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Conserved domains on  [gi|15597375|ref|NP_250869|]
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hypothetical protein PA2179 [Pseudomonas aeruginosa PAO1]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1002172)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA wybutosine-synthesizing protein 4

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmC super family cl34491
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 138-252 5.32e-26

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG2813:

Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 101.81  E-value: 5.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 138 RRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQ-APGRFDLIVANPPYllda 216
Cdd:COG2813  51 GRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGvPDGSFDLILSNPPF---- 126

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15597375 217 serayrHGGGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:COG2813 127 ------HAGRAVDKEVAHALIADAARHLRPGGELWL 156
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 138-252 5.32e-26

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 101.81  E-value: 5.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 138 RRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQ-APGRFDLIVANPPYllda 216
Cdd:COG2813  51 GRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGvPDGSFDLILSNPPF---- 126

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15597375 217 serayrHGGGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:COG2813 127 ------HAGRAVDKEVAHALIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 120-252 2.32e-21

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 88.80  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   120 RFD---RLIRSHLassDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLL 196
Cdd:pfam05175  15 RLDigsRLLLEHL---PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVY 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15597375   197 SQ-APGRFDLIVANPPYlldaserayrHGGGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:pfam05175  92 SGvEDGKFDLIISNPPF----------HAGLATTYNVAQRFIADAKRHLRPGGELWI 138
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 124-259 1.68e-19

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 86.41  E-value: 1.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   124 LIRSHLAS-SDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLSQAPG 201
Cdd:TIGR03533 108 LIEDGFAPwLEPEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDrVTLIQSDLFAALPG 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   202 -RFDLIVANPPYlLDASERA-----YRH------GGGMLGAGLSLAIVDAALERLEAGGSLLLYTGVAMV 259
Cdd:TIGR03533 188 rKYDLIVSNPPY-VDAEDMAdlpaeYHHepelalASGEDGLDLVRRILAEAADHLNENGVLVVEVGNSME 256
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 129-213 5.31e-19

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 84.83  E-value: 5.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  129 LASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAP-GRFDLIV 207
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPgGRFDLIV 180


                 ....*.
gi 15597375  208 ANPPYL 213
Cdd:PRK09328 181 SNPPYI 186
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 139-252 2.33e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.05  E-value: 2.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 139 RAADIGCGAGpGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSD---LLSQAPGRFDLIVANPPYlld 215
Cdd:cd02440   1 RVLDLGCGTG-ALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDaeeLPPEADESFDVIISDPPL--- 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15597375 216 aserayrhgggMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:cd02440  77 -----------HHLVEDLARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 138-252 5.32e-26

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 101.81  E-value: 5.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 138 RRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQ-APGRFDLIVANPPYllda 216
Cdd:COG2813  51 GRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGvPDGSFDLILSNPPF---- 126

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15597375 217 serayrHGGGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:COG2813 127 ------HAGRAVDKEVAHALIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 120-252 2.32e-21

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 88.80  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   120 RFD---RLIRSHLassDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLL 196
Cdd:pfam05175  15 RLDigsRLLLEHL---PKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVY 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15597375   197 SQ-APGRFDLIVANPPYlldaserayrHGGGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:pfam05175  92 SGvEDGKFDLIISNPPF----------HAGLATTYNVAQRFIADAKRHLRPGGELWI 138
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 124-252 2.58e-21

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 91.36  E-value: 2.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 124 LIRSHLASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLS--QAP 200
Cdd:COG2890 100 LVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEplPGD 179

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597375 201 GRFDLIVANPPYlLDASERAYRHG------------GGmlGAGLSL--AIVDAALERLEAGGSLLL 252
Cdd:COG2890 180 GRFDLIVSNPPY-IPEDEIALLPPevrdheprlaldGG--EDGLDFyrRIIAQAPRLLKPGGWLLL 242
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 124-259 1.68e-19

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 86.41  E-value: 1.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   124 LIRSHLAS-SDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLSQAPG 201
Cdd:TIGR03533 108 LIEDGFAPwLEPEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDrVTLIQSDLFAALPG 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   202 -RFDLIVANPPYlLDASERA-----YRH------GGGMLGAGLSLAIVDAALERLEAGGSLLLYTGVAMV 259
Cdd:TIGR03533 188 rKYDLIVSNPPY-VDAEDMAdlpaeYHHepelalASGEDGLDLVRRILAEAADHLNENGVLVVEVGNSME 256
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 129-213 5.31e-19

