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Conserved domains on  [gi|15598249|ref|NP_251743|]
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hydrolase [Pseudomonas aeruginosa PAO1]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-332 2.33e-43

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.00  E-value: 2.33e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  52 LSMAYLDVAPkkaNGRTILLMHGKNFCAGTWERTIDVLADaGYRVIAVDQVGFCKSSKPAHyQYSFQQLAANTHALLERL 131
Cdd:COG0596  12 VRLHYREAGP---DGPPVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAG-GYTLDDLADDLAALLDAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 132 GVARASVIGHSMGGMLATRYALLYPRQVERLVLVNpigledwkalgvpwrsvddwyrrdlqtsaEGIRQYQQATYYAGEW 211
Cdd:COG0596  87 GLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-----------------------------EVLAALAEPLRRPGLA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 212 RPEFDRWVqmqAGMYRGKGREsvawnsaltydmiftqpvvyELDRLQMPTLLLIGEKDntaigkDAAPAElkarlgnyaq 291
Cdd:COG0596 138 PEALAALL---RALARTDLRE--------------------RLARITVPTLVIWGEKD------PIVPPA---------- 178

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15598249 292 LGKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLEGLQ 332
Cdd:COG0596 179 LARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLA 219
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-332 2.33e-43

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.00  E-value: 2.33e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  52 LSMAYLDVAPkkaNGRTILLMHGKNFCAGTWERTIDVLADaGYRVIAVDQVGFCKSSKPAHyQYSFQQLAANTHALLERL 131
Cdd:COG0596  12 VRLHYREAGP---DGPPVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAG-GYTLDDLADDLAALLDAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 132 GVARASVIGHSMGGMLATRYALLYPRQVERLVLVNpigledwkalgvpwrsvddwyrrdlqtsaEGIRQYQQATYYAGEW 211
Cdd:COG0596  87 GLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-----------------------------EVLAALAEPLRRPGLA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 212 RPEFDRWVqmqAGMYRGKGREsvawnsaltydmiftqpvvyELDRLQMPTLLLIGEKDntaigkDAAPAElkarlgnyaq 291
Cdd:COG0596 138 PEALAALL---RALARTDLRE--------------------RLARITVPTLVIWGEKD------PIVPPA---------- 178

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15598249 292 LGKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLEGLQ 332
Cdd:COG0596 179 LARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 68-320 2.80e-26

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 104.51  E-value: 2.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    68 TILLMHGknFCAGT--WERTIDVLADAGYRVIAVDQVGFCKSSKPAH-YQYSFQQLAANTHALLERLGVARASVIGHSMG 144
Cdd:pfam00561   2 PVLLLHG--LPGSSdlWRKLAPALARDGFRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   145 GMLATRYALLYPRQVERLVLVNPIglEDWKALGVPWRSVDDWYRRDLQTSAEGIRQYQQATYYAGEWRPEFDRWVQMQAG 224
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGAL--DPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   225 MYRGKGRESVAWNSALTYDM--------IFTQPVVYELDRLQMPTLLLIGEKDNTaigkdaAPAELKARLgnyaqlgkda 296
Cdd:pfam00561 158 PLLNKRFPSGDYALAKSLVTgallfietWSTELRAKFLGRLDEPTLIIWGDQDPL------VPPQALEKL---------- 221

                         250       260
                  ....*....|....*....|....
gi 15598249   297 ARRIPQATLVEFPDLGHTPQIQAP 320
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 29-169 4.52e-21

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 91.57  E-value: 4.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   29 ERLEGF-DYAYPVHYLDFT-SQGQPLSMAYLDVAPkkANGRTILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCK 106
Cdd:PRK00870   9 SRFENLpDYPFAPHYVDVDdGDGGPLRMHYVDEGP--ADGPPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGR 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598249  107 SSKPAHYQ-YSFQQLAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVN---PIG 169
Cdd:PRK00870  87 SDKPTRREdYTYARHVEWMRSWFEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANtglPTG 153
pro_imino_pep_2 TIGR01250
proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a ...
 66-329 7.80e-11

proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase


Pssm-ID: 188121 [Multi-domain]  Cd Length: 289  Bit Score: 62.01  E-value: 7.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    66 GRTILLMHGKNfcAGT---WERTIDVLADAGYRVIAVDQVGFCKSSKPAH-------YQYSFQQLAAnthaLLERLGVAR 135
Cdd:TIGR01250  25 KIKLLLLHGGP--GMSheyLENLRELLKEEGREVIMYDQLGCGYSDQPDDsdeelwtIDYFVDELEE----VREKLGLDK 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   136 ASVIGHSMGGMLATRYALLYPRQVERLVLVNPIgledwkaLGVPWRSVDDWYRRDL--QTSAEGIRQYQQATYYAGewrP 213
Cdd:TIGR01250  99 FYLLGHSWGGMLAQEYALKYGQHLKGLIISSML-------DSAPEYVKELNRLRKElpPEVRAAIKRCEASGDYDN---P 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   214 EFDRWVQMqagMYRGKGRESVAWNSALTYDMIFTQPVVYEL-------------------DRL---QMPTLLLIGEKDNT 271
Cdd:TIGR01250 169 EYQEAVEV---FYHHLLCRLRKWPEALKHLKSGGNTNVYNImqgpneftitgnlkdwditDKLseiKVPTLLTVGEFDTM 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15598249   272 AIgkDAApaelkarlgnyaqlgKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLE 329
Cdd:TIGR01250 246 TP--EAA---------------REMQELIAGSRLVVFPDGSHMTMIEDPEVYFKLLSD 286
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 118-172 2.41e-03

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 39.15  E-value: 2.41e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15598249 118 QQLAAnTHALLERLGvaRASVIGHSMGGMLATRYALLYPRQVERLVLVNPIGLED 172
Cdd:cd12808 175 LTLAA-YDALLDRVG--PCIVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPD 226
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-332 2.33e-43

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 149.00  E-value: 2.33e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  52 LSMAYLDVAPkkaNGRTILLMHGKNFCAGTWERTIDVLADaGYRVIAVDQVGFCKSSKPAHyQYSFQQLAANTHALLERL 131
Cdd:COG0596  12 VRLHYREAGP---DGPPVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAG-GYTLDDLADDLAALLDAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 132 GVARASVIGHSMGGMLATRYALLYPRQVERLVLVNpigledwkalgvpwrsvddwyrrdlqtsaEGIRQYQQATYYAGEW 211
Cdd:COG0596  87 GLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-----------------------------EVLAALAEPLRRPGLA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 212 RPEFDRWVqmqAGMYRGKGREsvawnsaltydmiftqpvvyELDRLQMPTLLLIGEKDntaigkDAAPAElkarlgnyaq 291
Cdd:COG0596 138 PEALAALL---RALARTDLRE--------------------RLARITVPTLVIWGEKD------PIVPPA---------- 178

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15598249 292 LGKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLEGLQ 332
Cdd:COG0596 179 LARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 68-320 2.80e-26

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 104.51  E-value: 2.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    68 TILLMHGknFCAGT--WERTIDVLADAGYRVIAVDQVGFCKSSKPAH-YQYSFQQLAANTHALLERLGVARASVIGHSMG 144
Cdd:pfam00561   2 PVLLLHG--LPGSSdlWRKLAPALARDGFRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   145 GMLATRYALLYPRQVERLVLVNPIglEDWKALGVPWRSVDDWYRRDLQTSAEGIRQYQQATYYAGEWRPEFDRWVQMQAG 224
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGAL--DPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   225 MYRGKGRESVAWNSALTYDM--------IFTQPVVYELDRLQMPTLLLIGEKDNTaigkdaAPAELKARLgnyaqlgkda 296
Cdd:pfam00561 158 PLLNKRFPSGDYALAKSLVTgallfietWSTELRAKFLGRLDEPTLIIWGDQDPL------VPPQALEKL---------- 221

                         250       260
                  ....*....|....*....|....
gi 15598249   297 ARRIPQATLVEFPDLGHTPQIQAP 320
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
52-329 8.78e-23

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 94.30  E-value: 8.78e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  52 LSMAYLDVAPKKANGRTILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLERL 131
Cdd:COG2267  14 LRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDLRAALDAL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 132 GVARAS---VIGHSMGGMLATRYALLYPRQVERLVLVNPIGLEDwKALGVPWRSVDDWYRRDlqtsaegirqyqqatyya 208
Cdd:COG2267  94 RARPGLpvvLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRAD-PLLGPSARWLRALRLAE------------------ 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 209 gewrpefdrwvqmqagmyrgkgresvawnsaltydmiftqpvvyELDRLQMPTLLLIGEKDntaigkdaapaelkaRLGN 288
Cdd:COG2267 155 --------------------------------------------ALARIDVPVLVLHGGAD---------------RVVP 175

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15598249 289 YAQLGKDAARRIPQATLVEFPDLGHTPQIQAP-ERFHQALLE 329
Cdd:COG2267 176 PEAARRLAARLSPDVELVLLPGARHELLNEPArEEVLAAILA 217
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 29-169 4.52e-21

