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Conserved domains on  [gi|15598856|ref|NP_252350|]
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sodium/hydrogen antiporter [Pseudomonas aeruginosa PAO1]

Protein Classification

cation:proton antiporter family protein( domain architecture ID 3846)

cation:proton antiporter family protein functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Na_H_Exchanger super family cl01133
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 62-573 6.86e-100

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


The actual alignment was detected with superfamily member TIGR00831:

Pssm-ID: 470090 [Multi-domain]  Cd Length: 525  Bit Score: 312.97  E-value: 6.86e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    62 AAGALLALPSLGLHIALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHlLIPEIPLAA 141
Cdd:TIGR00831  30 LAGLLLGLAGLLPEVPLDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLN-WILGIPLAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   142 SFALAAVLSPTDALAVSAIT-QGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAAM-TGVFSLVDASLNFLVVAVGGLAI 219
Cdd:TIGR00831 109 ALILGAVLSPTDAVAVLGTFkSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVALgKGVFDPLNAALDFAVVCVGGIAA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   220 GVFLSWSLGRIRAWMIsrgwDDPATHVVLMLLLPFASYMVAEHLGVSGILSAVAAGMMQSWVDLLPR-QTSTRLLNRSVW 298
Cdd:TIGR00831 189 GLAVGYLAYRLLRAKI----DDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYGRDFSmSPTTRLIALDFW 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   299 SMLEFAFNGVVFLLLGLQLPDIMKSVANHHGDLLWRSSLLLAYVA-AITAVLMLIRYGWVYGYWklslrIDRWRGKSPPG 377
Cdd:TIGR00831 265 SVIVFLVNGIIFILIGVQTPGTIFSAWKEILVAPAAVILALFTNAfVIYPVMTYVRFLWTMKPF-----SNRFLKKKPME 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   378 LSgislRRLSALSALSGVRGAVTLAAVLSVPMSLMDGSAFPQRDLIIFIATSVILISLIGATIGLPLLLRGLPASNNGAH 457
Cdd:TIGR00831 340 FG----TRWKHVVSWAGLRGAIPLALALSFPNQLLSGMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFVSEHSER 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   458 ERERREAWRKTAEAAIRALES--EELPQVEGNDAANTSRVAEARAQIMAEYRQSLDTapttdeardqAQALEIADKALRL 535
Cdd:TIGR00831 416 ELEEIIARYIAARSAKFALMKavEQLRIVEPVARELLPELDARIEELRADGEEKIRS----------GMGEKNLRRRARL 485

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 15598856   536 KALRAQRLELYRQRRNNEIDDETLGDILRELDQQESWL 573
Cdd:TIGR00831 486 YVLDAKRSAVVDLRAGGLISQEVLLELMRELDLKEAEL 523
 
Name Accession Description Interval E-value
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
 62-573 6.86e-100

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 312.97  E-value: 6.86e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    62 AAGALLALPSLGLHIALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHlLIPEIPLAA 141
Cdd:TIGR00831  30 LAGLLLGLAGLLPEVPLDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLN-WILGIPLAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   142 SFALAAVLSPTDALAVSAIT-QGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAAM-TGVFSLVDASLNFLVVAVGGLAI 219
Cdd:TIGR00831 109 ALILGAVLSPTDAVAVLGTFkSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVALgKGVFDPLNAALDFAVVCVGGIAA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   220 GVFLSWSLGRIRAWMIsrgwDDPATHVVLMLLLPFASYMVAEHLGVSGILSAVAAGMMQSWVDLLPR-QTSTRLLNRSVW 298
Cdd:TIGR00831 189 GLAVGYLAYRLLRAKI----DDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYGRDFSmSPTTRLIALDFW 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   299 SMLEFAFNGVVFLLLGLQLPDIMKSVANHHGDLLWRSSLLLAYVA-AITAVLMLIRYGWVYGYWklslrIDRWRGKSPPG 377
Cdd:TIGR00831 265 SVIVFLVNGIIFILIGVQTPGTIFSAWKEILVAPAAVILALFTNAfVIYPVMTYVRFLWTMKPF-----SNRFLKKKPME 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   378 LSgislRRLSALSALSGVRGAVTLAAVLSVPMSLMDGSAFPQRDLIIFIATSVILISLIGATIGLPLLLRGLPASNNGAH 457
Cdd:TIGR00831 340 FG----TRWKHVVSWAGLRGAIPLALALSFPNQLLSGMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFVSEHSER 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   458 ERERREAWRKTAEAAIRALES--EELPQVEGNDAANTSRVAEARAQIMAEYRQSLDTapttdeardqAQALEIADKALRL 535
Cdd:TIGR00831 416 ELEEIIARYIAARSAKFALMKavEQLRIVEPVARELLPELDARIEELRADGEEKIRS----------GMGEKNLRRRARL 485

