V DLD AFK G L V AC GGFSYGD V L G AG EGW A K S I L FNA rardg FQ 1124
Cdd:cd01740 1 VA V LR FP G S N CDRD MA Y AF EL AGF E A E DV WHN D L LAGR K DLD DYD G V V LP GGFSYGD Y L R AG AIA A A S P L LME ----- EV 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1125 AF FA RKDSFA LG V CNG C Q MMSN L HE L IPGTEFWPHFVRNRSE Q F ea R VAMVQ V QESS S I F LQ G - M A G SR L P I AI AHGEG H 1203
Cdd:cd01740 76 KE FA ERGGLV LG I CNG F Q ILVE L GL L PGALIRNKGLKFICRW Q N -- R FVTLR V ENND S P F TK G y M E G EV L R I PV AHGEG R 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1204 AEF e SE E A L L E ADLS G CV s LRF VD NH G K VTE A YPANPNGS PR GI T G LSSR DGRV TI MMPHPER VFRAV Q NS wrpd DWQED 1283
Cdd:cd01740 154 FYA - DD E T L A E LEEN G QI - AQY VD DD G N VTE R YPANPNGS LD GI A G ICNE DGRV LG MMPHPER AVEPW Q WE ---- RLLGG 227
250
....*....|.
gi 15598958 1284 GGW L RM FRNA R 1294
Cdd:cd01740 228 SDG L KL FRNA V 238
PHA03366
PHA03366 FGAM-synthase; Provisional
558-1296
9.81e-83
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 297.32
E-value: 9.81e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 558 FETF K AI C ERER CP FAVV G EAIEQRQLTVADSHFDNKPVD --------- M PL EVLLGKA P R m HRAV -- TR EAELGDDF D A 626
Cdd:PHA03366 507 LDAL K RA C RLAG CP VHIL G RTVPLPGIHFVNDLGNPVYGE lrddqfkpt F PL QPSRPLS P V - SATS ed TR PSPQDESI D W 585
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 627 A GLE L QESVERV L R HP A V A SK SFLITIG DR TIT G L VA RDQM VGP WQV PV A D CAVTAT S ---------------------- 684
Cdd:PHA03366 586 A LFN L NSTLLQI L S HP T V G SK EYIVRHI DR CGN G R VA QQPG VGP LDL PV S D YSIVVH S svktrraietpsstedltyqea 665
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 685 ------------ F D VYT ------- G EAM A M GE RTPLAL LD APASGRM AI G E TV TNL AA A R V GK L S DI KLSAN -- W MAAAG 743
Cdd:PHA03366 666 delinspltwfd P D DES vlhpavp G TCS A L GE QGYKVQ LD PILGAKY AI V E AL TNL ML A P V AN L E DI TITLS vt W PPTDQ 745
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 744 HPG E dar LY DTVK A V g M E L C P ELG ITIPVGKD S M S mktrw QDNGEDKSVTSPVSL IV - T GF APV ADVRQS LTP Q L R ld K G 822
Cdd:PHA03366 746 AAS E --- LY RALA A C - K E F C R ELG VNFTFTSA S S S ----- PRQDQPPQPGPLFNT IV f T AS APV PSSTPR LTP D L K -- K P 814
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 823 ETD L ILIDLGRGKN r L G GS ILA Q VH G KLGRAV PD VD d AED LK AF F AVI Q G L NAD G HILAY HD R SDGGLI TSVL EMA F AG H 902
Cdd:PHA03366 815 GSA L VHLSISPEYT - L A GS VFE Q IF G LKSGTL PD IS - PSY LK NL F RAV Q H L ISE G LVVSG HD V SDGGLI ACLA EMA L AG G 892
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 903 C GV ELNL dala DSR E ELAAV LFSE EL G A VI Q V REGATPE VL AQFSAAGL dd CVAV IG QPVNGYEI N L --- NY NG ETVYSA 979
Cdd:PHA03366 893 R GV TITV ---- PAG E DPLQF LFSE TP G V VI E V PPSHLSA VL TRLRSRNI -- ICYP IG TVGPSGPS N T fsv SH NG TVLFRE 966
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 980 QRRI L QRI W SET S - Y Q IQR LR DNA -------- D CAEQ E F D ALLD E DNPGL S IKLS Y dvnddi AA P YI kkgv R PK VA I L RE 1050
Cdd:PHA03366 967 SLSS L RST W RSF S d E Q FEL LR PDL teesmyrk D YGNN E V D LGPL E EGLTT S PLRL Y ------ TC P DK ---- R HR VA V L LL 1036
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1051 Q G VN G QVEMA AAF DR AGF AAID V HMSDILA G R v D LD A F K GLV AC G GFSYG D VLGAGEGWAKSI L F N ARA RD GFQA F FA R K 1130
Cdd:PHA03366 1037 P G CP G PHALL AAF TN AGF DPYP V SIEELKD G T - F LD E F S GLV IG G SSGAE D SYTGARAAVAAL L S N PAV RD ALLR F LN R P 1115
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1131 D S F A LG VCN - GCQ MMSN L ---------- HELIPGT E F WP - HFVR N R S EQF E A R VAMVQVQ E SS - S IF L QGMA GS R LP i AI 1197
Cdd:PHA03366 1116 D T F S LG CGE l GCQ ILFA L kavgstapsp VPGTETE E Q WP i TLEP N A S GLY E S R WLNFYIP E TT k S VA L RPLR GS V LP - CW 1194
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1198 A H G E ---- GHAEFES E EA L LE adl SG CVSLR F vdn HG KVTEA ------ YP A NP N G - S P rg IT GL S S R DGR VTIMMPH P ER 1266
Cdd:PHA03366 1195 A Q G T hlgf RYPNDGM E YI L RN --- SG QIAAT F --- HG ADVDP gnparh YP R NP T G n S N -- VA GL C S A DGR HLALLFD P SL 1266
810 820 830
....*....|....*....|....*....|....*....
