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Conserved domains on  [gi|15598306|ref|NP_251800|]
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hypothetical protein PA3110 [Pseudomonas aeruginosa PAO1]

Protein Classification

SPOR domain-containing protein( domain architecture ID 11459733)

SPOR domain-containing protein similar to Bacillus subtilis stage II sporulation protein B and Escherichia coli cell division proteins FtsN, DamX, and DedD

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DedD COG3147
Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, ...
 142-215 1.07e-21

Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442381 [Multi-domain]  Cd Length: 140  Bit Score: 86.75  E-value: 1.07e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598306 142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSFD----GMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVVRFQ 215
Cdd:COG3147  63 GGGWVVQLGAFSNEDNAKELVAKLRAAGYPAYTEPVTtgggTLYRVRVGPFASRAEAEAALAKLKKLTGLKGFVVRYK 140
FtsN COG3087
Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];
18-213 8.51e-11

Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442321 [Multi-domain]  Cd Length: 198  Bit Score: 59.25  E-value: 8.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  18 LIALAVIFLPMLFTREDESRQVVVEAPPRPQSPAMPSVEVQPTEVPELQPGEEGIAPEIVEEGSPAAAGQPSQPIGGLPA 97
Cdd:COG3087   2 ETALAAILLAAAALLLELSAEAAAAASDNLRLAAGSAAAPALAEDALVASAAKAGLAETGAKAGAILAAAALAALNAAAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  98 TPPATQPPAQAQAPAASlppsQPQPPAAPPSPPPAEKRLDANNLPQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSF 177
Cdd:COG3087  82 ALAAASAAAAAAAAPAA----AAAEAAAAPAGMAKKEAAAAPAAKKPYYVQVGAFRSRANAERLRARLALLGLEARVVEV 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15598306 178 D----GMNRVFVGPVIQRAEADRLRDQLsKQQKLNGFVVR 213
Cdd:COG3087 158 EvgggTWYRVRVGPFSSRAEAEKAREKL-KAAGIDALVVR 196
 
Name Accession Description Interval E-value
DedD COG3147
Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, ...
 142-215 1.07e-21

Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442381 [Multi-domain]  Cd Length: 140  Bit Score: 86.75  E-value: 1.07e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598306 142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSFD----GMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVVRFQ 215
Cdd:COG3147  63 GGGWVVQLGAFSNEDNAKELVAKLRAAGYPAYTEPVTtgggTLYRVRVGPFASRAEAEAALAKLKKLTGLKGFVVRYK 140
SPOR pfam05036
SPOR domain; Bacterial SPOR domains bind peptidoglycan (PG) and target proteins to the cell ...
 142-213 2.50e-16

SPOR domain; Bacterial SPOR domains bind peptidoglycan (PG) and target proteins to the cell division site by binding to denuded glycan strands that lack stem peptides. This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM. This domain is involved in binding peptidoglycan. Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats. FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localizes to the septum ring complex.


Pssm-ID: 461531 [Multi-domain]  Cd Length: 76  Bit Score: 70.85  E-value: 2.50e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598306   142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSF---DGMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVVR 213
Cdd:pfam05036   2 SGGYYVQLGAFSNEANAEALAAKLRAKGFAAYVAVTskgGGLYRVRVGPFASREEARAALKKLKALAGLSPFVVK 76
FtsN COG3087
Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];
18-213 8.51e-11

Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442321 [Multi-domain]  Cd Length: 198  Bit Score: 59.25  E-value: 8.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  18 LIALAVIFLPMLFTREDESRQVVVEAPPRPQSPAMPSVEVQPTEVPELQPGEEGIAPEIVEEGSPAAAGQPSQPIGGLPA 97
Cdd:COG3087   2 ETALAAILLAAAALLLELSAEAAAAASDNLRLAAGSAAAPALAEDALVASAAKAGLAETGAKAGAILAAAALAALNAAAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  98 TPPATQPPAQAQAPAASlppsQPQPPAAPPSPPPAEKRLDANNLPQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSF 177
Cdd:COG3087  82 ALAAASAAAAAAAAPAA----AAAEAAAAPAGMAKKEAAAAPAAKKPYYVQVGAFRSRANAERLRARLALLGLEARVVEV 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15598306 178 D----GMNRVFVGPVIQRAEADRLRDQLsKQQKLNGFVVR 213
Cdd:COG3087 158 EvgggTWYRVRVGPFSSRAEAEKAREKL-KAAGIDALVVR 196
PRK10672 PRK10672
endolytic peptidoglycan transglycosylase RlpA;
147-212 1.60e-04

endolytic peptidoglycan transglycosylase RlpA;


