|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
2-311 |
1.74e-172 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 480.54 E-value: 1.74e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 2 QHVRLGNSGLKVSRLCLGCMTYGDPAWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDL 81
Cdd:cd19079 1 EYVRLGNSGLKVSRLCLGCMSFGDPKWRPWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 82 VIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPA 161
Cdd:cd19079 81 VIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 162 WRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAP--RW 239
Cdd:cd19079 161 WQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTTDTAklKY 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 240 YGGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLE 311
Cdd:cd19079 241 DYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-292 |
1.05e-125 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 362.19 E-value: 1.05e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYGDPAWRPwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAqRED 80
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTMTFGGPWGGV---DEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRP-RDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMP 160
Cdd:COG0667 77 VVIATKVGRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 161 AWRFMKMLAFQRhhGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAPRWY 240
Cdd:COG0667 157 AEQLRRALAIAE--GLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPEGDRAATNFV 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15596936 241 GG--REEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:COG0667 235 QGylTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLE 288
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-292 |
9.42e-124 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 356.88 E-value: 9.42e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQRED 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTMNFGGRT------DEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG--RRDD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMP 160
Cdd:cd19087 73 IVLATKVFGPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 161 AWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAG------ARSAGTLRTRTDE 234
Cdd:cd19087 153 AWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGkygkgkRPESGRLVERARY 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 235 QAPRWyggREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19087 233 QARYG---LEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLE 287
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-292 |
1.29e-118 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 344.21 E-value: 1.29e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYG--DPAWRPW-VLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQ 77
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGTMTFGggGGFFGAWgGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKG--R 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 78 REDLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19091 79 RDDVLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAG------ARSAGTLRTR 231
Cdd:cd19091 159 NFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGkyrrgqPAPEGSRLRR 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 232 TDEQAPRWygGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19091 239 TGFDFPPV--DRERGYDVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLE 297
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-292 |
2.14e-104 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 307.21 E-value: 2.14e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQREDLVIATKAF 88
Cdd:cd19074 1 GLKVSELSLGTwLTFGGQ------VDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGW-PRESYVISTKVF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 89 FPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKML 168
Cdd:cd19074 74 WPTGPGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 169 AFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAG---TLRTRTDEQAPRWYGGREE 245
Cdd:cd19074 154 DLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGKYRDGippPSRSRATDEDNRDKKRRLL 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 15596936 246 VESTLGALEKL---AAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19074 234 TDENLEKVKKLkpiADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLE 283
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
5-292 |
3.04e-104 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 307.22 E-value: 3.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 5 RLGNSGLKVSRLCLGCMTYGdpawrpWVLDEERARPFIREALEAGIDFFDSADIYST-------GESERILGRALRDFAQ 77
Cdd:cd19081 1 PLGRTGLSVSPLCLGTMVFG------WTADEETSFALLDAFVDAGGNFIDTADVYSAwvpgnagGESETIIGRWLKSRGK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 78 REDLVIATKAFFPMsdRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19081 75 RDRVVIATKVGFPM--GPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGAS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVRED-EEDLVPLCREEGIALTPWSPLARGLLAGA-RSAGTL--RTRTD 233
Cdd:cd19081 153 NYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGGFLTGKyRSEADLpgSTRRG 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596936 234 EQAPRWYGgrEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19081 233 EAAKRYLN--ERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLE 289
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
6-292 |
7.45e-96 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 286.04 E-value: 7.45e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 6 LGNSGLKVSRLCLGCMTYGDPAWrpWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQREDLVIAT 85
Cdd:cd19080 3 LGRSGLRVSPLALGTMTFGTEWG--WGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAG--NRDRIVLAT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 86 KafFPMSDR---PNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAW 162
Cdd:cd19080 79 K--YTMNRRpgdPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 RFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAPRWYGG 242
Cdd:cd19080 157 VVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGRAGEAKGVTVGFG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15596936 243 R--EEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19080 237 KltERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLK 288
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-292 |
4.27e-87 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 260.91 E-value: 4.27e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDLVIATKAFFPMSD 93
Cdd:cd06660 1 SRLGLGTMTFGGD------GDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGGHPPGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 94 RPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQRH 173
Cdd:cd06660 75 DPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 174 HGLAQFISMQSQYNLIVR-EDEEDLVPLCREEGIALTPWSPLARGllagarsagtlrtrtdeqaprwyggreevestlga 252
Cdd:cd06660 155 HGLPGFAAVQPQYSLLDRsPMEEELLDWAEENGLPLLAYSPLARG----------------------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 15596936 253 leklaaarglpPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd06660 200 -----------PAQLALAWLLSQPFVTVPIVGARSPEQLE 228
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-292 |
1.54e-86 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 261.69 E-value: 1.54e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTYGDPAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaqREDLVIATKAFF 89
Cdd:cd19084 1 DLKVSRIGLGTWAIGGTWWGE--VDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR--RDDVVIATKCGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 PMSDRPN-ACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKML 168
Cdd:cd19084 77 RWDGGKGvTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEAR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 169 AFqrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGT------LRTRTDE-QAPRWyg 241
Cdd:cd19084 157 KY------GPIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEPtfppddRRSRFPFfRGENF-- 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 15596936 242 grEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19084 229 --EKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLE 277
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-312 |
4.96e-83 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 252.62 E-value: 4.96e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 16 LCLGCMTYGdpaWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQ-REDLVIATKafFPMSDR 94
Cdd:pfam00248 1 IGLGTWQLG---GGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVkRDKVVIATK--VPDGDG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 95 PNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAfqrhH 174
Cdd:pfam00248 76 PWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALT----K 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 175 GLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGaRSAGTLRTRTDEQAPRWYGGREEVESTLGALE 254
Cdd:pfam00248 152 GKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTG-KYTRDPDKGPGERRRLLKKGTPLNLEALEALE 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 255 KLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLEA 312
Cdd:pfam00248 231 EIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDE 288
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
2-292 |
2.26e-81 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 249.05 E-value: 2.26e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 2 QHVRLGNSGLKVSRLCLGCM----TYGDPawrpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaq 77
Cdd:cd19076 1 PTRKLGTQGLEVSALGLGCMgmsaFYGPA-------DEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDR-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 78 REDLVIATKAFFPMSDRPNACGL--SRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLG 155
Cdd:cd19076 72 RDEVVIATKFGIVRDPGSGFRGVdgRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 156 ASSMPAwrfmkmLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGA-RSAGTL-RTRTD 233
Cdd:cd19076 152 LSEASA------DTIRRAHAVHPITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAiKSPEDLpEDDFR 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 234 EQAPRWYGgrEEVESTLG---ALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19076 226 RNNPRFQG--ENFDKNLKlveKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLE 285
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-292 |
7.21e-80 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 245.58 E-value: 7.21e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QR 78
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSwVTFGNQ------VDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGwPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 79 EDLVIATKAFFPMS-DRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19143 75 SDYVVSTKIFWGGGgPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVRED-EEDLVPLCREEGIALTPWSPLARGLLAGARSAGT--------- 227
Cdd:cd19143 155 EWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRERvEVEYAPLYEKYGLGTTTWSPLASGLLTGKYNNGIpegsrlalp 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596936 228 ----LRTRTDEQAPRWyggREEVEstlgALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19143 235 gyewLKDRKEELGQEK---IEKVR----KLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLE 296
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
13-292 |
5.14e-76 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 234.79 E-value: 5.14e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMTYGDPAWrPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQREDLVIATKAFfpms 92
Cdd:cd19085 1 VSRLGLGCWQFGGGYW-WGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG--RRDDVVIATKVS---- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 93 drpnACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRfmkmlaFQR 172
Cdd:cd19085 74 ----PDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQ------LEE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 173 HHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARS------AGTLRTRTdeqaPRWY--GGRE 244
Cdd:cd19085 144 ALDAGRIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTGKFSsaedfpPGDARTRL----FRHFepGAEE 219
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15596936 245 EVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19085 220 ETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLE 267
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-292 |
2.23e-73 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 228.68 E-value: 2.23e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 3 HVRLGNSGLKVSRLCLGcmtygdpAWRPW--VLDEERARPFIREALEAGIDFFDSADIY--STGESERILGRALRDF--A 76
Cdd:cd19089 1 YRRCGRSGLHLPAISLG-------LWHNFgdYTSPEEARELLRTAFDLGITHFDLANNYgpPPGSAEENFGRILKRDlrP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 77 QREDLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGA 156
Cdd:cd19089 74 YRDELVISTKAGYGMWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 157 SSMPAWRFMKMLAFQRHHGlAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGT---LRTRTD 233
Cdd:cd19089 154 SNYPGAKARRAIALLRELG-VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIppdSRRAAE 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596936 234 EQAPRWYGGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19089 233 SKFLTEEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLE 291
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
13-284 |
6.67e-72 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 225.52 E-value: 6.67e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYST-------GESERILGRALRDFAQREDLVIAT 85
Cdd:cd19094 1 VSEICLGTMTWGEQ------NTEAEAHEQLDYAFDEGVNFIDTAEMYPVppspetqGRTEEIIGSWLKKKGNRDKVVLAT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 86 KAFFPMSD----RPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHrfDPD--------------------TPIEETCET 141
Cdd:cd19094 75 KVAGPGEGitwpRGGGTRLDRENIREAVEGSLKRLGTDYIDLYQLH--WPDrytplfgggyytepseeedsVSFEEQLEA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 142 LDSLVRVGKVRYLGASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAG 221
Cdd:cd19094 153 LGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTG 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596936 222 ARSAGTLR-TRTDEQAPRWYGGR---EEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVG 284
Cdd:cd19094 233 KYLDGAARpEGGRLNLFPGYMARyrsPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIG 299
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-292 |
1.82e-70 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 220.95 E-value: 1.82e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCM----TYGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaqREDLVIAT 85
Cdd:cd19078 1 GLEVSAIGLGCMgmshGYGPPP------DKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF--RDQVVIAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 86 KAFF---PMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAw 162
Cdd:cd19078 73 KFGFkidGGKPGPLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGV- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 rfmkmLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQA--PRWY 240
Cdd:cd19078 152 -----ETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKFDEGDDRAslPRFT 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15596936 241 G-GREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19078 227 PeALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLE 279
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
1-292 |
9.19e-69 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 216.56 E-value: 9.19e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTygdpaWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALR-DFAQRE 79
Cdd:COG4989 1 MKRIKLGASGLSVSRIVLGCMR-----LGEWDLSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKlSPSLRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 80 DLVIATKA--FFPMSDRPNACG---LSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYL 154
Cdd:COG4989 76 KIELQTKCgiRLPSEARDNRVKhydTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 155 GASSMPAWRFmKMLafQRHhgLAQFISM-QSQYNLIVRE--DEEDLvPLCREEGIALTPWSPLARGLLAGArsagtlrtr 231
Cdd:COG4989 156 GVSNFTPSQF-ELL--QSA--LDQPLVTnQIELSLLHTDafDDGTL-DYCQLNGITPMAWSPLAGGRLFGG--------- 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 232 TDEQAPRwyggreevesTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:COG4989 221 FDEQFPR----------LRAALDELAEKYGVSPEAIALAWLLRHPAGIQPVIGTTNPERIK 271
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
10-312 |
3.27e-65 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 208.43 E-value: 3.27e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTYGDpAWRPW--VLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDLVIATK- 86
Cdd:cd19146 8 GVRVSPLCLGAMSFGE-AWKSMmgECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDEMVLATKy 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 --AFFPMSDRP---NACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPA 161
Cdd:cd19146 87 ttGYRRGGPIKiksNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDTPA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 162 WRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLagaRSAGTLRTRtdEQAPRWYG 241