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 91.57  E-value: 4.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   29 ERLEGF-DYAYPVHYLDFT-SQGQPLSMAYLDVAPkkANGRTILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCK 106
Cdd:PRK00870   9 SRFENLpDYPFAPHYVDVDdGDGGPLRMHYVDEGP--ADGPPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGR 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15598249  107 SSKPAHYQ-YSFQQLAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVN---PIG 169
Cdd:PRK00870  87 SDKPTRREdYTYARHVEWMRSWFEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANtglPTG 153
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 68-313 1.29e-19

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 86.11  E-value: 1.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    68 TILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSS-KPAHYQySFQQLAANTHALLERLGVARAS----VIGHS 142
Cdd:pfam12146   6 VVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDgKRGHVP-SFDDYVDDLDTFVDKIREEHPGlplfLLGHS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   143 MGGMLATRYALLYPRQVERLVLVNPigledwkALGVPWRSVDDWYRRDLQTSAEGIRQYQQATYYAGEWRpefDRWVQMQ 222
Cdd:pfam12146  85 MGGLIAALYALRYPDKVDGLILSAP-------ALKIKPYLAPPILKLLAKLLGKLFPRLRVPNNLLPDSL---SRDPEVV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   223 AGMYRG---KGRESVAWNSALTYDMIFTQPvvyELDRLQMPTLLLIGEKDntaigkdaapaelkaRLGNYAqLGKDAARR 299
Cdd:pfam12146 155 AAYAADplvHGGISARTLYELLDAGERLLR---RAAAITVPLLLLHGGAD---------------RVVDPA-GSREFYER 215

                         250
                  ....*....|....*.
gi 15598249   300 IP--QATLVEFPDLGH 313
Cdd:pfam12146 216 AGstDKTLKLYPGLYH 231
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
63-313 5.27e-16

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 76.13  E-value: 5.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  63 KANGRTILLMHGknFCAGTWE-RTI-DVLADAGYRVIAVDQVGFCKSskPAH-YQYSFQQLAANTHALLERL--GVARAS 137
Cdd:COG1647  12 EGGRKGVLLLHG--FTGSPAEmRPLaEALAKAGYTVYAPRLPGHGTS--PEDlLKTTWEDWLEDVEEAYEILkaGYDKVI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 138 VIGHSMGGMLATRYALLYPrQVERLVLVNP-IGLEDWKALGVPWRSvddWYRRDLQTSAEGIRQYQQATYYAgEWRPefd 216
Cdd:COG1647  88 VIGLSMGGLLALLLAARYP-DVAGLVLLSPaLKIDDPSAPLLPLLK---YLARSLRGIGSDIEDPEVAEYAY-DRTP--- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 217 rwVQMQAGMYRgkgresvawnsaltydmiFTQPVVYELDRLQMPTLLLIGEKDNTaIGKDAApAELKARLGNyaqlgkda 296
Cdd:COG1647 160 --LRALAELQR------------------LIREVRRDLPKITAPTLIIQSRKDEV-VPPESA-RYIYERLGS-------- 209

                       250
                ....*....|....*..
gi 15598249 297 arriPQATLVEFPDLGH 313
Cdd:COG1647 210 ----PDKELVWLEDSGH 222
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 53-332 8.07e-15

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 74.60  E-value: 8.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   53 SMAYLDVAPkkANGRTILLMHGKNFCAGTWERTIDVLAdAGYRVIAVDQVGFCKSSKpAHYQYSFQQLAANTHALLERLG 132
Cdd:PRK14875 120 TVRYLRLGE--GDGTPVVLIHGFGGDLNNWLFNHAALA-AGRPVIALDLPGHGASSK-AVGAGSLDELAAAVLAFLDALG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  133 VARASVIGHSMGGMLATRYALLYPRQVERLVLVNPIGLEDwkalgvpwrSVDDWYRRDLqTSAEGIRqyqqatyyagEWR 212
Cdd:PRK14875 196 IERAHLVGHSMGGAVALRLAARAPQRVASLTLIAPAGLGP---------EINGDYIDGF-VAAESRR----------ELK 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  213 PEFDRWV--------QMQAGMYRGKGRESVawNSALTY--DMIF---TQPVVY--ELDRLQMPTLLLIGEKDntAIgkda 277
Cdd:PRK14875 256 PVLELLFadpalvtrQMVEDLLKYKRLDGV--DDALRAlaDALFaggRQRVDLrdRLASLAIPVLVIWGEQD--RI---- 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15598249  278 APAELKARLGnyaqlgkdaarriPQATLVEFPDLGHTPQIQAPERFHQALLEGLQ 332
Cdd:PRK14875 328 IPAAHAQGLP-------------DGVAVHVLPGAGHMPQMEAAADVNRLLAEFLG 369
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 61-173 1.39e-13