gi 15598958 1267 V F ravq NS W R pdd WQ EDGG --------- W LR MF RNARV W 1296
Cdd:PHA03366 1267 S F ---- HP W Q --- WQ HVPP engplkvsp W KL MF QDLHL W 1298
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
677-960
4.96e-77
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 255.54
E-value: 4.96e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 677 D C AV TATSFDVYT G E AM AM GE RTPLA LLD AP A SGRM A IG E T V T NL A A AR v GKLSD I KLSA N WMAAAGHP GE DAR L YDT V K 756
Cdd:cd02204 1 D A AV LRIPGETDK G L AM ST GE NPRYS LLD PY A GAAL A VA E A V R NL V A VG - ADPLA I TDCL N FGNPEKPE GE MGQ L VEA V L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 757 AV G m EL C PE LG ITIPV GKDS MSMK T RW qdngedks V TS P VS L IVTGFAP V A DVR QSL T PQLR ld K GETD L I LI DLGRGKN 836
Cdd:cd02204 80 GL G - DA C RA LG TPVIG GKDS LYNE T EG -------- V AI P PT L VIGAVGV V D DVR KIV T LDFK -- K EGDL L Y LI GETKDEL 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 837 RLGGSI LA q V HG k LG RAV P DVD D A E DL KA F F AVI Q G L NAD G HI L AY HD R SDGGL ITSVL EMAFAG HC G V E LN L DALADSR 916
Cdd:cd02204 149 GGSEYA LA - Y HG - LG GGA P PLV D L E RE KA L F DAV Q E L IKE G LV L SA HD V SDGGL AVALA EMAFAG GL G A E VD L SKDDAED 226
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15598958 917 E elaa V LFSE E LG A V IQVRE gat PE VLAQ F S A AGLDDCVA VIG Q 960
Cdd:cd02204 227 E ---- L LFSE S LG R V LVEVK --- PE NEEV F E A EEAGVPAT VIG T 263
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
180-976
2.59e-73
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 259.54
E-value: 2.59e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 180 L AED E IDYLLK sfg E LGR N P H D V EL M MF AQAN SEHC RH K ifnaswdidgqa QD K S L F gmik NTYEMNREG V LSAYKDN A A 259
Cdd:TIGR01736 1 L SDE E MELIRE --- I LGR E P N D T EL A MF SAMW SEHC SY K ------------ SS K K L L ---- KQFPTKGPN V IQGPGED A G 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 260 V IV ghvagrf FP D pqtr E YA A srepvqi LM K V E T HNHP T AI A P FP GA S TG S GG EI RD eg ATGR GA K P K A G L TGFTVSN L Q 339
Cdd:TIGR01736 62 V VD ------- IG D ---- G YA V ------- VF K M E S HNHP S AI E P YN GA A TG V GG IL RD -- ILSM GA R P I A L L DSLRFGP L D 121
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 340 I P gfeqpwevpyg K PERIV taldimv EG PLG G - AAFN N EF G R P ALT G -- Y F - RTFE qkiatphgeevrgy HK P IMLAGGM 415
Cdd:TIGR01736 122 D P ----------- K NRYLF ------- EG VVA G i SDYG N RI G V P TVG G ev E F d ESYN -------------- GN P LVNVMCV 169
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 416 G NI R DEHVQK G EI - SV G A KL IVL GG PAMLI G L GG GAAS S MATGASSADL D FAS VQ RDN P EM E RR cqe V I DRCWQLGERNP 494
Cdd:TIGR01736 170 G LV R KDDIVT G KA k GP G N KL VLV GG KTGRD G I GG ATFA S EELSEEAEEE D RPA VQ VGD P FT E KL --- L I EATLEAVDTGL 246
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 495 ISF I H D V GA G GL SN A LP E LIND GG R G GRFE L RA VP ND EPGM S P L EI WCN ESQER YV L S V DAA D F E TFKA I C E RERC P FA V 574
Cdd:TIGR01736 247 VKG I K D L GA A GL TS A SS E MAAK GG L G AEIY L DK VP LR EPGM T P Y EI MLS ESQER ML L V V APE D V E EVLE I F E KYEL P AS V 326
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 575 V GE AIEQRQLTV ad SHFDNKPV D M P L E v LL GK AP RMH R - AVTREAELGDDFDAAGLE L QESVER VL RH P AV ASK SFLI -- 651
Cdd:TIGR01736 327 I GE VTDEGRIRL -- YYKGEVVA D L P I E - LL AD AP EYE R p SEPPKYPEEEKEPEPPAD L EDAFLK VL SS P NI ASK EWVY rq 403
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 652 --- TIGD RT I tglvardqmvgpw QV P VA D C AV TATSFDVYT G E A MAMGERTPLAL LD AP A SGRM A IG E TVT NLAA ar VG k 728