Cdd:cd19146 167 WVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQF---RTEEEFKRR--GRSGRKGG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 242 GREEVESTLG-ALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLEA 312
Cdd:cd19146 242 PQTEKERKVSeKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIED 313
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
5-292 |
6.06e-65 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 207.13 E-value: 6.06e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 5 RLGNSGLKVSRLCLGcmTY---GDPAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaqREDL 81
Cdd:cd19149 3 KLGKSGIEASVIGLG--TWaigGGPWWGG--SDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR--RDKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 82 VIATKA-----------FFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGK 150
Cdd:cd19149 77 VLATKCglrwdreggsfFFVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 151 VRYLGASSMPAWRFMKMLAFqrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGA------RS 224
Cdd:cd19149 157 IRAIGASNVSVEQIKEYVKA------GQLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKitpdreFD 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 225 AGTLRTRTDeqaprWY--GGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19149 231 AGDARSGIP-----WFspENREKVLALLEKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAE 295
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-292 |
3.13e-64 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 204.77 E-value: 3.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 12 KVSRLCLGCMTYGDPAWRPW-VLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDLVIATKaFFP 90
Cdd:cd19093 1 EVSPLGLGTWQWGDRLWWGYgEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATK-FAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 91 MSDRpnacgLSRKHLLASVDASLRRLGTDYLDLFVIH-RFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLA 169
Cdd:cd19093 80 LPWR-----LTRRSVVKALKASLERLGLDSIDLYQLHwPGPWYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 170 FQRHHGLaQFISMQSQYNLIVREDEED-LVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAPRWYgGREEVES 248
Cdd:cd19093 155 ALKERGV-PLASNQVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRK-NLEKVQP 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 15596936 249 TLGALEKLAAARGLPPAQLALAWLLGRNGVaaPIVGLSRPHHLE 292
Cdd:cd19093 233 LLDALEEIAEKYGKTPAQVALNWLIAKGVV--PIPGAKNAEQAE 274
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
11-292 |
1.56e-63 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 201.17 E-value: 1.56e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 11 LKVSRLCLGCMTYGDPAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQREDLVIATKA--- 87
Cdd:cd19086 1 LEVSEIGFGTWGLGGDWWGD--VDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG--RRDKVVIATKFgnr 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 88 FFPMSDRPNacGLSRKHLLASVDASLRRLGTDYLDLFVIHR-FDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRfmk 166
Cdd:cd19086 77 FDGGPERPQ--DFSPEYIREAVEASLKRLGTDYIDLYQLHNpPDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPEE--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 167 MLAFQRHHGLAqfiSMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGarsagtlrtrtdeqaprwyggreev 246
Cdd:cd19086 152 ALAALRRGGID---VVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTG------------------------- 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 15596936 247 estlgaleKLaaarglppAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19086 204 --------KL--------AQAALRFILSHPAVSTVIPGARSPEQVE 233
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
4-312 |
9.10e-63 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 201.49 E-value: 9.10e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 4 VRLGNSGLKVSRLCLGCMTYGDPAWRPwVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQREDLVI 83
Cdd:cd19083 2 VKLGKSDIDVNPIGLGTNAVGGHNLYP-NLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEY-NRNEVVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 84 ATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSmpawr 163
Cdd:cd19083 80 ATKGAHKFGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSN----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 fMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGT------LRTRTDE-QA 236
Cdd:cd19083 155 -FSLEQLKEANKDGYVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGKYTKDTkfpdndLRNDKPLfKG 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596936 237 PRWYGGREEVEStlgaLEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLEA 312
Cdd:cd19083 234 ERFSENLDKVDK----LKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDA 305
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-292 |
1.49e-61 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 197.94 E-value: 1.49e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDpawrpwVLDEERARPFIREALEAGIDFFDSADIYST-------GESERILGRALRDFAQREDLVIATK 86
Cdd:cd19752 1 SELCLGTMYFGT------RTDEETSFAILDRYVAAGGNFLDTANNYAFwteggvgGESERLIGRWLKDRGNRDDVVIATK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 AFF----PMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAW 162
Cdd:cd19752 75 VGAgprdPDGGPESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 RFMKMLAFQRHHGLAQFISMQSQYN-LIVRED---------EEDLVPLCREEG-IALTPWSPLARGLLagarsagtlrTR 231
Cdd:cd19752 155 RLERARQIARQQGWAEFSAIQQRHSyLRPRPGadfgvqrivTDELLDYASSRPdLTLLAYSPLLSGAY----------TR 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 232 TDEQAPRWYGGrEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19752 225 PDRPLPEQYDG-PDSDARLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLE 284
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-292 |
2.61e-61 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 196.30 E-value: 2.61e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTYGDPaWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAqREDLVIATKAFf 89
Cdd:cd19072 1 GEEVPVLGLGTWGIGGG-MSKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFD-REDLFITTKVS- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 pmsdrPNacGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGAS--SMP----AWR 163
Cdd:cd19072 78 -----PD--HLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSnfSLEeleeAQS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 FMKMlafqrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARsagtlrtrtdeqaprwyggr 243
Cdd:cd19072 151 YLKK---------GPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAK-------------------- 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 15596936 244 eevesTLGALEKLAAARGLPPAQLALAWLLGRNGVaAPIVGLSRPHHLE 292
Cdd:cd19072 202 -----GSPLLDEIAKKYGKTPAQIALNWLISKPNV-IAIPKASNIEHLE 244
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
8-292 |
2.77e-61 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 197.01 E-value: 2.77e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGCMTYGDpawrpWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALR-DFAQREDLVIATK 86
Cdd:cd19092 1 PEGLEVSRLVLGCMRLAD-----WGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALAlNPGLREKIEIQTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 -----AFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPA 161
Cdd:cd19092 76 cgirlGDDPRPGRIKHYDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 162 WRFmKMLafQRHhgLAQ-FISMQSQYNLIVREDEED-LVPLCREEGIALTPWSPLARGLLAGARsagtlrtrtDEQAPRw 239
Cdd:cd19092 156 SQI-ELL--QSY--LDQpLVTNQIELSLLHTEAIDDgTLDYCQLLDITPMAWSPLGGGRLFGGF---------DERFQR- 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15596936 240 yggreevesTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19092 221 ---------LRAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIR 264
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-314 |
9.75e-61 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 195.97 E-value: 9.75e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMTYGDPAWRPWV--LDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaqREDLVIATK-AFF 89
Cdd:cd19102 1 LTTIGLGTWAIGGGGWGGGWgpQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL--RDRPIVATKcGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 PMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAwrfMKMLA 169
Cdd:cd19102 79 WDEEGRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSV---DQMKR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 170 FQRHHGLAqfiSMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAPRwyGGREEVEST 249
Cdd:cd19102 156 CQAIHPIA---SLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTPERVASLPADDWRR--RSPFFQEPN 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 250 LG-------ALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLEAPL 314
Cdd:cd19102 231 LArnlalvdALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEALL 302
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
5-292 |
4.62e-58 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 189.54 E-value: 4.62e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 5 RLGNSGLKVSRLCLGCM-TYGDpawrpwVLDEERARPFIREALEAGIDFFDSADIYS--TGESERILGRALR-DFAQ-RE 79
Cdd:cd19151 4 RCGRSGLKLPAISLGLWhNFGD------VDRYENSRAMLRRAFDLGITHFDLANNYGppPGSAEENFGRILKeDLKPyRD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 80 DLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSM 159
Cdd:cd19151 78 ELIISTKAGYTMWPGPYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 160 PAWRFMKMLAFQRHHGLAQFISmQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLL---------AGARSAGTLRT 230
Cdd:cd19151 158 PPEEAREAAAILKDLGTPCLIH-QPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLtdrylngipEDSRAAKGSSF 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 231 RTDEQAPrwyggrEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19151 237 LKPEQIT------EEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIE 292
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
4-292 |
1.13e-57 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 188.02 E-value: 1.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 4 VRLGNSGLKVSRLCLGCM----TYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfAQRE 79
Cdd:cd19145 3 VKLGSQGLEVSAQGLGCMglsgDYGAP------KPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKD-GPRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 80 DLVIATKafFPMSDRPNACGLSR---KHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGA 156
Cdd:cd19145 76 KVQLATK--FGIHEIGGSGVEVRgdpAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 157 SSMPAwrfmkmLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTD--E 234
Cdd:cd19145 154 SEASA------DTIRRAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLENSDvrK 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 235 QAPRWYGgrEEVESTLGALEK---LAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19145 228 SHPRFQG--ENLEKNKVLYERveaLAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLN 286
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
13-292 |
7.91e-57 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 184.34 E-value: 7.91e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMT------YGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaqREDLVIATK 86
Cdd:cd19088 1 VSRLGYGAMRltgpgiWGPPA------DREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPY--PDDVVIATK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 --AFFPMSDRPNACGlSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAwrf 164
Cdd:cd19088 73 ggLVRTGPGWWGPDG-SPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTV--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 165 mkmLAFQRHHGLAQFISMQSQYNLIVREDeEDLVPLCREEGIALTPWSPLARGLLAGARsagtlrtrtdeqaprwyggre 244
Cdd:cd19088 149 ---AQIEEARAIVRIVSVQNRYNLANRDD-EGVLDYCEAAGIAFIPWFPLGGGDLAQPG--------------------- 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15596936 245 evestlGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19088 204 ------GLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLE 245
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-292 |
2.23e-56 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 184.82 E-value: 2.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTYGDPAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDLVIATKAFF 89
Cdd:cd19148 1 DLPVSRIALGTWAIGGWMWGG--TDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATKVGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 PMSDRPNAC-GLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSM-PAwrfmKM 167
Cdd:cd19148 79 EWDEGGEVVrNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFsPE----QM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 168 LAFQRHHGLAqfiSMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGT------LRtRTDE--QAPRW 239
Cdd:cd19148 155 ETFRKVAPLH---TVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKMTKDTkfegddLR-RTDPkfQEPRF 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15596936 240 YGGREEVEstlgALEKLAAAR-GLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19148 231 SQYLAAVE----ELDKLAQERyGKSVIHLAVRWLLDQPGVSIALWGARKPEQLD 280
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
14-292 |
6.52e-54 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 178.13 E-value: 6.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGdpawrpWVLDEERARPFIREALEAGIDFFDSADIYS----TGESERILGRALRDFAQREDLVIATKAFF 89
Cdd:cd19082 1 SRIVLGTADFG------TRIDEEEAFALLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKSRGNRDKVVIATKGGH 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 PMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSmpaWRFMKMLA 169
Cdd:cd19082 75 PDLEDMSRSRLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN---WSTERIAE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 170 FQRH---HGLAQFISMQSQYNL------------IVREDEEDLVPLcREEGIALTPWSPLARGLLAGARSAGTlrTRTDE 234
Cdd:cd19082 152 ANAYakaHGLPGFAASSPQWSLarpneppwpgptLVAMDEEMRAWH-EENQLPVFAYSSQARGFFSKRAAGGA--EDDSE 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 235 QAPRWYGgrEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19082 229 LRRVYYS--EENFERLERAKELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLR 284
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-292 |
8.26e-54 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 179.41 E-value: 8.26e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCmtygdpaWRPW----VLDEERArpFIREALEAGIDFFDSADIYS--TGESERILGRALR- 73
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGL-------WHNFghvnALESQRA--ILRKAFDLGITHFDLANNYGppPGSAEENFGRLLRe 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 74 DFAQ-REDLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVR 152
Cdd:PRK09912 84 DFAAyRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 153 YLGASSMPAWRFMKMLAFQRHHGLAQFISmQSQYNLIVR-EDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLR-T 230
Cdd:PRK09912 164 YVGISSYSPERTQKMVELLREWKIPLLIH-QPSYNLLNRwVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQdS 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596936 231 RTDEQAPRWYGGREEVES-----TLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:PRK09912 243 RMHREGNKVRGLTPKMLTeanlnSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLE 309
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
15-292 |
3.06e-53 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 176.59 E-value: 3.06e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 15 RLCLGCMTYGDPAwRPWvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALrdfAQREDLVIATKAFFPmsdr 94
Cdd:cd19075 2 KIILGTMTFGSQG-RFT--TAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELG---LGERGFKIDTKANPG---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 95 pNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQRHH 174
Cdd:cd19075 72 -VGGGLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKEN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 175 GlaqFIS---MQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLR---TRTDEQAP------RWYgG 242
Cdd:cd19075 151 G---WVLptvYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSEDKaggGRFDPNNAlgklyrDRY-W 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 15596936 243 REEVESTLGALEKLAAARGLPPAQLALAWLL------GRNGVAApIVGLSRPHHLE 292
Cdd:cd19075 227 KPSYFEALEKVEEAAEKEGISLAEAALRWLYhhsaldGEKGDGV-ILGASSLEQLE 281
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
2-292 |
6.77e-53 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 176.11 E-value: 6.77e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 2 QHVRLGNSGLKVSRLCLGCM-TYGDpawrpwVLDEERARPFIREALEAGIDFFDSADIYST--GESERILGRALR-DFA- 76
Cdd:cd19150 1 QYRRCGKSGLKLPALSLGLWhNFGD------DTPLETQRAILRTAFDLGITHFDLANNYGPppGSAEENFGRILReDFAg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 77 QREDLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGA 156
Cdd:cd19150 75 YRDELIISTKAGYDMWPGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 157 SSMPAWRFMKMLAFQRHHGLAQFISmQSQYNLIVR-EDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGtlrTRTDEQ 235
Cdd:cd19150 155 SSYSPERTREAAAILRELGTPLLIH-QPSYNMLNRwVEESGLLDTLQELGVGCIAFTPLAQGLLTDKYLNG---IPEGSR 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 236 APRWYGGREE--VESTLG---ALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19150 231 ASKERSLSPKmlTEANLNsirALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLE 292
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
9-311 |