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 15598856   536 KALRAQRLELYRQRRNNEIDDETLGDILRELDQQESWL 573
Cdd:TIGR00831 486 YVLDAKRSAVVDLRAGGLISQEVLLELMRELDLKEAEL 523
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
29-570 1.61e-98

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 308.82  E-value: 1.61e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  29 MQTVYTVLTLLLVVGATRLAAQLLPLPLPLIQIAAGALLalpSLGLHIALDPEL-----FLFLFIPPLLFVDGWRIPKRE 103
Cdd:COG0025   1 MELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILL---GPGLGLELDPELgdlepLLELFLPPLLFEAALNLDLRE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 104 VWRMRWPILMMAFGLVFFTVVGAGYFIHLLIpEIPLAASFALAAVLSPTDALAVSAITQG-RLPKRLMHLLEGEALMNDA 182
Cdd:COG0025  78 LRRNGRPILRLAVVGVLLTTLAVALAAHWLL-GLPLAAALLLGAILAPTDPVAVSPILRRlGVPKRLRTILEGESLLNDA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 183 SGLVAFKFAIAAAMTGVFSLVDASLNFLVVAVGGLAIGVFLSWSLGRIRAWMisrgwDDPATHVVLMLLLPFASYMVAEH 262
Cdd:COG0025 157 TALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRL-----PDPLLEILLTLALPFLAYLLAEA 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 263 LGVSGILSAVAAGMMQSWVDLLPRQTSTRLLNRSVWSMLEFAFNGVVFLLLGLQLPDIMksvanhhgdllwRSSLLLAYV 342
Cdd:COG0025 232 LHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLIL------------LGALGLGGI 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 343 AAITAVLMLIRYGWVYGYWKLSLRIDRWRGKsppglsgislrrlsALSALSGVRGAVTLAAVLSVPmsLMDGSAFPQRDL 422
Cdd:COG0025 300 LLVLLALLVVRPLWVFLSLALRGSRLSWRER--------------LFLSWGGPRGIVSLALALSLP--LHGGAGFPGRDL 363

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 423 IIFIATSVILISLIGATIGLPLLLRGLPASNNGAHERERReawrktaEAAIRALESEELPQVEGNDAANTSRVAEARAQI 502
Cdd:COG0025 364 ILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELE-------AALARAALLELLAAELLADDEEVVLRAARRARR 436

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598856 503 MAEYRQSLDTAPTTDEARDQAQALEIADKALRLKALRAQRLELYRQRRNNEIDDETLGDILRELDQQE 570
Cdd:COG0025 437 RREAAELLSEEAEEELDEDLLRLLLALLRLRLLNALAAARLERLLLRRRVEELLRLLERLLRERELEE 504
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 62-440 8.82e-56