Cdd:TIGR01736 404 ydh EVQT RT V ------------- VK P GE D A AV LRIKETGKL G L A LTADCNPRYVY LD PY A GAAG A VA E AYR NLAA -- VG - 467
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 729 lsdikls A NWM AA A ----- G H P g E DARL Y ---- DT VK AV G m EL C PE LG ITIPV G KD S MSMK T rwqdng EDKSVTSPVSLI 799
Cdd:TIGR01736 468 ------- A EPL AA V dclnf G N P - E RPEV Y wqfv EA VK GL G - DA C RA LG TPVVG G NV S LYNE T ------ NGVPIAPTPTIG 532
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 800 VT G F ap V A DV RQS LT PQL rld K G E T D L I LI d L G RG K NR LGGS - I L AQV HG KLGRA VP D VD DA E DLKAFF AV I q GLNAD G H 878
Cdd:TIGR01736 533 MV G L -- V E DV EKL LT SNF --- K K E G D A I YL - I G ET K DE LGGS e Y L RVI HG IVSGQ VP A VD LE E EKELAD AV R - EAIRA G L 605
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 879 IL A Y HD R S D GGL ITSVL EMA F A GHC G V E LNL D AL A DS R ee LAAV LFSE EL G - A VIQ V R E GA tpevl A QFSAAGLDDCVA V 957
Cdd:TIGR01736 606 VS A A HD V S R GGL AVALA EMA A A SGI G A E VDI D EI A SA R -- PDEL LFSE SN G r A IVA V P E EK ----- A EEAVKSKGVPAK V 678
810
....*....|....*....
gi 15598958 958 IG QPVNGY e INLNYNGE T V 976
Cdd:TIGR01736 679 IG KTGGDR - LTIKTGDD T I 696
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
178-991
8.45e-70
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 249.64
E-value: 8.45e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 178 LA L AE DE IDYLLK sfg E LGR N P HDV EL M MF AQAN SEHC RH K ifn A S wdidgqaqd K S L F gmik NTYEMNREG VL SAYKD N 257
Cdd:PRK01213 11 MG L TD DE YERIRE --- I LGR E P NFT EL G MF SVMW SEHC SY K --- S S --------- K P L L ---- RKFPTKGPR VL QGPGE N 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 258 A A V I - V G H vagrffpdpqtr EY A AS repvqil M K V E T HNHP T A IA P FP GA S TG S GG EI RD EGAT G rg A K P K A G L tgftv S 336
Cdd:PRK01213 72 A G V V d I G D ------------ GQ A VV ------- F K I E S HNHP S A VE P YQ GA A TG V GG IL RD IFSM G -- A R P I A L L ----- D 125
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 337 N L QIPGFEQ P wevpyg K PERIV tal DIM V E G p L GG aa FN N EF G R P ALT G yfrtfeqkiatphge EV R --- G Y HK - P IML A 412
Cdd:PRK01213 126 S L RFGELDH P ------ K TRYLL --- EGV V A G - I GG -- YG N CI G V P TVG G --------------- EV Y fde S Y NG n P LVN A 178
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 413 GGM G NI R DEHVQKGEI S - VG AKLIVL G GPAMLI G L GG gaa S S M A tgas SA D L DFA S ------ VQ RDN P E ME RR cqe V I DR 485
Cdd:PRK01213 179 MCV G LV R HDDIVLAKA S g VG NPVVYV G AKTGRD G I GG --- A S F A ---- SA E L SEE S eekrpa VQ VGD P F ME KL --- L I EA 248
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 486 C WQ L GERNPISF I H D V GA G GL SNALP E LIND GG R G GRFE L RA VP ND E P GM S P L EI WCN ESQER YV L S V DAADF E TFK AI C 565
Cdd:PRK01213 249 C LE L IKTGLVVG I Q D M GA A GL TCSSS E MAAK GG L G IELD L DK VP LR E E GM T P Y EI MLS ESQER ML L V V KPGKE E EVL AI F 328
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 566 E RERCPF AV V GE AIEQRQ L T V ad S H FDNKPV D M P L E V L LGK AP RMH R AVTRE A E L g D DFD A AGLE L Q E SVERV L RH P AV A 645
Cdd:PRK01213 329 E KWDLDA AV I GE VTDDGR L R V -- Y H HGEVVA D V P A E A L ADE AP VYD R PYKEP A Y L - D ELQ A DPED L K E ALLKL L SS P NI A 405
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 646 SK SFLI ----- TIGDR T I tglvardqmvgpw QV P VA D C AV TATS f DVYT G E A MAMGERTPLAL LD APASGRM A IG E TVT N 720
Cdd:PRK01213 406 SK EWVY eqydh EVQTN T V ------------- VK P GG D A AV LRIR - GGGK G L A LTTDCNPRYVY LD PYEGAKL A VA E AAR N 471
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 721 LAA ar VG klsdikls A NWM A A ----- A G H P GEDARLYDT V K AV - G M - EL C PE LG it I PV -- G K dsmsmktrwqdngedks 791