2.93e-51 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 171.93 E-value: 2.93e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 9 SGLKVSRLCLGCMTYGDpAWRPWV--LDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQREDLVIATK 86
Cdd:cd19147 6 AGIRVSPLILGAMSIGD-AWSGFMgsMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRDQIVIATK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 afFPMSDRP---------NACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19147 85 --FTTDYKAyevgkgkavNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAgARSAGTLRTRTDEQAP 237
Cdd:cd19147 163 DTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQ-SKKAVEERKKNGEGLR 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 238 RWYGGREEVESTLG---ALEKLAAARGLPP-AQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLDLAEEECATLE 311
Cdd:cd19147 242 SFVGGTEQTPEEVKiseALEKVAEEHGTESvTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-291 |
4.79e-49 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 166.49 E-value: 4.79e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCM-TYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QR 78
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWsTFSTA------ISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGwKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 79 EDLVIATKAFFpmSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASS 158
Cdd:cd19142 75 SSYIVSTKIYW--SYGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 159 MPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVP-LCREEGIALTPWSPLARGLLAG----ARSAGTLRTRTD 233
Cdd:cd19142 153 WSPVEIMEAFSIARQFNCPTPICEQSEYHMFCREKMELYMPeLYNKVGVGLITWSPLSLGLDPGiseeTRRLVTKLSFKS 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596936 234 EQAPRWYGGREEVEST------LGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHL 291
Cdd:cd19142 233 SKYKVGSDGNGIHEETrrashkLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQL 296
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-292 |
2.27e-47 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 159.67 E-value: 2.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYGDPAWrpwvldeerarPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQRED 80
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLPRESP-----------ELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGL-RRDK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKAFFPMSdrpnacGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPI---EETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19105 69 VFLATKASPRLD------KKDKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIGFS 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SmpawrfmkmlafqrHHGLAQFI----------SMQSQYNLIVREDE-EDLVPLCREEGIALTPWSPLARGLLAGARSAG 226
Cdd:cd19105 143 T--------------HDNMAEVLqaaiesgwfdVIMVAYNFLNQPAElEEALAAAAEKGIGVVAMKTLAGGYLQPALLSV 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596936 227 TLRTrtdeqaprwyggreevestlgaleklaaarGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19105 209 LKAK------------------------------GFSLPQAALKWVLSNPRVDTVVPGMRNFAELE 244
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-311 |
4.83e-47 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 160.48 E-value: 4.83e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 9 SGLKVSRLCLGCMTYgdpAWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGE---SERILGRALRDF-AQREDLVIA 84
Cdd:cd19077 1 NGKLVGPIGLGLMGL---TWRPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYpEYADKVVLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 85 TK-AFFPMSDRPNAcglSRKHLLASVDASLRRLG-TDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAw 162
Cdd:cd19077 78 VKgGLDPDTLRPDG---SPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSA- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 rfmkmLAFQRHHGLAQFISMQSQYNLIVREDEE-DLVPLCREEGIALTPWSPLARGLLAGA-RSAGTLrtrtDEQAPRWY 240
Cdd:cd19077 154 -----ETIRRAHAVHPIAAVEVEYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGLLTGRiKSLADI----PEGDFRRH 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 241 GGR---EEVESTLG---ALEKLAAARGLPPAQLALAWLLGRNG-VAAPIVGLSRPHHLEDALAALTLDLAEEECATLE 311
Cdd:cd19077 225 LDRfngENFEKNLKlvdALQELAEKKGCTPAQLALAWILAQSGpKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
1-292 |
6.22e-47 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 161.07 E-value: 6.22e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCM----TYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYstGESERILGRA-LRDF 75
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAMglsaFYGPP------KPDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWfKQNP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 76 AQREDLVIATKaFFPMSDRPNACGLSR---KHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVR 152
Cdd:cd19144 73 GKREKIFLATK-FGIEKNVETGEYSVDgspEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 153 YLGASSMPAwrfmkmLAFQRHHGLAQFISMQSQYN---LIVREDEEDLVPLCREEGIALTPWSPLARGLLAGA-RS---- 224
Cdd:cd19144 152 HIGLSECSA------ETLRRAHAVHPIAAVQIEYSpfsLDIERPEIGVLDTCRELGVAIVAYSPLGRGFLTGAiRSpddf 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 225 -AGTLRTRtdeqAPRWygGREEVESTL---GALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19144 226 eEGDFRRM----APRF--QAENFPKNLelvDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLE 291
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-292 |
1.98e-46 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 157.40 E-value: 1.98e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDPawrPWVLDEERARPFIREALEAGIDFFDSADIYstGESERILGRALRDFaQREDLVIATKAFFPMSD 93
Cdd:cd19095 1 SVLGLGTSGIGRV---WGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGL-RRDDLFIATKVGTHGEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 94 RPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASS--MPAWRFMKMLAFQ 171
Cdd:cd19095 75 GRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGdgEELEAAIASGVFD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 172 rhhglaqfiSMQSQYNLIVREdEEDLVPLCREEGIALTPWSPLARGLLAgARSAGTLRTRTDEQAPRWyggreevestlg 251
Cdd:cd19095 155 ---------VVQLPYNVLDRE-EEELLPLAAEAGLGVIVNRPLANGRLR-RRVRRRPLYADYARRPEF------------ 211
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 15596936 252 alekLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19095 212 ----AAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLE 248
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-312 |
2.95e-46 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 159.63 E-value: 2.95e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIY-------STGESERILGRALR 73
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGTMTFGEQN------SEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 74 DFAQREDLVIATKAFFPM-----SDRPNAcGLSRKHLLASVDASLRRLGTDYLDLFVIH--------------RFDPDTP 134
Cdd:PRK10625 75 KRGSREKLIIASKVSGPSrnndkGIRPNQ-ALDRKNIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgySWTDSAP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 135 IEETCETLDSL---VRVGKVRYLGASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPW 211
Cdd:PRK10625 154 AVSLLETLDALaeqQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 212 SPLARGLLA-----GARSAG---TLRTRTDEqaprwYGGrEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIV 283
Cdd:PRK10625 234 SCLAFGTLTgkylnGAKPAGarnTLFSRFTR-----YSG-EQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFVASTLL 307
|
330 340
....*....|....*....|....*....
gi 15596936 284 GLSRPHHLEDALAALTLDLAEEECATLEA 312
Cdd:PRK10625 308 GATTMEQLKTNIESLHLTLSEEVLAEIEA 336
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-292 |
2.41e-43 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 150.78 E-value: 2.41e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMTYGDpAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQRED 80
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGASPLGG-VFGP--VDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGI-PRDS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKA------FFPMSDrpnacgLSRKHLLASVDASLRRLGTDYLDLFVIH--RFDPDTP--IEETCETLDSLVRVGK 150
Cdd:cd19163 77 YYLATKVgrygldPDKMFD------FSAERITKSVEESLKRLGLDYIDIIQVHdiEFAPSLDqiLNETLPALQKLKEEGK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 151 VRYLGASSMPawrfMKMLA--FQRHHGLAQFISMQSQYNLIvreDEE--DLVPLCREEGIALTPWSPLARGLLagarsag 226
Cdd:cd19163 151 VRFIGITGYP----LDVLKevLERSPVKIDTVLSYCHYTLN---DTSllELLPFFKEKGVGVINASPLSMGLL------- 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596936 227 tlrtrTDEQAPRWYGGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19163 217 -----TERGPPDWHPASPEIKEACAKAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLR 277
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-292 |
1.01e-42 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 148.47 E-value: 1.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDpAWRPwvLDEERARPFIREALEAGIDFFDSADIYstGESERILGRALRDFaQREDLVIATKAFFPMSD 93
Cdd:cd19090 1 SALGLGTAGLGG-VFGG--VDDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGLALAEL-PREPLVLSTKVGRLPED 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 94 RPNacgLSRKHLLASVDASLRRLGTDYLDLFVIHrfDPDTP-------IEETCETLDSLVRVGKVRYLGASSMPAWRFMK 166
Cdd:cd19090 75 TAD---YSADRVRRSVEESLERLGRDRIDLLMIH--DPERVpwvdilaPGGALEALLELKEEGLIKHIGLGGGPPDLLRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 167 MLAfqrhHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSagtlrtrtDEQAPRWYGGREEV 246
Cdd:cd19090 150 AIE----TGDFDVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPP--------ERVRYTYRWLSPEL 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 15596936 247 ESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19090 218 LDRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELE 263
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
6-291 |
5.99e-42 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 147.59 E-value: 5.99e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 6 LGNSGLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QREDLVI 83
Cdd:cd19141 5 LGKSGLRVSCLGLGTwVTFGSQ------ISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGwRRSSYVI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 84 ATKAFF---PMSDRpnacGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMP 160
Cdd:cd19141 79 TTKIFWggkAETER----GLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 161 AWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVP-LCREEGIALTPWSPLARGLLAGARSAGT-LRTRTDEQAPR 238
Cdd:cd19141 155 AMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPeLFHKIGVGAMTWSPLACGILSGKYDDGVpEYSRASLKGYQ 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 15596936 239 WYGGREEVE------STLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHL 291
Cdd:cd19141 235 WLKEKILSEegrrqqAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQL 293
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-291 |
1.41e-41 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 147.11 E-value: 1.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QR 78
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTwVTFGGQ------ISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGwRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 79 EDLVIATKAFF---PMSDRpnacGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLG 155
Cdd:cd19159 75 SSLVITTKLYWggkAETER----GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 156 ASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVP-LCREEGIALTPWSPLARGLLAGARSAGTL-RTRTD 233
Cdd:cd19159 151 TSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPeLYHKIGVGAMTWSPLACGIISGKYGNGVPeSSRAS 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596936 234 EQAPRWYG-------GREEvESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHL 291
Cdd:cd19159 231 LKCYQWLKerivseeGRKQ-QNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQL 294
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-292 |
1.58e-41 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 147.66 E-value: 1.58e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGCMtygdpawRPWVLDEERARPFIREALEAGIDFFDSADIYstGESERILGRALRDfaQRED 80
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGM-------RLPRKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALKG--PRDK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKafFPMSDRpnacglSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETC------ETLDSLVRVGKVRYL 154
Cdd:COG1453 70 VILATK--LPPWVR------DPEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLkpggalEALEKAKAEGKIRHI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 155 GASS-MPAWRFMKMLAfqrhhgLAQFISMQSQYNLIVRED--EEDLVPLCREEGIALTPWSPLARGLLAgarsagtlrtr 231
Cdd:COG1453 142 GFSThGSLEVIKEAID------TGDFDFVQLQYNYLDQDNqaGEEALEAAAEKGIGVIIMKPLKGGRLA----------- 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 232 tdeqaprwyggreEVESTLGALEKlaaaRGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:COG1453 205 -------------NPPEKLVELLC----PPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLD 248
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-292 |
2.79e-41 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 143.78 E-value: 2.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 3 HVRLGNSGLKVSRLCLGCMTYGDpawrpwvLDEERARPFIREALEAGIDFFDSADIYstGESERILGRALRDFaqREDLV 82
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPLGR-------LSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKGR--RDKVF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAffpmsdrpnaCGLSRKHLLASVDASLRRLGTDYLDLFVIH----RFDPDTPIEE--TCETLDSLVRVGKVRYLGA 156
Cdd:cd19100 70 LATKT----------GARDYEGAKRDLERSLKRLGTDYIDLYQLHavdtEEDLDQVFGPggALEALLEAKEEGKIRFIGI 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 157 SSM---PAWRFMKMLAFQrhhglaqfiSMQSQYNLIVR---EDEEDLVPLCREEGIALTPWSPLARGLLAGARSagtlrt 230
Cdd:cd19100 140 SGHspeVLLRALETGEFD---------VVLFPINPAGDhidSFREELLPLAREKGVGVIAMKVLAGGRLLSGDP------ 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 231 rtdeqaprwyggreevestlgaleklaaarglPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19100 205 --------------------------------LDPEQALRYALSLPPVDVVIVGMDSPEELD 234
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-291 |
1.39e-40 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 144.36 E-value: 1.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QR 78
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTwVTFGSQ------ISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGwRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 79 EDLVIATKAFF---PMSDRpnacGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLG 155
Cdd:cd19160 77 SSYVVTTKIYWggqAETER----GLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 156 ASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVP-LCREEGIALTPWSPLARGLLAGaRSAGTL--RTRT 232
Cdd:cd19160 153 TSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPeLYHKIGVGSVTWSPLACGLITG-KYDGRVpdTCRA 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596936 233 DEQAPRWYggREEVESTLGA--------LEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHL 291
Cdd:cd19160 232 AVKGYQWL--KEKVQSEEGKkqqakvkeLHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQL 296
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-292 |
3.71e-40 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 143.30 E-value: 3.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNSGLKVSRLCLGC-MTYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QR 78
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTwVTFGGQ------ITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGwRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 79 EDLVIATKAFFPMSDRPNAcGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASS 158
Cdd:cd19158 75 SSLVITTKIFWGGKAETER-GLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 159 MPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVP-LCREEGIALTPWSPLARGLLAGARSAGT-LRTRTDEQA 236
Cdd:cd19158 154 WSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPeLFHKIGVGAMTWSPLACGIVSGKYDSGIpPYSRASLKG 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596936 237 PRWYG-------GREEvESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19158 234 YQWLKdkilseeGRRQ-QAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLM 295
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-312 |
1.25e-39 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 140.93 E-value: 1.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 11 LKVSRLCLGCMTYGDPAWRPWV-----LDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAqREDLVIAT 85
Cdd:cd19103 2 KKLPKIALGTWSWGSGGAGGDQvfgnhLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYP-REDYIIST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 86 KafFPmsdrPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHrfDPdTPIEETCETLDSLVRVGKVRYLGASSmpawrfm 165
Cdd:cd19103 81 K--FT----PQIAGQSADPVADMLEGSLARLGTDYIDIYWIH--NP-ADVERWTPELIPLLKSGKVKHVGVSN------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 166 kmlafqrhHGLAQF-------------IS-MQSQYNLIVREDEED-LVPLCREEGIALTPWSPLARGLLAGARS------ 224
Cdd:cd19103 145 --------HNLAEIkraneilakagvsLSaVQNHYSLLYRSSEEAgILDYCKENGITFFAYMVLEQGALSGKYDtkhplp 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 225 AGTLRTRTdeqaprwYGGRE-EVESTLGALEKLAAARGLPPAQLALAWLLGRNGVaaPIVGLSRPHHLEDALAALTLDLA 303
Cdd:cd19103 217 EGSGRAET-------YNPLLpQLEELTAVMAEIGAKHGASIAQVAIAWAIAKGTT--PIIGVTKPHHVEDAARAASITLT 287
|
....*....