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 71.09  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   61 PKKANGRTILLMHGKNFCAGTWERTIDVLAdAGYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLERL----GVARA 136
Cdd:PLN02894 100 DSKEDAPTLVMVHGYGASQGFFFRNFDALA-SRFRVIAIDQLGWGGSSRPDFTCKSTEETEAWFIDSFEEWrkakNLSNF 178

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15598249  137 SVIGHSMGGMLATRYALLYPRQVERLVLVNPIGL----EDW 173
Cdd:PLN02894 179 ILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFssesDDK 219
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 63-167 1.03e-12

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 63.70  E-value: 1.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  63 KANGRTILLMHGkNFC-AGTWERTIDVLADAGYRVIAVDQvgfckSSKPAHYQYSFQQLAANTHALLERLGVARASVIGH 141
Cdd:COG1075   2 AATRYPVVLVHG-LGGsAASWAPLAPRLRAAGYPVYALNY-----PSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLVGH 75

                        90       100
                ....*....|....*....|....*....
gi 15598249 142 SMGGMLAtRYAL---LYPRQVERLVLVNP 167
Cdd:COG1075  76 SMGGLVA-RYYLkrlGGAAKVARVVTLGT 103
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 63-327 3.64e-12

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 67.57  E-value: 3.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    63 KANGRTILLMHGKNFCAGTWERTIDVLADAGyRVIAVD-------QVGFCKSSKPAHYQYSFQQLAANTHALLERLGVAR 135
Cdd:PLN02980 1368 NAEGSVVLFLHGFLGTGEDWIPIMKAISGSA-RCISIDlpghggsKIQNHAKETQTEPTLSVELVADLLYKLIEHITPGK 1446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   136 ASVIGHSMGGMLATRYALLYPRQVERLVLV--NPiGLEDWKALGVpwRSVDDWYRRDLQTSaEGIRQYQQATYYAGEWR- 212
Cdd:PLN02980 1447 VTLVGYSMGARIALYMALRFSDKIEGAVIIsgSP-GLKDEVARKI--RSAKDDSRARMLID-HGLEIFLENWYSGELWKs 1522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   213 ----PEFDrwvQMQAGMYRGKGRESVAwnSALTYDMIFTQPVVYE-LDRLQMPTLLLIGEKDntAIGKDAApAELKARLG 287
Cdd:PLN02980 1523 lrnhPHFN---KIVASRLLHKDVPSLA--KLLSDLSIGRQPSLWEdLKQCDTPLLLVVGEKD--VKFKQIA-QKMYREIG 1594

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 15598249   288 NYAQLGKDAARRIPQatLVEFPDLGHTPQIQAPERFHQAL 327
Cdd:PLN02980 1595 KSKESGNDKGKEIIE--IVEIPNCGHAVHLENPLPVIRAL 1632
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
46-329 5.38e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 61.57  E-value: 5.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  46 TSQGQPLSmAYLDVAPKKANGRTILLMHG-KNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSSKPAHYQYSFQQLAAnT 124
Cdd:COG1506   4 SADGTTLP-GWLYLPADGKKYPVVVYVHGgPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAA-I 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 125 HALLERLGV--ARASVIGHSMGGMLATRYALLYPRQVERLVLVNPIGleDWKALGVPWRSVDDWYRRDLQTSAEGIRQYq 202
Cdd:COG1506  82 DYLAARPYVdpDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVS--DLRSYYGTTREYTERLMGGPWEDPEAYAAR- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 203 qatyyagewrpefdrwvqmqagmyrgkgresvawnSALTYdmiftqpvvyeLDRLQMPTLLLIGEKDNTAigkDAAPAEl 282
Cdd:COG1506 159 -----------------------------------SPLAY-----------ADKLKTPLLLIHGEADDRV---PPEQAE- 188

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 15598249 283 karlgnyaQLGKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLE 329
Cdd:COG1506 189 --------RLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227
pro_imino_pep_2 TIGR01250
proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a ...
 66-329 7.80e-11

proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase


Pssm-ID: 188121 [Multi-domain]  Cd Length: 289  Bit Score: 62.01  E-value: 7.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    66 GRTILLMHGKNfcAGT---WERTIDVLADAGYRVIAVDQVGFCKSSKPAH-------YQYSFQQLAAnthaLLERLGVAR 135
Cdd:TIGR01250  25 KIKLLLLHGGP--GMSheyLENLRELLKEEGREVIMYDQLGCGYSDQPDDsdeelwtIDYFVDELEE----VREKLGLDK 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   136 ASVIGHSMGGMLATRYALLYPRQVERLVLVNPIgledwkaLGVPWRSVDDWYRRDL--QTSAEGIRQYQQATYYAGewrP 213
Cdd:TIGR01250  99 FYLLGHSWGGMLAQEYALKYGQHLKGLIISSML-------DSAPEYVKELNRLRKElpPEVRAAIKRCEASGDYDN---P 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   214 EFDRWVQMqagMYRGKGRESVAWNSALTYDMIFTQPVVYEL-------------------DRL---QMPTLLLIGEKDNT 271
Cdd:TIGR01250 169 EYQEAVEV---FYHHLLCRLRKWPEALKHLKSGGNTNVYNImqgpneftitgnlkdwditDKLseiKVPTLLTVGEFDTM 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15598249   272 AIgkDAApaelkarlgnyaqlgKDAARRIPQATLVEFPDLGHTPQIQAPERFHQALLE 329
Cdd:TIGR01250 246 TP--EAA---------------REMQELIAGSRLVVFPDGSHMTMIEDPEVYFKLLSD 286
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 69-326 3.06e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 59.02  E-value: 3.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    69 ILLMHGknfcAGTWERTIDVLADAGYRVIAVDQVGFCKSSKPAhyqYSFQQLAANTHALLERLGVARASVIGHSMGGMLA 148
Cdd:pfam12697   1 VVLVHG----AGLSAAPLAALLAAGVAVLAPDLPGHGSSSPPP---LDLADLADLAALLDELGAARPVVLVGHSLGGAVA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   149 TRYALLYPRqveRLVLVNPIGL-EDWKALGVPWRSVDDWYRRDLQTSAEGIRqyqQATYYAGEwrPEFDRWVQMQAGMyr 227
Cdd:pfam12697  74 LAAAAAALV---VGVLVAPLAApPGLLAALLALLARLGAALAAPAWLAAESL---ARGFLDDL--PADAEWAAALARL-- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   228 gkgRESVAWNSALTYDMIFTQPVVYeldrlqmptlLLIGEKDNTAigkdaapaelkarlgnyAQLGKDAARRIPQATLVE 307
Cdd:pfam12697 144 ---AALLAALALLPLAAWRDLPVPV----------LVLAEEDRLV-----------------PELAQRLLAALAGARLVV 193

                         250
                  ....*....|....*....
gi 15598249   308 FPDLGHTPQIQaPERFHQA 326
Cdd:pfam12697 194 LPGAGHLPLDD-PEEVAEA 211
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 53-186 3.39e-09

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 57.54  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   53 SMAYLDVAPKKAN--GRTILLMHGKNFCAGTWERTIDVLADAgYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLER 130
Cdd:PLN02679  73 SINYLVKGSPEVTssGPPVLLVHGFGASIPHWRRNIGVLAKN-YTVYAIDLLGFGASDKPPGFSYTMETWAELILDFLEE 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15598249  131 LgVARASV-IGHSMGGMLATRYALLYPRQVER-LVLVNPIGLEDWKALgvpwrsVDDW 186
Cdd:PLN02679 152 V-VQKPTVlIGNSVGSLACVIAASESTRDLVRgLVLLNCAGGMNNKAV------VDDW 202
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 25-167 1.51e-08

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 55.66  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   25 PVYGERLEGFDyayPVHYLDFTSQGQPLSMAY--LDVAPKKANGRTILLMHGknFC--AGTWERTIDVLADaGYRVIAVD 100
Cdd:PLN03084  87 SVQGSGNKAKD---PIFGLKMGAQSQASSDLFrwFCVESGSNNNPPVLLIHG--FPsqAYSYRKVLPVLSK-NYHAIAFD 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  101 QVGFCKSSKPAH---YQYSFQQLAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVNP 167
Cdd:PLN03084 161 WLGFGFSDKPQPgygFNYTLDEYVSSLESLIDELKSDKVSLVVQGYFSPPVVKYASAHPDKIKKLILLNP 230
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 53-173 2.66e-08

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 54.23  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   53 SMAYLDVApkkaNGRTILLMHGKNFCAGTWERTIDVLADAGyRVIAVDQVGFCKSSKPAhYQYSFQQLAANTHALLERLG 132
Cdd:PRK03592  18 RMAYIETG----EGDPIVFLHGNPTSSYLWRNIIPHLAGLG-RCLAPDLIGMGASDKPD-IDYTFADHARYLDAWFDALG 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15598249  133 VARASVIGHSMGGMLATRYALLYPRQVERLV----LVNPIGLEDW 173
Cdd:PRK03592  92 LDDVVLVGHDWGSALGFDWAARHPDRVRGIAfmeaIVRPMTWDDF 136
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 60-167 3.97e-08