Cdd:PRK01213 472 LAA -- VG -------- A TPL A I tdcln F G N P EKPEVMWQF V E AV r G L a DA C RA LG -- T PV vg G N ----------------- 522
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 792 vtsp VSL ---- IV T GFA P --------- VA DV RQSL T P qlr LD K G E T DLI LI d LG RG K NR LGGS ILAQ V - HG KL G RAV P D V 857
Cdd:PRK01213 523 ---- VSL ynet GG T AIY P tpvigmvgl ID DV SKRT T S --- GF K K E G DLI YL - LG ET K DE LGGS EYLK V i HG HV G GRP P K V 594
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 858 D DAED l K AFFAVIQGLNAD G HILAY HD R S D GGL ITSVL EMA F AG HC G V E LN L DALAD sree LA A V LFSE EL G - A V IQ V RE 936
Cdd:PRK01213 595 D LEAE - K RLQELVREAIRE G LVTSA HD V S E GGL AVALA EMA I AG GL G A E VD L SDGLR ---- PD A L LFSE SQ G r Y V VS V PP 669
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 15598958 937 GATPEVL A QFS AAG LD dc VAV IG Q p V N G YEINLNY N GETVYSA qrri L QRI W SET 991
Cdd:PRK01213 670 ENEEAFE A LAE AAG VP -- ATR IG V - V G G DALKVKG N DTESLEE ---- L REA W EGA 717
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
168-1266
4.43e-69
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 254.77
E-value: 4.43e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 168 A L E K ANV E L GLA LAEDEIDYLLKS F GEL GRNP HDV E LMMFAQAN S E HCRH KI F NA sw DIDGQAQDK S L F G - MI K NT YE -- 244
Cdd:TIGR01857 175 D L A K FKA E Q GLA MSLEDLKFIQDY F KSI GRNP TET E IKVLDTYW S D HCRH TT F ET -- ELKHVTFSD S K F Q k QL K KA YE dy 252
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 245 - MN RE GVLSAY K DNAAVIVGHVAGRFFP -------- DPQTREY A A S ---------- R EP VQILM K V ETHNHPT A I A PF P G 305
Cdd:TIGR01857 253 l AM RE ELGRSE K PVTLMDMATIFAKYLR kngklddl EVSEEIN A C S veievdvdgv K EP WLLMF K N ETHNHPT E I E PF G G 332
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 306 A S T GS GG E IRD egatgrgak P KA G LT g FTVSNLQIP G FEQ P W ---- E VPY GK - P E R IV T aldim VEGPL G GAAFN N EF G r 380
Cdd:TIGR01857 333 A A T CI GG A IRD --------- P LS G RS - YVYQAMRVT G AGD P T vpis E TLK GK l P Q R KI T ----- TTAAH G YSSYG N QI G - 396
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 381 paltgyfrtfeqk I AT PHGE E V rg YH ----- K PIMLAGGMGNIRD E H V QKGEISV G AKL I V LGG PAMLI G L GG GAA SS MA 455
Cdd:TIGR01857 397 ------------- L AT GQVS E I -- YH pgyva K RMEVGAVVAATPK E N V VREKPEP G DVI I L LGG KTGRD G I GG ATG SS KE 461
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 456 TGAS S AD L DF A S VQ RD N PEM ER RC Q EVI drcwqlge RN P ----- I SFIH D V GAGG L S N A LP EL indg GR G GRFE L RA VP N 530
Cdd:TIGR01857 462 HTVE S LE L CG A E VQ KG N APE ER KI Q RLF -------- RN G nvtrl I KKCN D F GAGG V S V A IG EL ---- AD G LEID L NK VP K 529
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 531 DEP G MSPL E IWCN ESQER YVLS V DAA D FET F K A I C ER E RCPFA VV GEAI E QRQ L TV ads HFDN K P - VD MPLEV L LGKAP R 609
Cdd:TIGR01857 530 KYE G LNGT E LAIS ESQER MAVV V SPE D VDA F L A Y C NE E NLEAT VV ATVT E KPR L VM --- NWNG K T i VD LSRRF L DTNGV R 606
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 610 MH --- RA V TREAE L G - DDFDAAGLE L Q E SVER VL RHPA VAS KSF L ITIG D RTITGLVARDQMV G PW Q VPVAD ca VTATSF 685
Cdd:TIGR01857 607 QV ida KV V DKDVK L P e ERQKTSAET L E E DWLK VL SDLN VAS QKG L QERF D SSVGAGTVLMPLG G KY Q LTPTE -- ASVAKL 684
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 686 D V YT GE ----- A M A M G ERTPL A LLDAPASGRM A IG E TVTN L A AA rvgklsdikl S A NWMA A A ------- GHPGE DA - R LY 752