gi 15596936 304 EEECATLEA 312
Cdd:cd19103 288 DDEIKELEQ 296
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
10-311 |
4.49e-39 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 138.47 E-value: 4.49e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTYGDPAWRPWVLDEErARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQREDLVIATKAFf 89
Cdd:cd19137 1 GEKIPALGLGTWGIGGFLTPDYSRDEE-MVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDF-PREDLFIVTKVW- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 pmsdrpnACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPawrfMKMLA 169
Cdd:cd19137 78 -------PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFN----RRLLE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 170 FQRHHGLAQFISMQSQYNLIVREDEED-LVPLCREEGIALTPWSPLARGLLAGARSagtlrtrtdeqaprwyggreeves 248
Cdd:cd19137 147 EAISKSQTPIVCNQVKYNLEDRDPERDgLLEYCQKNGITVVAYSPLRRGLEKTNRT------------------------ 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15596936 249 tlgaLEKLAAARGLPPAQLALAWLLGR-NGVAAPIVGlsRPHHLEDALAALTLDLAEEECATLE 311
Cdd:cd19137 203 ----LEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAG--RVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
2-311 |
3.59e-37 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 133.53 E-value: 3.59e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 2 QHVRLGnSGLKVSRLCLGCMTYGDPAWRPwvLDEERArpfIREALEAGIDFFDSADIYSTGESERILGRALRDfaQREDL 81
Cdd:cd19138 1 RTVTLP-DGTKVPALGQGTWYMGEDPAKR--AQEIEA---LRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRG--RRDKV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 82 VIATKAFfPMsdrpNAcglSRKHLLASVDASLRRLGTDYLDLFVIHrFDPDTPIEETCETLDSLVRVGKVRYLGASSMPA 161
Cdd:cd19138 73 FLVSKVL-PS----NA---SRQGTVRACERSLRRLGTDYLDLYLLH-WRGGVPLAETVAAMEELKKEGKIRAWGVSNFDT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 162 wrfMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGllagarsaGTLRtrtdeqaprwyg 241
Cdd:cd19138 144 ---DDMEELWAVPGGGNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQG--------GLLR------------ 200
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 242 gREEVESTlgALEKLAAARGLPPAQLALAWLLGRNGVAApIVGLSRPHHLEDALAALTLDLAEEECATLE 311
Cdd:cd19138 201 -RGLLENP--TLKEIAARHGATPAQVALAWVLRDGNVIA-IPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
31-292 |
5.38e-37 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 132.87 E-value: 5.38e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-AQREDLVIATKafFPMSDrpnacgLSRKHLLASV 109
Cdd:COG0656 13 WQLPGEEAAAAVRTALEAGYRHIDTAAMY---GNEEGVGEAIAASgVPREELFVTTK--VWNDN------HGYDDTLAAF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDPDtPIEETCETLDSLVRVGKVRYLGASSmpawrfmkmlaFQRHHgLAQFISM------- 182
Cdd:COG0656 82 EESLERLGLDYLDLYLIHWPGPG-PYVETWRALEELYEEGLIRAIGVSN-----------FDPEH-LEELLAEtgvkpav 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 183 -QSQYNLivREDEEDLVPLCREEGIALTPWSPLARGLLAGarsagtlrtrtdeqaprwyggrEEVestlgaLEKLAAARG 261
Cdd:COG0656 149 nQVELHP--YLQQRELLAFCREHGIVVEAYSPLGRGKLLD----------------------DPV------LAEIAEKHG 198
|
250 260 270
....*....|....*....|....*....|.
gi 15596936 262 LPPAQLALAWLLgRNGVaAPIVGLSRPHHLE 292
Cdd:COG0656 199 KTPAQVVLRWHL-QRGV-VVIPKSVTPERIR 227
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-292 |
1.29e-35 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 131.23 E-value: 1.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 2 QHVRLGNSGLKVSRLCLGCMTYGDPawrpWVL-DEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDfaQRED 80
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGGGGIGGL----MGRtTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKG--LPAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKAFFPMSDRPNACGlsrkHLLASVDASLRRLGTDYLDLFVIH-RFDPDTPIE--------------ETCETLDSL 145
Cdd:cd19104 75 PYITTKVRLDPDDLGDIGG----QIERSVEKSLKRLKRDSVDLLQLHnRIGDERDKPvggtlsttdvlglgGVADAFERL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 146 VRVGKVRYLGASSMPAWRFMKMLAFQRHhglaqFISMQSQYNLI------------VREDEEDLVPLCREEGIALTPWSP 213
Cdd:cd19104 151 RSEGKIRFIGITGLGNPPAIRELLDSGK-----FDAVQVYYNLLnpsaaearprgwSAQDYGGIIDAAAEHGVGVMGIRV 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15596936 214 LARGLLAGARSAGtlRTRTDEQAPRWyggREEVESTLgALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19104 226 LAAGALTTSLDRG--REAPPTSDSDV---AIDFRRAA-AFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNREELE 298
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-292 |
2.19e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 127.33 E-value: 2.19e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMTYGDPAWRpwVLDEERARPFIREALEAGIDFFDSADIYstGESERILGRALRDFAQR----EDLVIATKaF 88
Cdd:cd19101 2 ISRVINGMWQLSGGHGG--IRDEDAAVRAMAAYVDAGLTTFDCADIY--GPAEELIGEFRKRLRRErdaaDDVQIHTK-W 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 89 FPmsdRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTP-IEETCETLDSLVRVGKVRYLGASSMPAWRFMKM 167
Cdd:cd19101 77 VP---DPGELTMTRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 168 LAfqrhHGlAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLA----GARSAGTLRTRT-----DEQAPR 238
Cdd:cd19101 154 LD----AG-VPIVSNQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGGLLSekylGVPEPTGPALETrslqkYKLMID 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 15596936 239 WYGGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19101 229 EWGGWDLFQELLRTLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHID 282
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
31-292 |
2.62e-33 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 122.76 E-value: 2.62e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-AQREDLVIATKAFfpmSDRpnacgLSRKHLLASV 109
Cdd:cd19073 9 WQLRGDDCANAVKEALELGYRHIDTAEIY---NNEAEVGEAIAESgVPREDLFITTKVW---RDH-----LRPEDLKKSV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSmpawrF-MKMLAFQRHHGLAQFISMQSQYNL 188
Cdd:cd19073 78 DRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSN-----FtIELLEEALDISPLPIAVNQVEFHP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 189 IVRedEEDLVPLCREEGIALTPWSPLARGllagarsagtlrtrTDEQAPRwyggreevestlgaLEKLAAARGLPPAQLA 268
Cdd:cd19073 153 FLY--QAELLEYCRENDIVITAYSPLARG--------------EVLRDPV--------------IQEIAEKYDKTPAQVA 202
|
250 260
....*....|....*....|....
gi 15596936 269 LAWLLGRNGVAAPivGLSRPHHLE 292
Cdd:cd19073 203 LRWLVQKGIVVIP--KASSEDHLK 224
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
31-292 |
1.00e-32 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 121.60 E-value: 1.00e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-AQREDLVIATKAFFPmsdrpnacGLSRKHLLASV 109
Cdd:cd19140 16 YPLTGEECTRAVEHALELGYRHIDTAQMY---GNEAQVGEAIAASgVPRDELFLTTKVWPD--------NYSPDDFLASV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAwrfmKMLAFQRHHGLAQFISMQSQYNLI 189
Cdd:cd19140 85 EESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTV----ALLREAVELSEAPLFTNQVEYHPY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 190 VreDEEDLVPLCREEGIALTPWSPLARGllagarsagtlRTRTDEqaprwyggreevestlgALEKLAAARGLPPAQLAL 269
Cdd:cd19140 161 L--DQRKLLDAAREHGIALTAYSPLARG-----------EVLKDP-----------------VLQEIGRKHGKTPAQVAL 210
|
250 260
....*....|....*....|...
gi 15596936 270 AWLLGRNGVAApIVGLSRPHHLE 292
Cdd:cd19140 211 RWLLQQEGVAA-IPKATNPERLE 232
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
31-292 |
2.53e-31 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 117.97 E-value: 2.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRD-FAQREDLVIATKafFPMSDrpnacgLSRKHLLASV 109
Cdd:cd19071 9 YKLKPEETAEAVLAALEAGYRHIDTAAAY---GNEAEVGEAIREsGVPREELFITTK--LWPTD------HGYERVREAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIH------RFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQR----------H 173
Cdd:cd19071 78 EESLKDLGLDYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARikpavnqielH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 174 HGLAQfismqsqynlivredeEDLVPLCREEGIALTPWSPLARgllagarsaGTLRTRTDEqaprwyggreevestlgAL 253
Cdd:cd19071 158 PYLQQ----------------KELVEFCKEHGIVVQAYSPLGR---------GRRPLLDDP-----------------VL 195
|
250 260 270
....*....|....*....|....*....|....*....
