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Conserved domains on  [gi|15597251|ref|NP_250745|]
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major facilitator superfamily transporter [Pseudomonas aeruginosa PAO1]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-404 4.46e-60

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 200.86  E-value: 4.46e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVPl 174
Cdd:cd17321  81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrfdlagaltvtAGATLLVFAlvqgpesgwdapsvrfglylsvplllaflaiehysrdp 254
Cdd:cd17321 159 ---------------------------------IGLVALLLA-------------------------------------- 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 lmplrllgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLV 334
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 335 AGLLLGALGLGLLAAcLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17321 239 AGLLLTAVGLLLLAL-LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-404 4.46e-60

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 200.86  E-value: 4.46e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVPl 174
Cdd:cd17321  81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrfdlagaltvtAGATLLVFAlvqgpesgwdapsvrfglylsvplllaflaiehysrdp 254
Cdd:cd17321 159 ---------------------------------IGLVALLLA-------------------------------------- 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 lmplrllgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLV 334
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 335 AGLLLGALGLGLLAAcLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17321 239 AGLLLTAVGLLLLAL-LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 11-404 2.43e-43

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 159.47  E-value: 2.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    11 MLALLAC--AQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:TIGR00711   1 LLLTIVLmlGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaeGPA-RNRALAIWSIASAFGLALGSALGGALTELFGWASI 167
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIY--PPEkRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   168 FLVNVPLAGAAALLALRLIPADARRQRgRRFDLAGALTVTAGATLLVFALVQGPESGWDAPS-VRFGLYLSVPLLLAFLA 246
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNeILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   247 IEHYSRDPLMPLRLLGNRNLQVA-MLLTAIFMSSYGVqYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLA 325
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGcVYMSLLGLGLYGS-FYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGD 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597251   326 RHGARATLVAGLLLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:TIGR00711 317 KIDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
PRK14995 PRK14995
SmvA family efflux MFS transporter;
10-330 6.62e-35

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 136.01  E-value: 6.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   10 WM-LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:PRK14995   5 WLtLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIF 168
Cdd:PRK14995  85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  169 LVNVPLAGAAALLALRLIPadarRQRGRR---FDLAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFL 245
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVP----RQAGRRdqpLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  246 AIEHYSRDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLA 325
Cdd:PRK14995 241 RTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320


                 ....*
gi 15597251  326 RHGAR 330
Cdd:PRK14995 321 RLGLR 325
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-404 1.25e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 132.41  E-value: 1.25e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   1 MTDRAAPSNWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVL 80
Cdd:COG2814   1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  81 GQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTE 160
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 161 LFGWASIFLVNVPLAGAAALLALRLIPADARRQRGRRFDLAgaltvtagatllvfalvqgpesgwdapsvrfglylsvpl 240
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL--------------------------------------- 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 241 llaflaiehysrdplmpLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVA 320
Cdd:COG2814 201 -----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 321 ERLLARHGARATLVagllLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASM 400
Cdd:COG2814 264 GRLADRFGRRRLLL----IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339


                ....
gi 15597251 401 TQQI 404
Cdd:COG2814 340 AFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
15-404 5.14e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.50  E-value: 5.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    15 LACAQLIIALDATIVFVALPE-ISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGG 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    94 LAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVP 173
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   174 lagaaallalrlipadarrqrgrrfdlagaltVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFlaiehysrd 253
Cdd:pfam07690 160 --------------------------------LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL--------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   254 plmplrllgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATL 333
Cdd:pfam07690 199 ----------RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597251   334 VAGLLLGALGLGLLAACLPLGRGFLALLpAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLL-ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-404 4.46e-60

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 200.86  E-value: 4.46e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVPl 174
Cdd:cd17321  81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrfdlagaltvtAGATLLVFAlvqgpesgwdapsvrfglylsvplllaflaiehysrdp 254
Cdd:cd17321 159 ---------------------------------IGLVALLLA-------------------------------------- 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 lmplrllgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLV 334
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 335 AGLLLGALGLGLLAAcLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17321 239 AGLLLTAVGLLLLAL-LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 11-404 2.43e-43

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 159.47  E-value: 2.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    11 MLALLAC--AQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:TIGR00711   1 LLLTIVLmlGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaeGPA-RNRALAIWSIASAFGLALGSALGGALTELFGWASI 167
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIY--PPEkRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   168 FLVNVPLAGAAALLALRLIPADARRQRgRRFDLAGALTVTAGATLLVFALVQGPESGWDAPS-VRFGLYLSVPLLLAFLA 246
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNeILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   247 IEHYSRDPLMPLRLLGNRNLQVA-MLLTAIFMSSYGVqYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLA 325
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGcVYMSLLGLGLYGS-FYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGD 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597251   326 RHGARATLVAGLLLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:TIGR00711 317 KIDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 23-404 1.36e-35