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 84.83  E-value: 5.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  129 LASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAP-GRFDLIV 207
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPgGRFDLIV 180


                 ....*.
gi 15597375  208 ANPPYL 213
Cdd:PRK09328 181 SNPPYI 186
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 130-250 2.82e-16

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 76.72  E-value: 2.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 130 ASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLSQA----PGRFD 204
Cdd:COG4123  31 AFAPVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAaelpPGSFD 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15597375 205 LIVANPPYLL--------DASERAYRHGGgmlgaGLSLA-IVDAALERLEAGGSL 250
Cdd:COG4123 111 LVVSNPPYFKagsgrkspDEARAIARHED-----ALTLEdLIRAAARLLKPGGRF 160
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 129-259 1.21e-13

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 70.07  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   129 LASSDParIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGV-GNLTLARSDLLSQAPG-RFDLI 206
Cdd:TIGR00536 109 LISQPP--ILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLeHRVEFIQSNLFEPLAGqKIDII 186

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597375   207 VANPPYlLDASERA-----YRH------GGGMLGAGLSLAIVDAALERLEAGGSLLLYTGVAMV 259
Cdd:TIGR00536 187 VSNPPY-IDEEDLAdlpnvVRFepllalVGGDDGLNILRQIIELAPDYLKPNGFLVCEIGNWQQ 249
PRK14968 PRK14968
putative methyltransferase; Provisional
 139-213 1.86e-12

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 64.92  E-value: 1.86e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597375  139 RAADIGCGAGPGAIRIAMAcpDAEVHGLDINPAALDLARVNAALAGVGNLTL--ARSDLLSQ-APGRFDLIVANPPYL 213
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNGVevIRSDLFEPfRGDKFDVILFNPPYL 101
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
138-209 4.20e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 4.20e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597375 138 RRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARvnaalAGVGNLTLARSDLLS-QAPGRFDLIVAN 209
Cdd:COG4106   3 RRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARAR-----ARLPNVRFVVADLRDlDPPEPFDLVVSN 70
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 139-213 4.93e-11

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 60.64  E-value: 4.93e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597375   139 RAADIGCGAGPGAIRIAMACpdAEVHGLDINPAALDLARVNAALAGVgNLTLARSDLLSQAPGRFDLIVANPPYL 213
Cdd:TIGR00537  22 DVLEIGAGTGLVAIRLKGKG--KCILTTDINPFAVKELRENAKLNNV-GLDVVMTDLFKGVRGKFDVILFNPPYL 93
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 142-209 1.72e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 58.58  E-value: 1.72e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597375   142 DIGCGAGPGAIRIAM-ACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLL----SQAPGRFDLIVAN 209
Cdd:pfam13847   9 DLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEelpeLLEDDKFDVVISN 81
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 142-225 2.26e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 56.42  E-value: 2.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   142 DIGCGAGPGAIRIAMACpDAEVHGLDINPAALDLARVNAALAGVgNLTLARSDL--LSQAPGRFDLIVAN-------PPY 212
Cdd:pfam13649   3 DLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAedLPFPDGSFDLVVSSgvlhhlpDPD 80

                          90
                  ....*....|....*.
gi 15597375   213 LLDASERAYRH---GG 225
Cdd:pfam13649  81 LEAALREIARVlkpGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 139-252 2.33e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.05  E-value: 2.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 139 RAADIGCGAGpGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSD---LLSQAPGRFDLIVANPPYlld 215
Cdd:cd02440   1 RVLDLGCGTG-ALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDaeeLPPEADESFDVIISDPPL--- 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15597375 216 aserayrhgggMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:cd02440  77 -----------HHLVEDLARFLEEARRLLKPGGVLVL 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 120-209 3.30e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.95  E-value: 3.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 120 RFDRLIRSHLASSdpariRRAADIGCGAGPGAIRIAMACpdAEVHGLDINPAALDLARvnaALAGVGNLTLARSDL--LS 197
Cdd:COG2227  13 RLAALLARLLPAG-----GRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIAR---ERAAELNVDFVQGDLedLP 82

                        90
                ....*....|..
gi 15597375 198 QAPGRFDLIVAN 209
Cdd:COG2227  83 LEDGSFDLVICS 94
PRK14967 PRK14967
putative methyltransferase; Provisional
 118-252 4.29e-10