Cdd:TIGR01857 685 P V LG GE thtas A I A W G FNPYI A EWSPYHGAAY A VI E SLAK L V AA ---------- G A DYKK A R lsfqeyf EKLDK DA e R WG 754
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 753 DTVK A V -- GMELCPE LG ITIPV GKDSMS mktrwqdn G EDKSV T S P VS LI VTGFA p V A DV R QSLT P QLR l DK GE T d LI LI D 830
Cdd:TIGR01857 755 KPFA A L lg AIKAQID LG LPAIG GKDSMS -------- G TFEEL T V P PT LI SFAVT - T A NS R RVIS P EFK - AA GE N - IY LI P 823
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 831 lgrgknrlggsilaqvhgkl G R A VP D VD - D AED LK AF FA V I QG L N AD GHILAYHDRSD GG LIT S VLE M A F AGHC G V ELN L 909
Cdd:TIGR01857 824 -------------------- G Q A LE D GT i D FDL LK EN FA Q I EE L I AD HKVVSASAVKY GG VAE S LAK M T F GNRI G A ELN N 883
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 910 DA L A D sreelaav LF SEEL G AV I Q vregatp E VLAQF S A A G lddc V AV IGQ PVNGYEINL ny NGE TVYSAQ rri L QRI W S 989
Cdd:TIGR01857 884 PE L E D -------- LF TAQY G SF I F ------- E SPEEL S I A N ---- V EK IGQ TTADFVLKV -- NGE KLDLEE --- L ESA W E 939
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 990 ET syqiqrlrdnadc A E QE F DALLDEDNPGLSIK lsy D V NDDIAAPYI K KG V - R P K V A I LREQ G V N GQVEM A A AF DRA G F 1068
Cdd:TIGR01857 940 GK ------------- L E EV F PSKFEDKKETVEVP --- A V ASEKKVIKA K EK V e K P R V V I PVFP G T N SEYDS A K AF EKE G A 1003
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1069 AAID V -------- HMSDILAGR VD - L D AFKG L VAC GGFS Y GD vlg AGE G W AK --- S IL F N ARA R DGFQA F F AR k D SFA LG 1136
Cdd:TIGR01857 1004 EVNL V ifrnlnee ALVESVETM VD e I D KSQI L MLP GGFS A GD --- EPD G S AK fia A IL R N PKV R VAIDS F L AR - D GLI LG 1079
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1137 V CNG C Q MMSNL ----- HELIPGT E FW P HFVR N RSEQFEARVAMVQVQESS S IF L Q G MA - G SRLP I AIA HGEG HA e FE S E E 1210
Cdd:TIGR01857 1080 I CNG F Q ALVKS gllpy GNIEAAN E TS P TLTY N DINRHVSKIVRTRIASTN S PW L S G VS v G DIHA I PVS HGEG RF - VA S D E 1158
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*.
gi 15598958 1211 A L L E ADLS G CVSLRF VD NH GK VTEAYPA NPNGS PRG I T G LS S R DGR VTIM M P H P ER 1266
Cdd:TIGR01857 1159 V L A E LREN G QIATQY VD FN GK PSMDSKY NPNGS SLA I E G IT S P DGR IFGK M G H S ER 1214
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
690-960
4.52e-59
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 204.45
E-value: 4.52e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 690 GEAM AMG E RTPL A LL D AP A SGRMAI G ETVTNL AA ARVG k LSD I K LSANWMA A AGHPGEDA R LYD T VK A V G m ELC PE LG IT 769
Cdd:cd02193 2 GEAM KIE E HNHP A AI D PA A GAATGV G GAIRDI AA TGID - AKP I A LSANWMA S AGHPGEDA I LYD A VK G V A - ELC NQ LG LP 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 770 IPVGKD S MSMKTRWQ DNG E DKSV T S P V SL IVTG F AP V A D V R QS L TPQLRLDKG etd L I LI DL G R G K N R LGG SI LA Q V --- 846
Cdd:cd02193 80 IPVGKD R MSMKTRWQ EGN E QREM T H P P SL VISA F GR V R D D R HT L PQLSTEGNA --- L L LI GG G K G H N G LGG TA LA S V als 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 847 HGK LG RAVPD V D D AEDL K A F FAVI Q G L N A D G HI LA Y HDR SD GGL ITSVL E MA FAGHCGV ELN L D AL A D --- SR E E L AAV L 923
Cdd:cd02193 157 YRQ LG DKSAQ V R D PAQE K G F YEAM Q A L V A A G KL LA W HDR GA GGL LVALA E LV FAGHCGV QVD L A AL G D dep DM E P L EIA L 236
250 260 270
....*....|....*....|....*....|....*..
gi 15598958 924 F SEELGA VIQVR EGATPE V LA qf SAA GL D DCV A V I GQ 960
Cdd:cd02193 237 F ESQERG VIQVR AEDRDA V EE -- AQY GL A DCV H V L GQ 271
FGAR-AT_N
pfam18076 Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain ...
35-148
1.39e-58
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway.
