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Conserved domains on  [gi|15597773|ref|NP_251267|]
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transcriptional regulator [Pseudomonas aeruginosa PAO1]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-132 1.17e-40

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 132.59  E-value: 1.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773   3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRPLPGRLHEVER 82
Cdd:COG1522   4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597773  83 QIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLD----RINGYAETNTAIV 132
Cdd:COG1522  84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLerlaALPGVRRTETSFV 137
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-132 1.17e-40

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 132.59  E-value: 1.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773   3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRPLPGRLHEVER 82
Cdd:COG1522   4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597773  83 QIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLD----RINGYAETNTAIV 132
Cdd:COG1522  84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLerlaALPGVRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-108 1.33e-27

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 98.36  E-value: 1.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773      3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRP-LPGRLHEVE 81
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFL 81

                           90       100
                   ....*....|....*....|....*..
gi 15597773     82 RQIQDIAEFTECDKVTGDDCFIARLQV 108
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-132 1.42e-13

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 64.01  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773    3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRI---RPLPGRLHE 79
Cdd:PRK11169  13 DRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEItlnRGAPDVFEQ 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15597773   80 VERQIQDIAEFTECDKVTGDDCFIARLQVRSM----EQLDTLLDRINGYAETNTAIV 132
Cdd:PRK11169  93 FNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMsayrKLLGETLLRLPGVNDTRTYVV 149
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 68-132 1.50e-12

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 58.69  E-value: 1.50e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773    68 VRIRPLPGR-LHEVERQIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLDR----INGYAETNTAIV 132
Cdd:pfam01037   1 VEVKLEPGHaLEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREklrsLPGVARTETSIV 70
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 5.67e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 5.67e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597773   1 MTDDIDQRLINALMaDSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGY 51
Cdd:cd00090   4 LSDPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-132 1.17e-40

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 132.59  E-value: 1.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773   3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRPLPGRLHEVER 82
Cdd:COG1522   4 DEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFAE 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597773  83 QIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLD----RINGYAETNTAIV 132
Cdd:COG1522  84 ALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLerlaALPGVRRTETSFV 137
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-108 1.33e-27

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 98.36  E-value: 1.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773      3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRP-LPGRLHEVE 81
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLeNPDKLEEFL 81

                           90       100
                   ....*....|....*....|....*..
gi 15597773     82 RQIQDIAEFTECDKVTGDDCFIARLQV 108
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-132 1.42e-13

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 64.01  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773    3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRI---RPLPGRLHE 79
Cdd:PRK11169  13 DRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEItlnRGAPDVFEQ 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15597773   80 VERQIQDIAEFTECDKVTGDDCFIARLQVRSM----EQLDTLLDRINGYAETNTAIV 132
Cdd:PRK11169  93 FNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMsayrKLLGETLLRLPGVNDTRTYVV 149
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 68-132 1.50e-12

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 58.69  E-value: 1.50e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773    68 VRIRPLPGR-LHEVERQIQDIAEFTECDKVTGDDCFIARLQVRSMEQLDTLLDR----INGYAETNTAIV 132
Cdd:pfam01037   1 VEVKLEPGHaLEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREklrsLPGVARTETSIV 70
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
3-43 1.82e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 55.07  E-value: 1.82e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15597773     3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLE 43
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 3-143 2.44e-11

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 57.80  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597773    3 DDIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGYTLDVDPRCFGYQFQAIVRIRPLPGR-LHEVE 81
Cdd:PRK11179   8 DNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKdYPSAL 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597773   82 RQIQDIAEFTECDKVTGDDCFIARLQVRSMEQL-DTLLDRINGYAE---TNTAIVKKSPVKRRLPP 143
Cdd:PRK11179  88 AKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALqHVLINKIQTIDEiqsTETLISLQNPIMRTIKP 153
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 1.81e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 52.82  E-value: 1.81e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15597773     4 DIDQRLINALMADSRLSLKALAQVSGLSAPSVAERLRKLEERGVI 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 5.67e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.51  E-value: 5.67e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597773   1 MTDDIDQRLINALMaDSRLSLKALAQVSGLSAPSVAERLRKLEERGVIRGY 51
Cdd:cd00090   4 LSDPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
HTH_IclR pfam09339
IclR helix-turn-helix domain;
8-49 4.86e-03

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 33.54  E-value: 4.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15597773     8 RLINALM-ADSRLSLKALAQVSGLSAPSVAERLRKLEERGVIR 49
Cdd:pfam09339   7 AILDALAeAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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