gi 15596936 254 EKLAAARGLPPAQLALAWLLgRNGVaAPIVGLSRPHHLE 292
Cdd:cd19071 196 KEIAKKYGKTPAQVLLRWAL-QRGV-VVIPKSSNPERIK 232
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
14-292 |
7.68e-30 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 114.76 E-value: 7.68e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDPAwrpwVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAqREDLVIATKA------ 87
Cdd:cd19162 1 PRLGLGAASLGNLA----RAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHP-RAEYVVSTKVgrllep 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 88 --FFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRFDP--DTPIEETCETLDSLVRVGKVRYLGASSMpAWR 163
Cdd:cd19162 76 gaAGRPAGADRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVGVT-DWA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 fmKMLAFQRHHGLAQFIsMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAgarsagtlrtrTDEQAPRWYGGR 243
Cdd:cd19162 155 --ALLRAARRADVDVVM-VAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILA-----------TDDPAGDRYDYR 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15596936 244 ---EEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19162 221 patPEVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELR 272
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
6-292 |
1.13e-29 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 114.88 E-value: 1.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 6 LGNSGLKVSRLCLGCMTYGDpAWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QREDLVIA 84
Cdd:PLN02587 4 LGSTGLKVSSVGFGASPLGS-VFGP--VSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGiPREKYVVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 85 TKaffpmsdrpnaCG-------LSRKHLLASVDASLRRLGTDYLDLFVIHRF---DPDTPIEETCETLDSLVRVGKVRYL 154
Cdd:PLN02587 81 TK-----------CGrygegfdFSAERVTKSVDESLARLQLDYVDILHCHDIefgSLDQIVNETIPALQKLKESGKVRFI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 155 GASSMPAWRFMKMLAfQRHHGLAQFISMQSQYNLivrEDE--EDLVPLCREEGIALTPWSPLARGLLagarsagtlrtrT 232
Cdd:PLN02587 150 GITGLPLAIFTYVLD-RVPPGTVDVILSYCHYSL---NDSslEDLLPYLKSKGVGVISASPLAMGLL------------T 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 233 DEQAPRWYGGREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:PLN02587 214 ENGPPEWHPAPPELKSACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVE 273
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-292 |
1.29e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 115.11 E-value: 1.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 11 LKVSRLCLGcmTY-GDPAWRpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAQ-----REDLVIA 84
Cdd:cd19099 1 LTLSSLGLG--TYrGDSDDE----TDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELIEkggikRDEVVIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 85 TKA--FFPMSDRP---------------------NACG--LSRKHLLASVDASLRRLGTDYLDLFVIH---RFDPDTP-- 134
Cdd:cd19099 75 TKAgyIPGDGDEPlrplkyleeklgrglidvadsAGLRhcISPAYLEDQIERSLKRLGLDTIDLYLLHnpeEQLLELGee 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 135 -----IEETCETLDSLVRVGKVRYLGASS------MPAWRF---------MKMLAFQRHHGLaQFIsmQSQYNLIvrEDE 194
Cdd:cd19099 155 efydrLEEAFEALEEAVAEGKIRYYGISTwdgfraPPALPGhlsleklvaAAEEVGGDNHHF-KVI--QLPLNLL--EPE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 195 ------------EDLVPLCREEGIALtpwspLARGLLAGARSAGTLRtrtdeqaprwyggreevestlgALEKLAAARGL 262
Cdd:cd19099 230 altekntvkgeaLSLLEAAKELGLGV-----IASRPLNQGQLLGELR----------------------LADLLALPGGA 282
|
330 340 350
....*....|....*....|....*....|
gi 15596936 263 PPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19099 283 TLAQRALQFARSTPGVDSALVGMRRPEHVD 312
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-292 |
5.07e-29 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 111.88 E-value: 5.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYgdPAWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQREDLVIATKaFFPMSD 93
Cdd:cd19096 1 SVLGFGTMRL--PESDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEG-PREKFYLATK-LPPWSV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 94 RPNACglSRKHLlasvDASLRRLGTDYLDLFVIHRFDPDTPIEETC-----ETLDSLVRVGKVRYLGASS-MPAWRFMKM 167
Cdd:cd19096 77 KSAED--FRRIL----EESLKRLGVDYIDFYLLHGLNSPEWLEKARkggllEFLEKAKKEGLIRHIGFSFhDSPELLKEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 168 LAFqrhhglAQFISMQSQYNLIVREDE--EDLVPLCREEGIALTPWSPLARGLLAgarsagtlrtrtdeQAPrwyggree 245
Cdd:cd19096 151 LDS------YDFDFVQLQYNYLDQENQagRPGIEYAAKKGMGVIIMEPLKGGGLA--------------NNP-------- 202
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15596936 246 vestlGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19096 203 -----PEALAILCGAPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLD 244
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
10-308 |
3.19e-28 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 110.01 E-value: 3.19e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 10 GLKVSRLCLGCMTygdpAWRPWVLDE--ERARPFIREALEAGIDFFDSADIYSTgesERILGRALRDF-AQREDLVIATK 86
Cdd:cd19120 1 GSKIPAIAFGTGT----AWYKSGDDDiqRDLVDSVKLALKAGFRHIDTAEMYGN---EKEVGEALKESgVPREDLFITTK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 AFFPMSDRPNACglsrkhllasvDASLRRLGTDYLDLFVIH--RFDP--DTPIEETCETLDSLVRVGKVRYLGASSMPAW 162
Cdd:cd19120 74 VSPGIKDPREAL-----------RKSLAKLGVDYVDLYLIHspFFAKegGPTLAEAWAELEALKDAGLVRSIGVSNFRIE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 RFMKMLAFQRHhglaqFISM-QSQYNLIVREDEEDLVPLCREEGIALTPWSPLargllagarsagtlrtrtdeqAPRWYG 241
Cdd:cd19120 143 DLEELLDTAKI-----KPAVnQIEFHPYLYPQQPALLEYCREHGIVVSAYSPL---------------------SPLTRD 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596936 242 GREEVESTlgaLEKLAAARGLPPAQLALAWLLGRNgvAAPIVGLSRPHHLEDALAALTLDLAEEECA 308
Cdd:cd19120 197 AGGPLDPV---LEKIAEKYGVTPAQVLLRWALQKG--IVVVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
14-292 |
4.84e-24 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 99.61 E-value: 4.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGCMTYGDPaWRPwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFAqREDLVIATKA------ 87
Cdd:cd19152 1 PKLGFGTAPLGNL-YEA--VSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG-REDYVISTKVgrllvp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 88 ---------FFPMSDRPNACGL--SRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEETCET-----------LDSL 145
Cdd:cd19152 77 lqeveptfePGFWNPLPFDAVFdySYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEHfaqaikgafraLEEL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 146 VRVGKVRYLGASSMpawrFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSA 225
Cdd:cd19152 157 REEGVIKAIGLGVN----DWEVILRILEEADLDWVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAGGDNF 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 226 GTLRTRT-DEQAPRWyggREEVEStlgalekLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19152 233 DYYEYGPaPPELIAR---RDRIEA-------LCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVE 290
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
1-312 |
5.72e-22 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 93.50 E-value: 5.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 1 MQHVRLGNS----GLKVSRLCLGCM------TYGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIYSTGESERILGR 70
Cdd:PRK10376 1 MSTIMSSGTftlgGRSVNRLGYGAMqlagpgVFGPPK------DRDAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 71 ALRDFaqREDLVIATKAFFPMSDR---PNAcgLSRKHLLASVDASLRRLGTDYLDLfVIHR--FDPDTP----IEETCET 141
Cdd:PRK10376 75 ALHPY--PDDLTIVTKVGARRGEDgswLPA--FSPAELRRAVHDNLRNLGLDVLDV-VNLRlmGDGHGPaegsIEEPLTV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 142 LDSLVRVGKVRYLGASSMPAwrfmKMLAFQRhhGLAQFISMQSQYNLIVREDEEdLVPLCREEGIALTPWSPLargllag 221
Cdd:PRK10376 150 LAELQRQGLVRHIGLSNVTP----TQVAEAR--KIAEIVCVQNHYNLAHRADDA-LIDALARDGIAYVPFFPL------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 222 arsagtlrtrtdeqaprwyGGREEVESTlgALEKLAAARGLPPAQLALAWLLGRngvaAP----IVGLSRPHHLEDALAA 297
Cdd:PRK10376 216 -------------------GGFTPLQSS--TLSDVAASLGATPMQVALAWLLQR----SPnillIPGTSSVAHLRENLAA 270
|
330
....*....|....*
gi 15596936 298 LTLDLAEEECATLEA 312
Cdd:PRK10376 271 AELVLSEEVLAELDG 285
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
6-286 |
4.81e-21 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 91.06 E-value: 4.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 6 LGNSGLKVSRLCLGCM----TYGDPawrpwvLDEERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFA-QRED 80
Cdd:cd19153 5 LEIALGNVSPVGLGTAalggVYGDG------LEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQvPRSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 81 LVIATKAffpmsDRPNACGL--SRKHLLASVDASLRRLGTDYLDLFVIHRF---DPDTPIEETCETLDSLVRVGKVRYLG 155
Cdd:cd19153 79 YTVATKV-----GRYRDSEFdySAERVRASVATSLERLHTTYLDVVYLHDIefvDYDTLVDEALPALRTLKDEGVIKRIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 156 ASSMPAwRFMKMLAFQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLagarsagtlrtrTDEQ 235
Cdd:cd19153 154 IAGYPL-DTLTRATRRCSPGSLDAVLSYCHLTLQDARLESDAPGLVRGAGPHVINASPLSMGLL------------TSQG 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 15596936 236 APRWYGGREEVESTLGALEKLAAARGLPPAQLALAWLLG-RNGVAAPIVGLS 286
Cdd:cd19153 221 PPPWHPASGELRHYAAAADAVCASVEASLPDLALQYSLAaHAGVGTVLLGPS 272
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
8-217 |
6.18e-21 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 90.14 E-value: 6.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGcmtygdpAWRpwVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRD-FAQREDLVIATK 86
Cdd:cd19157 5 NNGVKMPWLGLG-------VFK--VEEGSEVVNAVKTALKNGYRSIDTAAIY---GNEEGVGKGIKEsGIPREELFITSK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 87 AFfpmsdrpNAcGLSRKHLLASVDASLRRLGTDYLDLFVIHrfdpdTPIE----ETCETLDSLVRVGKVRYLGASSmpaw 162
Cdd:cd19157 73 VW-------NA-DQGYDSTLKAFEASLERLGLDYLDLYLIH-----WPVKgkykETWKALEKLYKDGRVRAIGVSN---- 135
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 163 rfmkmlaFQRHH-----GLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARG 217
Cdd:cd19157 136 -------FQVHHledllADAEIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQG 188
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-292 |
1.51e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 89.12 E-value: 1.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 14 SRLCLGC----MTYGDPAWRPWVLDEErARPFIREALEAGIDFFDSADIYstGESERILGRAlrdFAQREDLVIATKaff 89
Cdd:cd19097 1 SKLALGTaqfgLDYGIANKSGKPSEKE-AKKILEYALKAGINTLDTAPAY--GDSEKVLGKF---LKRLDKFKIITK--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 90 pMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLFVIHRF-DPDTPIEETCETLDSLVRVGKVRYLGAS---SMPAWRFM 165
Cdd:cd19097 72 -LPPLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSvysPEELEKAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 166 KMLAFQrhhglaqfiSMQSQYNLI-VREDEEDLVPLCREEGIALTPWSPLARGLLagarsagtlrTRTDEQAPRWYggrE 244
Cdd:cd19097 151 ESFKID---------IIQLPFNILdQRFLKSGLLAKLKKKGIEIHARSVFLQGLL----------LMEPDKLPAKF---A 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15596936 245 EVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19097 209 PAKPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLK 256
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
35-292 |
4.36e-20 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 88.54 E-value: 4.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 35 EERARPFIREALEAGIDFFDSADIYSTGESERILGRALRDFaQREDLVIATKA---FFPMSD--RPNACGL--------- 100
Cdd:cd19161 19 NADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREK-PRDEFVLSTKVgrlLKPAREgsVPDPNGFvdplpfeiv 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 101 ---SRKHLLASVDASLRRLGTDYLDLFVIHRFDPDTPIEE--------TCE----TLDSLVRVGKVRY--LGASSMPAwr 163
Cdd:cd19161 98 ydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRkerhhfaqLMSggfkALEELKKAGVIKAfgLGVNEVQI-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 fmkMLAFQRHHGLAQFIsMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLA-GARSAGTLRTRTdeqAPrwygg 242
Cdd:cd19161 176 ---CLEALDEADLDCFL-LAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILAtGTKSGAKFNYGD---AP----- 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 15596936 243 rEEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLE 292
Cdd:cd19161 244 -AEIISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLR 292
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
18-281 |
2.24e-19 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 85.70 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 18 LGCMTYGDPawrpwvlDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFFPMSDRPN 96
Cdd:cd19133 12 LGFGVFQIP-------DPEECERAVLEAIKAGYRLIDTAAAY---GNEEAVGRAIKKSGiPREELFITTKLWIQDAGYEK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 97 ACglsrkhllASVDASLRRLGTDYLDLFVIHRfdPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFqrhhgl 176
Cdd:cd19133 82 AK--------KAFERSLKRLGLDYLDLYLIHQ--PFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILH------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 177 AQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARG---LLagarsagtlrtrtdeqaprwyggREEVestlgaL 253
Cdd:cd19133 146 NEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGrnnLF-----------------------ENPV------L 196
|
250 260
....*....|....*....|....*...
gi 15596936 254 EKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19133 197 TEIAEKYGKSVAQVILRWLIQRGIVVIP 224
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
8-292 |
1.34e-18 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 84.26 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGcmTYGDpawrpwvLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFAQ-----REDLV 82
Cdd:cd19116 6 NDGNEIPAIALG--TWKL-------KDDEGVRQAVKHAIEAGYRHIDTAYLY---GNEAEVGEAIREKIAegvvkREDLF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKaffpmsdrpnacgL-----SRKHLLASVDASLRRLGTDYLDLFVIHrfdpdTPI---EETCETLDSLVRVGKVRYL 154
Cdd:cd19116 74 ITTK-------------LwnsyhEREQVEPALRESLKRLGLDYVDLYLIH-----WPVafkENNDSESNGDGSLSDIDYL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 155 gassmPAWRFM---KMLAFQRHHGLAQFISmqSQYNLIVRE----------------DEEDLVPLCREEGIALTPWSPLA 215
Cdd:cd19116 136 -----ETWRGMedlVKLGLTRSIGVSNFNS--EQINRLLSNcnikpavnqievhptlTQEKLVAYCQSNGIVVMAYSPFG 208
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15596936 216 RGLLAGARSAGtlrtrtdeqaPRWYGGReevestlgaLEKLAAARGLPPAQLALAWLLGRNGVaaPIVGLSRPHHLE 292
Cdd:cd19116 209 RLVPRGQTNPP----------PRLDDPT---------LVAIAKKYGKTTAQIVLRYLIDRGVV--PIPKSSNKKRIK 264
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
42-292 |
1.35e-18 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 83.56 E-value: 1.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFFpmsDRpnacgLSRKHLLASVDASLRRLGTDY 120
Cdd:cd19139 20 VRTALELGYRHIDTAQIY---DNEAAVGQAIAESGvPRDELFITTKIWI---DN-----LSKDKLLPSLEESLEKLRTDY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 121 LDLFVIHRFDPD--TPIEETCETLDSLVRVGKVRYLGASSmpawrfmkmlaFQRHHgLAQFISMQSQYNLIVREDE---- 194
Cdd:cd19139 89 VDLTLIHWPSPNdeVPVEEYIGALAEAKEQGLTRHIGVSN-----------FTIAL-LDEAIAVVGAGAIATNQIElspy 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 195 ---EDLVPLCREEGIALTPWSPLARGLLagarsagtlrtrtdeqaprwygGREEVestlgaLEKLAAARGLPPAQLALAW 271
Cdd:cd19139 157 lqnRKLVAHCKQHGIHVTSYMTLAYGKV----------------------LDDPV------LAAIAERHGATPAQIALAW 208
|
250 260
....*....|....*....|.