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 135.78  E-value: 1.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  23 ALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLI 102
Cdd:cd17503   9 ILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 103 LARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVPlagaaalla 182
Cdd:cd17503  89 IFRILQGFGGGVLIPLAQTILLRIYPPE-KRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP--------- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 183 lrlipadarrqrgrrfdlagaltvtagatllvfalvqgpesgwdapsvrfglylsvPLLLAFLAIehysrdPLMPLRLLG 262
Cdd:cd17503 159 --------------------------------------------------------IGILALLLA------PLLDLRLFK 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 263 NRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARaTLVAGLLLGAL 342
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPR-LLLLAGLLLLA 255

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597251 343 GLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17503 256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQL 317
PRK14995 PRK14995
SmvA family efflux MFS transporter;
10-330 6.62e-35

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 136.01  E-value: 6.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   10 WM-LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:PRK14995   5 WLtLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIF 168
Cdd:PRK14995  85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  169 LVNVPLAGAAALLALRLIPadarRQRGRR---FDLAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFL 245
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVP----RQAGRRdqpLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  246 AIEHYSRDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLA 325
Cdd:PRK14995 241 RTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320


                 ....*
gi 15597251  326 RHGAR 330
Cdd:PRK14995 321 RLGLR 325
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-404 1.25e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 132.41  E-value: 1.25e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   1 MTDRAAPSNWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVL 80
Cdd:COG2814   1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  81 GQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTE 160
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE-RRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 161 LFGWASIFLVNVPLAGAAALLALRLIPADARRQRGRRFDLAgaltvtagatllvfalvqgpesgwdapsvrfglylsvpl 240
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL--------------------------------------- 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 241 llaflaiehysrdplmpLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVA 320
Cdd:COG2814 201 -----------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 321 ERLLARHGARATLVagllLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASM 400
Cdd:COG2814 264 GRLADRFGRRRLLL----IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339


                ....
gi 15597251 401 TQQI 404
Cdd:COG2814 340 AFFL 343
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 15-404 3.05e-34

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 131.62  E-value: 3.05e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17476   3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFlvnvpl 174
Cdd:cd17476  83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF------ 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrFDLAGALTVTAGATLLVFalvqgpesgwdapsvrfglylsvplllaflaiehysrdp 254
Cdd:cd17476 157 -----------------------WFLAILAAIVAVAAIFWT--------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 lmplrllgNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARAtLV 334
Cdd:cd17476 175 --------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSY-IM 245

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597251 335 AGLLLGALGLGLLAACLPLGRGFLAL-LPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17476 246 AISMVAFLVGPILFATMPVHQTYWAQaFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNY 316
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 23-404 7.16e-32

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 124.60  E-value: 7.16e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  23 ALDATIVFVALPEISRALDfSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLI 102
Cdd:cd17502   9 ALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 103 LARAVQGLGGALLFPATLALIGNHFaegPARNRAL--AIWSIASAFGLALGSALGGALTELFGWASIFLVNVPLAgaaal 180
Cdd:cd17502  88 VGRAIQGIGGGGLMSLAFIIIADLV---PPRERGKyqGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG----- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 181 lalrlipadarrqrgrrfdlagaltvtagatLLVFALVqgpesgwdapsvrfglylsvplllaflaiehysrdplmplrl 260
Cdd:cd17502 160 -------------------------------GLALALL------------------------------------------ 166

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 261 lgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLVAGLLLG 340
Cdd:cd17502 167 ---RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTIL 243

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597251 341 ALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17502 244 MSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSL 307
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 4-291 4.36e-31

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 121.46  E-value: 4.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   4 RAAPSNWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQS 83
Cdd:COG0477   8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  84 LYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFG 163
Cdd:COG0477  88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 164 WASIFLVNVPLAGAAALLALRLIPADARRQRGRRFDLAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLA 243
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 15597251 244 FLAIEHYSRDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYF 291
Cdd:COG0477 247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-404 3.50e-26