Pssm-ID: 465635 [Multi-domain]
Cd Length: 115
Bit Score: 196.92
E-value: 1.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 35 E FA HF ADVTGA L T A D E EQV L AR LL K YGP SVPVQ EP S G R L F LV V PR F GTISPWSSKA S DIA R NCGL AKID R L ERGIAYY VQ 114
Cdd:pfam18076 1 E YV HF VELEAP L S A A E RAR L EQ LL T YGP PLEEP EP E G E L L LV T PR L GTISPWSSKA T DIA H NCGL DAVR R I ERGIAYY LT 80
90 100 110
....*....|....*....|....*....|....*
gi 15598958 115 G - E LS ESDAQQV AA R LHDRMT QL VL DR LE G AA E LF 148
Cdd:pfam18076 81 G k P LS AAELAAL AA L LHDRMT ES VL TD LE D AA A LF 115
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
287-577
1.36e-40
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 149.47
E-value: 1.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 287 IL M KVETH N H P T AI A P FP G ASTGS GG EIR D EG A T gr GA K P K A G L TGFTV SN L qipgfeqpwevpygkperiv TAL DI MVE 366
Cdd:cd00396 2 LA M STDGI N P P L AI N P WA G GRLAV GG AVN D IA A M -- GA R P I A L L ASLSL SN G -------------------- LEV DI LED 59
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 367 GPL G G A AFN N EF G R P ALT G YFRTFEQK iatphgeevr GY HK PIMLAGGM G NIRDEH V QKG - EISV G AK LI VL G gpamlig 445
Cdd:cd00396 60 VVD G V A EAC N QL G V P IVG G HTSVSPGT ---------- MG HK LSLAVFAI G VVEKDR V IDS s GARP G DV LI LT G ------- 122
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 446 lgggaassmatgassadldfasvqrdnpemerrc QEVIDRCWQL G ern PISFI HD VGA GGL SNA LPEL INDG G R G GRFE L 525
Cdd:cd00396 123 ---------------------------------- VDAVLELVAA G --- DVHAM HD ITD GGL LGT LPEL AQAS G V G AEID L 165
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 15598958 526 R A V P N DE PGMS ----- PL E IWCNE S QERYVLS V D A ADFETFKAICERERCPF AV V G E 577
Cdd:cd00396 166 E A I P L DE VVRW lcveh IE E ALLFN S SGGLLIA V P A EEADAVLLLLNGNGIDA AV I G R 222
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
1043-1287
3.38e-36
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 138.36
E-value: 3.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1043 PK VA I LR EQ G V N GQV E MAA AF D R A G FAAID VH MS D IL A G R VDLDAFKG LV AC GGFS Y GD VLG AG egwaks IL F N AR ARD g 1122
Cdd:PRK01175 4 IR VA V LR ME G T N CED E TVK AF R R L G VEPEY VH IN D LA A E R KSVSDYDC LV IP GGFS A GD YIR AG ------ AI F A AR LKA - 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1123 fqaf FA RKD -------- SFAL G V CNG C Q MMSN L HE L IPGT E FWPH ---- FVR N R S EQ FE A R VAMVQVQESSS IF LQGMAG 1190
Cdd:PRK01175 77 ---- VL RKD ieefideg YPII G I CNG F Q VLVE L GL L PGFD E IAEK pema LTV N E S NR FE C R PTYLKKENRKC IF TKLLKK 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1191 SRLPIAI AH G EG HAE F ES EE A L LEADLSGCVSL R F VD NH G k VTEA YP A NPNGS PRG I T G LSSRD G R V TIM MPHPER V F RA 1270
Cdd:PRK01175 153 DVFQVPV AH A EG RVV F SE EE I L ERLIENDQIVF R Y VD EN G - NYAG YP W NPNGS IYN I A G ITNEK G N V IGL MPHPER A F YG 231
250
....*....|....*...
gi 15598958 1271 V Q NS - W RPDDWQE DG GWL 1287
Cdd:PRK01175 232 Y Q HP y W EKEEDYG DG KIF 249
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
430-586
6.99e-35
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 130.54
E-value: 6.99e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 430 V G AK LI V LG G paml I GL G G GAA S SMAT G ASSAD L df A S VQ RDN P EM E RRCQE V IDRCWQ LG er NPISFI HD VGA GGL SN A 509
Cdd:pfam02769 2 P G DV LI L LG S ---- S GL H G AGL S LSRK G LEDSG L -- A A VQ LGD P LL E PTLIY V KLLLAA LG -- GLVKAM HD ITG GGL AG A 73
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598958 510 L P E LINDG G R G GRFE L RA VP ND E PG M S PLE IWCN E S Q E R YVLS V DAADF E TFK AI C E R E RCPF AV V GE AIEQRQ LTV 586
Cdd:pfam02769 74 L A E MAPAS G V G AEID L DK VP IF E EL M L PLE MLLS E N Q G R GLVV V APEEA E AVL AI L E K E GLEA AV I GE VTAGGR LTV 150
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
1044-1296
8.32e-35
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 133.27
E-value: 8.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1044 KVA IL R EQ G V N GQVEMAA A FDRA G FA A ID V HMS D ilagr VD L DAFK G L V AC GGFSYGD V L G AG egwak S I LFNARARDGF 1123
Cdd:TIGR01737 2 KVA VI R FP G T N CDRDTVY A LRLL G VD A EI V WYE D ----- GS L PDYD G V V LP GGFSYGD Y L R AG ----- A I AAASPIMQEV 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1124 QA F f A R K DSFA LG V CNG C Q MMSNL h E L I PG T efwph FVR N R S EQ F EA R VAMVQ V QESSS IF LQGMA - G SRLP I A IAHGEG 1202
Cdd:TIGR01737 72 RE F - A E K GVPV LG I CNG F Q ILVEA - G L L PG A ----- LLP N D S LR F IC R WVYLR V ENADT IF TKNYK k G EVIR I P IAHGEG 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1203 HAEFE s E E A L LEADLSGC V SL R FV D NH G K V T E ay P ANPNGS PRG I T G LSSRD G R V TI MMPHPER VFRAVQNS wrpddwq E 1282
Cdd:TIGR01737 145 RYYAD - D E T L ARLESNDQ V VF R YC D ED G D V A E -- E ANPNGS VGN I A G IVNER G N V LG MMPHPER ASEKLLGG ------- D 214
250
....*....|....