gi 15596936 272 LLGRNGVAAPivGLSRPHHLE 292
Cdd:cd19139 209 AMARGYAVIP--SSTKREHLR 227
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
30-220 |
1.50e-18 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 83.26 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 30 PW-------VLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFfpmSDRPNAcgls 101
Cdd:cd19126 10 PWlglgvfqTPDGDETERAVQTALENGYRSIDTAAIY---KNEEGVGEAIRESGvPREELFVTTKLW---NDDQRA---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 102 rKHLLASVDASLRRLGTDYLDLFVIHRFDPDTpIEETCETLDSLVRVGKVRYLGASSmpawrfmkmlaFQRHH-----GL 176
Cdd:cd19126 80 -RRTEDAFQESLDRLGLDYVDLYLIHWPGKDK-FIDTWKALEKLYASGKVKAIGVSN-----------FQEHHleellAH 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15596936 177 AQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLA 220
Cdd:cd19126 147 ADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGGLL 190
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
9-273 |
1.69e-18 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 83.86 E-value: 1.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 9 SGLKVSRLCLGcmTYGDPAwrpwvlDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRD------FAQREDLV 82
Cdd:cd19124 1 SGQTMPVIGMG--TASDPP------SPEDIKAAVLEAIEVGYRHFDTAAAY---GTEEALGEALAEalrlglVKSRDELF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAFfpMSDrpnacgLSRKHLLASVDASLRRLGTDYLDLFVIH--------RFDPDTP--------IEETCETLDSLV 146
Cdd:cd19124 70 VTSKLW--CSD------AHPDLVLPALKKSLRNLQLEYVDLYLIHwpvslkpgKFSFPIEeedflpfdIKGVWEAMEECQ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 147 RVGKVRYLGASSMPAWRFMKMLAFqrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLargllagaRSAG 226
Cdd:cd19124 142 RLGLTKAIGVSNFSCKKLQELLSF------ATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPL--------GAPG 207
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15596936 227 TlrtrtdeqapRWyGGREEVEStlGALEKLAAARGLPPAQLALAWLL 273
Cdd:cd19124 208 T----------KW-GSNAVMES--DVLKEIAAAKGKTVAQVSLRWVY 241
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
34-292 |
5.58e-18 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 81.91 E-value: 5.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 34 DEERARPFIREALEAGIDFFDSADIYSTgesERILGRALRDF-----AQREDLVIATKaffpmsdrpnacgLSRKHLL-- 106
Cdd:cd19136 13 GEEEVRQAVDAALKAGYRLIDTASVYRN---EADIGKALRDLlpkygLSREDIFITSK-------------LAPKDQGye 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 107 ---ASVDASLRRLGTDYLDLFVIH-----RFDPDTPIE-----ETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFqrh 173
Cdd:cd19136 77 karAACLGSLERLGTDYLDLYLIHwpgvqGLKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKY--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 174 hglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARgllagarsaGTLRTRTDEqaprwyggreevestlgAL 253
Cdd:cd19136 154 ---CEVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGS---------GDLRLLEDP-----------------TV 204
|
250 260 270
....*....|....*....|....*....|....*....
gi 15596936 254 EKLAAARGLPPAQLALAWLLgRNGVAApIVGLSRPHHLE 292
Cdd:cd19136 205 LAIAKKYGRTPAQVLLRWAL-QQGIGV-IPKSTNPERIA 241
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
13-292 |
2.02e-17 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 81.17 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 13 VSRLCLGCMTYGdpawRPWVLDEERARP--FIREALEAGIDFFDSADIYstGESERILGRAL---RDFAQREDLVIATKa 87
Cdd:cd19164 13 LPPLIFGAATFS----YQYTTDPESIPPvdIVRRALELGIRAFDTSPYY--GPSEIILGRALkalRDEFPRDTYFIITK- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 88 ffpmsdrpnaCG--------LSRKHLLASVDASLRRLGTDYLDLFVIH--RFDPDTPIEETCETLDSLVRVGKVRYLGAS 157
Cdd:cd19164 86 ----------VGrygpddfdYSPEWIRASVERSLRRLHTDYLDLVYLHdvEFVADEEVLEALKELFKLKDEGKIRNVGIS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 158 SMPAWRFMKMLAFQRHHGLA--QFISMQSQYNLivredeEDLVPLCREEGIALTPW-------SPLARGLLagaRSAGtl 228
Cdd:cd19164 156 GYPLPVLLRLAELARTTAGRplDAVLSYCHYTL------QNTTLLAYIPKFLAAAGvkvvlnaSPLSMGLL---RSQG-- 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15596936 229 rtrtdeqAPRWYGGREEVESTLGALEKLAAARGLPPAQLALAWLL-GRNGVAAPIVGLSRPHHLE 292
Cdd:cd19164 225 -------PPEWHPASPELRAAAAKAAEYCQAKGTDLADVALRYALrEWGGEGPTVVGCSNVDELE 282
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
4-281 |
2.32e-17 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 80.25 E-value: 2.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 4 VRLGNsGLKVSRLCLGcmtygdpAWRpwVLDEERARPFIREALEAGIDFFDSADIYSTGESeriLGRALRDFA-QREDLV 82
Cdd:cd19156 1 VKLAN-GVEMPRLGLG-------VWR--VQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEG---VGQGIRESGvPREEVF 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAFfpMSDRpnacglSRKHLLASVDASLRRLGTDYLDLFVIHrfdpdTPIE----ETCETLDSLVRVGKVRYLGASS 158
Cdd:cd19156 68 VTTKLW--NSDQ------GYESTLAAFEESLEKLGLDYVDLYLIH-----WPVKgkfkDTWKAFEKLYKEKKVRAIGVSN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 159 mpawrfmkmlaFQRHH-----GLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARG-LLAGARsagtlrtrt 232
Cdd:cd19156 135 -----------FHEHHleellKSCKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGkLLSNPV--------- 194
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 15596936 233 deqaprwyggreevestlgaLEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19156 195 --------------------LKAIGKKYGKSAAQVIIRWDIQHGIITIP 223
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
8-281 |
3.05e-17 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 80.61 E-value: 3.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGcmtygdpAWRpwvLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRD-FAQ----REDLV 82
Cdd:cd19112 6 NSGHKMPVIGLG-------VWR---MEPGEIKELILNAIKIGYRHFDCAADY---KNEKEVGEALAEaFKTglvkREDLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAFfpMSDRpnacglsrKHLLASVDASLRRLGTDYLDLFVIH-----------------------RFDPDTPIEETC 139
Cdd:cd19112 73 ITTKLW--NSDH--------GHVIEACKDSLKKLQLDYLDLYLVHfpvatkhtgvgttgsalgedgvlDIDVTISLETTW 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 140 ETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNlivredEEDLVPLCREEGIALTPWSPLArGLL 219
Cdd:cd19112 143 HAMEKLVSAGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQIETHPYFQ------RDSLVKFCQKHGISVTAHTPLG-GAA 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 220 AGArsagtlrtrtdeqapRWYGGREEVESTLgaLEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19112 216 ANA---------------EWFGSVSPLDDPV--LKDLAKKYGKSAAQIVLRWGIQRNTAVIP 260
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
31-275 |
3.09e-16 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 77.18 E-value: 3.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYStgeSERILGRALR-----DFAQREDLVIATKaFFPMSDRPNacgLSRKHL 105
Cdd:cd19128 9 YKITESESKEAVKNAIKAGYRHIDCAYYYG---NEAFIGIAFSeifkdGGVKREDLFITSK-LWPTMHQPE---NVKEQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 106 LASvdasLRRLGTDYLDLFVIH---RFDPDT----------------PIEETCETLDSLVRVGKVRYLGASSMPAWRFMK 166
Cdd:cd19128 82 LIT----LQDLQLEYLDLFLIHwplAFDMDTdgdprddnqiqslskkPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 167 MLAFQRHHGLAQFISMQSQYNlivredEEDLVPLCREEGIALTPWSPLargllaGARsagtlrtrtdeqaprwYGGREEV 246
Cdd:cd19128 158 LLNYCKIKPFMNQIECHPYFQ------NDKLIKFCIENNIHVTAYRPL------GGS----------------YGDGNLT 209
|
250 260
....*....|....*....|....*....
gi 15596936 247 ESTLGALEKLAAARGLPPAQLALAWLLGR 275
Cdd:cd19128 210 FLNDSELKALATKYNTTPPQVIIAWHLQK 238
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
31-281 |
3.20e-15 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 74.75 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYSTgESEriLGRALRD-FAQ----REDLVIATKAFfpmsdrpnacglSRKHL 105
Cdd:cd19123 20 WKSKPGEVGQAVKQALEAGYRHIDCAAIYGN-EAE--IGAALAEvFKEgkvkREDLWITSKLW------------NNSHA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 106 LASV----DASLRRLGTDYLDLFVIH---RFDPDT---------------PIEETCETLDSLVRVGKVRYLGASSMPAWR 163
Cdd:cd19123 85 PEDVlpalEKTLADLQLDYLDLYLMHwpvALKKGVgfpesgedllslspiPLEDTWRAMEELVDKGLCRHIGVSNFSVKK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 FMKMLAfqrhhgLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGllagarsagtlrtrtdeQAPRwyGGR 243
Cdd:cd19123 165 LEDLLA------TARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSG-----------------DRPA--AMK 219
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 15596936 244 EEVESTLGA---LEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19123 220 AEGEPVLLEdpvINKIAEKHGASPAQVLIAWAIQRGTVVIP 260
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
31-281 |
3.66e-15 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 74.46 E-value: 3.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYStgeSERILGRALRDFA-QREDLVIATKAFFPMSDRPNACglsrkhllasV 109
Cdd:cd19117 22 WQSKPNEVAKAVEAALKAGYRHIDTAAIYG---NEEEVGQGIKDSGvPREEIFITTKLWCTWHRRVEEA----------L 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIH---------------------RFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKML 168
Cdd:cd19117 89 DQSLKKLGLDYVDLYLMHwpvpldpdgndflfkkddgtkDHEPDWDFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 169 AFQRhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLargllaGARSAGTLRTRTdeqaprwyggreeves 248
Cdd:cd19117 169 ASPS----AKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPL------GSTNAPLLKEPV---------------- 222
|
250 260 270
....*....|....*....|....*....|...
gi 15596936 249 tlgaLEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19117 223 ----IIKIAKKHGKTPAQVIISWGLQRGYSVLP 251
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
31-273 |
4.56e-15 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 73.56 E-value: 4.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFFPMSDRPNAcglsrkhlLASV 109
Cdd:cd19131 18 WQVSNDEAASAVREALEVGYRSIDTAAIY---GNEEGVGKAIRASGvPREELFITTKLWNSDQGYDST--------LRAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDP--DTPIeETCETLDSLVRVGKVRYLGASSmpawrfmkmlaFQRHHgLAQFIS------ 181
Cdd:cd19131 87 DESLRKLGLDYVDLYLIHWPVPaqDKYV-ETWKALIELKKEGRVKSIGVSN-----------FTIEH-LQRLIDetgvvp 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 182 MQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGllagarsaGTLRTRTdeqaprwyggreevestlgaLEKLAAARG 261
Cdd:cd19131 154 VVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQG--------GLLSDPV--------------------IGEIAEKHG 205
|
250
....*....|..