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 109.20  E-value: 3.50e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVnvpl 174
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV---- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrfdlAGALTVtAGATLLVFALVQGPESGWDAPSVRfglylsvplllaflaiehySRDP 254
Cdd:cd17325 156 --------------------------CAALAL-LALVLALLLLPEPRPPPNKRAVSA-------------------ARLR 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 LMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLV 334
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 335 agllLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17325 270 ----IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
MFS_1 pfam07690
Major Facilitator Superfamily;
15-404 5.14e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.50  E-value: 5.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    15 LACAQLIIALDATIVFVALPE-ISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGG 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    94 LAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVP 173
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   174 lagaaallalrlipadarrqrgrrfdlagaltVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFlaiehysrd 253
Cdd:pfam07690 160 --------------------------------LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL--------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   254 plmplrllgnRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATL 333
Cdd:pfam07690 199 ----------RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597251   334 VAGLLLGALGLGLLAACLPLGRGFLALLpAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLL-ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 15-404 6.88e-21

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 93.80  E-value: 6.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd17504   1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGAlLFPATLALIGNHFaegPARNRALAIWSIASAFGL--ALGSALGGALTELFGWASIFlvnv 172
Cdd:cd17504  81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEF---PPERVPVAQGILSATFGIgaGIGLPLGGWIVQHLGWRWIF---- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 173 plagaaallalrlipadarrqrgrrfdlagalTVTAGATLLVFALVqgpesgwdapsvrfglylsvplllaflaiehysr 252
Cdd:cd17504 153 --------------------------------WTAAPVAVLLAALV---------------------------------- 166

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 253 dPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQS----VYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHG 328
Cdd:cd17504 167 -PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15597251 329 ARATLVAGLLLGALGLGLLAAclpLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLAL---LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTI 318
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-170 4.75e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 91.47  E-value: 4.75e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:COG2271  10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  90 LAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFL 169
Cdd:COG2271  90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168


                .
gi 15597251 170 V 170
Cdd:COG2271 169 I 169
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 14-407 5.65e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 88.38  E-value: 5.65e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  14 LLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGG 93
Cdd:cd17324   3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  94 LAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVnvp 173
Cdd:cd17324  83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE-KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA--- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 174 lagaaallalrlipadarrqrgrrfdlagaltvTAGATLLVFALvqgpesgwdapsvrfgLYLSVPLLLAFLAIEhySRD 253
Cdd:cd17324 159 ---------------------------------IAVLALLAALL----------------LWRLLPSLPPKKPGS--LGL 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 254 PLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATL 333
Cdd:cd17324 188 LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597251 334 VAGLLLGALGLGLlaacLPLGRGFLALLPAIVILSVGQGMTWTAMWvSAASGVDPAEQGVASGMASMTQQIGGA 407
Cdd:cd17324 268 IALLLLAAALLLL----TLLGPSPLLLLVGLVLWGLGFFAAHSALQ-TRVLRLAPEARGLASSLYLAAYNLGGA 336
PRK10504 PRK10504
putative transporter; Provisional
 1-334 9.14e-19

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 88.64  E-value: 9.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    1 MTDRAAPSNWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVL 80
Cdd:PRK10504   1 MTDLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   81 GQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATlALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTE 160
Cdd:PRK10504  81 AIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVG-RLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  161 LFGWASIFLVNVPLAGAAALLALRLIPadARRQRGRRFDLAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPL 240
Cdd:PRK10504 160 YASWHWIFLINIPVGIIGAIATLMLMP--NYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  241 LLAFLAIEHYSRDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPaTLLCTLGI-RV 319
Cdd:PRK10504 238 LLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIP-MVLGSMGMkRI 316

                        330
                 ....*....|....*
gi 15597251  320 AERLLARHGARATLV 334
Cdd:PRK10504 317 VVQVVNRFGYRRVLV 331
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 12-400 2.20e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 86.47  E-value: 2.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd17474   1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLGGALLFPATLALIGNhFAEGPARNRALAIWSIASAFGLALGSALGGALTeLFGWASIFLVn 171
Cdd:cd17474  81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGD-LFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFL- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 172 vplagaaallalrlipadarrqrgrrfdLAGALTVtagATLLVFALVQGPESGWDAPSVrfglylsvplllaflaiehys 251
Cdd:cd17474 158 ----------------------------LAALIPV---AFLAILFLLPEPKEKAKSSSA--------------------- 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 252 RDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARA 331
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGAR 265

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15597251 332 TLVAGLLLGALGLGLLaacLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASM 400
Cdd:cd17474 266 RILVIGLLLYALSLLL---LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNF 331
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 10-402 2.27e-18