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 58.91  E-value: 4.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  118 TYRFDRLIRSH---------------LASSDPARIRRAADIGCGAGPGAIRIAMACPdAEVHGLDINPAALDLARVNAAL 182
Cdd:PRK14967   3 TTPPDALLRAPgvyrpqedtqlladaLAAEGLGPGRRVLDLCTGSGALAVAAAAAGA-GSVTAVDISRRAVRSARLNALL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597375  183 AGVgNLTLARSDLLSQAPG-RFDLIVANPPYLLDASERAYRHG------GGMLGAGLSLAIVDAALERLEAGGSLLL 252
Cdd:PRK14967  82 AGV-DVDVRRGDWARAVEFrPFDVVVSNPPYVPAPPDAPPSRGparawdAGPDGRAVLDRLCDAAPALLAPGGSLLL 157
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 133-211 2.19e-09

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 57.88  E-value: 2.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 133 DPARIRRAADIGCGAGPGAIRIAMACpdAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAP-----GRFDLIV 207
Cdd:COG2265 230 DLTGGERVLDLYCGVGTFALPLARRA--KKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPellwgGRPDVVV 307


                ....
gi 15597375 208 ANPP 211
Cdd:COG2265 308 LDPP 311
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 142-209 6.81e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 52.37  E-value: 6.81e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597375   142 DIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGN---LTLARSDLLSQAPGRFDLIVAN 209
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNavrVELFQLDLGELDPGSFDVVVAS 72
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 117-209 1.00e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 53.07  E-value: 1.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 117 DTYRFDRLIRSHLASSDPARIrraADIGCGAGPGAIRIAMAcpDAEVHGLDINPAALDLARVNAALAGVgNLTLARSDL- 195
Cdd:COG2226   6 ARYDGREALLAALGLRPGARV---LDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAe 79

                        90
                ....*....|....*
gi 15597375 196 -LSQAPGRFDLIVAN 209
Cdd:COG2226  80 dLPFPDGSFDLVISS 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 138-302 1.26e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 54.15  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 138 RRAADIGCGAGPGAIRIAMAcPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDLLSQAP---GRFDLIVA------ 208
Cdd:COG0500  28 GRVLDLGCGTGRNLLALAAR-FGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPlpaESFDLVVAfgvlhh 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 209 -NPPYLLDASERAYRHgggmLGAG--LSLAIVDAALERLEAGGSLLLYTGVAMVEGGDPFLARIRERLASREWDWDYQEL 285
Cdd:COG0500 107 lPPEEREALLRELARA----LKPGgvLLLSASDAAAALSLARLLLLATASLLELLLLLRLLALELYLRALLAAAATEDLR 182

                       170
                ....*....|....*..
gi 15597375 286 DPDVFAEELDSPAYREA 302
Cdd:COG0500 183 SDALLESANALEYLLSK 199
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
163-212 1.63e-08

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 54.42  E-value: 1.63e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15597375 163 VHGLDINPAALDLARVNAALAGVGNLTLARSDLLS---QAPGRFDLIVANPPY 212
Cdd:COG0286  78 LYGQEINPTTYRLAKMNLLLHGIGDPNIELGDTLSndgDELEKFDVVLANPPF 130
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 159-212 1.72e-08

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 55.11  E-value: 1.72e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15597375 159 PDAEVHGLDINPAALDLARVNAALAGVGNL-TLARSDLL-SQAPGRFDLIVANPPY 212
Cdd:COG0116 249 PPLPIFGSDIDPRAIEAARENAERAGVADLiEFEQADFRdLEPPAEPGLIITNPPY 304
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
129-237 2.96e-08

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 54.17  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  129 LASSDPARIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLArSDLLSQAPGRFDLIVA 208
Cdd:PRK09489 189 LSTLTPHTKGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFA-SNVFSDIKGRFDMIIS 267

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 15597375  209 NPPY------LLDASERAYRHGGGMLGAGLSLAIV 237
Cdd:PRK09489 268 NPPFhdgiqtSLDAAQTLIRGAVRHLNSGGELRIV 302
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
138-209 3.20e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 54.02  E-value: 3.20e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15597375 138 RRAADIGCGAGPGAIrIAMACPDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLsqAPGRFDLIVAN 209
Cdd:COG2264 150 KTVLDVGCGSGILAI-AAAKLGAKRVLAVDIDPVAVEAARENAELNGVEDrIEVVLGDLL--EDGPYDLVVAN 219
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 145-281 6.87e-08