gi 15596936 262 LPPAQLALAWLL 273
Cdd:cd19131 206 KTPAQVVIRWHL 217
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
3-279 |
1.09e-14 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 73.22 E-value: 1.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 3 HVRLgNSGLKVSRLCLGCmtygdpawrpWVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-----AQ 77
Cdd:cd19154 3 SITL-SNGVKMPLIGLGT----------WQSKGAEGITAVRTALKAGYRLIDTAFLY---QNEEAIGEALAELleegvVK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 78 REDLVIATKAFfPMSDRPNAcglsrkhLLASVDASLRRLGTDYLDLFVIH-------------------RFDPDTPIEET 138
Cdd:cd19154 69 REDLFITTKLW-THEHAPED-------VEEALRESLKKLQLEYVDLYLIHapaafkddegesgtmengmSIHDAVDVEDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 139 CETLDSLVRVGKVRYLGASSmpaWRFMKMlafQRHHGLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLArgl 218
Cdd:cd19154 141 WRGMEKVYDEGLTKAIGVSN---FNNDQI---QRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLG--- 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15596936 219 lagarSAGTLRTRTDeqaPRWYGGREEVESTLgaLEKLAAARGLPPAQLALAWLLGRnGVA 279
Cdd:cd19154 212 -----SPGRANFTKS---TGVSPAPNLLQDPI--VKAIAEKHGKTPAQVLLRYLLQR-GIA 261
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
42-271 |
1.28e-14 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 72.83 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYSTgESEriLGRALRDFAQ------REDLVIATKAFfPMSDRPnacglsrKHLLASVDASLRR 115
Cdd:cd19118 26 VKIALKAGYRHLDLAKVYQN-QHE--VGQALKELLKeepgvkREDLFITSKLW-NNSHRP-------EYVEPALDDTLKE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 116 LGTDYLDLFVIH---RFDPDTPIE---------------------ETCETLDSLVRVGKVRYLGASSMPAWRFMKMLA-- 169
Cdd:cd19118 95 LGLDYLDLYLIHwpvAFKPTGDLNpltavptnggevdldlsvslvDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEet 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 170 --------FQRHHGLAQfismqsqynlivredeEDLVPLCREEGIALTPWSPLargllaGARSAGTLRTRTDEqaprwyg 241
Cdd:cd19118 175 gvvpavnqIEAHPLLLQ----------------DELVDYCKSKNIHITAYSPL------GNNLAGLPLLVQHP------- 225
|
250 260 270
....*....|....*....|....*....|
gi 15596936 242 greevestlgALEKLAAARGLPPAQLALAW 271
Cdd:cd19118 226 ----------EVKAIAAKLGKTPAQVLIAW 245
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
47-219 |
3.34e-14 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 71.20 E-value: 3.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 47 EAGIDFFDSADIYSTgesERILGRALRDFA-QREDLVIATKAFfpmsdrPNACGLSRkhLLASVDASLRRLGTDYLDLFV 125
Cdd:cd19135 37 ECGYRHIDTAKRYGC---EELLGKAIKESGvPREDLFLTTKLW------PSDYGYES--TKQAFEASLKRLGVDYLDLYL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 126 IHRfdPDTP---------IEETCETLDSLVRVGKVRYLGASSmpawrfmkmlaFQRHH--GLAQFISMQSQYNLI---VR 191
Cdd:cd19135 106 LHW--PDCPssgknvketRAETWRALEELYDEGLCRAIGVSN-----------FLIEHleQLLEDCSVVPHVNQVefhPF 172
|
170 180
....*....|....*....|....*...
gi 15596936 192 EDEEDLVPLCREEGIALTPWSPLARGLL 219
Cdd:cd19135 173 QNPVELIEYCRDNNIVFEGYCPLAKGKA 200
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
20-281 |
6.36e-14 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 71.02 E-value: 6.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 20 CMTYGDPAWRP------WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFAQ-----REDLVIATKaF 88
Cdd:cd19155 3 CVTFNNGEKMPvvglgtWQSSPEEIETAVDTALEAGYRHIDTAYVY---RNEAAIGNVLKKWIDsgkvkREELFIVTK-L 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 89 FPMSDRPNACglsRKHLLASvdasLRRLGTDYLDLFVIHrfdpdTPIEETCETLDSLVRVGKVRYLGASS---MPAWRFM 165
Cdd:cd19155 79 PPGGNRREKV---EKFLLKS----LEKLQLDYVDLYLIH-----FPVGSLSKEDDSGKLDPTGEHKQDYTtdlLDIWKAM 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 166 KMLAFQ---RHHGLAQFISMQ--------------SQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGArSAGTL 228
Cdd:cd19155 147 EAQVDQgltRSIGLSNFNREQmarilknarikpanLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPGAAHF-SPGTG 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 15596936 229 RTRTDEQAPRwyggreevesTLGALEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19155 226 SPSGSSPDLL----------QDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIP 268
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
42-275 |
1.78e-13 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 69.28 E-value: 1.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFFPmsdrpnacGLSRKHLLASVDASLRRLGTDY 120
Cdd:PRK11172 22 VKTALELGYRAIDTAQIY---DNEAAVGQAIAESGvPRDELFITTKIWID--------NLAKDKLIPSLKESLQKLRTDY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 121 LDLFVIHRFDPD--TPIEETCETLDSLVRVGKVRYLGASSmpawrFMKMLafqrhhgLAQFISMQSQYNLIVREDE---- 194
Cdd:PRK11172 91 VDLTLIHWPSPNdeVSVEEFMQALLEAKKQGLTREIGISN-----FTIAL-------MKQAIAAVGAENIATNQIElspy 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 195 ---EDLVPLCREEGIALTPWSPLARGllagarsagtlRTRTDEqaprwyggreevestlgALEKLAAARGLPPAQLALAW 271
Cdd:PRK11172 159 lqnRKVVAFAKEHGIHVTSYMTLAYG-----------KVLKDP-----------------VIARIAAKHNATPAQVILAW 210
|
....
gi 15596936 272 LLGR 275
Cdd:PRK11172 211 AMQL 214
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
31-290 |
7.16e-13 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 67.30 E-value: 7.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKafFPMSDRPnacglsRKHLLASV 109
Cdd:cd19132 15 YPLKGDEGVEAVVAALQAGYRLLDTAFNY---ENEGAVGEAVRRSGvPREELFVTTK--LPGRHHG------YEEALRTI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDP--DTPIeETCETLDSLVRVGKVRYLGASSMPAWRFMKMLA----------FQRHHGLA 177
Cdd:cd19132 84 EESLYRLGLDYVDLYLIHWPNPsrDLYV-EAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDetgvtpavnqIELHPYFP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 178 QfismqsqynlivredeEDLVPLCREEGIALTPWSPLARG--LLagarsagtlrtrtDEQaprwyggreevestlgALEK 255
Cdd:cd19132 163 Q----------------AEQRAYHREHGIVTQSWSPLGRGsgLL-------------DEP----------------VIKA 197
|
250 260 270
....*....|....*....|....*....|....*
gi 15596936 256 LAAARGLPPAQLALAWLLGRNGVaaPIVGLSRPHH 290
Cdd:cd19132 198 IAEKHGKTPAQVVLRWHVQLGVV--PIPKSANPER 230
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
8-214 |
1.48e-12 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 66.79 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGCmtygdpawrpWVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRD-FA---QREDLVI 83
Cdd:cd19121 7 NTGASIPAVGLGT----------WQAKAGEVKAAVAHALKIGYRHIDGALCY---QNEDEVGEGIKEaIAggvKREDLFV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 84 ATKAFFPMSDRPNACglsrkhllasVDASLRRLGTDYLDLFVIH----------------------RFDPDTPIEETCET 141
Cdd:cd19121 74 TTKLWSTYHRRVELC----------LDRSLKSLGLDYVDLYLVHwpvllnpngnhdlfptlpdgsrDLDWDWNHVDTWKQ 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15596936 142 LDSLVRVGKVRYLGASSMPAWRFMKMLAFqrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPL 214
Cdd:cd19121 144 MEKVLKTGKTKAIGVSNYSIPYLEELLKH------ATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPL 210
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
8-276 |
2.18e-12 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 66.70 E-value: 2.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGCmtygdpawrpWVLDEERARPFIREALEAGIDFFDSADIYStgeSERILG----RALRD-FAQREDLV 82
Cdd:cd19113 6 NSGYKMPSVGFGC----------WKLDNATAADQIYQAIKAGYRLFDGAEDYG---NEKEVGegvnRAIDEgLVKREELF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAFFPMSDRpnacglsrKHLLASVDASLRRLGTDYLDLFVIH-----RFDP--------------------DTPIEE 137
Cdd:cd19113 73 LTSKLWNNFHDP--------KNVETALNKTLSDLKLDYVDLFLIHfpiafKFVPieekyppgfycgdgdnfvyeDVPILD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 138 TCETLDSLVRVGKVRYLGASSMPAWRFMKML--------AFQ-RHHGLAQfismqsqynlivredEEDLVPLCREEGIAL 208
Cdd:cd19113 145 TWKALEKLVDAGKIKSIGVSNFPGALILDLLrgatikpaVLQiEHHPYLQ---------------QPKLIEYAQKAGITI 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596936 209 TPWSPLargllaGARSAGTLRTRTDEQAPRWYggREEVestlgaLEKLAAARGLPPAQLALAWLLGRN 276
Cdd:cd19113 210 TAYSSF------GPQSFVELNQGRALNTPTLF--EHDT------IKSIAAKHNKTPAQVLLRWATQRG 263
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
31-276 |
9.35e-12 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 64.75 E-value: 9.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSA-DIYSTGESERILGRALRD-FAQREDLVIATKAFFPMSDRPNACGLSRKhllas 108
Cdd:cd19115 21 WKVNNDTCADQVYNAIKAGYRLFDGAcDYGNEVEAGQGVARAIKEgIVKREDLFIVSKLWNTFHDGERVEPICRK----- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 109 vdaSLRRLGTDYLDLFVIH------------RFDP------------DTPIEETCETLDSLVRVGKVRYLGASSMPAWRF 164
Cdd:cd19115 96 ---QLADWGIDYFDLFLIHfpialkyvdpavRYPPgwfydgkkvefsNAPIQETWTAMEKLVDKGLARSIGVSNFSAQLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 165 MKMLAFQR---------HHGLAQfismqsqynlivredEEDLVPLCREEGIALTPWSPLargllaGARSAGTLRTRTDEQ 235
Cdd:cd19115 173 MDLLRYARirpatlqieHHPYLT---------------QPRLVKYAQKEGIAVTAYSSF------GPQSFLELDLPGAKD 231
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 15596936 236 APRWYggrEEvestlGALEKLAAARGLPPAQLALAWLLGRN 276
Cdd:cd19115 232 TPPLF---EH-----DVIKSIAEKHGKTPAQVLLRWATQRG 264
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
8-275 |
9.36e-12 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 64.67 E-value: 9.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGcmtygdpAWRPWVLDEERArpfIREALEAGIDFFDSADIYstgESERILGRALRD-----FAQREDLV 82
Cdd:cd19125 6 NTGAKIPAVGLG-------TWQADPGVVGNA---VKTAIKEGYRHIDCAAIY---GNEKEIGKALKKlfedgVVKREDLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATK----AFFPmSDRPNAcglsrkhllasVDASLRRLGTDYLDLFVIH----------RFDPD----TPIEETCETLDS 144
Cdd:cd19125 73 ITSKlwctDHAP-EDVPPA-----------LEKTLKDLQLDYLDLYLIHwpvrlkkgahMPEPEevlpPDIPSTWKAMEK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 145 LVRVGKVRYLGASSMPAWRFMKMLAFQR----------HHGLAQfismqsqynlivredeEDLVPLCREEGIALTPWSPL 214
Cdd:cd19125 141 LVDSGKVRAIGVSNFSVKKLEDLLAVARvppavnqvecHPGWQQ----------------DKLHEFCKSKGIHLSAYSPL 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15596936 215 ArgllagarSAGTLRTRTDE-QAPrwyggreevestlgALEKLAAARGLPPAQLALAWLLGR 275
Cdd:cd19125 205 G--------SPGTTWVKKNVlKDP--------------IVTKVAEKLGKTPAQVALRWGLQR 244
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
42-280 |
1.38e-11 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 63.97 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYStgeSERILGRALRDFA-QREDLVIATKAFFpmsdrpnaCGLSRKHLLASVDASLRRLGTDY 120
Cdd:cd19127 28 VATALADGYRLIDTAAAYG---NEREVGEGIRRSGvDRSDIFVTTKLWI--------SDYGYDKALRGFDASLRRLGLDY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 121 LDLFVIHRFDPdTPIEETCETLDSLVRV---GKVRYLGASSMPAWRFMKMLAfqrhhgLAQFISMQSQYNLIVREDEEDL 197
Cdd:cd19127 97 VDLYLLHWPVP-NDFDRTIQAYKALEKLlaeGRVRAIGVSNFTPEHLERLID------ATTVVPAVNQVELHPYFSQKDL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 198 VPLCREEGIALTPWSPLargllagarsAGTLRTRtdeqaPRWYGGREEVESTlGALEKLAAARGLPPAQLALAWLLgRNG 277
Cdd:cd19127 170 RAFHRRLGIVTQAWSPI----------GGVMRYG-----ASGPTGPGDVLQD-PTITGLAEKYGKTPAQIVLRWHL-QNG 232
|
...