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 86.48  E-value: 2.27e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIaldaTIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:cd17320   3 LLALLVALGPLAI----DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  90 LAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFL 169
Cdd:cd17320  79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLY-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 170 VnvplagaaallalrlipadarrqrgrrfdlagaLTVTAGATLLVFALVQgPESgwdaPSVRFGLYLSVPLLLAFlaieh 249
Cdd:cd17320 158 F---------------------------------LALLGLLLLLLVLLFL-PET----LPEEKRKPLLSSLLRAY----- 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 250 ysrdplmpLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGA 329
Cdd:cd17320 195 --------KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15597251 330 RATL-VAGLLLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMwVSAASGVDPAEQGVASGMASMTQ 402
Cdd:cd17320 267 RRLLrLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNA-TSLALEPFPHVAGTASALLGFLQ 339
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 12-399 2.15e-16

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 81.52  E-value: 2.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVfvaLPEISRALDFSAQRLqWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd06179   3 LCLAYFAQLFGVTLPAAV---LPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLGGALLFPATLALIgnhfAEGPARNR--ALAIWSIASAFGLALGSALGGALTE--LFGWASI 167
Cdd:cd06179  79 AGTAKSVNMLIGGQALIGIGAGTQGLGAAVAS----ELVPNKYRglVQGVVNLVASPGSALGPLIAGALVEanAAGWRWI 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 168 FLVNVPLAGAAALLAL--------RLIPADARRQRGRRFDLAGALTVTAGATLLVFALVQGPES-GWDAPSVRFGLYLSV 238
Cdd:cd06179 155 FYINAIFNALALILLFffyhppprPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVIGG 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 239 PLLLAFLAIEHYSRD--PLMPLRLLGNRNLqvAMLLTAIFMSsyGVQYYFLAIYF----QSVYGYSVLQTGLAFLPATLL 312
Cdd:cd06179 235 VLLIAFGLYEWKGTKdgLLPPRLLFRGRNF--ALILIVAFVE--GMIFYSLNIFWpqqiSLLFTTDPLKAGLYQLPFGLG 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 313 CTLGIRVAERLLARHG-ARATLVAGLLLGALGLGLLAACLPLGRGflALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQ 391
Cdd:cd06179 311 TLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNKA--LAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDI 388


                ....*...
gi 15597251 392 GVASGMAS 399
Cdd:cd06179 389 GTASGLLG 396
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 27-170 2.34e-15

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 77.23  E-value: 2.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  27 TIVFVALPEISRALDFSAQRL-QWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILAR 105
Cdd:cd17473  16 AAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15597251 106 AVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELfGWASIFLV 170
Cdd:cd17473  96 ALLGIGVAGIMTLATALIGDYF-EGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLV 158
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 10-170 3.62e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 76.84  E-value: 3.62e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIA-LDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:cd17319   2 WRIIPLLFLAYVINyLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaegPARNRALA--IWSIASAFGLALGSALGGALTELFGWAS 166
Cdd:cd17319  82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF---PARERGRAtgLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158


                ....
gi 15597251 167 IFLV 170
Cdd:cd17319 159 AFII 162
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-404 1.40e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.14  E-value: 1.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:COG2223   5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  90 LAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFaegPARNRALAIWSIASAFGL--ALGSALGGALTELFGWASI 167
Cdd:COG2223  85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF---PPDRRGLALGLAAGGGNLgaAVAAFLAPLLIAAFGWRNA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 168 FLVnvplagaaallalrlipadarrqrgrrfdlaGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVplllaflai 247
Cdd:COG2223 162 FLI-------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA--------- 201

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 248 ehysrdplmplrlLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARH 327
Cdd:COG2223 202 -------------LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597251 328 GARATLVAGLLLGALGLGLLAACLPlgrGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALALG---SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-404 1.86e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.53  E-value: 1.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  15 LACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGL 94
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  95 AQSELPLILARAVQGLGGALLFPATLALIGnHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASiflvnvpl 174
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIA-DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW-------- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 175 agaaallalrlipadarrqrgrrfdLAGALTVTAGATLLVFALVQGPESGWDAPSVRfglylsvplllafLAIEHYSRDP 254
Cdd:cd06174 152 -------------------------RAVFLIAAALALLAAILLLLVVPDPPESARAK-------------NEEASSKSVL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 255 LMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLV 334
Cdd:cd06174 194 KLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 335 AGLLLGALGLGLLaacLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd06174 274 LIGLLLMALGLAL---LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL 340
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 14-170 3.45e-11