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 52.94  E-value: 6.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 145 CGAGPGAIRIAMACPdAEVHGLDINPAALDLARVNAALAGV-GNLTLARSD---LLSQAPGRFDLIVANPPYlldasera 220
Cdd:COG2520 189 AGVGPFSIPIAKRSG-AKVVAIDINPDAVEYLKENIRLNKVeDRVTPILGDareVAPELEGKADRIIMNLPH-------- 259

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597375 221 yrhgggmlgagLSLAIVDAALERLEAGGSLLLYTGVAMVEGGDPFLARIRERLASREWDWD 281
Cdd:COG2520 260 -----------SADEFLDAALRALKPGGVIHYYEIVPEEDPFERAEERIEEAAEEAGYEVE 309
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 128-255 1.33e-07

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 52.39  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  128 HLASSDPARIR---RAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGV----GNLTLARSDLLSQap 200
Cdd:PRK14966 240 HLVEAVLARLPengRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLGArvefAHGSWFDTDMPSE-- 317

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597375  201 GRFDLIVANPPYlLDASERAYRHGGGMLGAGLSL-----------AIVDAALERLEAGGSLLLYTG 255
Cdd:PRK14966 318 GKWDIIVSNPPY-IENGDKHLLQGDLRFEPQIALtdfsdglscirTLAQGAPDRLAEGGFLLLEHG 382
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 123-271 3.00e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 49.41  E-value: 3.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 123 RLIRSHLASSDPariRRAADIGCGAGPGAIRIAMACP-DAEVHGLDINPAALDLARVNAALAGVGNLTLAR----SDLLS 197
Cdd:COG4122   6 RLLYLLARLLGA---KRILEIGTGTGYSTLWLARALPdDGRLTTIEIDPERAAIARENFARAGLADRIRLIlgdaLEVLP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 198 Q-APGRFDLIvanppyLLDASERAYrhgggmlgaglsLAIVDAALERLEAGGSL-----LLYTGVAMVEGGDPFLARIRE 271
Cdd:COG4122  83 RlADGPFDLV------FIDADKSNY------------PDYLELALPLLRPGGLIvadnvLWHGRVADPARRDPSTRAIRE 144
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 139-208 9.98e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 47.62  E-value: 9.98e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597375 139 RAADIGCGAGPGAIRIAMACpDAEVHGLDINPAALDLARVNAALAGV-GNLTLARSDLLS-QAPGRFDLIVA 208
Cdd:COG2230  54 RVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLaDRVEVRLADYRDlPADGQFDAIVS 124
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
123-209 1.48e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 47.69  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 123 RLIRSHLASSDPARIRRAADIGCGAGPGAIRIAMACpdAEVHGLDINPAALDLARVNAAlagvgNLTLARSDL--LSQAP 200
Cdd:COG4976  33 LLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG--YRLTGVDLSEEMLAKAREKGV-----YDRLLVADLadLAEPD 105


                ....*....
gi 15597375 201 GRFDLIVAN 209
Cdd:COG4976 106 GRFDLIVAA 114
PRK06202 PRK06202
hypothetical protein; Provisional
 123-209 6.53e-06

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 46.53  E-value: 6.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  123 RLIRSHLA-SSDPARIRRAADIGCGAGPGAIRIA-MACPD---AEVHGLDINPAALDLARVNAALAGVgNLTLARSDLLS 197
Cdd:PRK06202  46 GLYRRLLRpALSADRPLTLLDIGCGGGDLAIDLArWARRDglrLEVTAIDPDPRAVAFARANPRRPGV-TFRQAVSDELV 124

                         90
                 ....*....|..
gi 15597375  198 QAPGRFDLIVAN 209
Cdd:PRK06202 125 AEGERFDVVTSN 136
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
136-252 8.88e-06

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 45.38  E-value: 8.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  136 RIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLtlarsdllsqapgrfDLIVANPPYLLD 215
Cdd:PRK08287  31 RAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNI---------------DIIPGEAPIELP 95