gi 15598958 1283 DG gw L RM F RNARV W 1296
Cdd:TIGR01737 215 DG -- L KL F ESLVE W 226
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
1044-1291
4.16e-27
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 110.59
E-value: 4.16e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1044 KVA ILREQ G V N GQVE MA A A F - D RA G FAAID V - H MSD ilagrv DLD AFKGL V AC GGFSYGD V L GA G EGW A K S ILFN A RAR d 1121
Cdd:PRK03619 2 KVA VIVFP G S N CDRD MA R A L r D LL G AEPEY V w H KET ------ DLD GVDAV V LP GGFSYGD Y L RC G AIA A F S PIMK A VKE - 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1122 gfqaf FA R K DSFA LG V CNG C Q MMSNLH e L I PG T efwph FV RN R S EQ F EA R VAMVQ V QESSSI F LQ G M - A G SRLP I A IAHG 1200
Cdd:PRK03619 75 ----- FA E K GKPV LG I CNG F Q ILTEAG - L L PG A ----- LT RN A S LK F IC R DVHLR V ENNDTP F TS G Y e K G EVIR I P IAHG 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1201 EG HA e FES EE A L -- LE AD ls G C V SL R FV D nhgkvteayp A NPNGS PRG I T G LSSRD G R V TI MMPHPER VFRAVQN S wrpd 1278
Cdd:PRK03619 144 EG NY - YAD EE T L kr LE GN -- G Q V VF R YC D ---------- E NPNGS VND I A G IVNEK G N V LG MMPHPER AVEPLLG S ---- 206
250
....*....|...
gi 15598958 1279 dwq E DG gw L RM F R 1291
Cdd:PRK03619 207 --- T DG -- L KL F E 214
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
169-218
7.90e-27
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 103.70
E-value: 7.90e-27
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 15598958 169 LE K AN VE LGLAL AE DEIDYL LKS F GE LGRNP H DVEL M MFAQ AN SEHCRHK 218
Cdd:pfam18072 1 LE E AN RY LGLAL SD DEIDYL VEY F AG LGRNP T DVEL G MFAQ MW SEHCRHK 50
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
194-608
2.55e-21
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 99.93
E-value: 2.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 194 E LGR N P HD VEL MM F AQAN SEHC rhkifnaswdid G QAQD K slf GM I KNTYEMNR EG vlsaykd NA A V I vghvagrffpd P 273
Cdd:PRK14090 10 K LGR E P TF VEL QA F SVMW SEHC ------------ G YSHT K --- KY I RRLPKTGF EG ------- NA G V V ----------- N 56
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 274 QTRE Y A asrepvq I LM K V E T HNHP T AI A P FP GA S TG S GG E IRD EG A T G rg A K P K A GLTGFTV S nlqipgfeqpwevpygk 353
Cdd:PRK14090 57 LDDY Y S ------- I AF K I E S HNHP S AI E P YN GA A TG V GG I IRD VL A M G -- A R P T A IFDSLHM S ----------------- 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 354 pe RI V tal D IMV EG P lgg A AFN N EF G R P ALT G yfrtf E QK I ATPHG eevrgy H K P IMLAGGM G NI R DEH - V QKGEISV G A 432
Cdd:PRK14090 111 -- RI I --- D GII EG I --- A DYG N SI G V P TVG G ----- E LR I SSLYA ------ H N P LVNVLAA G VV R NDM l V DSKASRP G Q 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 433 KLIVL GG PAMLI G LG G GA - AS SMA TG ASSAD L dfa S V Q RDN P EM E R rcq EV I DRCWQLG E RNPISFIH D V GAGG LSN A LP 511
Cdd:PRK14090 172 VIVIF GG ATGRD G IH G AS f AS EDL TG EKATK L --- S I Q VGD P FA E K --- ML I EAFLEMV E EGLVEGAQ D L GAGG VLS A TS 245
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 512 EL IND GG R G GRFE L RA VP ND EP G M S P L EI WCN ESQER YVLSVDAADFETFKA I CERERCPFAV V G E A I EQRQLT V A ds HF 591
Cdd:PRK14090 246 EL VAK GG L G AIVH L DR VP LR EP D M E P W EI LIS ESQER MAVVTSPEKASRILE I AKKHLLFGDI V A E V I DDPIYR V M -- YR 323
410
....*....|....*..