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 64.71  E-value: 3.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    14 LLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGG 93
Cdd:TIGR00710   9 LLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLA 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597251    94 LAQSELPLILARAVQGLGGALLFPATLALIGNHFAeGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:TIGR00710  89 LSNNIETLLVLRFVQAFGASAGSVISQALVRDIYP-GEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 12-172 1.38e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.59  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLGGAllfpATLALIGNHFAE--GPA-RNRALAIWSIASAFGLALGSALGGALTELFGWASIF 168
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGS----SPLAIGAGTIADlfTPEeRGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156


                ....
gi 15597251 169 LVNV 172
Cdd:cd17323 157 WFLA 160
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 10-170 5.77e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.83  E-value: 5.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    10 WMLALLACAQLII--ALDATIVFVALPEISRALDFSAQRLQWVVSA--YTVAFGGflLLGGRATDLLGRRRMYVLGQSLY 85
Cdd:TIGR00895  15 QWRAIILSFLIMLmdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAglIGMAFGA--LFFGPLADRIGRRRVLLWSILLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    86 ALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHfaeGPARNRALAIWSIASAF--GLALGSALGGALTELFG 163
Cdd:TIGR00895  93 SVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY---APKRFRGTAVGLMFCGYpiGAAVGGFLAGWLIPVFG 169


                  ....*..
gi 15597251   164 WASIFLV 170
Cdd:TIGR00895 170 WRSLFYV 176
emrD PRK11652
multidrug transporter EmrD;
13-170 1.09e-09

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.92  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   13 ALLACAQLIialdATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAG 92
Cdd:PRK11652  15 LLVAVGQMA----QTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597251   93 GLAQSELPLILARAVQGLGGALLFPATLALIGNHFaEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:PRK11652  91 LFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLY-EGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLF 167
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 50-170 3.42e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.37  E-value: 3.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  50 VVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHfAE 129
Cdd:cd17489  36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI-IP 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15597251 130 GPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17489 115 PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 12-170 8.44e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.21  E-value: 8.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd17365   1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLGGALLFPATLALIGNHfaeGPARNRALAIWSIASAFGL--ALGSALGGALTELFGWASIFL 169
Cdd:cd17365  81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY---APARRRSLAVTLMFCGYPLgaALGGFLAAALIPAFGWRSVFL 157


                .
gi 15597251 170 V 170
Cdd:cd17365 158 L 158
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 49-404 9.55e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.24  E-value: 9.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  49 WVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGnHFA 128
Cdd:cd17329  39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA-DVT 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 129 EGPARNRALAIWSIASAFGLALGSALGGALTElfgwasiflvnvplagaaallalrlipadarrqrgrrFDLAGALTVTA 208
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-------------------------------------YSFRLLFLAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 209 GATLLVFALvqgpesgwdapsvrfgLYLSVPLLLAFLAIEHYSRDPLMPLRLLGNRNLQVAMLLTAIFMSSYGVQYYFLA 288
Cdd:cd17329 161 VLFLLAALV----------------LLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLP 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 289 IYFQSVYGYSVLQTGLAFlpatLLCTLGIRVAERLLARHGARATLVAGLLLGALGLGLLAACLPLGRGFLALLPAIVILS 368
Cdd:cd17329 225 VYVVEILGLGESLLGLLL----ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLT 300

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 15597251 369 VGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17329 301 LGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 13-170 1.90e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 56.02  E-value: 1.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  13 ALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYtvaFGGFLL---LGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:cd17380   2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSF---FWGYALtqvLGGYLADRFGGKKVLLLAVALWSLAT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  90 LAGGLA--QSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASI 167
Cdd:cd17380  79 LLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVS-ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157


                ...
gi 15597251 168 FLV 170
Cdd:cd17380 158 FYF 160
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 12-170 1.87e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.01  E-value: 1.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELF-GWASIFLV 170
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE-KRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRV 159
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 198-404 1.92e-07

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 53.47  E-value: 1.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 198 FDLAGALTVTAGAT--LLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFLAIE-HYSRDPLMPLRLLGNRNLQVAMLLTA 274
Cdd:cd17322 216 LDIFGVILLTAGLGliLVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKDRTILAACLIDF 295

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 275 IFMSSYGVQYYFLAIYFQSVYGYSVLQTGL-AFLPATLLCTLGIRVAERLLARHGARATLVAGLLLGALGLGLLAACLPL 353
Cdd:cd17322 296 FYFFSYYIFSDYLYTVLQVAVGESITSATRiTNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGG 375

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597251 354 GRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQGVASGMASMTQQI 404
Cdd:cd17322 376 SGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSI 426
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
32-170 4.28e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 51.84  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   32 ALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLG 111
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15597251  112 GALLFPATLALIGNHFaegpARN---RALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:PRK11102  93 AAAASVVINALMRDMF----PKEefsRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV 150
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 63-168 6.13e-07