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15597375  216 ASERAYRHGGGmlGAGLSlAIVDAALERLEAGGSLLL 252
Cdd:PRK08287  96 GKADAIFIGGS--GGNLT-AIIDWSLAHLHPGGRLVL 129
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 145-212 9.00e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.32  E-value: 9.00e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 145 CGAGPGAIRIAMAcpDAEVHGLDINPAALDLARVNAALAGVGNLTLARSD--LLSQAPGRFDLIVANPPY 212
Cdd:COG1041  35 CGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDarDLPLADESVDAIVTDPPY 102
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 112-212 1.18e-05

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 45.04  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   112 VFFGPDTYRfDRLIRSHLASSDPARIRRAADIGCGAGPGAIRIAM-----------ACPDAEVHGLDINPAALDLARVNA 180
Cdd:pfam01170   5 PFNGPAPLK-ETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALmganiapgkfdARVRAPLYGSDIDRRMVQGARLNA 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15597375   181 ALAGVGNLTLARSDLLSQAP---GRFDLIVANPPY 212
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPlleGSVDVIVTNPPY 118
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
138-209 1.75e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 45.14  E-value: 1.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597375  138 RRAADIGCGAGPGAIRIAM--AcpdAEVHGLDINPAALDLARVNAALAGVG-NLTLARSDLlsqapgRFDLIVAN 209
Cdd:PRK00517 121 KTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVElNVYLPQGDL------KADVIVAN 186
PRK08317 PRK08317
hypothetical protein; Provisional
 139-223 1.79e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 45.31  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  139 RAADIGCGAGPGAIRIAMA-CPDAEVHGLDINPAALDLARvNAALAGVGNLTLARSDL--LSQAPGRFDLIVanppylld 215
Cdd:PRK08317  22 RVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAK-ERAAGLGPNVEFVRGDAdgLPFPDGSFDAVR-------- 92


                 ....*...
gi 15597375  216 aSERAYRH 223
Cdd:PRK08317  93 -SDRVLQH 99
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 146-213 6.82e-05

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 44.09  E-value: 6.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597375  146 GAGPGAIRIAMAC--PDAEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLSQ-APGRFDLIVANPPYL 213
Cdd:PRK01544 146 GTGSGCIAISLLCelPNANVIATDISLDAIEVAKSNAIKYEVTDrIQIIHSNWFENiEKQKFDFIVSNPPYI 217
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 142-209 8.00e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.41  E-value: 8.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597375   142 DIGCGAGPGAIRIAMACPdAEVHGLDINPAALDLARVNAALAGV-GNLTLARSDLLSQAPgrFDLIVAN 209
Cdd:pfam06325 167 DVGCGSGILAIAALKLGA-KKVVGVDIDPVAVRAAKENAELNGVeARLEVYLPGDLPKEK--ADVVVAN 232
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 142-209 1.53e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597375   142 DIGCGagPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVgNLTLARSDLLSQAPGRFDLIVAN 209
Cdd:pfam08241   2 DVGCG--TGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-TFVVGDAEDLPFPDNSFDLVLSS 66
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 161-254 2.01e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 42.48  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 161 AEVHGLDINPAALDLARVNAALAGV-GNLTLARSD----L--LSQAPGRFDLIVANPP-------YLLDAsERAYRhggg 226
Cdd:COG1092 240 KSVTSVDLSATALEWAKENAALNGLdDRHEFVQADafdwLreLAREGERFDLIILDPPafakskkDLFDA-QRDYK---- 314

                        90       100
                ....*....|....*....|....*...
gi 15597375 227 mlgaglslAIVDAALERLEAGGSLLLYT 254
Cdd:COG1092 315 --------DLNRLALKLLAPGGILVTSS 334
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 142-281 2.53e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 42.46  E-value: 2.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 142 DIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTlarsdllsqapgrfdLIVANPPYLLDASERAY 221
Cdd:COG2242 253 DIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVE---------------VVEGEAPEALADLPDPD 317

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597375 222 R----HGGGMLGaglslAIVDAALERLEAGGSLLLYTgvAMVEGgdpfLARIRERLASREWDWD 281
Cdd:COG2242 318 AvfigGSGGNLP-----EILEACWARLRPGGRLVANA--VTLET----LALALEALAELGYGGE 370
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 152-225 4.09e-04

