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Conserved domains on  [gi|15596929|ref|NP_250423|]
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hypothetical protein PA1732 [Pseudomonas aeruginosa PAO1]

Protein Classification

transglutaminase family protein( domain architecture ID 12090973)

transglutaminase family protein may act as a cysteine protease

CATH:  3.10.620.30|2.60.40.2250

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 89-214 6.94e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 6.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929  89 DRQSPLPFLRSTRLTGADAEMRAFAERAMGGRKD-RGGLLDLMHALHEHILYQPGATRVDSTAIEAFGARAGVCQDHAHA 167
Cdd:COG1305  43 GGTELLAGPGELLSASYDPELRALAAELTGGATTpYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596929 168 FLACVRSQGVPGRYVSGYLYTED----DTHLASHAWAEAWL-GDGWYSFDVT 214
Cdd:COG1305 123 LVALLRALGIPARYVSGYLPGEPppggGRADDAHAWVEVYLpGAGWVPFDPT 174
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-79 3.45e-23

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


:

Pssm-ID: 462455  Cd Length: 80  Bit Score: 89.91  E-value: 3.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929     3 LSITHDTTYRYEDRVRASIQYLRLTPQDSERQHVVDWRLDL-PRPA--RPLRDPYGNILHVLTLDEPHESVLIAAHGLVE 79
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDIsPEPAarRWRRDAFGNRVARFSFDEPHTELVITAESEVE 80
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 89-214 6.94e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 6.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929  89 DRQSPLPFLRSTRLTGADAEMRAFAERAMGGRKD-RGGLLDLMHALHEHILYQPGATRVDSTAIEAFGARAGVCQDHAHA 167
Cdd:COG1305  43 GGTELLAGPGELLSASYDPELRALAAELTGGATTpYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596929 168 FLACVRSQGVPGRYVSGYLYTED----DTHLASHAWAEAWL-GDGWYSFDVT 214
Cdd:COG1305 123 LVALLRALGIPARYVSGYLPGEPppggGRADDAHAWVEVYLpGAGWVPFDPT 174
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-79 3.45e-23

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


Pssm-ID: 462455  Cd Length: 80  Bit Score: 89.91  E-value: 3.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929     3 LSITHDTTYRYEDRVRASIQYLRLTPQDSERQHVVDWRLDL-PRPA--RPLRDPYGNILHVLTLDEPHESVLIAAHGLVE 79
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDIsPEPAarRWRRDAFGNRVARFSFDEPHTELVITAESEVE 80
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 110-212 1.46e-20

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 83.99  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929   110 RAFAERAMGGRKD-RGGLLDLMHALHEHILYQ-PGATRVDSTAIEAFGARAGVCQDHAHAFLACVRSQGVPGRYVSGYLY 187
Cdd:pfam01841   1 KALADRITGGATDpLEKARAIYDYVRKNITYDlPGRSPGDGDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLR 80

                          90       100
                  ....*....|....*....|....*..
gi 15596929   188 TEDD-THLASHAWAEAWL-GDGWYSFD 212
Cdd:pfam01841  81 GPDTvRGGDAHAWVEVYLpGYGWVPVD 107
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 153-215 6.82e-16

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 70.49  E-value: 6.82e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596929    153 AFGARAGVCQDHAHAFLACVRSQGVPGRYVSGYLYTEDDTHLAS-----HAWAEAWLGDGWYSFDVTN 215
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLKAPDTIGGLRsiweaHAWAEVYLEGGWVPVDPTP 68
 
Name Accession Description Interval E-value
YebA COG1305
Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, ...
 89-214 6.94e-35

Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440916 [Multi-domain]  Cd Length: 174  Bit Score: 123.58  E-value: 6.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929  89 DRQSPLPFLRSTRLTGADAEMRAFAERAMGGRKD-RGGLLDLMHALHEHILYQPGATRVDSTAIEAFGARAGVCQDHAHA 167
Cdd:COG1305  43 GGTELLAGPGELLSASYDPELRALAAELTGGATTpYEKARALYDWVRDNIRYDPGSTGVGTTALETLERRRGVCRDFAHL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15596929 168 FLACVRSQGVPGRYVSGYLYTED----DTHLASHAWAEAWL-GDGWYSFDVT 214
Cdd:COG1305 123 LVALLRALGIPARYVSGYLPGEPppggGRADDAHAWVEVYLpGAGWVPFDPT 174
Bact_transglu_N pfam08379
Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus ...
 3-79 3.45e-23

Bacterial transglutaminase-like N-terminal region; This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (pfam01841).


Pssm-ID: 462455  Cd Length: 80  Bit Score: 89.91  E-value: 3.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929     3 LSITHDTTYRYEDRVRASIQYLRLTPQDSERQHVVDWRLDL-PRPA--RPLRDPYGNILHVLTLDEPHESVLIAAHGLVE 79
Cdd:pfam08379   1 YRIRHRTRYRYDEPVSLSPHRLRLRPRSHPGQRVLSYSLDIsPEPAarRWRRDAFGNRVARFSFDEPHTELVITAESEVE 80
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 110-212 1.46e-20

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 83.99  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15596929   110 RAFAERAMGGRKD-RGGLLDLMHALHEHILYQ-PGATRVDSTAIEAFGARAGVCQDHAHAFLACVRSQGVPGRYVSGYLY 187
Cdd:pfam01841   1 KALADRITGGATDpLEKARAIYDYVRKNITYDlPGRSPGDGDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLR 80

                          90       100
                  ....*....|....*....|....*..
gi 15596929   188 TEDD-THLASHAWAEAWL-GDGWYSFD 212
Cdd:pfam01841  81 GPDTvRGGDAHAWVEVYLpGYGWVPVD 107
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 153-215 6.82e-16

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 70.49  E-value: 6.82e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15596929    153 AFGARAGVCQDHAHAFLACVRSQGVPGRYVSGYLYTEDDTHLAS-----HAWAEAWLGDGWYSFDVTN 215
Cdd:smart00460   1 LLKTKYGTCGEFAALFVALLRSLGIPARVVSGYLKAPDTIGGLRsiweaHAWAEVYLEGGWVPVDPTP 68
CYK3 COG5279
Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle ...
 149-214 7.25e-09

Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444090 [Multi-domain]  Cd Length: 250  Bit Score: 55.02  E-value: 7.25e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15596929 149 TAIEAFGARAGVCQDHAHAFLACVRSQGVPGRYVSGYLYTEDDThLASHAWAEAWLGDGWYSFDVT 214
Cdd:COG5279 132 SAYGALKNGKGVCEGYAKLFKLLCNKAGIECYIVTGYARGSGGE-SGNHAWNAVKIDGKWYLVDAT 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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