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 54.43  E-value: 3.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   60 APKKANGR-TILLMHGKNFCAGTWERTI----DVLADAGYRVIAVDQVGFCKSSKPAHYQYSFQQ-LAANTHALLERLGV 133
Cdd:PLN03087 194 QPKDNKAKeDVLFIHGFISSSAFWTETLfpnfSDAAKSTYRLFAVDLLGFGRSPKPADSLYTLREhLEMIERSVLERYKV 273

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15598249  134 ARASVIGHSMGGMLATRYALLYPRQVERLVLVNP 167
Cdd:PLN03087 274 KSFHIVAHSLGCILALALAVKHPGAVKSLTLLAP 307
MET2 COG2021
Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine ...
 125-165 6.77e-08

Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine O-acetyltransferase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441624 [Multi-domain]  Cd Length: 355  Bit Score: 53.56  E-value: 6.77e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15598249 125 HALLERLGVAR-ASVIGHSMGGMLATRYALLYPRQVERLVLV 165
Cdd:COG2021 118 KRLLDHLGIERlAAVIGGSMGGMQALEWAVSYPDRVRRAIVI 159
PLN02578 PLN02578
hydrolase
 17-169 3.24e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 51.38  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   17 GPALASQAPVYGERL----EGFDY----AYPVHYLdftSQGQplsmayldvapkkanGRTILLMHGKNFCAGTWERTIDV 88
Cdd:PLN02578  47 GSSSASQSVQGLERLpfkkEGYNFwtwrGHKIHYV---VQGE---------------GLPIVLIHGFGASAFHWRYNIPE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   89 LADAgYRVIAVDQVGFCKSSKpAHYQYSFQQLAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVNPI 168
Cdd:PLN02578 109 LAKK-YKVYALDLLGFGWSDK-ALIEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNSA 186


                 .
gi 15598249  169 G 169
Cdd:PLN02578 187 G 187
PRK06765 PRK06765
homoserine O-acetyltransferase; Provisional
 126-210 7.06e-07

homoserine O-acetyltransferase; Provisional


Pssm-ID: 235859 [Multi-domain]  Cd Length: 389  Bit Score: 50.47  E-value: 7.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  126 ALLERLGVARA-SVIGHSMGGMLATRYALLYPRQVERLVLV-----NPIgledWKALGVpwrsvddwyrrdLQTSAEGIR 199
Cdd:PRK06765 152 ELIKSLGIARLhAVMGPSMGGMQAQEWAVHYPHMVERMIGVignpqNDA----WTSVNV------------LQNWAEAIR 215

                         90
                 ....*....|....
gi 15598249  200 ---QYQQATYYAGE 210
Cdd:PRK06765 216 ldpNWKGGKYYGEE 229
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 64-321 3.18e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 48.20  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   64 ANGRTILLMHGKNFCAGTWERTIDVLADAGyRVIAVDQVGFCKSSKP------AHYQYSFQQLAANTHALLERLGVARAS 137
Cdd:PLN02824  27 TSGPALVLVHGFGGNADHWRKNTPVLAKSH-RVYAIDLLGYGYSDKPnprsapPNSFYTFETWGEQLNDFCSDVVGDPAF 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  138 VIGHSMGGMLATRYALLYPRQVERLVLVNpIGLEDWKALGVPW--RSVDDWYRRDLQTSAEGirqyqqATYYAGEWRPEF 215
Cdd:PLN02824 106 VICNSVGGVVGLQAAVDAPELVRGVMLIN-ISLRGLHIKKQPWlgRPFIKAFQNLLRETAVG------KAFFKSVATPET 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  216 DRWVQMQAgmYRGK--------------GRESVAWNSALTYDMIFTQPVVYE-LDRLQMPTLLLIGEKDntaigkDAAPA 280
Cdd:PLN02824 179 VKNILCQC--YHDDsavtdelveailrpGLEPGAVDVFLDFISYSGGPLPEElLPAVKCPVLIAWGEKD------PWEPV 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 15598249  281 ELKARLGNYaqlgkDAARRipqatLVEFPDLGHTPQIQAPE 321
Cdd:PLN02824 251 ELGRAYANF-----DAVED-----FIVLPGVGHCPQDEAPE 281
metX PRK00175
homoserine O-acetyltransferase; Provisional
 125-165 3.82e-06

homoserine O-acetyltransferase; Provisional


Pssm-ID: 234678 [Multi-domain]  Cd Length: 379  Bit Score: 48.26  E-value: 3.82e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 15598249  125 HALLERLGVAR-ASVIGHSMGGMLATRYALLYPRQVERLVLV 165
Cdd:PRK00175 137 ARLLDALGITRlAAVVGGSMGGMQALEWAIDYPDRVRSALVI 178
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 54-166 6.64e-06