gi 15598958 592 D NKPVDM P LE v LL GK AP 608
Cdd:PRK14090 324 D DLVMEV P VQ - LL AN AP 339
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
690-960
1.70e-19
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 88.61
E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 690 GE AM AMGERT P LALLDAP A S GR M A I G ET V TNL AA -- AR vgkls D I K L S A NWMAAA G H pg E DAR L Y D T V KA V G m E L C PE LG 767
Cdd:cd00396 1 SL AM STDGIN P PLAINPW A G GR L A V G GA V NDI AA mg AR ----- P I A L L A SLSLSN G L -- E VDI L E D V V DG V A - E A C NQ LG 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 768 IT I PV G KD S M S MK T rwqdngedks VTSPV SL I V TGFAP V ADV R QSLT pqlrldkgetdlilidlgr GKN R L G GSIL aqvh 847
Cdd:cd00396 73 VP I VG G HT S V S PG T ---------- MGHKL SL A V FAIGV V EKD R VIDS ------------------- SGA R P G DVLI ---- 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 848 gklgra VPD VD daedlkaffa VIQG L N A D G HIL A Y HD RS DGGL ITSVL E M A F A GHC G V E LN L D A LADSREE -------- L 919
Cdd:cd00396 120 ------ LTG VD ---------- AVLE L V A A G DVH A M HD IT DGGL LGTLP E L A Q A SGV G A E ID L E A IPLDEVV rwlcvehi E 183
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 15598958 920 A A V LF SEEL G AV I Q V REGATPE VL A qf SAA G LDDCV AVIG Q 960
Cdd:cd00396 184 E A L LF NSSG G LL I A V PAEEADA VL L -- LLN G NGIDA AVIG R 222
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
839-960
1.33e-12
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 66.60
E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 839 G GSILAQVH G KL -- G R A VPDVD D AEDLKAFFA V IQG L N A D - G HIL A Y HD RSD GGL ITSVL EMA F A GHC G V E LN LD A -- LA 913
Cdd:pfam02769 16 G AGLSLSRK G LE ds G L A AVQLG D PLLEPTLIY V KLL L A A L g G LVK A M HD ITG GGL AGALA EMA P A SGV G A E ID LD K vp IF 95
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 15598958 914 DSREELAAV L F SE EL G - AVIQ V REGATPE VLA QFSAA GL D dc V AVIG Q 960
Cdd:pfam02769 96 EELMLPLEM L L SE NQ G r GLVV V APEEAEA VLA ILEKE GL E -- A AVIG E 141
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
431-577
1.04e-05
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 48.69
E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 431 G AK L IVL G GPAMLI G LGGG A ASSMAT G ASSAD ldfasvq RDNP E M E RRCQEVI drc WQ L GERNPISFI HDV GA GGL SN AL 510
Cdd:cd02204 135 G DL L YLI G ETKDEL G GSEY A LAYHGL G GGAPP ------- LVDL E R E KALFDAV --- QE L IKEGLVLSA HDV SD GGL AV AL 204
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598958 511 P E LIND GG R G GRFE L RAVPN depgms PL E IWCN ES QE R YVLS V DAADF E T F K A ic E RERC P FA V V G E 577
Cdd:cd02204 205 A E MAFA GG L G AEVD L SKDDA ------ ED E LLFS ES LG R VLVE V KPENE E V F E A -- E EAGV P AT V I G T 263
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1045-1163
2.26e-04
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 42.20
E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1045 VA I L REQ G VNGQ -- VEMAA A FDR AG FAAID V HMS - DILAGR VDLD AFK GL VAC GG FSYG D V L gagegwaksi LFNARARD 1121
Cdd:cd01653 1 VA V L LFP G FEEL el ASPLD A LRE AG AEVDV V SPD g GPVESD VDLD DYD GL ILP GG PGTP D D L ---------- ARDEALLA 70
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 15598958 1122 GFQAFF A RKDSF a LG V C N G C Q MM ---- SNLH E L I P G T E FWPHFVR N 1163
Cdd:cd01653 71 LLREAA A AGKPI - LG I C L G A Q LL vlgv QFHP E A I D G A E AGARLLV N 115
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
873-976
1.30e-03
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 42.46
E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 873 LNAD G H I LAYH D RSD GGL ITS V L EMA FA G HC G V E LN LD A l ADS RE E - LAA -- VLF SE -- E LGAVI q V REGATP E V LA QFS 947
Cdd:cd02203 206 ARET G L I VGIQ D LGA GGL SSA V S EMA AK G GL G A E ID LD K - VPL RE P g MSP we IWI SE sq E RMLLV - V PPEDLE E F LA ICK 283
90 100
....*....|....*....|....*....
gi 15598958 948 AAG L D dc V AVIG QPVNGYEIN L N Y N GE T V 976
Cdd:cd02203 284 KED L E -- A AVIG EVTDDGRLR L Y Y K GE V V 310
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1045-1144
2.02e-03
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 38.72
E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 1045 VA I L REQ G VNGQ -- VEMAA A FDR AG FAAID V HMS - DILAGR VDLD AFK GL VAC GG FSYG D V L gagegwaksi LFNARARD 1121
Cdd:cd03128 1 VA V L LFG G SEEL el ASPLD A LRE AG AEVDV V SPD g GPVESD VDLD DYD GL ILP GG PGTP D D L ---------- AWDEALLA 70
90 100
....*....|....*....|...
gi 15598958 1122 GFQAFF A RKDSF a LG V C N G C Q MM 1144
Cdd:cd03128 71 LLREAA A AGKPV - LG I C L G A Q LL 92
PHA03366
PHA03366 FGAM-synthase; Provisional
488-591
5.16e-03
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 41.16
E-value: 5.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598958 488 Q L GERNPISFI HDV GA GGL SNA L P E LIND GGRG GRFE lra VP ND E P gms PL EIWCN E SQE r Y V LS V DAADFETFKAICER 567
Cdd:PHA03366 862 H L ISEGLVVSG HDV SD GGL IAC L A E MALA GGRG VTIT --- VP AG E D --- PL QFLFS E TPG - V V IE V PPSHLSAVLTRLRS 934
90 100
....*....|....*....|....
gi 15598958 568 ERCPFAVV G EAIEQ rqlt VADSH F 591
Cdd:PHA03366 935 RNIICYPI G TVGPS ---- GPSNT F 954
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