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 51.47  E-value: 6.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  63 LLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQ--SELPLILARAVQGLGGALLFPATLALIGnHFAEGPARNRALAIW 140
Cdd:cd17318  74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWA-KWAPPLERSRLTSIA 152

                        90       100
                ....*....|....*....|....*...
gi 15597251 141 SIASAFGLALGSALGGALTELFGWASIF 168
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIF 180
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-154 6.14e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 6.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   9 NWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALA 88
Cdd:COG0738   7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597251  89 SLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGPAR--NRALAIWSIASAFGLALGSAL 154
Cdd:COG0738  87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASrlNLLHAFFSLGALLGPLLGGLL 154
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 20-170 6.50e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 6.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  20 LIIALDATIVFVALPEISRALDFSAQrLQWVVSAYTVAFGGFL---LLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQ 96
Cdd:cd17316   9 FFDAYDFFLIGFVAPVLAAEFSLGLS-LLQTGLLFAAGFLGRPigaLLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  97 SELPLILARAVQGLGGALLFPATLALIGNHFaegPARNRALAI------WSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17316  88 TPILLLVLRFLQGIGIGGEYPGASTYVAEFA---PSKRRGFALgllqsgWALGALLAALVASLLIPLLSGDWGWRILFLI 164
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 2-170 8.24e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 51.12  E-value: 8.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    2 TDRAAPSNWMLALLACaqLIIAL----DATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRM 77
Cdd:PRK11551   5 TSSASSSRLALTIGLC--FLVALleglDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   78 YVLGQSLYALASLAGGLAQSELPLILARAVQ--GLGGALlfPATLALIGNHfAEGPARNRALAIWSIASAFGLALGSALG 155
Cdd:PRK11551  83 LIVSVALFGLFSLATAQAWDFPSLLVARLLTgvGLGGAL--PNLIALTSEA-VGPRLRGTAVSLMYCGVPFGGALASVIG 159

                        170
                 ....*....|....*
gi 15597251  156 GALTELFGWASIFLV 170
Cdd:PRK11551 160 VLAAGDAAWRHIFYV 174
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 31-170 1.43e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 50.35  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  31 VALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGL 110
Cdd:cd17312  24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 111 GGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKK-ERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 57-172 1.73e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  57 AFGGflLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRA 136
Cdd:cd17371  48 AIGG--ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR-HRGKA 124

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15597251 137 LAIWSIASAFGLALGSALGGAL----TELFGWASIFLVNV 172
Cdd:cd17371 125 LGYVQSGWAVGWLLATLLAALLfpllPPEIAWRVLFLLGA 164
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-398 4.06e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 48.72  E-value: 4.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   4 RAAPSNWMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQS 83
Cdd:COG2807  12 RRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  84 LYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEgpARNRALAIWSIASAFGLALGSALGGALTELFG 163
Cdd:COG2807  92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD--RVGLMTGLYTAAMGLGAALAAGLTVPLAAALG 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 164 WASIFLVnvplagaaallalrlipadarrqrgrrfdlAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLA 243
Cdd:COG2807 170 WRGALAV------------------------------WALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWL 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 244 FlaiehysrdplmplrllgnrnlqvamlltAIFMSSYGVQYY----FLAIYFQSvYGYSVLQTGLAFLPATLLCTLGIRV 319
Cdd:COG2807 220 L-----------------------------TLFFGLQSLLYYavvaWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLL 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 320 AERLLARHGARATLVAGLLLGALGLGLLAACLPLGrgflALLPAIVILSVGQGMTWT-AMWVSAASGVDPAEQGVASGMA 398
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGS----LPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMA 345
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
40-170 1.40e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  40 LDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPAT 119
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15597251 120 LALIGNHFAEGPARnrALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:COG0738 321 FSLALDGLGKRTAA--AVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
31-123 3.40e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 45.78  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   31 VALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGL 110
Cdd:PRK10473  24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                         90
                 ....*....|...
gi 15597251  111 GGALLFPATLALI 123
Cdd:PRK10473 104 GAGCCYVVAFAIL 116
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 101-170 6.82e-05