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 47.16  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   54 MAYLDvapkKANGRTILLMHGKNFCAGTWERTIDVLADAgYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLERLGV 133
Cdd:PRK03204  26 IHYID----EGTGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGL 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 15598249  134 ARASVIGHSMGGMLATRYALLYPRQVERLVLVN 166
Cdd:PRK03204 101 DRYLSMGQDWGGPISMAVAVERADRVRGVVLGN 133
PRK10673 PRK10673
esterase;
120-212 1.07e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 46.26  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  120 LAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVN--PI------------GLEDWKALGVPWRS-VD 184
Cdd:PRK10673  67 MAQDLLDTLDALQIEKATFIGHSMGGKAVMALTALAPDRIDKLVAIDiaPVdyhvrrhdeifaAINAVSEAGATTRQqAA 146

                         90       100
                 ....*....|....*....|....*...
gi 15598249  185 DWYRRDLQtsAEGIRQYQQATYYAGEWR 212
Cdd:PRK10673 147 AIMRQHLN--EEGVIQFLLKSFVDGEWR 172
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
46-157 5.16e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 43.80  E-value: 5.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  46 TSQGQPLSmAYLDVAPKKANGRTILLMHGknfCAGTWERTIDV---LADAGYRVIAVD----QVGFCKSSKPAHYQYSF- 117
Cdd:COG0412  10 TPDGVTLP-GYLARPAGGGPRPGVVVLHE---IFGLNPHIRDVarrLAAAGYVVLAPDlygrGGPGDDPDEARALMGALd 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15598249 118 -QQLAANTHALLERL------GVARASVIGHSMGGMLATRYALLYPR 157
Cdd:COG0412  86 pELLAADLRAALDWLkaqpevDAGRVGVVGFCFGGGLALLAAARGPD 132
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 61-314 2.01e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 42.21  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  61 PKKANGR--TILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSS-KPAHYQ-YSFQQLAANTHALLERLGVARA 136
Cdd:COG1073  30 PAGASKKypAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEgEPREEGsPERRDARAAVDYLRTLPGVDPE 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 137 S--VIGHSMGGMLATRYALLYPRqVERLVLVnpigledwkalgVPWRSVDDWYRrdlqtsaegirqyqqatyyagewrpe 214
Cdd:COG1073 110 RigLLGISLGGGYALNAAATDPR-VKAVILD------------SPFTSLEDLAA-------------------------- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249 215 fDRWVQMQAGMYRGKG-RESVAWNSALTYDMiftqPVVYELDRLQMPTLLLIGEKDntaigkDAAPAElkarlgnyaqLG 293
Cdd:COG1073 151 -QRAKEARGAYLPGVPyLPNVRLASLLNDEF----DPLAKIEKISRPLLFIHGEKD------EAVPFY----------MS 209

                       250       260
                ....*....|....*....|..
gi 15598249 294 KDAARRIPQA-TLVEFPDLGHT 314
Cdd:COG1073 210 EDLYEAAAEPkELLIVPGAGHV 231
PRK06489 PRK06489
hypothetical protein; Provisional
 40-163 2.44e-04

hypothetical protein; Provisional


Pssm-ID: 235815 [Multi-domain]  Cd Length: 360  Bit Score: 42.28  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   40 VHYldfTSQGQPLSMAYLDVAPkkangrTILLMHG-----KNFCAGTWErtiDVLADAG-------YRVIAVDQVGFCKS 107
Cdd:PRK06489  52 LHY---TTLGTPHRNADGEIDN------AVLVLHGtggsgKSFLSPTFA---GELFGPGqpldaskYFIILPDGIGHGKS 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15598249  108 SKP-----AHY-QYSFQQLAANTHALL-ERLGVARAS-VIGHSMGGMLATRYALLYPRQVERLV 163
Cdd:PRK06489 120 SKPsdglrAAFpRYDYDDMVEAQYRLVtEGLGVKHLRlILGTSMGGMHAWMWGEKYPDFMDALM 183
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
89-165 6.41e-04

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 41.02  E-value: 6.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  89 LADAGYRVIAVDQVGFCKSSKPA--HYQYSFQQLA-----ANTHALLERLGVARASVIGHSMGGMLATryALLYPRQVER 161
Cdd:COG4757  55 LAERGFAVLTYDYRGIGLSRPGSlrGFDAGYRDWGeldlpAVLDALRARFPGLPLLLVGHSLGGQLLG--LAPNAERVDR 132


                ....
gi 15598249 162 LVLV 165
Cdd:COG4757 133 LVTV 136
PRK05855 PRK05855
SDR family oxidoreductase;
68-144 1.26e-03