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 41.82  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  152 IRIAMACPDAEVHGLDINPAALDLARVNAALAGVGNLTLARSD--LLSQAPGRFDLIVANP-----PYlLDASERAYRHG 224
Cdd:PRK04338  73 IRYALETGVEKVTLNDINPDAVELIKKNLELNGLENEKVFNKDanALLHEERKFDVVDIDPfgspaPF-LDSAIRSVKRG 151


                 .
gi 15597375  225 G 225
Cdd:PRK04338 152 G 152
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
137-211 5.32e-04

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 41.01  E-value: 5.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375  137 IRRAADIGCGAGPgairIAMAC--PDAEVHGLDINPAALDLARVNAALAGVGNLTLARSD---LLSQAPGRFDLIVANPP 211
Cdd:PRK03522 174 PRSMWDLFCGVGG----FGLHCatPGMQLTGIEISAEAIACAKQSAAELGLTNVQFQALDstqFATAQGEVPDLVLVNPP 249
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 138-208 6.65e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 40.21  E-value: 6.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597375  138 RRAADIGCGAGPGAIRIAMAcpDAEVHGLDINPAALDLARVNAALAGV-GNLTLARSDlLSQAPGRFDLIVA 208
Cdd:PRK07580  65 LRILDAGCGVGSLSIPLARR--GAKVVASDISPQMVEEARERAPEAGLaGNITFEVGD-LESLLGRFDTVVC 133
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 137-212 2.44e-03

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 38.08  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   137 IRRAADIGCGAGPGAIRIAMACPdaEVHGLDINPAALDLARVNAALAGVGN-LTLARSDLLSQAPG------RFDLIVAN 209
Cdd:pfam09445   1 ATRILDVFCGGGGNTIQFANVFD--SVISIDINLEHLACAQHNAEVYGVSDrIWLIHGDWFELLAKlkfekiKYDCVFAS 78


                  ...
gi 15597375   210 PPY 212
Cdd:pfam09445  79 PPW 81
PLN02672 PLN02672
methionine S-methyltransferase
 136-182 2.96e-03

methionine S-methyltransferase


Pssm-ID: 215360 [Multi-domain]  Cd Length: 1082  Bit Score: 39.37  E-value: 2.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15597375   136 RIRRAADIGCGAGpgAIRIAMA---CPdAEVHGLDINPAALDLARVNAAL 182
Cdd:PLN02672  118 RDKTVAELGCGNG--WISIAIAekwLP-SKVYGLDINPRAVKVAWINLYL 164
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 136-209 5.48e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 37.62  E-value: 5.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597375  136 RIRRAADIGCGAGPGAIRIAMACPDAEVHGLDINPAALDLARVnaALAGVgnlTLARSDLLSQAPGR-FDLIVAN 209
Cdd:PRK01683  31 NPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARS--RLPDC---QFVEADIASWQPPQaLDLIFAN 100
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 159-212 6.43e-03

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 37.68  E-value: 6.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375   159 PDAEVHGLDINPAALDLARVNAALAGV-GNLTLAR-SDLLSQ----APGRFDLIVANPPY 212
Cdd:pfam02384  75 NDLSIYGQEKNPTTYRLARMNMILHGIeYDDFHIRhGDTLTSpkfeDDKKFDVVVANPPF 134
arsM PRK11873
arsenite methyltransferase;
142-209 7.42e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 37.24  E-value: 7.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597375  142 DIGCGAGPGAIRIAMAC-PDAEVHGLDINPAALDLARVNAALAGVGNLTLARSDL--LSQAPGRFDLIVAN 209
Cdd:PRK11873  83 DLGSGGGFDCFLAARRVgPTGKVIGVDMTPEMLAKARANARKAGYTNVEFRLGEIeaLPVADNSVDVIISN 153
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 134-228 9.58e-03

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 36.67  E-value: 9.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597375 134 PARIRRAADIGCGAG-PGaIRIAMACPDAEVHGLDINP----------AALDLARVNAALAGVGNLtlarsdllsQAPGR 202
Cdd:COG0357  65 PKEGARVLDVGSGAGfPG-IPLAIARPDLQVTLVDSLGkkiaflrevvRELGLKNVTVVHGRAEEL---------APREK 134

                        90       100       110
                ....*....|....*....|....*....|
gi 15597375 203 FDLI----VANPPYLLDASERAYRHGGGML 228
Cdd:COG0357 135 FDVVtaraVAPLPDLLELALPLLKPGGRLL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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