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 45.00  E-value: 6.82e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 101 LILARAVQGLGGALLFPATLALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17383  86 LFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLI 155
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 20-170 7.98e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.49  E-value: 7.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  20 LIIALDA---TIVFVALPEISR-ALDFSAQRLQWVVSAYTVAFGGFLL--LGGRATDLLGRRRMYVLGQSLYALASLAGG 93
Cdd:cd17330   3 LVVFLDAlgfGIVFPVLPFYVReFNKLGASGYYVGLLQSSYSLGQFLAspLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15597251  94 LAQSELPLILARAVQGLGGALLfPATLALIGNHFAEgPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17330  83 LSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDE-EERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 28-218 8.06e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 8.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  28 IVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAV 107
Cdd:cd17478  14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 108 QGLGGALLFPATLALIGNhfAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLVNVPLAGAAALLALRLIP 187
Cdd:cd17478  94 AGIGSAAFHPEGARLASQ--AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171

                       170       180       190
                ....*....|....*....|....*....|...
gi 15597251 188 ADARR--QRGRRFDLAGALTVTAGATLLVFALV 218
Cdd:cd17478 172 LKKPEakKAAAKSSARSTLKGVWRALLLLLIIV 204
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
10-163 8.26e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.89  E-value: 8.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIALdATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:COG2211 230 FLLLLLAYLLFFLAL-ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  90 LAGGLAQSE--LPLILARAVQGLGGALLFPATLALIGNHFAEGPARNR------ALAIWSIASAFGLALGSALGGALTEL 161
Cdd:COG2211 309 LLLFFLGPGnlWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrreglYFGIFTFAIKLGQALAGALAGLLLAL 388


                ..
gi 15597251 162 FG 163
Cdd:COG2211 389 FG 390
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 87-170 1.77e-04

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 43.72  E-value: 1.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  87 LASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWAS 166
Cdd:cd17384  73 ISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSA 152


                ....
gi 15597251 167 IFLV 170
Cdd:cd17384 153 PFLI 156
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 66-169 3.04e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 42.97  E-value: 3.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  66 GRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGalLFPATLALIGNHFAEGpARNRALAIWSIASA 145
Cdd:cd17472  53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREE-NRTKAMALIGASIG 129

                        90       100
                ....*....|....*....|....
gi 15597251 146 FGLALGSALGGALTELFGWASIFL 169
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFL 153
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 12-172 6.20e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 6.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  12 LALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd06173   1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  92 GGLA-----QSELPLILARAVQGLGGALLFPATLALIGNHfAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWAS 166
Cdd:cd06173  81 LALLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159


                ....*.
gi 15597251 167 IFLVNV 172
Cdd:cd06173 160 AFAINA 165
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 8-170 9.19e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 9.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   8 SNWMLALLACAQLIIALDATIVFVALPEISR-ALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYA 86
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  87 LASLAGGLAQSELPLILARAVQGLGGALLFPATLALIgNHFAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWAS 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL-QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364


                ....
gi 15597251 167 IFLV 170
Cdd:cd06173 365 VFLL 368
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 48-170 9.30e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.37  E-value: 9.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  48 QWVVSAYTVAFG---GFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGAL---LFPATLA 121
Cdd:cd17370 234 ALIPLLYALFNLvyaLAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqesIERAAVA 313

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15597251 122 LIgnhfAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17370 314 DL----VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 25-170 9.50e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.61  E-value: 9.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   25 DATIVFVALPEISRALDFSAQRLQWVVSAYTVA--FGGFLLlgGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLI 102
Cdd:PRK03893  35 DFVLITLVLTEVQGEFGLTTVQAASLISAAFISrwFGGLLL--GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLF 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15597251  103 LARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:PRK03893 113 IARLVIGMGMAGEYGSSATYVIESWPKH-LRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI 179
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
198-379 1.03e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 198 FDLAGALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPLLLAFLAIE--HYSRDPLMPLR-----LLGNRNLQVAM 270
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKerPVPEEEKVSLKeslkaLLKNRPFLLLL 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 271 LLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARHGARATLVAGLLLGALGLGLLAAC 350
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                       170       180
                ....*....|....*....|....*....
gi 15597251 351 LPlgRGFLALLPAIVILSVGQGMTWTAMW 379
Cdd:COG2211 315 GP--GNLWLLLVLAALAGIGLGAILVLPW 341
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 36-170 1.13e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 41.09  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  36 ISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALL 115
Cdd:cd17393 226 LRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVV 305