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 192.47  E-value: 8.82e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    62 AAGALLALPSLGL--HIALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHLLIPEIPL 139
Cdd:pfam00999  28 IAGILLGPSGLGLisEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLGLGIPL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   140 AASFALAAVLSPTDALAVSAI--TQGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAAM--TGVFSLVDASLNFLVVAVG 215
Cdd:pfam00999 108 LEALLFGAILSATSPVVVLAIlkELGRVPERLGTLLLGESVLNDGVAVVLLAVLLALAQgvGGGSDLGWLLLIFLVVAVG 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   216 GLAIGVFLSWSLGRIRAWMisrgWDDPATHVVLMLLLPFASYMVAEHLGVSGILSAVAAGMMQSWVDLLPRqtstrlLNR 295
Cdd:pfam00999 188 GLLLGLLIGWLLRLITRFT----DDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANK------LSE 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   296 SVWSMLEFAFNGVVFLLLGLQLPDimkSVANHHgdllwrsslLLAYVAAITAVLMLIRYGWVYGYWKlslridrwrgksp 375
Cdd:pfam00999 258 KLEPFGYGLFNPLFFVLVGLSLDL---SSLLLS---------VWILVLLALVAILLGRFLGVFLLLR------------- 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598856   376 pgLSGISLRRLSALSALSGVRGAVTLAAVLSVPMSLmdgsaFPQRDLiIFIATSVILISLIGATI 440
Cdd:pfam00999 313 --LLGLSLREALIIGFGGLQRGAVSLALAAIGPLLG-----IIAREL-YPLLIVVVLFTVLVQGI 369
PRK05326 PRK05326
potassium/proton antiporter;
109-277 1.76e-08

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 57.13  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  109 WPILMMAFGLVFFTVVGAGYFIHLLIpEIPLAASFALAAVLSPTDALAVSAITQGR---LPKRLMHLLEGEALMNDASGL 185
Cdd:PRK05326  88 GPALSLATLGVLITAGLTGLFAHWLL-GLDWLEGLLLGAIVGSTDAAAVFSLLRGKglnLKERVASTLEIESGSNDPMAV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  186 ---VAFKFAIAAAMTGVFSLVdaSLNFLVVAVGGLAIGVFLSWSLgrirAWMISR-GWDDPATHVVLMLLLPFASYMVAE 261
Cdd:PRK05326 167 fltITLIELITGGETGLSWGF--LLLFLQQFGLGALIGLLGGWLL----VQLLNRiALPAEGLYPILVLAGALLIFALTA 240

                        170
                 ....*....|....*.
gi 15598856  262 HLGVSGILSAVAAGMM 277
Cdd:PRK05326 241 ALGGSGFLAVYLAGLV 256
 
Name Accession Description Interval E-value
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
 62-573 6.86e-100

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 312.97  E-value: 6.86e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    62 AAGALLALPSLGLHIALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHlLIPEIPLAA 141
Cdd:TIGR00831  30 LAGLLLGLAGLLPEVPLDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLN-WILGIPLAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   142 SFALAAVLSPTDALAVSAIT-QGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAAM-TGVFSLVDASLNFLVVAVGGLAI 219
Cdd:TIGR00831 109 ALILGAVLSPTDAVAVLGTFkSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVALgKGVFDPLNAALDFAVVCVGGIAA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   220 GVFLSWSLGRIRAWMIsrgwDDPATHVVLMLLLPFASYMVAEHLGVSGILSAVAAGMMQSWVDLLPR-QTSTRLLNRSVW 298
Cdd:TIGR00831 189 GLAVGYLAYRLLRAKI----DDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYGRDFSmSPTTRLIALDFW 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   299 SMLEFAFNGVVFLLLGLQLPDIMKSVANHHGDLLWRSSLLLAYVA-AITAVLMLIRYGWVYGYWklslrIDRWRGKSPPG 377
Cdd:TIGR00831 265 SVIVFLVNGIIFILIGVQTPGTIFSAWKEILVAPAAVILALFTNAfVIYPVMTYVRFLWTMKPF-----SNRFLKKKPME 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   378 LSgislRRLSALSALSGVRGAVTLAAVLSVPMSLMDGSAFPQRDLIIFIATSVILISLIGATIGLPLLLRGLPASNNGAH 457
Cdd:TIGR00831 340 FG----TRWKHVVSWAGLRGAIPLALALSFPNQLLSGMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFVSEHSER 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   458 ERERREAWRKTAEAAIRALES--EELPQVEGNDAANTSRVAEARAQIMAEYRQSLDTapttdeardqAQALEIADKALRL 535
Cdd:TIGR00831 416 ELEEIIARYIAARSAKFALMKavEQLRIVEPVARELLPELDARIEELRADGEEKIRS----------GMGEKNLRRRARL 485

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 15598856   536 KALRAQRLELYRQRRNNEIDDETLGDILRELDQQESWL 573
Cdd:TIGR00831 486 YVLDAKRSAVVDLRAGGLISQEVLLELMRELDLKEAEL 523
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
29-570 1.61e-98