Pssm-ID: 236733 [Multi-domain]  Cd Length: 361  Bit Score: 41.97  E-value: 1.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598306  147 VQLASLSNRARAEELQKTLRSQ-GYNAYIRSFDGMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVV 212
Cdd:PRK10672 292 VQVGAVSDQQRAQQWQQSLSQRfGVPGRVTQNGAVYRVQLGPFASRQQASALQQRLQTEAQQQSFIT 358
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 145-203 4.16e-04

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 40.45  E-value: 4.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598306   145 WSVQLASLSNRARAEELQKTLRSQGYNAYIRSFDG--MNRVFVGPVIQRAEADRLRDQLSK 203
Cdd:TIGR02223 228 AALQCGAYANKEQAESVRAKLAFLGISSKITTTDGgkWYRVVSGPYKNKDDAEKDLNKLKV 288
PRK11633 PRK11633
cell division protein DedD; Provisional
 11-213 1.25e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 38.83  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306   11 RIVGALVLIALAVIFLPMLFT-----REDE--SRQVVVEAPPRPQSPAMPSVE----VQPTE--VPELQPGEEG---IAP 74
Cdd:PRK11633   8 RLVGTIVLVALGVIVLPGLLDgqkkhYQDEfaAIPLVPKPGDRDEPDMMPAATqalpTQPPEgaAEAVRAGDAAapsLDP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306   75 EIV--EEGSPAAAGQPSQPIGGLPATPPATQPPAQAQAPAASLPPSQPQPPAAPPSPPPAekrldannlpQSWSVQLASL 152
Cdd:PRK11633  88 ATVapPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAPTG----------KAYVVQLGAL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598306  153 SNRARAEELQKTLRSQGYNAYI---RSFDG-MNRVFVGPviqRAEADRLRDQLSKQQKLNGF--VVR 213
Cdd:PRK11633 158 KNADKVNEIVAKLRLSGYRVYTvpsTPVQGkITRIYVGP---DASKDKLKGSLGELKQLSGLsgVVM 221
 
Name Accession Description Interval E-value
DedD COG3147
Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, ...
 142-215 1.07e-21

Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442381 [Multi-domain]  Cd Length: 140  Bit Score: 86.75  E-value: 1.07e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15598306 142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSFD----GMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVVRFQ 215
Cdd:COG3147  63 GGGWVVQLGAFSNEDNAKELVAKLRAAGYPAYTEPVTtgggTLYRVRVGPFASRAEAEAALAKLKKLTGLKGFVVRYK 140
SPOR pfam05036
SPOR domain; Bacterial SPOR domains bind peptidoglycan (PG) and target proteins to the cell ...
 142-213 2.50e-16

SPOR domain; Bacterial SPOR domains bind peptidoglycan (PG) and target proteins to the cell division site by binding to denuded glycan strands that lack stem peptides. This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM. This domain is involved in binding peptidoglycan. Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats. FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localizes to the septum ring complex.