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15597251 116 FPATLALIGNhfAEGPARNRALAIWSIASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17393 306 VPLAFSAAGA--LPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLV 358
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 10-149 1.28e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.06  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  10 WMLALLACAQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALAS 89
Cdd:cd17353   3 WLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGF 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597251  90 LAGGLAQSELPLILARAV-QGLGGALLFPATLALIGNHFAEgparNRALAIWSIASAFGLA 149
Cdd:cd17353  83 ILSAFAISLPLLFLGYGVlGGIGAGIGYITPVSTAVKWFPD----KRGLATGIVIAGFGLG 139
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-170 2.73e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251   5 AAPSNWMLALLACAQLIIALdaTIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRR--MYVLGQ 82
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGL 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  83 SLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEGpARNRALAIWSIASAFGLALGSALGGALTELF 162
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK-ARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334


                ....*...
gi 15597251 163 GWASIFLV 170
Cdd:COG2271 335 GYQAAFLL 342
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 18-404 3.23e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 3.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  18 AQLIIALDATIVFVALPEISRALDFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQS 97
Cdd:cd17475   4 AQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  98 ELPLILARAVQGLGGALLFPATLALIGNHFaegPARNRALA--IWSIASAFGLALGSALGGALTELFGWASIFLVnvpla 175
Cdd:cd17475  84 YPVLLVLLFLVGAGYGSVQPGGGRAIMRWF---PPRERGLAmgIRQTGVPLGGALAAALLPPLALHYGWRAAFVV----- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 176 gaaallalrlipadarrqrgrrfdlagALTVTAGATLLVFALVQGPESGWDAPSVRFGLYLSVPlllaflaiehysrdpl 255
Cdd:cd17475 156 ---------------------------AGLVSILAAVLFWLFYREPPAASAATESASTLLRSLK---------------- 192

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251 256 mplRLLGNRNLQVAMLLTAIFMSSYGVQYYFLAIYFQSVYGYSVLQTGLAFLPATLLCTLGIRVAERLLARH-GARATLV 334
Cdd:cd17475 193 ---EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfGGRRRPV 269

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15597251 335 AGLLLGALGLGLLAACLPLGRGFLALLPAIVILSVGQGMTWTAMWVSAASGVDPAEQ-GVASGMASMTQQI 404
Cdd:cd17475 270 LVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQaGTALGLANTINFI 340
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 41-170 4.26e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  41 DFSAQRLQWVVSAYTVAFGGFLLLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATL 120
Cdd:cd17477  27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 15597251 121 ALIgNHFAEGPARNRALAIWSIASAFGLALGSALGGALTE----LFGWASIFLV 170
Cdd:cd17477 107 SWL-NALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTagalPFLIAAVLLL 159
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 16-111 5.68e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.71  E-value: 5.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  16 ACAQLIIALDATIVFVALPEISRALDF--SAQRLQWVVSAYTVafGGFL--LLGGRATDLLGRRRMYVLGQSLYALASLA 91
Cdd:cd17315   3 ALGGLLFGYDLGVINGALLYIAKDLGFglSTSLQGLVVSSLLL--GAAIgsLFGGPLADRFGRRKSLLIAAVLYVIGALL 80

                        90       100
                ....*....|....*....|
gi 15597251  92 GGLAQSELPLILARAVQGLG 111
Cdd:cd17315  81 SALAPNVWVLIVGRFLLGLG 100
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 66-170 7.30e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 7.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  66 GRATDLLGRRRMYV-LGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLaLIGNHFAEGPArNRALAIWSIAS 144
Cdd:cd17490  52 GILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTV-LYASYFPPDEA-AKAMGLINLVN 129

                        90       100
                ....*....|....*....|....*.
gi 15597251 145 AFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17490 130 NLGQLIAFLIGGLIAEHFGMRAPFLL 155
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 61-172 7.51e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 38.58  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251    61 FLLLGGRATDLLGRRRMYVLGQSLYALAS-----LAGGLAQSELPLILARAVQGLGGALLFPATLALIGN--HFAEGPAr 133
Cdd:pfam05977  61 LSIPAGALADNFDRRKIMLAGQLLLALVStlltlLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPElvPRRDLPA- 139

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 15597251   134 nrALAIWSIASAFGLALGSALGGALTELFGWASIFLVNV 172
Cdd:pfam05977 140 --AVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNA 176
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 63-170 8.56e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.30  E-value: 8.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15597251  63 LLGGRATDLLGRRRMYVLGQSLYALASLAGGLAQSELPLILARAVQGLGGALLFPATLALIGNHFAEgpARNRALAIWSI 142
Cdd:cd17324 252 PLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE--ARGLASSLYLA 329

                        90       100
                ....*....|....*....|....*...
gi 15597251 143 ASAFGLALGSALGGALTELFGWASIFLV 170
Cdd:cd17324 330 AYNLGGALGAALGGLVLDHGGWAGVGWV 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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