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 308.82  E-value: 1.61e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  29 MQTVYTVLTLLLVVGATRLAAQLLPLPLPLIQIAAGALLalpSLGLHIALDPEL-----FLFLFIPPLLFVDGWRIPKRE 103
Cdd:COG0025   1 MELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILL---GPGLGLELDPELgdlepLLELFLPPLLFEAALNLDLRE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 104 VWRMRWPILMMAFGLVFFTVVGAGYFIHLLIpEIPLAASFALAAVLSPTDALAVSAITQG-RLPKRLMHLLEGEALMNDA 182
Cdd:COG0025  78 LRRNGRPILRLAVVGVLLTTLAVALAAHWLL-GLPLAAALLLGAILAPTDPVAVSPILRRlGVPKRLRTILEGESLLNDA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 183 SGLVAFKFAIAAAMTGVFSLVDASLNFLVVAVGGLAIGVFLSWSLGRIRAWMisrgwDDPATHVVLMLLLPFASYMVAEH 262
Cdd:COG0025 157 TALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRL-----PDPLLEILLTLALPFLAYLLAEA 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 263 LGVSGILSAVAAGMMQSWVDLLPRQTSTRLLNRSVWSMLEFAFNGVVFLLLGLQLPDIMksvanhhgdllwRSSLLLAYV 342
Cdd:COG0025 232 LHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLIL------------LGALGLGGI 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 343 AAITAVLMLIRYGWVYGYWKLSLRIDRWRGKsppglsgislrrlsALSALSGVRGAVTLAAVLSVPmsLMDGSAFPQRDL 422
Cdd:COG0025 300 LLVLLALLVVRPLWVFLSLALRGSRLSWRER--------------LFLSWGGPRGIVSLALALSLP--LHGGAGFPGRDL 363

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 423 IIFIATSVILISLIGATIGLPLLLRGLPASNNGAHERERReawrktaEAAIRALESEELPQVEGNDAANTSRVAEARAQI 502
Cdd:COG0025 364 ILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELE-------AALARAALLELLAAELLADDEEVVLRAARRARR 436

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598856 503 MAEYRQSLDTAPTTDEARDQAQALEIADKALRLKALRAQRLELYRQRRNNEIDDETLGDILRELDQQE 570
Cdd:COG0025 437 RREAAELLSEEAEEELDEDLLRLLLALLRLRLLNALAAARLERLLLRRRVEELLRLLERLLRERELEE 504
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 62-440 8.82e-56

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 192.47  E-value: 8.82e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    62 AAGALLALPSLGL--HIALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHLLIPEIPL 139
Cdd:pfam00999  28 IAGILLGPSGLGLisEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLGLGIPL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   140 AASFALAAVLSPTDALAVSAI--TQGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAAM--TGVFSLVDASLNFLVVAVG 215
Cdd:pfam00999 108 LEALLFGAILSATSPVVVLAIlkELGRVPERLGTLLLGESVLNDGVAVVLLAVLLALAQgvGGGSDLGWLLLIFLVVAVG 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   216 GLAIGVFLSWSLGRIRAWMisrgWDDPATHVVLMLLLPFASYMVAEHLGVSGILSAVAAGMMQSWVDLLPRqtstrlLNR 295
Cdd:pfam00999 188 GLLLGLLIGWLLRLITRFT----DDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANK------LSE 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   296 SVWSMLEFAFNGVVFLLLGLQLPDimkSVANHHgdllwrsslLLAYVAAITAVLMLIRYGWVYGYWKlslridrwrgksp 375
Cdd:pfam00999 258 KLEPFGYGLFNPLFFVLVGLSLDL---SSLLLS---------VWILVLLALVAILLGRFLGVFLLLR------------- 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598856   376 pgLSGISLRRLSALSALSGVRGAVTLAAVLSVPMSLmdgsaFPQRDLiIFIATSVILISLIGATI 440
Cdd:pfam00999 313 --LLGLSLREALIIGFGGLQRGAVSLALAAIGPLLG-----IIAREL-YPLLIVVVLFTVLVQGI 369
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
 64-433 1.06e-16