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 40.35  E-value: 1.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15598249   68 TILLMHGKNFCAGTWERTIDVLADAgYRVIAVDQVGFCKSSKPAHY-QYSFQQLAANTHALLERLGVARA-SVIGHSMG 144
Cdd:PRK05855  27 TVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPKRTaAYTLARLADDFAAVIDAVSPDRPvHLLAHDWG 104
PRK07581 PRK07581
hypothetical protein; Validated
 94-163 2.01e-03

hypothetical protein; Validated


Pssm-ID: 236060 [Multi-domain]  Cd Length: 339  Bit Score: 39.53  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   94 YRVIAVDQVGFCKSSKPAHYQYSFqqLAAN------------THALL-ERLGVAR-ASVIGHSMGGMLATRYALLYPRQV 159
Cdd:PRK07581  72 YFIIIPNMFGNGLSSSPSNTPAPF--NAARfphvtiydnvraQHRLLtEKFGIERlALVVGWSMGAQQTYHWAVRYPDMV 149


                 ....
gi 15598249  160 ERLV 163
Cdd:PRK07581 150 ERAA 153
YpfH COG0400
Predicted esterase [General function prediction only];
89-164 2.25e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 38.73  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249  89 LADAGYRVIAV------DQVGFC--------KSSKPAHYQYSFQQLAANTHALLERLGVARASVI--GHSMGGMLATRYA 152
Cdd:COG0400  28 LALPGAAVLAPrapvpeGPGGRAwfdlsfleGREDEEGLAAAAEALAAFIDELEARYGIDPERIVlaGFSQGAAMALSLA 107

                        90
                ....*....|..
gi 15598249 153 LLYPRQVERLVL 164
Cdd:COG0400 108 LRRPELLAGVVA 119
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 118-172 2.41e-03

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 39.15  E-value: 2.41e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15598249 118 QQLAAnTHALLERLGvaRASVIGHSMGGMLATRYALLYPRQVERLVLVNPIGLED 172
Cdd:cd12808 175 LTLAA-YDALLDRVG--PCIVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPD 226
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 110-169 2.63e-03

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 38.87  E-value: 2.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15598249   110 PAHYQY-SFQQLAANTHALLERLGVARASVIGHSMGGMLATRYALLYPRQVERLVLVNPIG 169
Cdd:pfam03096  74 PGGYPYpSMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTP 134
COG4814 COG4814
Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];
125-165 2.91e-03

Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];


Pssm-ID: 443842  Cd Length: 286  Bit Score: 38.77  E-value: 2.91e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15598249 125 HALLERLGVARASVIGHSMGGMLATRYALLY------PrQVERLVLV 165
Cdd:COG4814 125 KYLKKKYGFKKFNAVGHSMGGLALTYYLEKYgndkslP-KLNKLVTI 170
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 60-167 4.94e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 38.34  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249   60 APKKANGRTIL-LMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLERLGVARASV 138
Cdd:PLN02652 129 APAAGEMRGILiIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYVPSLDYVVEDTEAFLEKIRSENPGV 208

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15598249  139 ----IGHSMGGMLATRyALLYPR---QVERLVLVNP 167
Cdd:PLN02652 209 pcflFGHSTGGAVVLK-AASYPSiedKLEGIVLTSP 243
DUF1057 pfam06342
Alpha/beta hydrolase of unknown function (DUF1057); This family consists of several ...
 56-170 6.91e-03

Alpha/beta hydrolase of unknown function (DUF1057); This family consists of several Caenorhabditis elegans specific proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.


Pssm-ID: 115027  Cd Length: 297  Bit Score: 37.81  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15598249    56 YLDVAPKKANGRTILLMHGKNFCAGTWERTIDVLADAGYRVIAVDQVGFCKSSKPAHYQYSFQQLAANTHALLERLGV-A 134
Cdd:pfam06342  25 YEDSLTSGSPFGTVVAFHGSPGSHNDFKYIRSKFEDLNIRFIGVNYPGFEFTTGYPGQSHTNQERNSYSKALLEELELkG 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15598249   135 RASVIGHSMGGMLATRYALLYPrqVERLVLVNPIGL 170
Cdd:pfam06342 105 KLIIMGHSRGCENALQTATTRP--AHGLVMINPTGF 138
PRK08775 PRK08775
homoserine O-succinyltransferase;
126-165 8.10e-03

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 37.85  E-value: 8.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 15598249  126 ALLERLGVARASVI-GHSMGGMLATRYALLYPRQVERLVLV 165
Cdd:PRK08775 129 LLLDALGIARLHAFvGYSYGALVGLQFASRHPARVRTLVVV 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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