gi 15596936 278 VAA 280
Cdd:cd19127 233 VSA 235
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
34-218 |
3.33e-11 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 62.86 E-value: 3.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 34 DEERARPFIREALEAGIDFFDSADIYSTgesERILGRALRD-FA----QREDLVIATKaFFPMSDRPnacglsrKHLLAS 108
Cdd:cd19129 17 DPSATRNAVKAALEAGFRHFDCAERYRN---EAEVGEAMQEvFKagkiRREDLFVTTK-LWNTNHRP-------ERVKPA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 109 VDASLRRLGTDYLDLFVIHR--------------------FDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKML 168
Cdd:cd19129 86 FEASLKRLQLDYLDLYLIHTpfafqpgdeqdprdangnviYDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIF 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15596936 169 AFQRHHGLAqfISMQSQYNLivreDEEDLVPLCREEGIALTPWSPLARGL 218
Cdd:cd19129 166 EAARIKPAV--VQVESHPYL----PEWELLDFCKNHGIVLQAFAPLGHGM 209
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
31-281 |
7.29e-11 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 61.75 E-value: 7.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-----AQREDLVIATKAFfpmsdrpnACGLSRKHL 105
Cdd:cd19111 12 YQSPPEEVRAAVDYALFVGYRHIDTALSY---QNEKAIGEALKWWlkngkLKREEVFITTKLP--------PVYLEFKDT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 106 LASVDASLRRLGTDYLDLFVIH-------------RFDPDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAfqr 172
Cdd:cd19111 81 EKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILA--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 173 hhgLAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQaprwyggreevestlgA 252
Cdd:cd19111 158 ---YAKVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSPGRANQSLWPDQPDLLEDP----------------T 218
|
250 260
....*....|....*....|....*....
gi 15596936 253 LEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19111 219 VLAIAKELDKTPAQVLLRFVLQRGTGVLP 247
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
45-281 |
2.14e-10 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 60.71 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 45 ALEAGIDFFDSADIYstgESERILGRALRDF------AQREDLVIATKAFFPMSdRPnacglsrKHLLASVDASLRRLGT 118
Cdd:cd19122 33 ALDVGYRHLDCAWFY---LNEDEVGDAVRDFlkenpsVKREDLFICTKVWNHLH-EP-------EDVKWSIDNSLKNLKL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 119 DYLDLFVIH-------------RFDPD-----------TPiEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFqrhh 174
Cdd:cd19122 102 DYIDLFLVHwpiaaekndqrspKLGPDgkyvilkdlteNP-EPTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSF---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 175 glAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLArgllagarsagtlrtrTDEQAPrwygGREEVESTLGALE 254
Cdd:cd19122 177 --AKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLG----------------SQNQVP----STGERVSENPTLN 234
|
250 260
....*....|....*....|....*..
gi 15596936 255 KLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19122 235 EVAEKGGYSLAQVLIAWGLRRGYVVLP 261
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
31-291 |
8.70e-10 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 58.33 E-value: 8.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYStgeSERILGRALRDFA-QREDLVIATKAFFPmsDRpnacGLSRKHllASV 109
Cdd:cd19134 19 GELSDDEAERSVSAALEAGYRLIDTAAAYG---NEAAVGRAIAASGiPRGELFVTTKLATP--DQ----GFTASQ--AAC 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRfdPDTPIEETCETLDSLVRV---GKVRYLGASSMPAWRFMKMLafqrhhGLAQFISMQSQY 186
Cdd:cd19134 88 RASLERLGLDYVDLYLIHW--PAGREGKYVDSWGGLMKLreeGLARSIGVSNFTAEHLENLI------DLTFFTPAVNQI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 187 NLIVREDEEDLVPLCREEGIALTPWSPLARGLLAgarsagtlrtrtdeQAPrwyggreevestlgALEKLAAARGLPPAQ 266
Cdd:cd19134 160 ELHPLLNQAELRKVNAQHGIVTQAYSPLGVGRLL--------------DNP--------------AVTAIAAAHGRTPAQ 211
|
250 260
....*....|....*....|....*
gi 15596936 267 LALAWLLgRNGVAApIVGLSRPHHL 291
Cdd:cd19134 212 VLLRWSL-QLGNVV-ISRSSNPERI 234
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
34-312 |
1.05e-09 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 58.00 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 34 DEERArpfIREALEAGIDFFDSADIYStgeSERILGRAL--RDFAqREDLVIATKAFfpmSDRPNAcglsrKHLLASVDA 111
Cdd:cd19130 24 DTQRA---VATALEVGYRHIDTAAIYG---NEEGVGAAIaaSGIP-RDELFVTTKLW---NDRHDG-----DEPAAAFAE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 112 SLRRLGTDYLDLFVIHRFDPDTPIE-ETCETLDSLVRVGKVRYLGASS-MPAwrfmkmlAFQRHHGLAQFISMQSQYNLI 189
Cdd:cd19130 89 SLAKLGLDQVDLYLVHWPTPAAGNYvHTWEAMIELRAAGRTRSIGVSNfLPP-------HLERIVAATGVVPAVNQIELH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 190 VREDEEDLVPLCREEGIALTPWSPLARGLLAGARSAGtlrtrtdeqaprwyggreevestlgaleKLAAARGLPPAQLAL 269
Cdd:cd19130 162 PAYQQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVG----------------------------AIAAAHGKTPAQIVL 213
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15596936 270 AWLLGRNGVAAPivGLSRPHHLEDALAALTLDLAEEECATLEA 312
Cdd:cd19130 214 RWHLQKGHVVFP--KSVRRERMEDNLDVFDFDLTDTEIAAIDA 254
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
42-281 |
1.07e-09 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 58.43 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYstgESERILGRALRD-----FAQREDLVIATKAFfpmsdrpnaCGLSRKHLLASV-DASLRR 115
Cdd:cd19110 23 VKVAIDAGYRHFDCAYLY---HNESEVGAGIREkikegVVRREDLFIVSKLW---------CTCHKKSLVKTAcTRSLKA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 116 LGTDYLDLFVIH---RFDP---DTPIEE-------------TCETLDSLVRVGKVRYLGASSMPAWRFMKMLafqRHHGL 176
Cdd:cd19110 91 LKLNYLDLYLIHwpmGFKPgepDLPLDRsgmvipsdtdfldTWEAMEDLVIEGLVKNIGVSNFNHEQLERLL---NKPGL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 177 aQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLargllaGARSagtlrtrtdeqaprwyGGREEVESTLgaLEKL 256
Cdd:cd19110 168 -RVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPL------GGSC----------------EGVDLIDDPV--IQRI 222
|
250 260
....*....|....*....|....*
gi 15596936 257 AAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19110 223 AKKHGKSPAQILIRFQIQRNVIVIP 247
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
31-217 |
5.55e-08 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 53.15 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDFA-QREDLVIATKAFfpmSDRpnacglsRKHLLASV 109
Cdd:PRK11565 23 WQASNEEVITAIHKALEVGYRSIDTAAIY---KNEEGVGKALKEASvAREELFITTKLW---NDD-------HKRPREAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 110 DASLRRLGTDYLDLFVIHRFDP--DTPIEETCETLDsLVRVGKVRYLGASSmpawrfmkmlaFQRHHgLAQFISMQSQYN 187
Cdd:PRK11565 90 EESLKKLQLDYVDLYLMHWPVPaiDHYVEAWKGMIE-LQKEGLIKSIGVCN-----------FQIHH-LQRLIDETGVTP 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 15596936 188 LIvreDEEDLVPLCRE---------EGIALTPWSPLARG 217
Cdd:PRK11565 157 VI---NQIELHPLMQQrqlhawnatHKIQTESWSPLAQG 192
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
31-281 |
5.89e-08 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 53.33 E-value: 5.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 31 WVLDEERARPFIREALEAGIDFFDSADIYST-GESERILGRALRD-FAQREDLVIATKAFfpmsdrpNACGlSRKHLLAS 108
Cdd:cd19114 12 AKIKANETEEVIYNAIKVGYRLIDGALLYGNeAEVGRGIRKAIQEgLVKREDLFIVTKLW-------NNFH-GKDHVREA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 109 VDASLRRLGTDYLDLFVIH-----------------RFDPDT--------PIEETCETLDSLVRVGKVRYLGASSMPAWR 163
Cdd:cd19114 84 FDRQLKDYGLDYIDLYLIHfpipaayvdpaenypflWKDKELkkfpleqsPMQECWREMEKLVDAGLVRNIGIANFNVQL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 164 FMKMLAFQR---------HHGLAQfismqsqynlivredEEDLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDE 234
Cdd:cd19114 164 ILDLLTYAKikpavlqieHHPYLQ---------------QKRLIDWAKKQGIQITAYSSFGNAVYTKVTKHLKHFTNLLE 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 15596936 235 QAprwyggreevestlgALEKLAAARGLPPAQLALAWLLGRNGVAAP 281
Cdd:cd19114 229 HP---------------VVKKLADKHKRDTGQVLLRWAVQRNITVIP 260
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
42-214 |
1.07e-07 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 52.39 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYStgeSERILGRALRD------FAQREDLVIATKAFfpmsdrpnacglSRKHLLASVDASLRR 115
Cdd:cd19106 26 VKYALDAGYRHIDCAAVYG---NEQEVGEALKEkvgpgkAVPREDLFVTSKLW------------NTKHHPEDVEPALRK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 116 ----LGTDYLDLFVIH--------------------RFDpDTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQ 171
Cdd:cd19106 91 tlkdLQLDYLDLYLIHwpyafergdnpfpknpdgtiRYD-STHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVA 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 15596936 172 R----------HHGLAQfismqsqynlivredeEDLVPLCREEGIALTPWSPL 214
Cdd:cd19106 170 RikpavlqvecHPYLAQ----------------NELIAHCKARGLVVTAYSPL 206
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
42-214 |
3.04e-07 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 51.26 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 42 IREALEAGIDFFDSADIYstgESERILGRALRD-----FAQREDLVIATKAFfpmsdrpnaCGLSRKHLL-ASVDASLRR 115
Cdd:cd19107 23 VKVAIDAGYRHIDCAYVY---QNENEVGEAIQEkikeqVVKREDLFIVSKLW---------CTFHEKGLVkGACQKTLSD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 116 LGTDYLDLFVIH---RFDP----------------DTPIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLafqRHHGL 176
Cdd:cd19107 91 LKLDYLDLYLIHwptGFKPgkelfpldesgnvipsDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERIL---NKPGL 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15596936 177 aqfismqsQYNLIVREDE-------EDLVPLCREEGIALTPWSPL 214
Cdd:cd19107 168 --------KYKPAVNQIEchpyltqEKLIQYCQSKGIVVTAYSPL 204
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
8-217 |
5.04e-07 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 50.19 E-value: 5.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 8 NSGLKVSRLCLGcmtygdpAWRPwVLDEERARPFIREALEAGIDFFDSADIYstgESERILGRALRDF-----AQREDLV 82
Cdd:cd19119 7 NTGASIPALGLG-------TASP-HEDRAEVKEAVEAAIKEGYRHIDTAYAY---ETEDFVGEAIKRAiddgsIKREELF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 83 IATKAFFPMSDRPNACglsrkhllasVDASLRRLGTDYLDLFVIH------RFDPDTPIEETCETLDSLVRV-------- 148
Cdd:cd19119 76 ITTKVWPTFYDEVERS----------LDESLKALGLDYVDLLLVHwpvcfeKDSDDSGKPFTPVNDDGKTRYaasgdhit 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 149 -----------GKVRYLGAS--SMPawrFMKMLAFQrhhglAQFISMQSQYNLIVREDEEDLVPLCREEGIALTPWSPLA 215
Cdd:cd19119 146 tykqlekiyldGRAKAIGVSnySIV---YLERLIKE-----CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLG 217
|
..
gi 15596936 216 RG 217
Cdd:cd19119 218 SH 219
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
45-127 |
1.01e-05 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 46.45 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 45 ALEAGIDFFDSADIYSTgesERILGRALRD-----FAQREDLVIATK---AFFpmsdRPNacgLSRKHLlasvDASLRRL 116
Cdd:cd19108 36 AIDAGFRHIDSAYLYQN---EEEVGQAIRSkiadgTVKREDIFYTSKlwcTFH----RPE---LVRPAL----EKSLKKL 101
|
90
....*....|.
gi 15596936 117 GTDYLDLFVIH 127
Cdd:cd19108 102 QLDYVDLYLIH 112
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
45-292 |
1.24e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 40.02 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 45 ALEAGIDFFDSADIYstGESERILGRALRDFAQ-REDLVIATKAFFPMSDRPNACG-------LSRKHLLASVDASLRRL 116
Cdd:cd19098 44 AWAAGVRYFDAARSY--GRAEEFLGSWLRSRNIaPDAVFVGSKWGYTYTADWQVDAavhevkdHSLARLLKQWEETRSLL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 117 GtDYLDLFVIHRFDPDTPIEETCETLDSLVRVGK--VRY-LGASSMPAWRFMKMLAFQRHHGLAQFISMQSQYNLIVRED 193
Cdd:cd19098 122 G-KHLDLYQIHSATLESGVLEDADVLAALAELKAegVKIgLSLSGPQQAETLRRALEIEIDGARLFDSVQATWNLLEQSA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596936 194 EEDLVpLCREEGIALTPWSPLARGLLAGarsagtlRTRTDEQAPRWyggreevestlGALEKLAAARGLPPAQLALAWLL 273
Cdd:cd19098 201 GEALE-EAHEAGMGVIVKEALANGRLTD-------RNPSPELAPLM-----------AVLKAVADRLGVTPDALALAAVL 261
|
250
....*....|....*....
gi 15596936 274 GRNGVAAPIVGLSRPHHLE 292
Cdd:cd19098 262 AQPFVDVVLSGAATPEQLR 280
|
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