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 83.29  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856    64 GALLALPSLGLH----IALDPELFLFLFIPPLLFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAG---YFIHLL--- 133
Cdd:TIGR00840  45 GLLVGGIIKASPhidpPTLDSSYFFLYLLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTLINAFVIGlslYGICLIggf 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   134 -IPEIPLAASFALAAVLSPTDALAVSAI-TQGRLPKRLMHLLEGEALMNDASGLVAFKFAIAAA-----MTGVFSLVDAS 206
Cdd:TIGR00840 125 gSIDIGLLDNLLFGSLISAVDPVAVLAVfEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKFHktadePVTIVDVFEGC 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   207 LNFLVVAVGGLAIGVFLSWSLGRIRAWMISRGWDDPathvVLMLLLPFASYMVAEHLGVSGILSAVAAGM-MQSWVDL-L 284
Cdd:TIGR00840 205 ASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP----LFVFLISYLSYLFAETLHLSGILALIFCGItMKKYVEAnM 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   285 PRQTSTRLlnRSVWSMLEFAFNGVVFLLLGLQLPDimksvANHHGDllWrsslllaYVAAITAVLMLIrygwvygywkls 364
Cdd:TIGR00840 281 SRRSQTTI--KYFMKMLSSLSETLIFIFLGVSLVT-----ENHEWN--W-------AFVVATLSFCVI------------ 332

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598856   365 lridrWRGKSPPGLSGIS-LRRLSALS-------ALSGVRGAVTLAAVLsvpmsLMDGSAFPQRDLiiFIATSVILI 433
Cdd:TIGR00840 333 -----YRVLGVRTLSWITnEFRPVEIPykdqlviFYAGLRGAVAFALAL-----LLDEKIFPYKFL--FVTTTLVVV 397
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 92-277 3.16e-12

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 68.98  E-value: 3.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  92 LFVDGWRIPKREVWRMRWPILMMAFGLVFFTVVGAGYFIHLLIPeIPLAASFALAAVLSPTDALAVSAITQGR---LPKR 168
Cdd:COG3263  71 LFDGGLRTRWSSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLG-LSWLEGLLLGAIVSSTDAAAVFSILRSKglnLKER 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 169 LMHLLEGEALMNDASGLVAFKFAIAAAMTGVFSLVDASLNFLVVAVGGLAIGVFLSWSLgrirAWMISR-GWDDPATHVV 247
Cdd:COG3263 150 LASTLELESGSNDPMAVFLTIALIELITGGGASGWSLLLLFVLQMGLGALVGLAGGWLG----VWLLNRiRLPAEGLYPV 225

                       170       180       190
                ....*....|....*....|....*....|
gi 15598856 248 LMLLLPFASYMVAEHLGVSGILSAVAAGMM 277
Cdd:COG3263 226 LVLALALLAFGATALLGGSGFLAVYLAGLV 255
PRK05326 PRK05326
potassium/proton antiporter;
109-277 1.76e-08

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 57.13  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  109 WPILMMAFGLVFFTVVGAGYFIHLLIpEIPLAASFALAAVLSPTDALAVSAITQGR---LPKRLMHLLEGEALMNDASGL 185
Cdd:PRK05326  88 GPALSLATLGVLITAGLTGLFAHWLL-GLDWLEGLLLGAIVGSTDAAAVFSLLRGKglnLKERVASTLEIESGSNDPMAV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  186 ---VAFKFAIAAAMTGVFSLVdaSLNFLVVAVGGLAIGVFLSWSLgrirAWMISR-GWDDPATHVVLMLLLPFASYMVAE 261
Cdd:PRK05326 167 fltITLIELITGGETGLSWGF--LLLFLQQFGLGALIGLLGGWLL----VQLLNRiALPAEGLYPILVLAGALLIFALTA 240

                        170
                 ....*....|....*.
gi 15598856  262 HLGVSGILSAVAAGMM 277
Cdd:PRK05326 241 ALGGSGFLAVYLAGLV 256
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 91-277 2.05e-08