Pssm-ID: 461531 [Multi-domain]  Cd Length: 76  Bit Score: 70.85  E-value: 2.50e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15598306   142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSF---DGMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVVR 213
Cdd:pfam05036   2 SGGYYVQLGAFSNEANAEALAAKLRAKGFAAYVAVTskgGGLYRVRVGPFASREEARAALKKLKALAGLSPFVVK 76
FtsN COG3087
Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];
18-213 8.51e-11

Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442321 [Multi-domain]  Cd Length: 198  Bit Score: 59.25  E-value: 8.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  18 LIALAVIFLPMLFTREDESRQVVVEAPPRPQSPAMPSVEVQPTEVPELQPGEEGIAPEIVEEGSPAAAGQPSQPIGGLPA 97
Cdd:COG3087   2 ETALAAILLAAAALLLELSAEAAAAASDNLRLAAGSAAAPALAEDALVASAAKAGLAETGAKAGAILAAAALAALNAAAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  98 TPPATQPPAQAQAPAASlppsQPQPPAAPPSPPPAEKRLDANNLPQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSF 177
Cdd:COG3087  82 ALAAASAAAAAAAAPAA----AAAEAAAAPAGMAKKEAAAAPAAKKPYYVQVGAFRSRANAERLRARLALLGLEARVVEV 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15598306 178 D----GMNRVFVGPVIQRAEADRLRDQLsKQQKLNGFVVR 213
Cdd:COG3087 158 EvgggTWYRVRVGPFSSRAEAEKAREKL-KAAGIDALVVR 196
PRK10672 PRK10672
endolytic peptidoglycan transglycosylase RlpA;
147-212 1.60e-04

endolytic peptidoglycan transglycosylase RlpA;


Pssm-ID: 236733 [Multi-domain]  Cd Length: 361  Bit Score: 41.97  E-value: 1.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598306  147 VQLASLSNRARAEELQKTLRSQ-GYNAYIRSFDGMNRVFVGPVIQRAEADRLRDQLSKQQKLNGFVV 212
Cdd:PRK10672 292 VQVGAVSDQQRAQQWQQSLSQRfGVPGRVTQNGAVYRVQLGPFASRQQASALQQRLQTEAQQQSFIT 358
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 145-203 4.16e-04

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 40.45  E-value: 4.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598306   145 WSVQLASLSNRARAEELQKTLRSQGYNAYIRSFDG--MNRVFVGPVIQRAEADRLRDQLSK 203
Cdd:TIGR02223 228 AALQCGAYANKEQAESVRAKLAFLGISSKITTTDGgkWYRVVSGPYKNKDDAEKDLNKLKV 288
PRK11633 PRK11633
cell division protein DedD; Provisional
 11-213 1.25e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 38.83  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306   11 RIVGALVLIALAVIFLPMLFT-----REDE--SRQVVVEAPPRPQSPAMPSVE----VQPTE--VPELQPGEEG---IAP 74
Cdd:PRK11633   8 RLVGTIVLVALGVIVLPGLLDgqkkhYQDEfaAIPLVPKPGDRDEPDMMPAATqalpTQPPEgaAEAVRAGDAAapsLDP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306   75 EIV--EEGSPAAAGQPSQPIGGLPATPPATQPPAQAQAPAASLPPSQPQPPAAPPSPPPAekrldannlpQSWSVQLASL 152
Cdd:PRK11633  88 ATVapPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAPTG----------KAYVVQLGAL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598306  153 SNRARAEELQKTLRSQGYNAYI---RSFDG-MNRVFVGPviqRAEADRLRDQLSKQQKLNGF--VVR 213
Cdd:PRK11633 158 KNADKVNEIVAKLRLSGYRVYTvpsTPVQGkITRIYVGP---DASKDKLKGSLGELKQLSGLsgVVM 221
PRK10927 PRK10927
cell division protein FtsN;
145-195 1.59e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 38.89  E-value: 1.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15598306  145 WSVQLASLSNRARAEELQKTLRSQGYNAYIRSFDGMNRVFVGPVIQRAEAD 195
Cdd:PRK10927 248 WMVQCGSFRGAEQAETVRAQLAFEGFDSKITTNNGWNRVVIGPVKGKENAD 298
PRK12757 PRK12757
cell division protein FtsN; Provisional
 142-201 4.29e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 37.33  E-value: 4.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598306  142 PQSWSVQLASLSNRARAEELQKTLRSQGYNAYIRSFDGMNRVFVGPVIQRAEADRLRDQL 201
Cdd:PRK12757 182 EQRWMVQCGSFKGTEQAESVRAQLAFAGIESRITTGGGWNRVVLGPYNSKAAADKMLQRL 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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