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 56.69  E-value: 2.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  91 LLFVDGWRIPKREVWRMRWPILMMA---FGLVFFTVVGAGYFIHLlipeiPLAASFALAAVLSPTDALAVSAITQ--GRL 165
Cdd:COG0475  66 LLFLIGLELDLKRLRKMGRRALGIGllqVLLPFLLGFLLALLLGL-----SLAAALFLGAALAATSTAIVLKVLKelGLL 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 166 PKRLMHLLEGEALMNDASGLVAFKFAIAAAMTGVFSLVDASLnfLVVAVGGLAIGVFLSWSLGRIRAWMISRgWDDPATH 245
Cdd:COG0475 141 KTPLGQLILGVALFDDIAAILLLALVPALAGGGSVAGSLLLA--LLKALLFLALLLLVGRYLLRRLFRLVAR-TRSRELF 217

                       170       180       190
                ....*....|....*....|....*....|..
gi 15598856 246 VVLMLLLPFASYMVAEHLGVSGILSAVAAGMM 277
Cdd:COG0475 218 LLFALLLVLLAAALAELLGLSAALGAFLAGLV 249
V-ATPase_G_2 pfam16999
Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from ...
 458-543 1.38e-05

Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from several bacterial and archaeal species. Subunit G is a component of the peripheral stalk of the ATPase complex


Pssm-ID: 339878 [Multi-domain]  Cd Length: 104  Bit Score: 44.35  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856   458 ERE-----RREAWRKTAEAAIRALESEelpqvegndAANTSRVAEARAQIM-AEYRQSLD--TAPTTDEARDQAQAleia 529
Cdd:pfam16999  12 EREaaldqQIEAARKEAEREVEAAEAE---------AARILREAEAKAKALqAEYRQELAaeTARIREEARARAEA---- 78

                          90
                  ....*....|....
gi 15598856   530 dKALRLKALRAQRL 543
Cdd:pfam16999  79 -EAQAVRTRAEGRL 91
PRK09039 PRK09039
peptidoglycan -binding protein;
457-547 1.34e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.10  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  457 HERERREAWRKTAEAAIRALE------SEELPQVEGNDAANTSRVAEARAQIMAEYRQ--SLDTAPTTDEARDQAQALEI 528
Cdd:PRK09039  95 AERSRLQALLAELAGAGAAAEgragelAQELDSEKQVSARALAQVELLNQQIAALRRQlaALEAALDASEKRDRESQAKI 174

                         90       100
                 ....*....|....*....|..
gi 15598856  529 ADKALRLK---ALRAQRLELYR 547
Cdd:PRK09039 175 ADLGRRLNvalAQRVQELNRYR 196
PDCD5 COG2118
DNA-binding TFAR19-related protein, PDSD5 family [General function prediction only];
459-566 4.20e-03

DNA-binding TFAR19-related protein, PDSD5 family [General function prediction only];


Pssm-ID: 441721 [Multi-domain]  Cd Length: 114  Bit Score: 37.16  E-value: 4.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856 459 RERREAWRKTAEAAIRALESEELPQvegndaantsrvaEARAQIMAEYRQSLdtaptTDEARDQAQALEIADKALrLKAL 538
Cdd:COG2118  13 RRKLEELQRQQAAQQAAEAQEQAQQ-------------QAEAQKQAILRQIL-----TPEARERLNNVKLVKPEF-AEQV 73

                        90       100
                ....*....|....*....|....*....
gi 15598856 539 RAQRLELYRQRR-NNEIDDETLGDILREL 566
Cdd:COG2118  74 EQQLIQLAQSGRlQGPIDDEQLKELLREL 102
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
454-580 8.99e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 8.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598856  454 NGAHE-----RERREAWRKTAEAAIRALESEElpQVEGNDAANTSRVAEARAQIMAEYRQSLDTApttDEARDQAQAlEI 528
Cdd:COG4913  238 ERAHEaledaREQIELLEPIRELAERYAAARE--RLAELEYLRAALRLWFAQRRLELLEAELEEL---RAELARLEA-EL 311

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15598856  529 ADKALRLKALRAQRLELYRQRRNNeiDDETLGDILRELDQQESWLTNRFARW 580
Cdd:COG4913  312 ERLEARLDALREELDELEAQIRGN--GGDRLEQLEREIERLERELEERERRR 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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